Research Article
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Year 2020, Volume: 10 Issue: 3, 279 - 284, 29.09.2020

Halil Aksoy Azize Sener Dilek Akakın Ali Şen Özlem Bingöl Akpınar Gül Sinemcan Özcan Ahmet Kaan Şimşek Turgut Şekerler Şevket Ergun Güzel Ahmet Midi

https://doi.org/10.33808/marusbed.767312
Cited By: 1

Abstract

References

  • Thiruvoth FM, Mohapatra DP, Kumar D, Chittoria SRK, Nandhagopal V. Current concepts in the physiology of adult wound healing. Plast Aesthet Res 2015; 2: 250-256.
  • Guo S, Di Pietro LA. Factors Affecting Wound Healing. J Dent Res 2010; 89(3): 219-229.
  • Krafts KP. Tissue repair: The hidden drama. Organogenesis 2010; 6(4): 225–233.
  • Ibrahim N, Wong SK, Mohamed IN, Mohamed N, Chin KY, Ima-Nirwana S, Shuid AN. Wound Healing Properties of Selected Natural Products. Int J Environ Res Public Health 2018; 15(11): 2360.
  • Aksoy H, Sen A, Sancar M, Sekerler T, Akakin D, Bitis L, Uras F, Kultur S, İzzettin FV. Ethanol extract of Cotinus coggygria leaves accelerates wound healing process in diabetic rats. Pharm Biol 2016a; 54(11): 2732-2736.
  • Aksoy H, Sancar M, Sen A, Okuyan B, Bitis L, Uras F, Akakin D, Çevik O, Kultur S, İzzettin FV. The effect of topical ethanol extract of Cotinus coggygria Scop. on cutaneous wound healing in rats. Nat Prod Res 2016b; 30(4): 452-455.
  • Aksoy H, Çevik Ö, Şen A, Göğer F, Şekerler T, Şener A. Effect of Horse‐chestnut seed extract on matrix metalloproteinase‐1 and‐9 during diabetic wound healing. J Food Biochem 2019; 43(3): e12758.
  • Midi A, Ekici H, Kumandas A, Durmus O, Bodic B, Tiryaki M. Balik MS, Yesilada E. Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats. Marmara Med J 2019a; 32(1): 27-32.
  • Midi A, Kumandaş A, Ekici H, Arda S, Karahan S, Şimşek Ak, Yesilada E. Investigation of the effectiveness of algan hemostatic agent in renal venous bleeding model in rats. Eurasian J Med 2018a; 2: 129-132.
  • Midi A, Kumandas A, Ekici H, Bayraktar F, Karapirli K, Karahan S, Turk M, Ozyurek HE. Investigation of the efficacy of algan hemostatic agent in liver laceration model in rats. Eurasian J Med Oncol 2019b; 3(1): 37–42.
  • Midi A, Ozyurek He, Karahan S, Ekici H, Kumandas A, Turkmen I, Kocabas E, Turk M, Demirel OU, Yesilada E. Investigation of efficacy of the plant based algan hemostatic agent in hepatectomy bleeding model in rats. Eurasian J Med Inves 2018b; 2: 195-201.
  • Hickman DA, Pawlowski Cl, Sekhon UDS, Marks J, Gupta AS. Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding. Adv Mater 2018; 30(4).
  • Kaya H, Gokdemir MT, Sogut O. Effects of folk medicinal plant extract ankaferd blood stopper on burn wound healing. Acta Med Mediterr 2013; 29: 497–502.
  • Satar G, Cangül IT, Topal A, Oktay A, İnan K, Akgül MB. Effects of ankaferd blood stopper (ABS) and topical tripeptide copper complex (TCC) on wound healing in rats: An experimental study. Kafkas Univ Vet Fak Derg 2014; 20 (4): 545-551.
  • Aktaş A, Er N, Korkusuz P, Zeybek D, Onur MA, Tan G, Özdemir O, Karaismailoğlu E, Karabulut E. Ankaferd-induced early soft tissue wound healing in an experimental rat model. Turkiye Klinikleri J Med Sci 2013; 33(6): 1344-1353.
