Abstract
Amaç: Bu çalışmada pediatrik migren hastalarında biyometri ölçümlerinin ve ön segment parametrelerinin değerlendirilmesi ve sağlıklı çocuklarla karşılaştırılması amaçlanmıştır.
Gereç ve Yöntem: Bu prospektif vaka-kontrol çalışmasına yaş ve cinsiyeti uyumlu 40 pediatrik migren hastası ve 45 sağlıklı çocuk dahil edildi. Ölçümlerden önce tüm katılımcılar tam bir oftalmolojik muayeneden geçirildi. Ön kamara derinliği (ÖKD), vitreus uzunluğu (VU), lens kalınlığı (LK), aksiyel uzunluk (AU), merkezi kornea kalınlığı (MKK), kornea hacmi (KH), ön kamara hacmi (ÖKH), iridokorneal açı (İKA), pupil çapı (PÇ) ve ortalama kornea kırıcılığı (Km) değerlendirildi. Tüm değerlendirmeler ataksız dönemde yapıldı. Fotofobisi olan ve olmayan migrenli hastalarda pupil çapı karşılaştırıldı. Diürnal varyasyondan en az oranda etkilenmek açısından göz içi basınç ölçümleri ve biyometri değerlendirmeleri günün aynı saatlerinde (10:00–12:00) yapıldı. Tüm katılımcıların sağ gözü çalışmaya dahil edildi.
Bulgular: Pediatrik migren grubuyla (27 kız, 13 erkek) kontrol grubu (30 kız, 15 erkek) arasında ÖKD, VU, LK, AU, MKK, KH, ÖKH, İKA, PÇ, göz içi basıncı, sferik eşdeğer ve Km ölçümleri bakımından istatistiksel olarak anlamlı farklılık görülmedi. Migren grubu içerisinde fotofobisi olan hastalar ile olmayanların pupil çapları arasında anlamlı farklılık görülmedi.
Sonuç: Pediatrik migren hastalarında biyometri, korneal topografi ve keratometri ölçümlerinde sağlıklı çocuklara göre farklılık görülmemektedir. Pediatrik migren ile oküler biyometrik ölçümler arasındaki ilişkiyi incelemek için daha geniş hasta popülasyonlu çalışmalara ihtiyaç vardır.
Supporting Institution
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References
- Referans1. Lewis DW. Headaches in Infants and Children. In: Swaiman KF, Ashwal S, Ferriero DM, Schor NF, eds. Swaiman’s Pediatric Neurology. Principles and Practice. 5th ed. UK/USA; Elsevier Saunders; 2012. p.881-99.
- Referans2. Poyrazoğlu HG, Kumandas S, Canpolat M, Gümüs H, Elmali F, Kara A et al. The prevalence of migraine and tension-type headache among schoolchildren in Kayseri, Turkey: an evaluation of sensitivity and specificity using multivariate analysis. J Child Neurol 2015;30 (7):889-95.
- Referans3. Rho YI, Chung HJ, Lee KH, Eun BL, Eun SH, Nam SO et al. Prevalence and clinical characteristics of primary headaches among school children in South Korea: a nationwide survey. Headache 2012;52(4):592-9.
- Referans4. Okan M, Özdemir H. Çocuklarda Başağrısı. Güncel Pediatri 2003;1:10-8.
- Referans5. Rothner AD. Heaaches in children: a review. Headache 1978;18:169-73.
- Referans6. Şenbil N, Aysun S. Çocukluk Çağı Başağrıları. Çocuk Nörolojisi. Ankara: Anıl Grup Matbaacılık; 2010. p.335-44.
- Referans7. Powers SW, Patton SR, Hommel KA, Hershey AD. Quality of life in childhood migraines: Clinical impact and comparison to other chronic illnesses. Pediatrics 2003, 112, e1–e5.
