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Temperament Characteristics, Anxiety and Depression in People with Familial Mediterranean Fever

Year 2023, Volume: 10 Issue: 4, 312 - 317, 28.12.2023

İrem Şahinoğlu Gözde Yıldırım Çetin

https://doi.org/10.34087/cbusbed.1294256

Abstract

ABSTRACT
Aim: Familial Mediterranean Fever (FMF) is an autosomal recessive and self-limiting disease. FMF is characterized by recurrent episodes of fever, peritonitis, synovitis and pleuritis. Individuals with chronic illness tend to experience depression or anxiety. It has also been stated that affective temperaments are the basis of mood disorders. The aim of our study is to determine the frequency of anxiety and depression in FMF patients, to determine the dominant temperament type, and to compare the findings with the healthy control group.
Method: 73 patients with FMF and 30 age- and gender-matched healthy individuals without any systemic disease were included in the study. The hospital anxiety and depression scale were used to measure depression and anxiety, and the Temperament Evaluation of Memphis, Pisa, Paris and San Diego –Autoquestionnaire (TEMPS-A) temperament scale was used to determine the temperament type.
Results: The number of cases diagnosed with anxiety was 33 (45.2%) in the patient group and 5 (16.6%) in the control group; The number of cases diagnosed with depression was 23 (31.5%) in the patient group and 2 (6.6%) in the control group, and both were also found to be statistically significantly higher. (P values p=0.02 and p=0.002, respectively)
No statistically significant correlation was found between gender, age, disease duration, regular use of treatment, presence of gene mutation and attack type, and anxiety and depression scores.
According to the TEMPS-A temperament scale, the percentage of patients diagnosed with depressive temperament (20.5%) was higher than the control group (3.3%), and the difference was statistically significant. (p=0.02).
Conclusion: When the clinical picture in FMF patients becomes complicated with anxiety or depression or in the presence of a temperament predisposed to these conditions, there may be various problems in patients' compliance and response to treatment. FMF patients should be monitored for accompanying anxiety or depression during follow-up.
Key Words: Anxiety, Depression, Familial Mediterranean Fever, Temperament

