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Dysregulation of HPA Axis in Post-Traumatic Stress Disorder

Year 2018, Volume: 27 Issue: 1, 109 - 125, 31.03.2018

Miraç Barış Usta

https://doi.org/10.17827/aktd.345474

Abstract

Many endocrinological studies have evaluated the role of the hypothalamic-pituitary-adrenal axis in the pathophysiology of post-traumatic stress disorder and have created models. There are many reasons for looking for biomarkers, especially in monitoring treatment effectiveness, and the fact that trauma victims differ in terms of comorbidity, clinical appearance, trauma etiology, and time after trauma lead to variatons in findings. In this review, methods and findings of studies investigating the effects on hypothalamic-pituitary-adrenal function in post-traumatic stress disorder and the findings about hypothalamic-pituitary-adrenal axis hormones tested as biological therapy markers have been discussed.

Keywords

HPA PTSD Biological biomarker psychotherapy

References

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Travma Sonrası Stres Bozukluğunda HPA Ekseninin Disregülasyonu

Year 2018, Volume: 27 Issue: 1, 109 - 125, 31.03.2018

Miraç Barış Usta

https://doi.org/10.17827/aktd.345474

Abstract

Endokrinolojik çalışmalar hipotalamik-pitüiter-adrenal ekseninin travma sonrası stres bozukluğu patofizyolojisinde rolünü değerlendirmiş ve modeller oluşturmuştur. Travma sonrası stres bozukluğunda tedavi etkinliğinin izlenmesi başta olmak üzere birçok nedenle biyolojik belirteç arayışı söz konusudur ve travma mağduru hastalarının komorbidite, klinik görünüm, travma etiyolojisi ve travmadan sonra geçen zaman açısından farklılar göstermesi bulgularda çeşitliliklere sebep olmuştur. Bu gözden geçirmede, travma sonrası stres bozukluğunda hipotalamik-pitüiter-adrenal ekseninin fonksiyonu üzerine etkilerini araştıran çalışmaların yöntem ve bulguları gözden geçirilmiştir ve biyolojik terapi belirteci olarak denenen hipotalamik-pitüiter-adrenal ekseninin hormonları ile ilgili bulgular tartışılmıştır.

Keywords

TSSB psikoterapi HPA biyolojik belirtec

References

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  • 21. Gerardi M, Rothbaum BO, Astin MC, Kelley M. Cortisol response following exposure treatment for PTSD in rape victims. J Aggress Maltreat Trauma 2010;19:349-56.
  • 22. Nijdam M, van Amsterdam J, Gersons B, Olff M. Dexamethasone-suppressed cortisol awakening response predicts treatment outcome in posttraumatic stress disorder. J Affect Disord 2015;184:205-8.
  • 23. Kimbrel NA, Morissette SB, Meyer EC, Chrestman R, Jamroz R, Silvia PJ, et al. Effect of the 5-HTTLPR polymorphism on posttraumatic stress disorder, depression, anxiety, and quality of life among Iraq and Afghanistan veterans. Anxiety Stress Coping 2015;28(4):456-66.
  • 24. Heim C, Mletzko T, Purselle D, Musselman DL, Nemeroff CB. The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma. Biol Psychiatry 2008;63:398-405.
  • 25. Yehuda R, Brand S, Golier J, Yang RK. Clinical correlates of DHEA associated with post‐traumatic stress disorder. Acta Psychiatr Scand 2006;114:187-93.
  • 26. Lupien SJ, Maheu F, Tu M, Fiocco A, Schramek TE. The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition. Brain Cogn 2007;65:209-37.
  • 27. Herman JP, Figueiredo H, Mueller NK, Ulrich-Lai Y, Ostrander MM, Choi DC, et al. Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo–pituitary–adrenocortical responsiveness. Front Neuroendocrinol 2003;24:151-80.
  • 28. Brown RE. An introduction to neuroendocrinology: Cambridge University Press Cambridge; 1994.
  • 29. McEwen BS. The neurobiology of stress: from serendipity to clinical relevance. Brain Res Rev 2000;886:172-89.
  • 30. Herman JP, Cullinan WE. Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis. Trends Neurosci 1997;20:78-84.
  • 31. Herman JP, Ostrander MM, Mueller NK, Figueiredo H. Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:1201-13.
  • 32. Weitzman ED, Fukushima D, Nogeire C, Roffwarg H, Gallagher T, Hellman L. Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects. J Clin Endocrinol Metab 1971;33:14-22.
  • 33. Pruessner JC, Dedovic K, Khalili-Mahani N, Engert V, Pruessner M, Buss C, et al. Deactivation of the limbic system during acute psychosocial stress: evidence from positron emission tomography and functional magnetic resonance imaging studies. Biol Psychiatry. 2008;63:234-40.
  • 34. Dickerson SS, Kemeny ME. Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol Bull 2004;130:355.
  • 35. Price JL. Comparative aspects of amygdala connectivity. Annals of the New York Academy of Sciences 2003;985:50-8.
  • 36. Meaney MJ, Plotsky PM. Long-term behavioral and neuroendocrine adaptations to adverse early experience. The Biological Basis For Mind Body Interactions 2000;122:81.
  • 37. Plotsky PM, Thrivikraman K, Nemeroff CB, Caldji C, Sharma S, Meaney MJ. Long-term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring. Neuropsychopharmacology 2005;30:2192-204.
  • 38. Härfstrand A, Fuxe K, Cintra A, Agnati LF, Zini I, Wikström A-C, et al. Glucocorticoid receptor immunoreactivity in monoaminergic neurons of rat brain. Proceedings of the National Academy of Sciences 1986;83:9779-83.
  • 39. Pruessner JC, Champagne F, Meaney MJ, Dagher A. Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C] raclopride. J Neurosci 2004;24:2825-31.
  • 40. Glover DA, Poland RE. Urinary cortisol and catecholamines in mothers of child cancer survivors with and without PTSD. Psychoneuroendocrinology 2002;27:805-19.
  • 41. Jensen CF, Keller TW, Peskind ER, McFall ME, Veith RC, Martin D, et al. Behavioral and neuroendocrine responses to sodium lactate infusion in subjects with posttraumatic stress disorder. Am J Psychiatry 1997;154:266-8.
  • 42. Kellner M, Baker DG, Yehuda R. Salivary cortisol in Operation Desert Storm returnees. Biol Psychiatry 1997;42:849-50.
  • 43. Mason JW, Giller EL, Kosten TR, Ostroff RB, Podd L. Urinary free-cortisol levels in posttraumatic stress disorder patients. J Nerv Ment Dis 1986;174:145-9.
  • 44. Thaller V, Vrkljan M, Hotujac L, Thakore J. The potential role of hypocortisolism in the pathophysiology of PTSD and psoriasis. Coll Antropol 1999;23:611-9.
  • 45. Yehuda R. Psychoneuroendocrinology of post-traumatic stress disorder. Psychiatr Clin North Am 1998;21:359-79.
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There are 88 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Review
Authors

Miraç Barış Usta

Publication Date March 31, 2018
Acceptance Date November 6, 2017
Published in Issue Year 2018 Volume: 27 Issue: 1

Cite

AMA Usta MB. Travma Sonrası Stres Bozukluğunda HPA Ekseninin Disregülasyonu. aktd. March 2018;27(1):109-125. doi:10.17827/aktd.345474
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