  • Sener A, Cevik O, Doğan O, Altindiş Ng, Aksoy H, Okuyan B. The effects of topical melatonin on oxidative stress, apoptosis signals, and p53 protein expression during cutaneous wound healing. Turk J Biol 2015; 39(6): 888-895.
  • Reddy GK, Enwemeka CS. A simplified method for the analysis of hydroxyproline in biological tissues. Clin Biochem 1996; 29(3): 225-229.
  • Akalin Ç, Kuru S, Barlas AM, Kismet K, Kaptanoglu B, Demir A, Astarci HM, Ustun H.. Beneficial effects of Ankaferd Blood Stopper on dermal wound healing: an experimental study. Int Wound J 2014; 11(1): 64-68.
  • Sahana TG, Rekha PD. Biopolymers: Applications in wound healing and skin tissue engineering. Mol Biol Rep 2018; 45(6): 2857-2867.
  • Hemmati AA, Arzi A, Amin M. Effect of Achillea millefolium extract in wound healing of rabbit. J Nat Rem 2002; 2(2): 164-167.
  • Hajhashemi M, Ghanbari Z, Movahedi M, Rafieian M, Keivani A, Haghollahi F. The effect of Achillea millefolium and Hypericum perforatum ointments on episiotomy wound healing in primiparous women. J Matern Fetal Neonatal Med 2018; 31(1): 63-69.
  • Al-Nadaf AH, Seder NJ, Rayyan WA. Wound healing; antimicrobial and anti-oxidant activity for Jordanian Juglans Regia L. unripe fruits. J Innov Pharm Biol Sci 2018; 5 (3): 26-34.
  • Banerjee J, Biswas S, Madhu NR, Karmakar SR, Biswas SJ. A better understanding of pharmacological activities and uses of phytochemicals of Lycopodium clavatum: A review. J Pharmacogn Phytochem 2014; 3(1): 207-210.
  • Das S, Das J, Paul A, Samadder A, Khuda-Bukhsh AR. Apigenin, a bioactive flavonoid from Lycopodium clavatum, stimulates nucleotide excision repair genes to protect skin keratinocytes from ultraviolet B-induced reactive oxygen species and DNA damage. J Acupunct Meridian Stud 2013; 6(5): 252-262.
  • Kuonen R, Weissenstein U, Urech K, Kunz M, Hostanska K, Estko M, Heusser P, Baumgartner S. Effects of Lipophilic Extract of Viscum album L. and Oleanolic Acid on Migratory Activity of NIH/3T3 Fibroblasts and on HaCat Keratinocytes. Evid Based Complement Alternat Med 2013; 2013: 718105.
  • Shivananda Nayak B, Dan Ramdath D, Marshall JR, Isitor G, Xue S, Shi J. Wound-healing properties of the oils of Vitis vinifera and Vaccinium macrocarpon. Phytother Res 2011; 25(8): 1201-1208.
  • Grochowski DM, Uysal S, Zengin G, Tomczyk M. In vitro antioxidant and enzyme inhibitory properties of Rubus caesius L., Int J Environ Heal Res 2019; 29(3): 237-245.
  • George BP, Parimelazhagan T, Sajeesh T, Saravanan S. Antitumor and wound healing properties of Rubus niveus Thunb. root. J Environ Pathol Tox Oncol 2014a; 33(2): 145-158.
  • George BP, Parimelazhagan T, Kumar YT, Sajeesh T. Antitumor and wound healing properties of Rubus ellipticus Smith. J Acupunct Meridian Stud 2015; 8(3): 134-141.
  • George BP, Parimelazhagan T, Chandran R. Anti-inflammatory and wound healing properties of Rubus fairholmianus Gard. root—An in vivo study. Ind Crop Prod 2014b; 54: 216-225.
  • Süntar I, Koca U, Keleş H, Akkol EK. Wound healing activity of Rubus sanctus Schreber (Rosaceae): Preclinical Study in Animal Models. Evid-Based Compl Alt Med 2011; 2011: 816156.