Keywords

Anxiety Depression Familial Mediterranean Fever Temperament Characteristics

Project Number

yok

References

  • 1. Ben-Chetrit E, Levy M. Familial Mediterranean Fever. The Lancet, 1998; 351(9103):659-664.
  • 2. Orbach H, Ben-Chetrit E. Familial Mediterranean Fever-a review and update. Minerva Medica, 2001,92(6): 421-430.
  • 3. Sohar E, Pras M, Gafni J. Familial Mediterranean Fever and its articular manifestations. Clinics in Rheumatic Diseases, 1975, 1, 1, 195–209.
  • 4. Livneh A,  P Langevitz, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis & Rheumatism, 1997; 40(10): 1879-1885.
  • 5. Ozkan E, Okur O, Ekmekci A, Ozcan R, Tag T. A new approach to the treatment of periodic fever. Medical bulletin of Istanbul Medical Faculty, 1972; 5: 44-49.
  • 6. Molad Y. Update on colchicine and its mechanism of action. Current rheumatology reports, 2002; 4(3): 252-256.
  • 7. Cronstein B, Molad Y, Reibman J, Balakhane E, Levin RI, Weissmann G. Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils. Journal of Clinical Investigation, 1995; 96(2): 994.
  • 8. DeJean D, Giacomini M, Vanstone M, Brundisini F. Patient experiences of depression and anxiety with chronic disease: a systematic review and qualitative meta-synthesis. Ontario health technology assessment series, 2013 Sep 1;13(16):1-33.
  • 9. Isik A, Koca SS, Ozturk A, Mermi O. Anxiety and depression in patients with rheumatoid arthritis. Clinical rheumatology, 2007; 26(6): 872-878.
  • 10. Hanly JG, Fisk JD, McCurdy G, Fougere L, Douglas JA. Neuropsychiatric syndromes in patients with systemic lupus erythematosus and rheumatoid arthritis. The Journal of rheumatology, 2005; 32(8): 1459-1466.
  • 11. Martindale J, Smith J, Sutton CJ, Grennan D, Goodacre L, Goodacre JA. Disease and psychological status in ankylosing spondylitis. Rheumatology, 2006; 45(10): 1288-1293.
  • 12. Bremmer M, Beekman ATF, et al. Inflammatory markers in late-life depression: results from a population-based study. Journal of affective disorders, 2008; 106(3): 249-255.
  • 13. Von Känel R, Hepp U, et al. Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. Journal of psychiatric research, 2007; 41(9): 744-752.
  • 14. Cetin GY, Balkarli A, et al. Evaluation of frequency and the attacks features of patients with colchicine resistance in FMF. Rev Bras Reumatol, 2014;54(5):356-9.
  • 15. Akiskal HS, Mallya G. Criteria for the "soft" bipolar spectrum: treatment implications. Psychopharmacol Bulletin, 1987;23:68-73.
  • 16. Yildirim T, Solmaz D, Emul M, Akgol G, Yalvac D, Ersoy Y. Affective temperament profile in ankylosing spondylitis patients using TEMPS-A. Journal of Physical Therapy Science, 2017 Mar; 29(3): 394–400.
  • 17. Vahip S, Kesebir S, Alkan M, Yazıcı O, Akiskal KK, Akiskal HS. Affective temperaments in clinically-well subjects in Turkey: initial psychometric data on the TEMPS-A. Journal of affective disorders, 2005; 85(1): 113-125.
  • 18. Aydemir O, Güvenir T, Küey L, Kültür S. Hastane anksiyete ve depresyon ölçeği Türkçe formunun geçerlilik ve güvenilirliği. Türk Psikiyatri Dergisi, 1997; 8(4):280-7.
  • 19. Stoudemire A. Epidemiology and psychopharmacology of anxiety in medical patients. The Journal of clinical psychiatry, 1995; 57: 64-72;73-5.
  • 20. Deger SM, Ozturk MA, et al. Health-related quality of life and its associations with mood condition in familial Mediterranean fever patients. Rheumatology international, 2011; 31(5): 623-628.
  • 21. Makay B, Emiroğlu N, Ünsal E. Depression and anxiety in children and adolescents with familial Mediterranean fever. Clinical rheumatology, 2010; 29(4): 375-379.
  • 22. Giese A, Örnek A,  et al. Anxiety and depression in adult patients with familial Mediterranean fever: a study comparing patients living in Germany and Turkey. International Journal of Rheumatic Diseases, 2017;20(12):2093-2100.
  • 23. Lidor I, Tiosano S, Sharif K, Amital H, Cohen AD, Amital D. "The risk of depression and anxiety in patients with familial Mediterranean fever–a cross-sectional study." Journal of Affective Disorders, 2021 Sep 1;292:695-699.
  • 24. Bagci S, Toy B, et al. Continuity of cytokine activation in patients with familial Mediterranean fever. Clinical rheumatology, 2004; 23(4): 333-337
  • 25. Onat A,  Ozçakar L,  et al. Plasma and platelet serotonin levels in familial Mediterranean fever. Clinical and experimental rheumatology, Jul-Aug 2007;25(4 Suppl 45): S16-20.
  • 26. Onat AM, Oztürk MA, et al. Selective serotonin reuptake inhibitors reduce the attack frequency in familial Mediterranean fever. The Tohoku journal of experimental medicine, 2007; 211(1): 9-14.
  • 27. Sönmez AÖ, Sönmez HE, Çakan M, Yavuz M, Keskindemirci G, Aktay Ayaz N. The evaluation of anxiety, depression and quality of life scores of children and adolescents with familial Mediterranean fever. Rheumatol Int, 2020;40(5):757-763.
  • 28. Rezvani A, Aytüre L, Arslan M, Kurt E, Eroğlu Demir S, Karacan İ. Affective temperaments in patients with rheumatoid arthritis. International journal of rheumatic diseases, 2014 Jan;17(1):34-8.

