Helicobacter Pylori Might be a Contributing Factor in Gallbladder Polyps or Gallstones: A Single Center Case-Control Matching Study of Turkish İndividuals

Cenk Özkan; Serhan Yılmaz; Emre Bozdağ; Osman Sıbıç; Erkan Somuncu

doi:10.31067/acusaglik.1454441

Research Article

Helicobacter Pylori Might be a Contributing Factor in Gallbladder Polyps or Gallstones: A Single Center Case-Control Matching Study of Turkish İndividuals

Year 2024, , 374 - 379, 01.10.2024

Cenk Özkan , Serhan Yılmaz , Emre Bozdağ , Osman Sıbıç , Erkan Somuncu

https://doi.org/10.31067/acusaglik.1454441

Cited By: 1

Abstract

Background/Purpose: In recent studies, Helicobacter pylori (Hp) infection; It was stated that it may be associated with diseases such as obesity, diabetes, chronic obstructive pulmonary disease and kidney failure. In our study, we aimed to examine the relationship between Hp infection and gallstones and gallbladder polyps.
Methods: Patients who underwent elective cholecystectomy between January 2017 and December 2021 were retrospectively examined. Patients were divided into those with only polyps in the gallbladder (Group P), those with polyps and stones together (Group SP), and those with only stones (Group S). The control group consisted of patients who underwent gastroscopy due to dyspeptic complaints (Group No). The groups were screened for the presence of Helicobacter pylori. Demographic data, comorbidities, presence of hepatosteatosis and laboratory values were recorded and compared.
Results: 244 patients were included in the study. HP was positive in 141 (57.8%) of the patients and negative in 103 (42.2%). There were 58 (23.8%) patients in Group P, 22 (9%) in Group SP, 90 (36.9%) in Group S, and 74 (30.3%) in Group No. There was a significant difference in age between Group P and Group No (P = 0.012). Female gender was significantly higher in Group S (P=0.009). Helicobacter pylori positivity rate was significantly higher in Group P and Group SP (P = 0.012).
Conclusion: HP infection may be associated with gallbladder polyps. We recommend that prospective randomized controlled studies be supported by large sample data.

Keywords

Helicobacter pylori, gallbladder polyp, gallbladder disease, case-control study, gallstone

Ethical Statement

Ethical approval for the study was granted by the hospital in which the procedures were performed (IRB No: KAEK/2024.04.73).