The Effect of algan hemostatic agent (AHA) on wound healing

Year 2020, Volume: 10 Issue: 3, 279 - 284, 29.09.2020

Halil Aksoy Azize Sener Dilek Akakın Ali Şen Özlem Bingöl Akpınar Gül Sinemcan Özcan Ahmet Kaan Şimşek Turgut Şekerler Şevket Ergun Güzel Ahmet Midi

https://doi.org/10.33808/marusbed.767312
Cited By: 1

Abstract

Objective: The Algan Hemostatic Agent (AHA) is a novel herbal originated blood stopper. The aim of this study is to investigate the effect of AHA on wound healing on excisional wound model in rats.
Methods: In this study, 54 adult Wistar albino rats were used. Rats were divided into 3 groups (saline, Madecassol and AHA). Each group was then divided into 3 subgroups as 3rd, 7th and 14th days. Two wounds were created in the dorsal thoracic region of the rats. One of the lesions was used for histopathological examinations and the other for hydroxyproline measurement. In order to evaluate the wound healing, wound area were measured during the whole treatment period and animals were sacrificed at the end of 3rd, 7th and 14th days and tissue samples were taken for the determination of hydroxyproline levels.
Results: AHA treatment did not cause significantly difference in hydroxyproline level on days 3, 7, 14. The contraction percentage of wound area was higher in the AHA group on day 7 than control group. However, the difference was not statistically significant (p> 0.05). On days 3 and 14, no significant difference was detected in the contraction percentage of wound area between the control and AHA groups. AHA and Madecassol results of epidermis regeneration on the 14th day, neutrophil infiltration on the 7th day and edema on the 3rd, 7th and 14th days were different in terms of histopathological parameters compared to the control group.
Conclusion: Despite good histological findings, AHA did not significantly accelerate wound healing. but did not adversely affect on wound healing. AHA may be used safely on excisional wounds.

