Research Article
Year 2024,
Volume: 14 Issue: 1, 188 - 193, 28.03.2024
Abstract
Objective: Subcutaneous and visceral adipose tissue have distinct physiological roles. The correlation between the amount of visceral tissue and the immunity response following vaccination remains unclear, despite its known effects on immunity. The purpose of this study is to examine the relationship between SARS-CoV-2 IgG antibody levels after vaccination and body fat tissue values measured using a specialized software on specific magnetic resonance imaging sequences.
Methods: After ethics committee approval, prospectively 60 volunteers (27 males, 33 females; median age of 33 years) were vaccinated with inactivated SARS-CoV-2 vaccine and tested for IgG levels. Abdominal MRI was performed to measure subcutaneous and visceral fat tissue areas using a semiautomatic application.
Results: The median value of IgG antibody titers after vaccination was 1039 (113 – 6613). Median subcutaneous adipose tissue(cm2), visceral adipose tissue (cm2), SAT index (SATI) (cm2/m2), VAT index (VATI) (cm2/m2), total fat area (TFA) (cm2), and SAT/VAT (cm2) were 178.5 (38.1-552.5), 51.5 (7.1-273.2), 61.4 (14.3-213.1), 19.1 (2.7-90.6), 251.3 (45.3-683.2), and 3.3 (0.4-12.3) respectively. There was no significant
correlation between the adipose tissue measurements and antibody titers (p>.05).
Conclusion: This study demonstrated that automated software can efficiently and accurately evaluate body fat distribution using MRI. However, the results showed no significant association between fat distribution and the immunization response to the SARS-CoV-2 vaccine.
References
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Year 2024,
Volume: 14 Issue: 1, 188 - 193, 28.03.2024
Abstract
References
- Kassir R. Risk of COVID‐19 for patients with obesity. Obesity Reviews 2020;21(6):1-2. DOI: 10.1111/obr.13034
- Grant RW, Dixit VD. Adipose tissue as an immunological organ. Obesity 2015;23(3):512-518. DOI: 10.1002/oby.21003
- Karlsson EA, Sheridan PA, Beck MA. Diet-induced obesity in mice reduces the maintenance of influenza-specific CD8+ memory T cells. J Nutr. 2010;140(9):1691-1697. DOI: 10.3945/jn.110.123653
- Karlsson EA, Sheridan PA, Beck MA. Diet-induced obesity impairs the T cell memory response to influenza virus infection. The Journal of Immunology 2010;184(6):3127-3133. DOI: 10.4049/jimmunol.0903220
- Zhang AJ, To KK, Li C, Lau CC, Poon VK, Chan CC, Zheng BJ, Hung IF, Lam KS, Xu A, Yuen KY. Leptin mediates the pathogenesis of severe 2009 pandemic influenza A(H1N1) infection associated with cytokine dysregulation in mice With Diet-Induced Obesity. J Infect Dis. 2013;207(8):1270-1280. DOI: 10.1093/infdis/jit031
- Ibrahim MM. Subcutaneous and visceral adipose tissue: structural and functional differences. Obesity Reviews 2010;11(1):11-18. DOI: 10.1111/j.1467-789X.2009.00623.x
- WHO Coronavirus (COVID-19) Dashboard | WHO Coronavirus (COVID-19) Dashboard With Vaccination Data. Accessed December 14, 2022. https://covid19.who.int/
- Smith AG, Sheridan PA, Harp JB, Beck MA. Diet-induced obese mice have increased mortality and altered immune responses when infected with influenza virus. Journal of Nutrition 2007;137(5):1236-1243. DOI: 10.1093/jn/137.5.1236
- Eliakim A, Swindt C, Zaldivar F, Casali P, Cooper DM. Reduced tetanus antibody titers in overweight children. Autoimmunity 2006;39(2):137-141. DOI: 10.1080/08916930600597326
- Borga M. MRI adipose tissue and muscle composition analysis-a review of automation techniques. British Journal of Radiology 2018;91(1089):20180252. DOI: 10.1259/bjr.20180252
- MacQueen J. Classification and analysis of multivariate observations. In: 5th Berkeley Symp. Math. Statist. Probability 1987:281-297. Accessed December 4, 2022.