Ailesel Akdeniz Ateşi Olan Kişilerde Mizaç Özellikleri, Anksiyete ve Depresyon

Year 2023, Volume: 10 Issue: 4, 312 - 317, 28.12.2023

İrem Şahinoğlu Gözde Yıldırım Çetin

https://doi.org/10.34087/cbusbed.1294256

Abstract

ÖZET
Amaç: Ailesel Akdeniz Ateşi (AAA), tekrarlayan ateş, peritonit, plörit ve sinovit atakları ile karakterize, otozomal resesif geçişli, kendi kendini sınırlayan bir hastalıktır. Kronik hastalığa sahip olan bireyler depresyon veya anksiyete yaşama eğilimindedir. Ayrıca duygulanımla ilgili mizaçların duygudurum bozukluklarının temeli olduğu belirtilmiştir. Çalışmamızın amacı, AAA hastalarında anksiyete ve depresyon sıklığını belirlemek, baskın mizaç türünü belirlemek ve bulguları sağlıklı kontrol grubu ile karşılaştırmaktır.
Yöntem: Çalışmaya 73 AAA tanılı hastayla birlikte herhangi sistemik hastalığa sahip olmayan yaş ve cinsiyeti uyumlu 30 sağlıklı birey alındı. Hastane anksiyete ve depresyon ölçeği depresyon ve anksiyeteyi ölçmek için ve Temperament Evaluation of Memphis, Pisa, Paris and San Diego –Autoquestionnaire (TEMPS-A) mizaç ölçeği mizaç tipini belirleme amaçlı kullanıldı.
Bulgular: Hasta grubunda 33 (%45,2), kontrol grubunda 5 (%16,6) kişi anksiyete tanısı aldı ve aradaki fark istatistiksel olarak anlamlı yüksek bulundu (p=0,02). Hasta grubunda 23 (%31,5), kontrol grubunda 2 (%6,6) kişi depresyon tanısı aldı ve aradaki fark istatistiksel olarak anlamlı yüksek bulundu (p=0,002). Yaş, cinsiyet, hastalık süresi, tedaviyi düzenli kullanma, gen mutasyonu varlığı ve atak tipi ile anksiyete ve depresyon puanları arasında istatistiksel olarak anlamlı ilişki saptanmadı.
TEMPS-A mizaç ölçeğine göre hastalardan depresif mizaç tanısı alanların yüzdesi ( %20,5) kontrol grubuna göre (%3,3) daha yüksekti ve aradaki fark istatistiksel olarak anlamlıydı (p=0,02).
Sonuç: AAA hastalarındaki klinik tablo anksiyete veya depresyon ile komplike hale geldiğinde veya bu durumlara yatkın mizaç varlığında hastaların tedaviye uyumunda ve tedaviye yanıtında çeşitli sorunlar olabilmektedir. AAA hastaları, takip sırasında eşlik eden anksiyete veya depresyon açısından izlenmelidir.

