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İrritabl Bağırsak Sendromlu Hastalarda Laktoz İntoleransı ve Osteoporoz Gelişimi

Year 2022, Volume: 4 Issue: 3, 253 - 260, 26.12.2022
https://doi.org/10.46413/boneyusbad.1184664

Abstract

İrritabl bağırsak sendromu (IBS), gastrointestinal sistem hastalıkları arasında en sık görülen kronik fonksiyonel bozukluklardan biridir. Dünya genelinde prevalansı yüksek olan IBS, hastaların yaşam kalitesini olumsuz yönde etkilemektedir. IBS'nin gelişiminde etkili olan mekanizmalar tam olarak anlaşılamamıştır. Ancak mekanizmasının multifaktöriyel olduğu düşünülmektedir. IBS, karın ağrısı, ishal, kabızlık, gaz ve hazımsızlık gibi belirli semptomlarla karakterizedir. Bununla birlikte, bu semptomlar IBS'ye özgü değildir ve sıklıkla laktoz intoleransı (LI) semptomları ile karşılaşılabilmektedir. Öte yandan İBS hastalarında aynı anda LI görülme olasılığı oldukça yüksektir. IBS hastaları, semptomlarını tetikledikleri düşüncesiyle laktoz içeren gıdaları özellikle süt ve süt ürünlerini kısıtlamakta ve bunun sonucunda kalsiyum eksikliği oluşabilmektedir. Bu hastaların uzun süre yetersiz kalsiyum alması sonucunda osteoporoz ve osteoporotik kırık riski önemli bir sorun haline gelmektedir. Tüm bu faktörler doğrultusunda bu derleme, İBS hastalarında LI varlığına bağlı olarak gelişebilecek osteoporozu incelemeyi ve beslenme önerilerinde bulunmayı amaçlamaktadır.

References

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Lactose Intolerance and Osteoporosis Development in Irritable Bowel Syndrome Patients

Year 2022, Volume: 4 Issue: 3, 253 - 260, 26.12.2022
https://doi.org/10.46413/boneyusbad.1184664

Abstract

Irritable bowel syndrome (IBS) is one of the most common chronic functional disorders among gastrointestinal system diseases. IBS, which has a high prevalence worldwide, negatively affects the quality of life of patients. The mechanisms that are effective in the development of IBS has not clearly been defined. However, its mechanism is thought to be multifactorial. IBS is characterized by certain symptoms, such as abdominal pain, diarrhea, constipation, flatulence, and indigestion. Nevertheless, these symptoms aren’t specific to IBS and can often be confused with lactose intolerance (LI) symptoms. On the other hand, the probability of having LI at the same time is quite high in IBS patients. IBS patients restrict lactose-containing foods, especially milk and dairy products, due to the thought that they trigger their symptoms, and thus calcium deficiency may occur as a result. Due to insufficient calcium intake for a long time, the risk of osteoporosis and osteoporotic fractures becomes an important problem. In line with all these factors, this review aims to examine osteoporosis that may develop due to the presence of LI in IBS patients and to make nutritional recommendations.

