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Year 2022, Volume: 3 Issue: 2, 45 - 49, 30.12.2022

Beytullah Özkaya Davut Sinan Kaplan Caner Yıldırım Hakim Çelik Fırat Akcan Tugba Kılıç

https://doi.org/10.51539/biotech.1180314

Abstract

References

  • Aydin, S. (2014). Three new players in energy regulation: preptin, adropin and irisin. Peptides, 56, 94-110. doi:10.1016/j.peptides.2014.03.021
  • Bostrom, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., . Spiegelman, B. M. (2012). A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 481(7382), 463-468. doi:10.1038/nature10777
  • Butler, A. A., Tam, C. S., Stanhope, K. L., Wolfe, B. M., Ali, M. R., O'Keeffe, M., Havel, P. J. (2012). Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans. J Clin Endocrinol Metab, 97(10), 3783-3791. doi:10.1210/jc.2012-2194
  • Cheng, K. C., Li, Y. X., Asakawa, A., Ushikai, M., Kato, I., Sato, Y., . . . Inui, A. (2012). Characterization of preptin-induced insulin secretion in pancreatic beta-cells. J Endocrinol, 215(1), 43-49. doi:10.1530/JOE-12-0176
  • El-Eshmawy, M., & Abdel Aal, I. (2015). Relationships between preptin and osteocalcin in obese, overweight, and normal weight adults. Appl Physiol Nutr Metab, 40(3), 218-222. doi:10.1139/apnm-2014-0338
  • Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012). FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism, 61(12), 1725-1738. doi:10.1016/j.metabol.2012.09.002
  • Irving, B. A., Still, C. D., & Argyropoulos, G. (2014). Does IRISIN Have a BRITE Future as a Therapeutic Agent in Humans? Curr Obes Rep, 3, 235-241. doi:10.1007/s13679-014-0091-1
  • Kristin I. Stanford, R. J. W. M., Kristy L. Townsend, Ding An, Eva B. Nygaard, Kristen M. Hitchcox, Kathleen R. Markan, Kazuhiro Nakano, Michael F. Hirshman, Yu-Hua Tseng, Laurie J. Goodyear. (2013). Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. The Journal of Clinical Investigation, 123, 215-223. doi:10.1172/JCI62308
  • Kumar, K. G., Trevaskis, J. L., Lam, D. D., Sutton, G. M., Koza, R. A., Chouljenko, V. N., . . . Butler, A. A. (2008). Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab, 8(6), 468-481. doi:10.1016/j.cmet.2008.10.011
  • Lovren, F., Pan, Y., Quan, A., Singh, K. K., Shukla, P. C., Gupta, M., . . . Verma, S. (2010). Adropin is a novel regulator of endothelial function. Circulation, 122(11 Suppl), S185-192. doi:10.1161/CIRCULATIONAHA.109.931782
  • Mohammad Rahimi, G. R., Bijeh, N., & Rashidlamir, A. (2020). Effects of exercise training on serum preptin, undercarboxylated osteocalcin and high molecular weight adiponectin in adults with metabolic syndrome. Exp Physiol, 105(3), 449-459. doi:10.1113/EP088036
  • Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., . . . Drevon, C. A. (2014). The effects of acute and chronic exercise on PGC-1alpha, irisin and browning of subcutaneous adipose tissue in humans. FEBS J, 281(3), 739-749. doi:10.1111/febs.12619
  • Pardo, M., Crujeiras, A. B., Amil, M., Aguera, Z., Jimenez-Murcia, S., Banos, R., . . . Casanueva, F. F. (2014). Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index. Int J Endocrinol, 2014, 857270. doi:10.1155/2014/857270
  • Pekkala, S., Wiklund, P. K., Hulmi, J. J., Ahtiainen, J. P., Horttanainen, M., Pollanen, E., . . . Cheng, S. (2013). Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health? J Physiol, 591(21), 5393-5400. doi:10.1113/jphysiol.2013.263707
  • Perakakis, N., Triantafyllou, G. A., Fernandez-Real, J. M., Huh, J. Y., Park, K. H., Seufert, J., & Mantzoros, C. S. (2017). Physiology and role of irisin in glucose homeostasis. Nat Rev Endocrinol, 13(6), 324-337. doi:10.1038/nrendo.2016.221
  • Polyzos, S. A., Anastasilakis, A. D., Efstathiadou, Z. A., Makras, P., Perakakis, N., Kountouras, J., & Mantzoros, C. S. (2018). Irisin in metabolic diseases. Endocrine, 59(2), 260-274. doi:10.1007/s12020-017-1476-1
  • Sayin, O., Tokgoz, Y., & Arslan, N. (2014). Investigation of adropin and leptin levels in pediatric obesity-related nonalcoholic fatty liver disease. J Pediatr Endocrinol Metab, 27(5-6), 479-484. doi:10.1515/jpem-2013-0296
  • Spiegelman, B. M., & Korsmeyer, S. J. (2012). Irisin and the therapeutic benefits of exercise. BMC Proceedings, 6(Suppl 3), O23. doi:10.1186/1753-6561-6-s3-o23
  • Stengel, A., Hofmann, T., Goebel-Stengel, M., Elbelt, U., Kobelt, P., & Klapp, B. F. (2013). Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity--correlation with body mass index. Peptides, 39, 125-130. doi:10.1016/j.peptides.2012.11.014
  • Timmons, J. A., Baar, K., Davidsen, P. K., & Atherton, P. J. (2012). Is irisin a human exercise gene? Nature, 488(7413), E9-10; discussion E10-11. doi:10.1038/nature11364
  • Yang, G., Li, L., Chen, W., Liu, H., Boden, G., & Li, K. (2009). Circulating preptin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects. Ann Med, 41(1), 52-56. doi:10.1080/07853890802244142
  • Yu, H. Y., Zhao, P., Wu, M. C., Liu, J., & Yin, W. (2014). Serum adropin levels are decreased in patients with acute myocardial infarction. Regul Pept, 190-191, 46-49. doi:10.1016/j.regpep.2014.04.001
  • Zhao, L. P., Xu, W. T., Wang, L., You, T., Chan, S. P., Zhao, X., & Yang, X. J. (2015). Serum adropin level in patients with stable coronary artery disease. Heart Lung Circ, 24(10), 975-979. doi:10.1016/j.hlc.2015.03.008