- Dunn JC. A fuzzy relative of the ISODATA process and its use in detecting compact well-separated clusters. Journal of Cybernetics 1973;3(3):32-57. DOI: 10.1080/01969727308546046
- Romu T, Borga M, Dahlqvist O. MANA - Multi scale adaptive normalized averaging. In: IEEE International Symposium on Biomedical Imaging 2011:361-364. DOI: 10.1109/ISBI.2011.5872424
- Andersson T, Romu T, Karlsson A, Norén B, Forsgren MF, Smedby Ö, Kechagias S, Almer S, Lundberg P, Borga M, Leinhard OD. Consistent intensity inhomogeneity correction in water-fat MRI. Journal of Magnetic Resonance Imaging 2015;42(2):468-476. DOI: 10.1002/jmri.24778
- Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods 2012;9(7):671-675. DOI: 10.1038/nmeth.2089
- Maddalo M, Zorza I, Zubani S, Nocivelli G, Calandra G, Soldini P, Mascaro L, Maroldi R. Validation of a free software for unsupervised assessment of abdominal fat in MRI. Physica Medica 2017;37:24-31. DOI: 10.1016/j.ejmp.2017.04.002
- Watanabe M, Balena A, Tuccinardi D, Tozzi R, Risi R, Masi D, Caputi A, Rossetti R, Spoltore ME, Filippi V, Gangitano E. Central obesity, smoking habit, and hypertension are associated with lower antibody titres in response to COVID‐19 mRNA vaccine. Diabetes Metab Res Rev. 2021;38(1):e3465. DOI: 10.1002/dmrr.3465
- Painter SD, Ovsyannikova IG, Poland GA. The weight of obesity on the human immune response to vaccination. Vaccine 2015;33(36):4422-4429. DOI: 10.1016/j.vaccine.2015.06.101
- Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B.Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006;17(1):4-12.
- Xie L, Ortega MT, Mora S, Chapes SK. Interactive changes between macrophages and adipocytes. Clinical and Vaccine Immunology 2010;17(4):651-659. DOI: 10.1128/CVI.00494-09
- Bouwman JJM, Diepersloot RJA, Visseren FLJ. Intracellular infections enhance interleukin-6 and plasminogen activator inhibitor 1 production by cocultivated human adipocytes and THP-1 monocytes. Clinical and Vaccine Immunology 2009;16(8):1222-1227. DOI: 10.1128/CVI.00166-09
- Hamilton-Basich M. AMRA to Present Study on MRI-Based Body Composition in Liver Disease. AXIS Imaging News. Published 2022. Accessed December 4, 2022.
- Newman D, Kelly‐Morland C, Leinhard OD, Kasmai B, Greenwood R, Malcolm PN, Romu T, Borga M, Toms AP.Test-retest reliability of rapid whole body and compartmental fat volume quantification on a widebore 3T MR system in normal-weight, overweight, and obese subjects. Journal of Magnetic Resonance Imaging 2016;44(6):1464-1473. DOI: 10.1002/jmri.25326
- Orsso CE, Mackenzie M, Alberga AS, Sharma AM, Richer L, Rubin DA, Prado CM, Haqq AM. The use of magnetic resonance imaging to characterize abnormal body composition phenotypes in youth with Prader–Willi syndrome. Metabolism 2017;69:67-75. DOI: 10.1016/j.metabol.2017.01.020
There are 24 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Microbiology, Radiology and Organ Imaging |
| Journal Section | Articles |
| Authors | |
| Early Pub Date | March 23, 2024 |
| Publication Date | March 28, 2024 |
| Submission Date | March 6, 2023 |
| Published in Issue | Year 2024 Volume: 14 Issue: 1 |
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