References

1. Eusebi LH, Zagari RM, Bazzoli F. Epidemiology of Helicobacter pylori infection. Helicobacter. 2014 Sep;19 Suppl 1:1-5. doi: 10.1111/hel.12165.
2. Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the ¹³C-Urea breath test. BMC Public Health. 2013 Dec 21;13:1215. doi: 10.1186/1471-2458-13-1215.
3. Xu MY, Cao B, Yuan BS, et al. Association of anaemia with Helicobacter pylori infection: a retrospective study. Sci Rep. 2017 Oct 18;7(1):13434. doi: 10.1038/s41598-017-13955-3.
4. Chen YY, Fang WH, Wang CC, et al. Helicobacter pylori infection increases risk of incident metabolic syndrome and diabetes: A cohort study. PLoS One. 2019 Feb 19;14(2):e0208913. doi: 10.1371/journal.pone.0208913.
5. Wang JW, Hsu CN, Tai WC, et al. The Association of Helicobacter pylori Eradication with the Occurrences of Chronic Kidney Diseases in Patients with Peptic Ulcer Diseases. PLoS One. 2016 Oct 20;11(10):e0164824. doi: 10.1371/journal.pone.0164824.
6. Terada T. Histopathologic features and frequency of gall bladder lesions in consecutive 540 cholecystectomies. Int J Clin Exp Pathol. 2013;6(1):91-6. Epub 2012 Nov 20.
7. Abdullah AAN, Rangaraj A, Rashid M, et al. Gallbladder polypoid lesions are inaccurately reported and undermanaged: a retrospective study of the management of gallbladder polypoid lesions detected at ultrasound in symptomatic patients during a 36-month period. Clin Radiol. 2019 Jun;74(6):489.e17-489.e23. doi: 10.1016/j.crad.2019.02.009.
8. Foley KG, Lahaye MJ, Thoeni RF, et al. Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE. Eur Radiol. 2022 May;32(5):3358-3368. doi: 10.1007/s00330-021-08384-w.
9. Shabanzadeh DM. Incidence of gallstone disease and complications. Curr Opin Gastroenterol. 2018 Mar;34(2):81-89. doi: 10.1097/MOG.0000000000000418.
10. Hattori T, Sugihara H. The pathological sequence in the development of gastric cancer: I. Scand J Gastroenterol Suppl. 1996;214:34-5; discussion 40-3. doi: 10.3109/00365529609094514.
11. Patnayak R, Reddy V, Jena A, et al. Helicobacter pylori in Cholecystectomy Specimens-Morphological and Immunohistochemical Assessment. J Clin Diagn Res. 2016 May;10(5):EC01-3. doi: 10.7860/JCDR/2016/14802.7716.
12. Pandey M, Shukla M. Helicobacter species are associated with possible increase in risk of hepatobiliary tract cancers. Surg Oncol. 2009 Mar;18(1):51-6. doi: 10.1016/j.suronc.2008.07.002.
13. Abayli B, Colakoglu S, Serin M, et al. Helicobacter pylori in the etiology of cholesterol gallstones. J Clin Gastroenterol. 2005 Feb;39(2):134-7.
14. Bulajic M, Maisonneuve P, Schneider-Brachert W, et al. Helicobacter pylori and the risk of benign and malignant biliary tract disease. Cancer. 2002 Nov 1;95(9):1946-53. doi: 10.1002/cncr.10893.
15. Zhou D, Guan WB, Wang JD, et al. A comparative study of clinicopathological features between chronic cholecystitis patients with and without Helicobacter pylori infection in gallbladder mucosa. PLoS One. 2013 Jul 30;8(7):e70265. doi: 10.1371/journal.pone.0070265.
16. Zhou D, Zhang Y, Gong W, et al. Are Helicobacter pylori and other Helicobacter species infection associated with human biliary lithiasis? A meta-analysis. PLoS One. 2011;6(11):e27390. doi: 10.1371/journal.pone.0027390.
17. Hassan EH, Gerges SS, El-Atrebi KA, et al. The role of H. pylori infection in gall bladder cancer: clinicopathological study. Tumour Biol. 2015 Sep;36(9):7093-8. doi: 10.1007/s13277-015-3444-9.
18. Sipos P, Krisztina H, Blázovics A, et al. Cholecystitis, gallstones and free radical reactions in human gallbladder. Med Sci Monit. 2001 Jan-Feb;7(1):84-8.
19. Monstein HJ, Jonsson Y, Zdolsek J, et al. Identification of Helicobacter pylori DNA in human cholesterol gallstones. Scand J Gastroenterol. 2002 Jan;37(1):112-9. doi: 10.1080/003655202753387455.
20. Belzer C, Kusters JG, Kuipers EJ, et al. Urease induced calcium precipitation by Helicobacter species may initiate gallstone formation. Gut. 2006 Nov;55(11):1678-9. doi: 10.1136/gut.2006.098319.
21. Wang Y, Qi M, Qin C, et al. Role of the biliary microbiome in gallstone disease. Expert Rev Gastroenterol Hepatol. 2018 Dec;12(12):1193-1205. doi: 10.1080/17474124.2018.1533812.
22. Fatemi SM, Doosti A, Shokri D, et al. Is There a Correlation between Helicobacter Pylori and Enterohepatic Helicobacter Species and Gallstone Cholecystitis? Middle East J Dig Dis. 2018 Jan;10(1):24-30. doi: 10.15171/mejdd.2017.86.
23. Cen L, Pan J, Zhou B, et al. Helicobacter Pylori infection of the gallbladder and the risk of chronic cholecystitis and cholelithiasis: A systematic review and meta-analysis. Helicobacter. 2018 Feb;23(1). doi: 10.1111/hel.12457.
24. Helaly GF, El-Ghazzawi EF, Kazem AH, et al. Detection of Helicobacter pylori infection in Egyptian patients with chronic calcular cholecystitis. Br J Biomed Sci. 2014;71(1):13-8. doi: 10.1080/09674845.2014.11669957.
25. Takahashi Y, Yamamichi N, Shimamoto T, et al. Helicobacter pylori infection is positively associated with gallstones: a large-scale cross-sectional study in Japan. J Gastroenterol. 2014 May;49(5):882-9. doi: 10.1007/s00535-013-0832-z.
26. Ari A, Tatar C, Yarikkaya E. Relationship between Helicobacter pylori-positivity in the gallbladder and stomach and effect on gallbladder pathologies. J Int Med Res. 2019 Oct;47(10):4904-4910. doi: 10.1177/0300060519847345.
27. Apostolopoulos P, Vafiadis-Zouboulis I, Tzivras M, et al. Helicobacter pylori (H pylori) infection in Greece: the changing prevalence during a ten-year period and its antigenic profile. BMC Gastroenterol. 2002 May 16;2:11. doi: 10.1186/1471-230x-2-11.
28. Everhart JE, Khare M, Hill M, et al. Prevalence and ethnic differences in gallbladder disease in the United States. Gastroenterology. 1999 Sep;117(3):632-9. doi: 10.1016/s0016-5085(99)70456-7.
29. Stampfer MJ, Maclure KM, Colditz GA, et al. Risk of symptomatic gallstones in women with severe obesity. Am J Clin Nutr. 1992 Mar;55(3):652-8. doi: 10.1093/ajcn/55.3.652.
30. Zhang J, Zhang Y, Chen Y, et al. Helicobacter pylori is not a contributing factor in gallbladder polyps or gallstones: a case-control matching study of Chinese individuals. J Int Med Res. 2020 Oct;48(10):300060520959220. doi: 10.1177/0300060520959220.