Serum levels of irisin, adropin and preptin in obese and athletes

Year 2022, Volume: 3 Issue: 2, 45 - 49, 30.12.2022

Beytullah Özkaya Davut Sinan Kaplan Caner Yıldırım Hakim Çelik Fırat Akcan Tugba Kılıç

https://doi.org/10.51539/biotech.1180314

Abstract

The aim of this study is to investigate the endocrine factors thought to play a role in the regulation of energy homeostasis of irisin, adropin and preptin. Our study consists of men between 30-40 years of age including individuals from overweight or obese (n = 25), practicing regular aerobic exercise (n = 25) and sedentary (control, n = 25) groups. Irisin, adropin and preptin levels were studied on blood serum samples prepared using commercially available ELISA kit. The serum irisin level in the obese group was significantly higher than the both exercising and control groups (p <0,05). The serum adropin level in the obese group were significantly lower than control and exercising groups (p <0,05). The serum preptin level in the exercising groups were significantly lower than control (p <0,05). In addition, negative correlation was found between serum adropin and irisin levels (p <0,05). When ROC curves are analyzed, it is seen that high irisin value and low adropin value in obese individuals distinguish obese individuals from other groups with high sensitivity. In this study, serum irisin levels may increase in the obese individuals is due to more muscle activity. In addition, low levels of serum adropin and no change in preptin levels in obese individuals were considered as risk factors in terms of metabolic diseases. As a result, an active lifestyle is suggested to take advantage of the physiological benefits of irisin