- Referans8. Abu-Arafeh I, Razak S, Sivaraman B, Graham C. Prevalence of headache and migraine in children and adolescents: A systematic review of population-based studies. Dev. Med. Child Neurol. 2010, 52, 1088–97.
- Referans9. Wober-Bingol C. Epidemiology of migraine and headache in children and adolescents. Curr. Pain Headache Rep. 2013, 17, 341.
- Referans10. Abu-Arefeh I, Russell G. Prevalence of headache and migraine in schoolchildren. BMJ 1994; 309: 765–769.
- Referans11. Aromaa M, Sillanpää ML, Rautava P, Helenius H. Childhood headache at school entry: a controlled clinical study. Neurology 1998; 50: 1729–36.
- Referans12. Congdon PJ, Forsythe WI. Migraine in childhood. A review. Clin Pediatr 1979; 18: 353–9.
- Referans13. Lee LH, Olness KN. Clinical and demographic characteristics of migraine in urban children. Headache 1997;37: 269–76.
- Referans14. Ducros A, Tournier-Lasserve E, Bousser MG. The genetics of migraine. Lancet Neurol 2002; 1:285.
- Referans15. Amin FM, Asghar MS, Hougaard A, Hansen AE, Larsen VA, de Koning PJ et al. Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study. Lancet Neurol 2013; 12:454.
- Referans16. Nalcacioglu P, Taslipinar Uzel AG, Uzel MM, Cagil N, Citak Kurt AN. Are there any changes in posterior ocular structure parameters in pediatric migraine patients? Eur J Ophthalmol. 2017 Jun 26;27(4):495-501.
- Referans17. Yener AÜ, Yılmaz D. Topographic changes measured by the swept source optical coherence tomography in retinal nerve fiber layer, optic nerve head and macula in children with migraine. Acta Neurol Belg. 2020 Jun;120(3):661-8.
- Referans18. Koban Y, Ozlece HK, Bilgin G, Koc M, Cagatay HH, Durgunlu EI et al. Intraocular pressure and ocular biometric parameters changes in migraine. BMC Ophthalmol. 2016 May 31;16:70.
- Referans19. Eidlitz-Markus T, Gorali O, Haimi-Cohen Y, Zeharia A. Symptoms of migraine in the pediatric population by age group. Cephalalgia 2008. 28:1259–63.
- Referans20. Kara SA, Erdemoğlu AK, Karadeniz MY, Altinok D. Color Doppler sonography of orbital and vertebral arteries in migraineurs without aura. J Clin Ultrasound. 2003;31(6):308-14.
- Referans21. Pekel G, Acer S, Yagci R, Kaya H, Pekel E. Impact of valsalva maneuver on corneal morphology and anterior chamber parameters. Cornea. 2014;33: 271–3.
- Referans22. Liu Z, Pflugfelder SC. Corneal thickness is reduced in dry eye. Cornea. 1999;18:403–407.
- Referans23. Celikbilek A, Adam M. The relationship between dry eye and migraine. Acta Neurol Belg. 2015;115:329–33.
- Referans24. Jonsson M, Markström K, Behndig A. Slit-scan tomography evaluation of the anterior chamber and corneal configurations at different ages. Acta Ophthalmol Scand. 2006; 84;116-20.
- Referans25. Ambrósio R Jr, Alonso RS, Luz A, Coca Velarde LG. Cornealthickness spatial profile and corneal-volume distribution: Tomographic indices to detect keratoconus. J Cataract Refract Surg. 2006; 32:1851-9.
- Referans26. Youssef PE, Mack KJ. Episodic and chronic migraine in children. Dev Med Child Neurol. 2020 Jan;62(1):34-41.
- Referans27. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018; 38(1): 1–211.
- Referans28. Avnon Y, Nitzan M, Sprecher E, Rogowski Z, Yarnitsky D. Different patterns of parasympathetic activation in uni- and bilateral migraineurs. Brain. 2003;126:1660–70.