Year 2024, , 374 - 379, 01.10.2024

Cenk Özkan , Serhan Yılmaz , Emre Bozdağ , Osman Sıbıç , Erkan Somuncu

https://doi.org/10.31067/acusaglik.1454441

Cited By: 1

Abstract

References

1. Eusebi LH, Zagari RM, Bazzoli F. Epidemiology of Helicobacter pylori infection. Helicobacter. 2014 Sep;19 Suppl 1:1-5. doi: 10.1111/hel.12165.
2. Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the ¹³C-Urea breath test. BMC Public Health. 2013 Dec 21;13:1215. doi: 10.1186/1471-2458-13-1215.
3. Xu MY, Cao B, Yuan BS, et al. Association of anaemia with Helicobacter pylori infection: a retrospective study. Sci Rep. 2017 Oct 18;7(1):13434. doi: 10.1038/s41598-017-13955-3.
4. Chen YY, Fang WH, Wang CC, et al. Helicobacter pylori infection increases risk of incident metabolic syndrome and diabetes: A cohort study. PLoS One. 2019 Feb 19;14(2):e0208913. doi: 10.1371/journal.pone.0208913.
5. Wang JW, Hsu CN, Tai WC, et al. The Association of Helicobacter pylori Eradication with the Occurrences of Chronic Kidney Diseases in Patients with Peptic Ulcer Diseases. PLoS One. 2016 Oct 20;11(10):e0164824. doi: 10.1371/journal.pone.0164824.
6. Terada T. Histopathologic features and frequency of gall bladder lesions in consecutive 540 cholecystectomies. Int J Clin Exp Pathol. 2013;6(1):91-6. Epub 2012 Nov 20.
7. Abdullah AAN, Rangaraj A, Rashid M, et al. Gallbladder polypoid lesions are inaccurately reported and undermanaged: a retrospective study of the management of gallbladder polypoid lesions detected at ultrasound in symptomatic patients during a 36-month period. Clin Radiol. 2019 Jun;74(6):489.e17-489.e23. doi: 10.1016/j.crad.2019.02.009.
8. Foley KG, Lahaye MJ, Thoeni RF, et al. Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE. Eur Radiol. 2022 May;32(5):3358-3368. doi: 10.1007/s00330-021-08384-w.
9. Shabanzadeh DM. Incidence of gallstone disease and complications. Curr Opin Gastroenterol. 2018 Mar;34(2):81-89. doi: 10.1097/MOG.0000000000000418.
10. Hattori T, Sugihara H. The pathological sequence in the development of gastric cancer: I. Scand J Gastroenterol Suppl. 1996;214:34-5; discussion 40-3. doi: 10.3109/00365529609094514.
11. Patnayak R, Reddy V, Jena A, et al. Helicobacter pylori in Cholecystectomy Specimens-Morphological and Immunohistochemical Assessment. J Clin Diagn Res. 2016 May;10(5):EC01-3. doi: 10.7860/JCDR/2016/14802.7716.
12. Pandey M, Shukla M. Helicobacter species are associated with possible increase in risk of hepatobiliary tract cancers. Surg Oncol. 2009 Mar;18(1):51-6. doi: 10.1016/j.suronc.2008.07.002.
13. Abayli B, Colakoglu S, Serin M, et al. Helicobacter pylori in the etiology of cholesterol gallstones. J Clin Gastroenterol. 2005 Feb;39(2):134-7.
14. Bulajic M, Maisonneuve P, Schneider-Brachert W, et al. Helicobacter pylori and the risk of benign and malignant biliary tract disease. Cancer. 2002 Nov 1;95(9):1946-53. doi: 10.1002/cncr.10893.
15. Zhou D, Guan WB, Wang JD, et al. A comparative study of clinicopathological features between chronic cholecystitis patients with and without Helicobacter pylori infection in gallbladder mucosa. PLoS One. 2013 Jul 30;8(7):e70265. doi: 10.1371/journal.pone.0070265.