Anahtar Kelimeler: Ailesel Akdeniz Ateşi, Anksiyete, Depresyon, Mizaç

Keywords

Ailesel Akdeniz Ateşi Mizaç Özellikleri Anksiyete Depresyon

Supporting Institution

yok

Project Number

yok

Thanks

yok

References

  • 1. Ben-Chetrit E, Levy M. Familial Mediterranean Fever. The Lancet, 1998; 351(9103):659-664.
  • 2. Orbach H, Ben-Chetrit E. Familial Mediterranean Fever-a review and update. Minerva Medica, 2001,92(6): 421-430.
  • 3. Sohar E, Pras M, Gafni J. Familial Mediterranean Fever and its articular manifestations. Clinics in Rheumatic Diseases, 1975, 1, 1, 195–209.
  • 4. Livneh A,  P Langevitz, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis & Rheumatism, 1997; 40(10): 1879-1885.
  • 5. Ozkan E, Okur O, Ekmekci A, Ozcan R, Tag T. A new approach to the treatment of periodic fever. Medical bulletin of Istanbul Medical Faculty, 1972; 5: 44-49.
  • 6. Molad Y. Update on colchicine and its mechanism of action. Current rheumatology reports, 2002; 4(3): 252-256.
  • 7. Cronstein B, Molad Y, Reibman J, Balakhane E, Levin RI, Weissmann G. Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils. Journal of Clinical Investigation, 1995; 96(2): 994.
  • 8. DeJean D, Giacomini M, Vanstone M, Brundisini F. Patient experiences of depression and anxiety with chronic disease: a systematic review and qualitative meta-synthesis. Ontario health technology assessment series, 2013 Sep 1;13(16):1-33.
  • 9. Isik A, Koca SS, Ozturk A, Mermi O. Anxiety and depression in patients with rheumatoid arthritis. Clinical rheumatology, 2007; 26(6): 872-878.
  • 10. Hanly JG, Fisk JD, McCurdy G, Fougere L, Douglas JA. Neuropsychiatric syndromes in patients with systemic lupus erythematosus and rheumatoid arthritis. The Journal of rheumatology, 2005; 32(8): 1459-1466.
  • 11. Martindale J, Smith J, Sutton CJ, Grennan D, Goodacre L, Goodacre JA. Disease and psychological status in ankylosing spondylitis. Rheumatology, 2006; 45(10): 1288-1293.
  • 12. Bremmer M, Beekman ATF, et al. Inflammatory markers in late-life depression: results from a population-based study. Journal of affective disorders, 2008; 106(3): 249-255.
  • 13. Von Känel R, Hepp U, et al. Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. Journal of psychiatric research, 2007; 41(9): 744-752.
  • 14. Cetin GY, Balkarli A, et al. Evaluation of frequency and the attacks features of patients with colchicine resistance in FMF. Rev Bras Reumatol, 2014;54(5):356-9.
  • 15. Akiskal HS, Mallya G. Criteria for the "soft" bipolar spectrum: treatment implications. Psychopharmacol Bulletin, 1987;23:68-73.
  • 16. Yildirim T, Solmaz D, Emul M, Akgol G, Yalvac D, Ersoy Y. Affective temperament profile in ankylosing spondylitis patients using TEMPS-A. Journal of Physical Therapy Science, 2017 Mar; 29(3): 394–400.
  • 17. Vahip S, Kesebir S, Alkan M, Yazıcı O, Akiskal KK, Akiskal HS. Affective temperaments in clinically-well subjects in Turkey: initial psychometric data on the TEMPS-A. Journal of affective disorders, 2005; 85(1): 113-125.
  • 18. Aydemir O, Güvenir T, Küey L, Kültür S. Hastane anksiyete ve depresyon ölçeği Türkçe formunun geçerlilik ve güvenilirliği. Türk Psikiyatri Dergisi, 1997; 8(4):280-7.
  • 19. Stoudemire A. Epidemiology and psychopharmacology of anxiety in medical patients. The Journal of clinical psychiatry, 1995; 57: 64-72;73-5.
  • 20. Deger SM, Ozturk MA, et al. Health-related quality of life and its associations with mood condition in familial Mediterranean fever patients. Rheumatology international, 2011; 31(5): 623-628.
  • 21. Makay B, Emiroğlu N, Ünsal E. Depression and anxiety in children and adolescents with familial Mediterranean fever. Clinical rheumatology, 2010; 29(4): 375-379.
  • 22. Giese A, Örnek A,  et al. Anxiety and depression in adult patients with familial Mediterranean fever: a study comparing patients living in Germany and Turkey. International Journal of Rheumatic Diseases, 2017;20(12):2093-2100.
  • 23. Lidor I, Tiosano S, Sharif K, Amital H, Cohen AD, Amital D. "The risk of depression and anxiety in patients with familial Mediterranean fever–a cross-sectional study." Journal of Affective Disorders, 2021 Sep 1;292:695-699.
  • 24. Bagci S, Toy B, et al. Continuity of cytokine activation in patients with familial Mediterranean fever. Clinical rheumatology, 2004; 23(4): 333-337
  • 25. Onat A,  Ozçakar L,  et al. Plasma and platelet serotonin levels in familial Mediterranean fever. Clinical and experimental rheumatology, Jul-Aug 2007;25(4 Suppl 45): S16-20.
  • 26. Onat AM, Oztürk MA, et al. Selective serotonin reuptake inhibitors reduce the attack frequency in familial Mediterranean fever. The Tohoku journal of experimental medicine, 2007; 211(1): 9-14.
  • 27. Sönmez AÖ, Sönmez HE, Çakan M, Yavuz M, Keskindemirci G, Aktay Ayaz N. The evaluation of anxiety, depression and quality of life scores of children and adolescents with familial Mediterranean fever. Rheumatol Int, 2020;40(5):757-763.
  • 28. Rezvani A, Aytüre L, Arslan M, Kurt E, Eroğlu Demir S, Karacan İ. Affective temperaments in patients with rheumatoid arthritis. International journal of rheumatic diseases, 2014 Jan;17(1):34-8.
There are 28 citations in total.