References

  • Algera, J., Colomier, E., Simrén, M. (2019). The dietary management of patients with irritable bowel syndrome: A narrative review of the existing and emerging evidence. Nutrients, 11(9). doi:10.3390/nu11092162
  • Ali, T., Lam, D., Bronze, M. S., Humphrey, M. B. (2009). Osteoporosis in inflammatory bowel disease. American Journal of Medicine, 122(7), 599-604. doi:10.1016/j.amjmed.2009.01.022
  • Alkan, B. M., Fidan, F., Tosun, A., Ardıçoğlu, Ö. (2011). Fiziksel Tıp ve rehabilitasyon polikliniğimize başvuran hastalarda osteoporoz insidansı. Turkish Journal of Osteoporosis, 17(1), 0-0.
  • Almazar, A. E., Chang, J. Y., Larson, J. J., Atkinson, E. J., Locke, G. R., Talley, . . . N. J., Saito, Y. A. (2019). Comparison of lactase variant MCM6 -13910 C>T testing and self-report of dairy sensitivity in patients with irritable bowel syndrome. Journal of Clinical Gastroenterology, 53(6), e227-e231. doi:10.1097/mcg.0000000000001065
  • Bellini, M., Tonarelli, S., Mumolo, M. G., Bronzini, F., Pancetti, A., Bertani, L., . . . Rossi, A. (2020). Low fermentable oligo- di- and mono-saccharides and polyols (FODMAPs) or gluten free diet: What is best for irritable bowel syndrome? Nutrients, 12(11). doi:10.3390/nu12113368
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  • Campbell, A. K., Matthews, S. B., Vassel, N., Cox, C. D., Naseem, R., Chaichi, J., . . . Wann, K. T. (2010). Bacterial metabolic 'toxins': a new mechanism for lactose and food intolerance, and irritable bowel syndrome. Toxicology, 278(3), 268-276. doi:10.1016/j.tox.2010.09.001
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  • Chey, W. D., Keefer, L., Whelan, K., Gibson, P. R. (2021). Behavioral and diet therapies in integrated care for patients with irritable bowel syndrome. Gastroenterology, 160(1), 47-62. doi:10.1053/j.gastro.2020.06.099
  • Chey, W. D., Kurlander, J., Eswaran, S. (2015). Irritable bowel syndrome: A clinical review. Jama, 313(9), 949-958. doi:10.1001/jama.2015.0954
  • Compston, J. E. (2013). Bone: Risk of osteoporotic fractures in irritable bowel syndrome. Nature Reviews Endocrinology, 9(1), 8-9. doi:10.1038/nrendo.2012.216
  • Cozma-Petruţ, A., Loghin, F., Miere, D., Dumitraşcu, D. L. (2017). Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients! World Journal of Gastroenterology: WJG, 23(21), 3771-3783. doi:10.3748/wjg.v23.i21.3771
  • Dabak, M. R., Küçük, T. A., Tüzün, S., Çetin, H., Ahıshalı, E., Dolapçıoğlu, C. (2019). İrritabl barsak sendromu ve laktoz İntoleransı İlişkisi. Namık Kemal Tıp Dergisi, 7(3), 217-221.
  • Deng, Y., Misselwitz, B., Dai, N., Fox, M. (2015). Lactose intolerance in adults: Biological mechanism and dietary management. Nutrients, 7(9), 8020-8035. doi:10.3390/nu7095380
  • Facioni, M. S., Raspini, B., Pivari, F., Dogliotti, E., Cena, H. (2020). Nutritional management of lactose intolerance: the importance of diet and food labelling. Journal of Translational Medicine, 18(1), 260. doi:10.1186/s12967-020-02429-2
  • Hodges, J. K., Cao, S., Cladis, D. P., Weaver, C. M. (2019). Lactose intolerance and bone health: The challenge of ensuring adequate calcium intake. Nutrients, 11(4). doi:10.3390/nu11040718
  • Jackson, K. A., Savaiano, D. A. (2001). Lactose maldigestion, calcium intake and osteoporosis in African-, Asian-, and Hispanic-Americans. Journal of the American College of Nutrition, 20(2 Suppl), 198s-207s. doi:10.1080/07315724.2001.10719032
  • Jansson-Knodell, C. L., Krajicek, E. J., Savaiano, D. A., Shin, A. S. (2020). Lactose intolerance: A concise review to skim the surface. Mayo Clinic Proceedings, 95(7), 1499-1505. doi:10.1016/j.mayocp.2020.04.036
  • Kumar, S., Ranjan, P., Mittal, B., Singh, R., Ghoshal, U. C. (2012). Lactase persistence/non-persistence genetic variants in irritable bowel syndrome in an endemic area for lactose malabsorption. Journal of Gastroenterology and Hepatology, 27(12), 1825-1830. doi:10.1111/j.1440-1746.2012.07259.x
  • Le Morvan de Sequeira, C., Kaeber, M., Cekin, S. E., Enck, P., Mack, I. (2021). The effect of probiotics on quality of life, depression and anxiety in patients with irritable bowel syndrome: A systematic review and meta- analysis. Journal of Clinical Medicine, 10(16). doi:10.3390/jcm10163497
  • Lee, H. J., Kim, H. J., Kang, E. H., Jung, K. W., Myung, S. J., Min, Y. W., . . . Park, K. S. (2019). Self-reported food intolerance in Korean patients with irritable bowel syndrome. Journal of Neurogastroenterololgy and Motility, 25(2), 222-232. doi:10.5056/jnm18125
  • Lee, H. S., Chen, C. Y., Huang, W. T., Chang, L. J., Chen, S. C., Yang, H. Y. (2018). Risk of fractures at different anatomic sites in patients with irritable bowel syndrome: A nationwide population-based cohort study. Archives of Osteoporosis, 13(1), 80. doi:10.1007/s11657-018-0496-7
  • Lomer, M. C., Parkes, G. C., Sanderson, J. D. (2008). Review article: Lactose intolerance in clinical practice-myths and realities. Alimentary Pharmacology & Therapeutics, 27(2), 93-103. doi:10.1111/j.1365-2036.2007.03557.x
  • Lopes, S. S., Miszputen, S. J., Sachs, A., Lima, M. M., Ambrogini, O., Jr. (2019). Evaluation of carbohydrate and fiber consumption in patients with irritable bowel syndrome in outpatient treatment. Arquivos de Gastroenterologia, 56(1), 3-9. doi:10.1590/s0004-2803.201900000-12
  • Lovell, R. M., Ford, A. C. (2012). Global prevalence of and risk factors for irritable bowel syndrome: A meta-analysis. Clinical Gastroenterology and Hepatology, 10(7), 712-721.e714. doi:10.1016/j.cgh.2012.02.029
  • Mądry, E., Fidler, E. (2010). Lactose intolerance–current state of knowledge. Acta Scientiarum Polonorum Technologia Alimentaria, 9(3), 343-350.
  • Malik, T. F., Panuganti, K. K. (2021). Lactose intolerance. In StatPearls. Treasure Island (FL): StatPearls Publishing.
  • McKenzie, Y. A., Alder, A., Anderson, W., Wills, A., Goddard, L., Gulia, P., . . . Lomer, M. C. (2012). British Dietetic Association evidence-based guidelines for the dietary management of irritable bowel syndrome in adults. Journal of Human Nutrition and Dietetics, 25(3), 260-274. doi:10.1111/j.1365-277X.2012.01242.x
  • Misselwitz, B., Butter, M., Verbeke, K., Fox, M. R. (2019). Update on lactose malabsorption and intolerance: pathogenesis, diagnosis and clinical management. Gut, 68(11), 2080-2091. doi:10.1136/gutjnl-2019-318404
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There are 51 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section REVIEW ARTICLE
Authors