16. Zhou D, Zhang Y, Gong W, et al. Are Helicobacter pylori and other Helicobacter species infection associated with human biliary lithiasis? A meta-analysis. PLoS One. 2011;6(11):e27390. doi: 10.1371/journal.pone.0027390.
17. Hassan EH, Gerges SS, El-Atrebi KA, et al. The role of H. pylori infection in gall bladder cancer: clinicopathological study. Tumour Biol. 2015 Sep;36(9):7093-8. doi: 10.1007/s13277-015-3444-9.
18. Sipos P, Krisztina H, Blázovics A, et al. Cholecystitis, gallstones and free radical reactions in human gallbladder. Med Sci Monit. 2001 Jan-Feb;7(1):84-8.
19. Monstein HJ, Jonsson Y, Zdolsek J, et al. Identification of Helicobacter pylori DNA in human cholesterol gallstones. Scand J Gastroenterol. 2002 Jan;37(1):112-9. doi: 10.1080/003655202753387455.
20. Belzer C, Kusters JG, Kuipers EJ, et al. Urease induced calcium precipitation by Helicobacter species may initiate gallstone formation. Gut. 2006 Nov;55(11):1678-9. doi: 10.1136/gut.2006.098319.
21. Wang Y, Qi M, Qin C, et al. Role of the biliary microbiome in gallstone disease. Expert Rev Gastroenterol Hepatol. 2018 Dec;12(12):1193-1205. doi: 10.1080/17474124.2018.1533812.
22. Fatemi SM, Doosti A, Shokri D, et al. Is There a Correlation between Helicobacter Pylori and Enterohepatic Helicobacter Species and Gallstone Cholecystitis? Middle East J Dig Dis. 2018 Jan;10(1):24-30. doi: 10.15171/mejdd.2017.86.
23. Cen L, Pan J, Zhou B, et al. Helicobacter Pylori infection of the gallbladder and the risk of chronic cholecystitis and cholelithiasis: A systematic review and meta-analysis. Helicobacter. 2018 Feb;23(1). doi: 10.1111/hel.12457.
24. Helaly GF, El-Ghazzawi EF, Kazem AH, et al. Detection of Helicobacter pylori infection in Egyptian patients with chronic calcular cholecystitis. Br J Biomed Sci. 2014;71(1):13-8. doi: 10.1080/09674845.2014.11669957.
25. Takahashi Y, Yamamichi N, Shimamoto T, et al. Helicobacter pylori infection is positively associated with gallstones: a large-scale cross-sectional study in Japan. J Gastroenterol. 2014 May;49(5):882-9. doi: 10.1007/s00535-013-0832-z.
26. Ari A, Tatar C, Yarikkaya E. Relationship between Helicobacter pylori-positivity in the gallbladder and stomach and effect on gallbladder pathologies. J Int Med Res. 2019 Oct;47(10):4904-4910. doi: 10.1177/0300060519847345.
27. Apostolopoulos P, Vafiadis-Zouboulis I, Tzivras M, et al. Helicobacter pylori (H pylori) infection in Greece: the changing prevalence during a ten-year period and its antigenic profile. BMC Gastroenterol. 2002 May 16;2:11. doi: 10.1186/1471-230x-2-11.
28. Everhart JE, Khare M, Hill M, et al. Prevalence and ethnic differences in gallbladder disease in the United States. Gastroenterology. 1999 Sep;117(3):632-9. doi: 10.1016/s0016-5085(99)70456-7.
29. Stampfer MJ, Maclure KM, Colditz GA, et al. Risk of symptomatic gallstones in women with severe obesity. Am J Clin Nutr. 1992 Mar;55(3):652-8. doi: 10.1093/ajcn/55.3.652.
30. Zhang J, Zhang Y, Chen Y, et al. Helicobacter pylori is not a contributing factor in gallbladder polyps or gallstones: a case-control matching study of Chinese individuals. J Int Med Res. 2020 Oct;48(10):300060520959220. doi: 10.1177/0300060520959220.