Keywords

irisin adropin preptin exercise obesity

References

  • Aydin, S. (2014). Three new players in energy regulation: preptin, adropin and irisin. Peptides, 56, 94-110. doi:10.1016/j.peptides.2014.03.021
  • Bostrom, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., . Spiegelman, B. M. (2012). A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 481(7382), 463-468. doi:10.1038/nature10777
  • Butler, A. A., Tam, C. S., Stanhope, K. L., Wolfe, B. M., Ali, M. R., O'Keeffe, M., Havel, P. J. (2012). Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans. J Clin Endocrinol Metab, 97(10), 3783-3791. doi:10.1210/jc.2012-2194
  • Cheng, K. C., Li, Y. X., Asakawa, A., Ushikai, M., Kato, I., Sato, Y., . . . Inui, A. (2012). Characterization of preptin-induced insulin secretion in pancreatic beta-cells. J Endocrinol, 215(1), 43-49. doi:10.1530/JOE-12-0176
  • El-Eshmawy, M., & Abdel Aal, I. (2015). Relationships between preptin and osteocalcin in obese, overweight, and normal weight adults. Appl Physiol Nutr Metab, 40(3), 218-222. doi:10.1139/apnm-2014-0338
  • Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012). FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism, 61(12), 1725-1738. doi:10.1016/j.metabol.2012.09.002
  • Irving, B. A., Still, C. D., & Argyropoulos, G. (2014). Does IRISIN Have a BRITE Future as a Therapeutic Agent in Humans? Curr Obes Rep, 3, 235-241. doi:10.1007/s13679-014-0091-1
  • Kristin I. Stanford, R. J. W. M., Kristy L. Townsend, Ding An, Eva B. Nygaard, Kristen M. Hitchcox, Kathleen R. Markan, Kazuhiro Nakano, Michael F. Hirshman, Yu-Hua Tseng, Laurie J. Goodyear. (2013). Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. The Journal of Clinical Investigation, 123, 215-223. doi:10.1172/JCI62308
  • Kumar, K. G., Trevaskis, J. L., Lam, D. D., Sutton, G. M., Koza, R. A., Chouljenko, V. N., . . . Butler, A. A. (2008). Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab, 8(6), 468-481. doi:10.1016/j.cmet.2008.10.011
  • Lovren, F., Pan, Y., Quan, A., Singh, K. K., Shukla, P. C., Gupta, M., . . . Verma, S. (2010). Adropin is a novel regulator of endothelial function. Circulation, 122(11 Suppl), S185-192. doi:10.1161/CIRCULATIONAHA.109.931782
  • Mohammad Rahimi, G. R., Bijeh, N., & Rashidlamir, A. (2020). Effects of exercise training on serum preptin, undercarboxylated osteocalcin and high molecular weight adiponectin in adults with metabolic syndrome. Exp Physiol, 105(3), 449-459. doi:10.1113/EP088036
  • Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., . . . Drevon, C. A. (2014). The effects of acute and chronic exercise on PGC-1alpha, irisin and browning of subcutaneous adipose tissue in humans. FEBS J, 281(3), 739-749. doi:10.1111/febs.12619
  • Pardo, M., Crujeiras, A. B., Amil, M., Aguera, Z., Jimenez-Murcia, S., Banos, R., . . . Casanueva, F. F. (2014). Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index. Int J Endocrinol, 2014, 857270. doi:10.1155/2014/857270
  • Pekkala, S., Wiklund, P. K., Hulmi, J. J., Ahtiainen, J. P., Horttanainen, M., Pollanen, E., . . . Cheng, S. (2013). Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health? J Physiol, 591(21), 5393-5400. doi:10.1113/jphysiol.2013.263707
  • Perakakis, N., Triantafyllou, G. A., Fernandez-Real, J. M., Huh, J. Y., Park, K. H., Seufert, J., & Mantzoros, C. S. (2017). Physiology and role of irisin in glucose homeostasis. Nat Rev Endocrinol, 13(6), 324-337. doi:10.1038/nrendo.2016.221
  • Polyzos, S. A., Anastasilakis, A. D., Efstathiadou, Z. A., Makras, P., Perakakis, N., Kountouras, J., & Mantzoros, C. S. (2018). Irisin in metabolic diseases. Endocrine, 59(2), 260-274. doi:10.1007/s12020-017-1476-1
  • Sayin, O., Tokgoz, Y., & Arslan, N. (2014). Investigation of adropin and leptin levels in pediatric obesity-related nonalcoholic fatty liver disease. J Pediatr Endocrinol Metab, 27(5-6), 479-484. doi:10.1515/jpem-2013-0296
  • Spiegelman, B. M., & Korsmeyer, S. J. (2012). Irisin and the therapeutic benefits of exercise. BMC Proceedings, 6(Suppl 3), O23. doi:10.1186/1753-6561-6-s3-o23
  • Stengel, A., Hofmann, T., Goebel-Stengel, M., Elbelt, U., Kobelt, P., & Klapp, B. F. (2013). Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity--correlation with body mass index. Peptides, 39, 125-130. doi:10.1016/j.peptides.2012.11.014
  • Timmons, J. A., Baar, K., Davidsen, P. K., & Atherton, P. J. (2012). Is irisin a human exercise gene? Nature, 488(7413), E9-10; discussion E10-11. doi:10.1038/nature11364
  • Yang, G., Li, L., Chen, W., Liu, H., Boden, G., & Li, K. (2009). Circulating preptin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects. Ann Med, 41(1), 52-56. doi:10.1080/07853890802244142
  • Yu, H. Y., Zhao, P., Wu, M. C., Liu, J., & Yin, W. (2014). Serum adropin levels are decreased in patients with acute myocardial infarction. Regul Pept, 190-191, 46-49. doi:10.1016/j.regpep.2014.04.001
  • Zhao, L. P., Xu, W. T., Wang, L., You, T., Chan, S. P., Zhao, X., & Yang, X. J. (2015). Serum adropin level in patients with stable coronary artery disease. Heart Lung Circ, 24(10), 975-979. doi:10.1016/j.hlc.2015.03.008
There are 23 citations in total.