Melis Aycan 0000-0001-8530-5900

Aylin Açıkgöz Pınar 0000-0002-8847-9305

Early Pub Date December 26, 2022
Publication Date December 26, 2022
Submission Date October 6, 2022
Acceptance Date November 24, 2022
Published in Issue Year 2022 Volume: 4 Issue: 3

Cite

APA Aycan, M., & Açıkgöz Pınar, A. (2022). Lactose Intolerance and Osteoporosis Development in Irritable Bowel Syndrome Patients. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri Ve Araştırmaları Dergisi, 4(3), 253-260. https://doi.org/10.46413/boneyusbad.1184664
AMA Aycan M, Açıkgöz Pınar A. Lactose Intolerance and Osteoporosis Development in Irritable Bowel Syndrome Patients. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi. December 2022;4(3):253-260. doi:10.46413/boneyusbad.1184664
Chicago Aycan, Melis, and Aylin Açıkgöz Pınar. “Lactose Intolerance and Osteoporosis Development in Irritable Bowel Syndrome Patients”. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri Ve Araştırmaları Dergisi 4, no. 3 (December 2022): 253-60. https://doi.org/10.46413/boneyusbad.1184664.
EndNote Aycan M, Açıkgöz Pınar A (December 1, 2022) Lactose Intolerance and Osteoporosis Development in Irritable Bowel Syndrome Patients. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi 4 3 253–260.
IEEE M. Aycan and A. Açıkgöz Pınar, “Lactose Intolerance and Osteoporosis Development in Irritable Bowel Syndrome Patients”, Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi, vol. 4, no. 3, pp. 253–260, 2022, doi: 10.46413/boneyusbad.1184664.
ISNAD Aycan, Melis - Açıkgöz Pınar, Aylin. “Lactose Intolerance and Osteoporosis Development in Irritable Bowel Syndrome Patients”. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi 4/3 (December 2022), 253-260. https://doi.org/10.46413/boneyusbad.1184664.
JAMA Aycan M, Açıkgöz Pınar A. Lactose Intolerance and Osteoporosis Development in Irritable Bowel Syndrome Patients. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi. 2022;4:253–260.
MLA Aycan, Melis and Aylin Açıkgöz Pınar. “Lactose Intolerance and Osteoporosis Development in Irritable Bowel Syndrome Patients”. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri Ve Araştırmaları Dergisi, vol. 4, no. 3, 2022, pp. 253-60, doi:10.46413/boneyusbad.1184664.
Vancouver Aycan M, Açıkgöz Pınar A. Lactose Intolerance and Osteoporosis Development in Irritable Bowel Syndrome Patients. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi. 2022;4(3):253-60.

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