There are 30 citations in total.

Details

Primary Language	English
Subjects	Surgery (Other), Gastroenterology and Hepatology
Journal Section	Research Articles
Authors	Cenk Özkan 0000-0001-6801-7704 Serhan Yılmaz 0000-0002-5612-5932 Emre Bozdağ 0000-0002-2729-1667 Osman Sıbıç 0000-0002-7600-9154 Erkan Somuncu 0000-0002-5622-1983
Early Pub Date	September 17, 2024
Publication Date	October 1, 2024
Submission Date	June 5, 2024
Acceptance Date	August 26, 2024
Published in Issue	Year 2024

Cite

EndNote	Özkan C, Yılmaz S, Bozdağ E, Sıbıç O, Somuncu E (October 1, 2024) Helicobacter Pylori Might be a Contributing Factor in Gallbladder Polyps or Gallstones: A Single Center Case-Control Matching Study of Turkish İndividuals. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 15 4 374–379.

Acıbadem Üniversitesi Sağlık Bilimleri Dergisi

Helicobacter Pylori Might be a Contributing Factor in Gallbladder Polyps or Gallstones: A Single Center Case-Control Matching Study of Turkish İndividuals

Abstract

Keywords

Ethical Statement

References

Abstract

References

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Cited By

Should Gallbladder Pathologies Be Investigated in Patients With Colon Polyps?

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https://doi.org/10.7759/cureus.71545