- Referans29. Xu C, Li J, Li Z, Mao X. Migraine as a risk factor for primary open angle glaucoma: A systematic review and meta-analysis. Medicine (Baltimore). 2018 Jul;97(28):e11377.
- Referans30. Elgin U, Şen E, Uzel M, Yılmazbaş P. Comparison of Refractive Status and Anterior Segment Parameters of Juvenile Open-Angle Glaucoma and Normal Subjects. Turk J Ophthalmol. 2018 Dec 27;48(6):295-98.
Abstract
Purpose: The aim of this study was to evaluate biometry parameters and anterior segment parameters in pediatric migraine patients compared to controls.
Materials and Methods: This prospective case-control study included 40 patients and 45 controls. All participants underwent a complete ophthalmological examination followed by measurement of anterior chamber depth (ACD), vitreous chamber depth (VCD), lens thickness (LT), axial length (AL), central corneal thickness (CCT), corneal volume (CV), anterior chamber volume (ACV), iridocorneal angle (ICA), pupil diameter (PD) and mean keratometry (Km). Pupil diameter was compared between patients with and without photophobia. All evaluations were made in attack-free period. Pupil diameter was compared in migraine patients with and without photophobia. Intraocular pressure and biometery measurements were taken at the same time of day (10:00–12:00) in order to minimize the effects of diurnal variation. Right eye measurements were included in the study.
Results: The two groups showed no statistical differences in ACD, VCD, LT, AL, CCT, CV, ACV, ICA, PD, IOP, spherical equivalent or Km. There was no difference in PD between patients with and without photophobia .
Conclusion: Pediatric migraine patients do not differ from controls in terms of biometry, corneal topography, or keratometry parameters. Studies with larger patient populations are needed to determine the relationship between ocular biometric parameters and migraine.
References
- Referans1. Lewis DW. Headaches in Infants and Children. In: Swaiman KF, Ashwal S, Ferriero DM, Schor NF, eds. Swaiman’s Pediatric Neurology. Principles and Practice. 5th ed. UK/USA; Elsevier Saunders; 2012. p.881-99.
- Referans2. Poyrazoğlu HG, Kumandas S, Canpolat M, Gümüs H, Elmali F, Kara A et al. The prevalence of migraine and tension-type headache among schoolchildren in Kayseri, Turkey: an evaluation of sensitivity and specificity using multivariate analysis. J Child Neurol 2015;30 (7):889-95.
- Referans3. Rho YI, Chung HJ, Lee KH, Eun BL, Eun SH, Nam SO et al. Prevalence and clinical characteristics of primary headaches among school children in South Korea: a nationwide survey. Headache 2012;52(4):592-9.
- Referans4. Okan M, Özdemir H. Çocuklarda Başağrısı. Güncel Pediatri 2003;1:10-8.
- Referans5. Rothner AD. Heaaches in children: a review. Headache 1978;18:169-73.
- Referans6. Şenbil N, Aysun S. Çocukluk Çağı Başağrıları. Çocuk Nörolojisi. Ankara: Anıl Grup Matbaacılık; 2010. p.335-44.
- Referans7. Powers SW, Patton SR, Hommel KA, Hershey AD. Quality of life in childhood migraines: Clinical impact and comparison to other chronic illnesses. Pediatrics 2003, 112, e1–e5.
- Referans8. Abu-Arafeh I, Razak S, Sivaraman B, Graham C. Prevalence of headache and migraine in children and adolescents: A systematic review of population-based studies. Dev. Med. Child Neurol. 2010, 52, 1088–97.
- Referans9. Wober-Bingol C. Epidemiology of migraine and headache in children and adolescents. Curr. Pain Headache Rep. 2013, 17, 341.
- Referans10. Abu-Arefeh I, Russell G. Prevalence of headache and migraine in schoolchildren. BMJ 1994; 309: 765–769.
- Referans11. Aromaa M, Sillanpää ML, Rautava P, Helenius H. Childhood headache at school entry: a controlled clinical study. Neurology 1998; 50: 1729–36.