Keywords

Algan hemostatic agent madecassol wound healing hydroxyproline

References

  • Thiruvoth FM, Mohapatra DP, Kumar D, Chittoria SRK, Nandhagopal V. Current concepts in the physiology of adult wound healing. Plast Aesthet Res 2015; 2: 250-256.
  • Guo S, Di Pietro LA. Factors Affecting Wound Healing. J Dent Res 2010; 89(3): 219-229.
  • Krafts KP. Tissue repair: The hidden drama. Organogenesis 2010; 6(4): 225–233.
  • Ibrahim N, Wong SK, Mohamed IN, Mohamed N, Chin KY, Ima-Nirwana S, Shuid AN. Wound Healing Properties of Selected Natural Products. Int J Environ Res Public Health 2018; 15(11): 2360.
  • Aksoy H, Sen A, Sancar M, Sekerler T, Akakin D, Bitis L, Uras F, Kultur S, İzzettin FV. Ethanol extract of Cotinus coggygria leaves accelerates wound healing process in diabetic rats. Pharm Biol 2016a; 54(11): 2732-2736.
  • Aksoy H, Sancar M, Sen A, Okuyan B, Bitis L, Uras F, Akakin D, Çevik O, Kultur S, İzzettin FV. The effect of topical ethanol extract of Cotinus coggygria Scop. on cutaneous wound healing in rats. Nat Prod Res 2016b; 30(4): 452-455.
  • Aksoy H, Çevik Ö, Şen A, Göğer F, Şekerler T, Şener A. Effect of Horse‐chestnut seed extract on matrix metalloproteinase‐1 and‐9 during diabetic wound healing. J Food Biochem 2019; 43(3): e12758.
  • Midi A, Ekici H, Kumandas A, Durmus O, Bodic B, Tiryaki M. Balik MS, Yesilada E. Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats. Marmara Med J 2019a; 32(1): 27-32.
  • Midi A, Kumandaş A, Ekici H, Arda S, Karahan S, Şimşek Ak, Yesilada E. Investigation of the effectiveness of algan hemostatic agent in renal venous bleeding model in rats. Eurasian J Med 2018a; 2: 129-132.
  • Midi A, Kumandas A, Ekici H, Bayraktar F, Karapirli K, Karahan S, Turk M, Ozyurek HE. Investigation of the efficacy of algan hemostatic agent in liver laceration model in rats. Eurasian J Med Oncol 2019b; 3(1): 37–42.
  • Midi A, Ozyurek He, Karahan S, Ekici H, Kumandas A, Turkmen I, Kocabas E, Turk M, Demirel OU, Yesilada E. Investigation of efficacy of the plant based algan hemostatic agent in hepatectomy bleeding model in rats. Eurasian J Med Inves 2018b; 2: 195-201.
  • Hickman DA, Pawlowski Cl, Sekhon UDS, Marks J, Gupta AS. Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding. Adv Mater 2018; 30(4).
  • Kaya H, Gokdemir MT, Sogut O. Effects of folk medicinal plant extract ankaferd blood stopper on burn wound healing. Acta Med Mediterr 2013; 29: 497–502.
  • Satar G, Cangül IT, Topal A, Oktay A, İnan K, Akgül MB. Effects of ankaferd blood stopper (ABS) and topical tripeptide copper complex (TCC) on wound healing in rats: An experimental study. Kafkas Univ Vet Fak Derg 2014; 20 (4): 545-551.
  • Aktaş A, Er N, Korkusuz P, Zeybek D, Onur MA, Tan G, Özdemir O, Karaismailoğlu E, Karabulut E. Ankaferd-induced early soft tissue wound healing in an experimental rat model. Turkiye Klinikleri J Med Sci 2013; 33(6): 1344-1353.
  • Sener A, Cevik O, Doğan O, Altindiş Ng, Aksoy H, Okuyan B. The effects of topical melatonin on oxidative stress, apoptosis signals, and p53 protein expression during cutaneous wound healing. Turk J Biol 2015; 39(6): 888-895.
  • Reddy GK, Enwemeka CS. A simplified method for the analysis of hydroxyproline in biological tissues. Clin Biochem 1996; 29(3): 225-229.
  • Akalin Ç, Kuru S, Barlas AM, Kismet K, Kaptanoglu B, Demir A, Astarci HM, Ustun H.. Beneficial effects of Ankaferd Blood Stopper on dermal wound healing: an experimental study. Int Wound J 2014; 11(1): 64-68.
  • Sahana TG, Rekha PD. Biopolymers: Applications in wound healing and skin tissue engineering. Mol Biol Rep 2018; 45(6): 2857-2867.
  • Hemmati AA, Arzi A, Amin M. Effect of Achillea millefolium extract in wound healing of rabbit. J Nat Rem 2002; 2(2): 164-167.
  • Hajhashemi M, Ghanbari Z, Movahedi M, Rafieian M, Keivani A, Haghollahi F. The effect of Achillea millefolium and Hypericum perforatum ointments on episiotomy wound healing in primiparous women. J Matern Fetal Neonatal Med 2018; 31(1): 63-69.
  • Al-Nadaf AH, Seder NJ, Rayyan WA. Wound healing; antimicrobial and anti-oxidant activity for Jordanian Juglans Regia L. unripe fruits. J Innov Pharm Biol Sci 2018; 5 (3): 26-34.
  • Banerjee J, Biswas S, Madhu NR, Karmakar SR, Biswas SJ. A better understanding of pharmacological activities and uses of phytochemicals of Lycopodium clavatum: A review. J Pharmacogn Phytochem 2014; 3(1): 207-210.
  • Das S, Das J, Paul A, Samadder A, Khuda-Bukhsh AR. Apigenin, a bioactive flavonoid from Lycopodium clavatum, stimulates nucleotide excision repair genes to protect skin keratinocytes from ultraviolet B-induced reactive oxygen species and DNA damage. J Acupunct Meridian Stud 2013; 6(5): 252-262.
  • Kuonen R, Weissenstein U, Urech K, Kunz M, Hostanska K, Estko M, Heusser P, Baumgartner S. Effects of Lipophilic Extract of Viscum album L. and Oleanolic Acid on Migratory Activity of NIH/3T3 Fibroblasts and on HaCat Keratinocytes. Evid Based Complement Alternat Med 2013; 2013: 718105.
  • Shivananda Nayak B, Dan Ramdath D, Marshall JR, Isitor G, Xue S, Shi J. Wound-healing properties of the oils of Vitis vinifera and Vaccinium macrocarpon. Phytother Res 2011; 25(8): 1201-1208.
  • Grochowski DM, Uysal S, Zengin G, Tomczyk M. In vitro antioxidant and enzyme inhibitory properties of Rubus caesius L., Int J Environ Heal Res 2019; 29(3): 237-245.
  • George BP, Parimelazhagan T, Sajeesh T, Saravanan S. Antitumor and wound healing properties of Rubus niveus Thunb. root. J Environ Pathol Tox Oncol 2014a; 33(2): 145-158.
  • George BP, Parimelazhagan T, Kumar YT, Sajeesh T. Antitumor and wound healing properties of Rubus ellipticus Smith. J Acupunct Meridian Stud 2015; 8(3): 134-141.
  • George BP, Parimelazhagan T, Chandran R. Anti-inflammatory and wound healing properties of Rubus fairholmianus Gard. root—An in vivo study. Ind Crop Prod 2014b; 54: 216-225.
  • Süntar I, Koca U, Keleş H, Akkol EK. Wound healing activity of Rubus sanctus Schreber (Rosaceae): Preclinical Study in Animal Models. Evid-Based Compl Alt Med 2011; 2011: 816156.
There are 31 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Halil Aksoy 0000-0002-7256-0037

