Abstract
References
- Pelosof LC, Gerber DE. Paraneoplastic syndromes: an approach to diagnosis and treatment. Mayo Clin Proc. 2010;85:838-854. doi:10.4065/mcp.2010.0099.
- Honnorat J. Didelot A, Karantoni E, et al. Autoimmune limbic encephalopathy and anti-Hu antibodies in children without cancer. Neurology 2013;80:2226-2232. doi:10.1212/wnl.0b013e318296e9c3.
- Broadley J, Seneriratne U, Beech P, et al. Prognosticating autoimmune encephalitis: A systematic review. Journal of Autoimmunity 2019;96:24-34. doi:10.1016/j.jaut.2018.10.014.
- Dalmau J, Graus F, Villarejo A, et al. Clinical analysis of anti-Ma2-associated encephalitis,Brain 2004;127:1831-1844. doi:10.1093/brain/awh203.
- De Beukelaar JW, Sillevis Smitt PA. Managing paraneoplastic neurological disorders. Oncologist 2006;11:292-305. doi:10.1634/theoncologist.11-3-292.
- Lou Y, Xu S, Zhang S, Shu Q, Liu X. Anti-Yo antibody-positive paraneoplastic cerebellar degeneration in a patient with possible cholangiocarcinoma: A case report and review of the literature. World Journal of Clinical Cases. 2021;9(17);4423-4432. doi:10.12998/wjcc.v9.i17.4423.
- Hasadsri L, Lee J, Wang BH, Yekkirala L, Wang M. Anti-yo associated paraneoplastic cerebellar degeneration in a man with large cell cancer of the lung. Case Rep Neurol Med. 2013;2013:725936. doi:10.1155/2013/725936.
- Meglic B, Graus F, Grad A. Anti-Yo associated paraneoplastic cerebellar degeneration in a man with gastric adenocarcinoma. J Neurol Sci 2001;185:135–138. doi:10.1016/s0022-510x(01)00467-1.
- Tsukamoto T, Mochizuki R, Mochizuki H, et al. Paraneoplastic cerebellar degeneration and limbic encephalitis in a patient with adenocarcinoma of the colon. Journal of Neurology, Neurosurgery, and Psychiatry 1993;56:713-716. doi:10.1136/jnnp.56.6.713.
- Adam VN, Budinčević H, Mršić V, Stojčić E, Matolić M, Markić A. Paraneoplastic limbic encephalitis in a patient with adenocarcinoma of the colon: a case report. Journal of Clinical Anesthesia 2013;25:491-495. doi:10.1016/j.jclinane.2013.03.014.
NADİR GÖRÜLEN BİR PARANEOPLASTİK LİMBİK ENSEFALİT OLGUSU: ANTİ-YO ANTİKOR POZİTİF KOLON ADENOKARSİNOMU
Abstract
Paraneoplastik otoimmün ensefalit (PAE) nöropsikiyatrik semptomlarla karakterize olan, malignite ile ilişkili nadir görülen bir sendromdur. Malignite varlığında direk neoplastik invazyon olmadan gelişir. Anti-Yo antikoru ile ilişkili paraneoplastik sendromlar genellikle over ve meme kanseri ile ilişkilendirilmiş olup; 60 yaş üstü kadınlarda erkeklerden daha sık gözükmektedir Biz de literatürde nadir gözüken kolon adenokarsinomuna eşlik eden, anti-Yo pozitif meningoensefalit gelişen erkek bir olgu sunmayı amaçladık. 77 yaşında, kolon adenokarsinom tanısı olan bir erkek hasta epileptik nöbet ve konfüzyon tablosu ile başvurdu. Beyin omurilik sıvısında ılımlı düzeyde protein artışı mevcuttu. Kranial MR’da bilateral serebral hemisferlerde yaygın kortikal vazojenik ödem izlendi. Serumda anti-Yo antikoru pozitif tespit edildi. 0,4 mg/g dozunda, 5 gün Ivıg tesdavisi verilen hastada sekelsiz düzelme izlendi. Anti-Yo antikoru otoimmün ensefalitten ziyade genellikle paraneoplastik serebeller dejenerasyon (PCD) kliniğine sebep olur ve genellikle over ve meme kanseri ile ilişkilendirilmiştir. Literatürde kolon adenokarsinomu birlikteliği oldukça nadir bulunmuştur.
References
- Pelosof LC, Gerber DE. Paraneoplastic syndromes: an approach to diagnosis and treatment. Mayo Clin Proc. 2010;85:838-854. doi:10.4065/mcp.2010.0099.
- Honnorat J. Didelot A, Karantoni E, et al. Autoimmune limbic encephalopathy and anti-Hu antibodies in children without cancer. Neurology 2013;80:2226-2232. doi:10.1212/wnl.0b013e318296e9c3.
- Broadley J, Seneriratne U, Beech P, et al. Prognosticating autoimmune encephalitis: A systematic review. Journal of Autoimmunity 2019;96:24-34. doi:10.1016/j.jaut.2018.10.014.
- Dalmau J, Graus F, Villarejo A, et al. Clinical analysis of anti-Ma2-associated encephalitis,Brain 2004;127:1831-1844. doi:10.1093/brain/awh203.
- De Beukelaar JW, Sillevis Smitt PA. Managing paraneoplastic neurological disorders. Oncologist 2006;11:292-305. doi:10.1634/theoncologist.11-3-292.
- Lou Y, Xu S, Zhang S, Shu Q, Liu X. Anti-Yo antibody-positive paraneoplastic cerebellar degeneration in a patient with possible cholangiocarcinoma: A case report and review of the literature. World Journal of Clinical Cases. 2021;9(17);4423-4432. doi:10.12998/wjcc.v9.i17.4423.
- Hasadsri L, Lee J, Wang BH, Yekkirala L, Wang M. Anti-yo associated paraneoplastic cerebellar degeneration in a man with large cell cancer of the lung. Case Rep Neurol Med. 2013;2013:725936. doi:10.1155/2013/725936.
- Meglic B, Graus F, Grad A. Anti-Yo associated paraneoplastic cerebellar degeneration in a man with gastric adenocarcinoma. J Neurol Sci 2001;185:135–138. doi:10.1016/s0022-510x(01)00467-1.
- Tsukamoto T, Mochizuki R, Mochizuki H, et al. Paraneoplastic cerebellar degeneration and limbic encephalitis in a patient with adenocarcinoma of the colon. Journal of Neurology, Neurosurgery, and Psychiatry 1993;56:713-716. doi:10.1136/jnnp.56.6.713.
- Adam VN, Budinčević H, Mršić V, Stojčić E, Matolić M, Markić A. Paraneoplastic limbic encephalitis in a patient with adenocarcinoma of the colon: a case report. Journal of Clinical Anesthesia 2013;25:491-495. doi:10.1016/j.jclinane.2013.03.014.
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Olgu Sunumu |
| Authors | |
| Publication Date | October 21, 2023 |
| Submission Date | November 1, 2022 |
| Acceptance Date | October 17, 2023 |
| Published in Issue | Year 2023 Volume: 6 Issue: 3 |
The articles in the Journal of "Acta Medica Nicomedia" are open access articles licensed under a Creative Commons Attribution-ShareAlike 4.0 International License at the web address https://dergipark.org.tr/tr/pub/actamednicomedia