- Referans12. Congdon PJ, Forsythe WI. Migraine in childhood. A review. Clin Pediatr 1979; 18: 353–9.
- Referans13. Lee LH, Olness KN. Clinical and demographic characteristics of migraine in urban children. Headache 1997;37: 269–76.
- Referans14. Ducros A, Tournier-Lasserve E, Bousser MG. The genetics of migraine. Lancet Neurol 2002; 1:285.
- Referans15. Amin FM, Asghar MS, Hougaard A, Hansen AE, Larsen VA, de Koning PJ et al. Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study. Lancet Neurol 2013; 12:454.
- Referans16. Nalcacioglu P, Taslipinar Uzel AG, Uzel MM, Cagil N, Citak Kurt AN. Are there any changes in posterior ocular structure parameters in pediatric migraine patients? Eur J Ophthalmol. 2017 Jun 26;27(4):495-501.
- Referans17. Yener AÜ, Yılmaz D. Topographic changes measured by the swept source optical coherence tomography in retinal nerve fiber layer, optic nerve head and macula in children with migraine. Acta Neurol Belg. 2020 Jun;120(3):661-8.
- Referans18. Koban Y, Ozlece HK, Bilgin G, Koc M, Cagatay HH, Durgunlu EI et al. Intraocular pressure and ocular biometric parameters changes in migraine. BMC Ophthalmol. 2016 May 31;16:70.
- Referans19. Eidlitz-Markus T, Gorali O, Haimi-Cohen Y, Zeharia A. Symptoms of migraine in the pediatric population by age group. Cephalalgia 2008. 28:1259–63.
- Referans20. Kara SA, Erdemoğlu AK, Karadeniz MY, Altinok D. Color Doppler sonography of orbital and vertebral arteries in migraineurs without aura. J Clin Ultrasound. 2003;31(6):308-14.
- Referans21. Pekel G, Acer S, Yagci R, Kaya H, Pekel E. Impact of valsalva maneuver on corneal morphology and anterior chamber parameters. Cornea. 2014;33: 271–3.
- Referans22. Liu Z, Pflugfelder SC. Corneal thickness is reduced in dry eye. Cornea. 1999;18:403–407.
- Referans23. Celikbilek A, Adam M. The relationship between dry eye and migraine. Acta Neurol Belg. 2015;115:329–33.
- Referans24. Jonsson M, Markström K, Behndig A. Slit-scan tomography evaluation of the anterior chamber and corneal configurations at different ages. Acta Ophthalmol Scand. 2006; 84;116-20.
- Referans25. Ambrósio R Jr, Alonso RS, Luz A, Coca Velarde LG. Cornealthickness spatial profile and corneal-volume distribution: Tomographic indices to detect keratoconus. J Cataract Refract Surg. 2006; 32:1851-9.
- Referans26. Youssef PE, Mack KJ. Episodic and chronic migraine in children. Dev Med Child Neurol. 2020 Jan;62(1):34-41.
- Referans27. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018; 38(1): 1–211.
- Referans28. Avnon Y, Nitzan M, Sprecher E, Rogowski Z, Yarnitsky D. Different patterns of parasympathetic activation in uni- and bilateral migraineurs. Brain. 2003;126:1660–70.
- Referans29. Xu C, Li J, Li Z, Mao X. Migraine as a risk factor for primary open angle glaucoma: A systematic review and meta-analysis. Medicine (Baltimore). 2018 Jul;97(28):e11377.
- Referans30. Elgin U, Şen E, Uzel M, Yılmazbaş P. Comparison of Refractive Status and Anterior Segment Parameters of Juvenile Open-Angle Glaucoma and Normal Subjects. Turk J Ophthalmol. 2018 Dec 27;48(6):295-98.
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Research |
| Authors | |
| Publication Date | June 30, 2022 |
| Acceptance Date | May 27, 2022 |
| Published in Issue | Year 2022 Volume: 47 Issue: 2 |