Azize Sener 0000-0002-3125-8720

Dilek Akakın This is me 0000-0002-1781-3708

Ali Şen 0000-0002-2144-5741

Özlem Bingöl Akpınar 0000-0003-0287-5639

Gül Sinemcan Özcan 0000-0003-2168-1629

Ahmet Kaan Şimşek This is me

Turgut Şekerler This is me 0000-0002-3120-2911

Şevket Ergun Güzel This is me 0000-0001-9790-4388

Ahmet Midi 0000-0002-6197-7654

Publication Date September 29, 2020
Submission Date July 10, 2020
Published in Issue Year 2020 Volume: 10 Issue: 3

Cite

APA Aksoy, H., Sener, A., Akakın, D., Şen, A., et al. (2020). The Effect of algan hemostatic agent (AHA) on wound healing. Clinical and Experimental Health Sciences, 10(3), 279-284. https://doi.org/10.33808/marusbed.767312
AMA Aksoy H, Sener A, Akakın D, Şen A, Bingöl Akpınar Ö, Özcan GS, Şimşek AK, Şekerler T, Güzel ŞE, Midi A. The Effect of algan hemostatic agent (AHA) on wound healing. Clinical and Experimental Health Sciences. September 2020;10(3):279-284. doi:10.33808/marusbed.767312
Chicago Aksoy, Halil, Azize Sener, Dilek Akakın, Ali Şen, Özlem Bingöl Akpınar, Gül Sinemcan Özcan, Ahmet Kaan Şimşek, Turgut Şekerler, Şevket Ergun Güzel, and Ahmet Midi. “The Effect of Algan Hemostatic Agent (AHA) on Wound Healing”. Clinical and Experimental Health Sciences 10, no. 3 (September 2020): 279-84. https://doi.org/10.33808/marusbed.767312.
EndNote Aksoy H, Sener A, Akakın D, Şen A, Bingöl Akpınar Ö, Özcan GS, Şimşek AK, Şekerler T, Güzel ŞE, Midi A (September 1, 2020) The Effect of algan hemostatic agent (AHA) on wound healing. Clinical and Experimental Health Sciences 10 3 279–284.
IEEE H. Aksoy, “The Effect of algan hemostatic agent (AHA) on wound healing”, Clinical and Experimental Health Sciences, vol. 10, no. 3, pp. 279–284, 2020, doi: 10.33808/marusbed.767312.
ISNAD Aksoy, Halil et al. “The Effect of Algan Hemostatic Agent (AHA) on Wound Healing”. Clinical and Experimental Health Sciences 10/3 (September 2020), 279-284. https://doi.org/10.33808/marusbed.767312.
JAMA Aksoy H, Sener A, Akakın D, Şen A, Bingöl Akpınar Ö, Özcan GS, Şimşek AK, Şekerler T, Güzel ŞE, Midi A. The Effect of algan hemostatic agent (AHA) on wound healing. Clinical and Experimental Health Sciences. 2020;10:279–284.
MLA Aksoy, Halil et al. “The Effect of Algan Hemostatic Agent (AHA) on Wound Healing”. Clinical and Experimental Health Sciences, vol. 10, no. 3, 2020, pp. 279-84, doi:10.33808/marusbed.767312.
Vancouver Aksoy H, Sener A, Akakın D, Şen A, Bingöl Akpınar Ö, Özcan GS, Şimşek AK, Şekerler T, Güzel ŞE, Midi A. The Effect of algan hemostatic agent (AHA) on wound healing. Clinical and Experimental Health Sciences. 2020;10(3):279-84.

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