Details

Primary Language English
Subjects Rheumatology and Arthritis
Journal Section Araştırma Makalesi
Authors

İrem Şahinoğlu 0000-0003-4871-6035

Gözde Yıldırım Çetin 0000-0001-9680-7535

Project Number yok
Publication Date December 28, 2023
Published in Issue Year 2023 Volume: 10 Issue: 4

Cite

APA Şahinoğlu, İ., & Yıldırım Çetin, G. (2023). Temperament Characteristics, Anxiety and Depression in People with Familial Mediterranean Fever. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 10(4), 312-317. https://doi.org/10.34087/cbusbed.1294256
AMA Şahinoğlu İ, Yıldırım Çetin G. Temperament Characteristics, Anxiety and Depression in People with Familial Mediterranean Fever. CBU-SBED: Celal Bayar University-Health Sciences Institute Journal. December 2023;10(4):312-317. doi:10.34087/cbusbed.1294256
Chicago Şahinoğlu, İrem, and Gözde Yıldırım Çetin. “Temperament Characteristics, Anxiety and Depression in People With Familial Mediterranean Fever”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 10, no. 4 (December 2023): 312-17. https://doi.org/10.34087/cbusbed.1294256.
EndNote Şahinoğlu İ, Yıldırım Çetin G (December 1, 2023) Temperament Characteristics, Anxiety and Depression in People with Familial Mediterranean Fever. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 10 4 312–317.
IEEE İ. Şahinoğlu and G. Yıldırım Çetin, “Temperament Characteristics, Anxiety and Depression in People with Familial Mediterranean Fever”, CBU-SBED: Celal Bayar University-Health Sciences Institute Journal, vol. 10, no. 4, pp. 312–317, 2023, doi: 10.34087/cbusbed.1294256.
ISNAD Şahinoğlu, İrem - Yıldırım Çetin, Gözde. “Temperament Characteristics, Anxiety and Depression in People With Familial Mediterranean Fever”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 10/4 (December 2023), 312-317. https://doi.org/10.34087/cbusbed.1294256.
JAMA Şahinoğlu İ, Yıldırım Çetin G. Temperament Characteristics, Anxiety and Depression in People with Familial Mediterranean Fever. CBU-SBED: Celal Bayar University-Health Sciences Institute Journal. 2023;10:312–317.
MLA Şahinoğlu, İrem and Gözde Yıldırım Çetin. “Temperament Characteristics, Anxiety and Depression in People With Familial Mediterranean Fever”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, vol. 10, no. 4, 2023, pp. 312-7, doi:10.34087/cbusbed.1294256.
Vancouver Şahinoğlu İ, Yıldırım Çetin G. Temperament Characteristics, Anxiety and Depression in People with Familial Mediterranean Fever. CBU-SBED: Celal Bayar University-Health Sciences Institute Journal. 2023;10(4):312-7.
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