Abstract
Otofaji hasarlı veya gereksiz protein ve organellerin temizlenmesi ve besinsel strese yanıt olarak enerji kaynaklarını dengelemek amacıyla hücrenin kendini parçalama sürecidir. Apoptozis mekanizması hasarlı olan tümör hücrelerinde otofaji, hücrenin sağ-kalım süresini uzatmaktadır. Bununla birlikte otofaji, tümör oluşumunun erken evrelerinde tümör baskılanmasını sağlayabilir. Bu durumda otofajinin uyarılması kanserin önlenmesinde yararlı olabilir. Bu derlemede otofajinin önemi, normal dokulara kıyasla tümör dokusuna olan bağımlılığına ve tümör oluşumunda metabolizmaya olan etkisi tartışılarak genel bir bakış açısı ile sunulmuştur.
References
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- 12. Blasiak J, Piechota M, Pawlowska E, Szatkowska M, Sikora E, Kaarniranta K, Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?, Oxid Med Cell Longev.2017;doi: 10.1155.
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Abstract
Autophagy is the process of self-disruption of the cell in order to clean up damaged or unnecessary proteins and organelle and to balance energy resources in response to nutritional stress. In tumor cells that are damaged by the mechanism of apoptosis, autophagy prolongs the survival time of the cell. However, autophagy may provide tumor suppression in the early stages of tumor formation. In this case, induction of autophagia may be beneficial in the prevention of cancer. In this review, the autophagy is presented with a general view on the effect of autophagy on the tumor tissue dependence compared to normal tissues and on the metabolism in tumor formation
References
- 1. Arslan D, Korkmaz G, Gözüaçık D. Otofaji: Bir Hücresel Stres Yanıtı ve Ölüm Mekanizması. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi.2011;4:184-194.
- 2. Karadağ A. Otofaji: Programlı Hücre Ölümü. Ankara Sağlık Hizmetleri Dergisi.2016;15:20-26.
- 3. Cho K. Autophagy and cancer. EXPERIMENTAL and MOLECULAR MEDICINE.2012;44:109-120.
- 4. Vassiliki R, Wadsworth K, White E. Role of autophagy in cancer, Nat Rev Cancer.2007; 12:961–967.
- 5. Sipos F, Székely H, Kis D, Tulassay Z, Műzes G, Relation of the IGF/IGF1R system to autophagy in colitis and colorectal cancer.2017;46:8109-8119.
- 6. Yu C, Li W, Liu J, Lu W, Feng F, Autophagy: novel applications of nonsteroidal anti-inflammatory drugs for primary cancer, Cancer Med.2017;DOI:10.1002/cam4.1287.
- 7. Molino D, Nascimbeni A, Giordano F, Codogno P, Morel E, ER-driven membrane contact sites: Evolutionary conserved machineries for stress response and autophagy regulation?, Commun Integr Biol.2017;10:5-6.
- 8. Takahama M, Akira S, Saitoh T, Autophagy limits activation of the inflammasomes, Immunol Rev.2018;1:62-73.
- 9. Taewook N, Jong H, Sushil D, Lee H, Emerging Paradigm of Crosstalk between Autophagy and the Ubiquitin-Proteasome System, Mol. Cells.2017;12:897-905.
- 10. Mialet-Perez J, Vindis C, Autophagy in health and disease: focus on the cardiovascular system. Essays Biochem.2017;61:721-732.
- 11. Johnson C, Tee, ‘Exploiting cancer vulnerabilities: mTOR, autophagy, and homeostatic imbalance’, Essays Biochem.2017;6:699-710.
- 12. Blasiak J, Piechota M, Pawlowska E, Szatkowska M, Sikora E, Kaarniranta K, Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?, Oxid Med Cell Longev.2017;doi: 10.1155.
- 13. Boone B, Zeh H, Bahary N, Autophagy Inhibition in Pancreatic Adenocarcinoma, Clin Colorectal Cancer.2017;DOI: 10.1016/j.clcc.2017.10.013.
- 14. Kang R, Tang D, Autophagy in pancreatic cancer pathogenesis and treatment Am J Cancer Res. 2012;2:383-396.
- 15. Kim S.E, Park H.J, Jeong H.K, Autophagy sustains the survival of human pancreatic cancer PANC-1 cells under extreme nutrient deprivation conditions. Biochem Biophys Res Commun. 2015;46:205-210.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Review |
| Authors | |
| Publication Date | December 31, 2018 |
| Acceptance Date | March 2, 2018 |
| Published in Issue | Year 2018 Volume: 27 Issue: 4 |