Details

Primary Language English
Subjects Biochemistry and Cell Biology (Other), Clinical Sciences
Journal Section Research Articles
Authors

Beytullah Özkaya

Davut Sinan Kaplan 0000-0003-4663-209X

Caner Yıldırım 0000-0003-0091-9925

Hakim Çelik

Fırat Akcan 0000-0002-3610-0973

Tugba Kılıç

Publication Date December 30, 2022
Acceptance Date October 23, 2022
Published in Issue Year 2022 Volume: 3 Issue: 2

Cite

APA Özkaya, B., Kaplan, D. S., Yıldırım, C., Çelik, H., et al. (2022). Serum levels of irisin, adropin and preptin in obese and athletes. Bulletin of Biotechnology, 3(2), 45-49. https://doi.org/10.51539/biotech.1180314
AMA Özkaya B, Kaplan DS, Yıldırım C, Çelik H, Akcan F, Kılıç T. Serum levels of irisin, adropin and preptin in obese and athletes. Bull. Biotechnol. December 2022;3(2):45-49. doi:10.51539/biotech.1180314
Chicago Özkaya, Beytullah, Davut Sinan Kaplan, Caner Yıldırım, Hakim Çelik, Fırat Akcan, and Tugba Kılıç. “Serum Levels of Irisin, Adropin and Preptin in Obese and Athletes”. Bulletin of Biotechnology 3, no. 2 (December 2022): 45-49. https://doi.org/10.51539/biotech.1180314.
EndNote Özkaya B, Kaplan DS, Yıldırım C, Çelik H, Akcan F, Kılıç T (December 1, 2022) Serum levels of irisin, adropin and preptin in obese and athletes. Bulletin of Biotechnology 3 2 45–49.
IEEE B. Özkaya, D. S. Kaplan, C. Yıldırım, H. Çelik, F. Akcan, and T. Kılıç, “Serum levels of irisin, adropin and preptin in obese and athletes”, Bull. Biotechnol., vol. 3, no. 2, pp. 45–49, 2022, doi: 10.51539/biotech.1180314.
ISNAD Özkaya, Beytullah et al. “Serum Levels of Irisin, Adropin and Preptin in Obese and Athletes”. Bulletin of Biotechnology 3/2 (December 2022), 45-49. https://doi.org/10.51539/biotech.1180314.
JAMA Özkaya B, Kaplan DS, Yıldırım C, Çelik H, Akcan F, Kılıç T. Serum levels of irisin, adropin and preptin in obese and athletes. Bull. Biotechnol. 2022;3:45–49.
MLA Özkaya, Beytullah et al. “Serum Levels of Irisin, Adropin and Preptin in Obese and Athletes”. Bulletin of Biotechnology, vol. 3, no. 2, 2022, pp. 45-49, doi:10.51539/biotech.1180314.
Vancouver Özkaya B, Kaplan DS, Yıldırım C, Çelik H, Akcan F, Kılıç T. Serum levels of irisin, adropin and preptin in obese and athletes. Bull. Biotechnol. 2022;3(2):45-9.
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