Abstract
Amaç: Çalışmamızın amacı, Covid-19 pnömonisinde C-reaktif protein/albüminin yaşa bağlı bir belirteç olup olmadığını belirlemekti.
Gereç ve Yöntem: Covid-19 pnömonisi olan 296 (166 erkek/ 130 kadın) hasta üzerinde retrospektif bir araştırma yaptık. Katılımcılar <65 ve ≥65 yaş olmak üzere iki gruba ayrıldı. Yoğun bakım yatışı, pulse steroid ihtiyacı ve ölüm oranları C-Reaktif protein/albümin oranı kullanılarak karşılaştırıldı.
Bulgular: CRP/albümin oranı; yoğun bakım ünitesi ve kliniğe alınan 65 yaş üstü ve 65 yaş altı hastalarda istatistiksel olarak yüksekti ve 65 yaş ve üzeri hastalarda mortaliteyi göstermede anlamlı bulundu. Tek değişkenli regresyon analizine göre C-reaktif protein/albümin oranı hem 65 yaş altı hem de 65 yaş üstü hastalarda yoğun bakıma yatış riski için istatistiksel olarak anlamlı idi (sırasıyla OR:1.515 ve OR:1,357). Çok değişkenli analize göre ise CRP/albümin oranı 65 yaş üstü hastalarda istatistiksel olarak anlamlı bulundu (OR: 1.209).
Sonuç: Artmış CRP/albümin oranının Covid-19 ciddiyeti, hastanede kalış süresi ve ölüm oranlarını tahmin etmede faydalı olduğu düşünülmektedir. Bu değişken kolay hesaplanabilir ve yaştan bağımsız olarak Covid-19 hastalarının klinik seyrini tahmin etmek için kullanılabilir.
Keywords
Supporting Institution
YOK
Project Number
YOK
Thanks
YOK
References
- 1- Lia T, Lub H and Zhangc W. Clinical observation and management of COVID-19 patients; Emerging Microbes and Infections 2020; 9: 687–690. (PMID: 32208840)
- 2- Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020; 395: 507-513. (PMID: 32007143)
- 3- Feketea GM, Vlacha V. The Diagnostic Significance of Usual Biochemical Parameters in Coronavirus Disease 19 (COVID-19): Albumin to Globulin Ratio and CRP to Albumin Ratio; Front Med (Lausanne) 2020;7:566591.3. (PMID: 33224959)
- 4- Pepys M.B, Hirschfield G.M. C-reactive protein: a critical update. J. Clin. Invest. 2013;111:1805–1812. (PMID: 12813013)
- 5- Mooiweer E, Luijk B, Bonten M.J, Ekkelenkamp M.B. C-Reactive protein levels but not CRP dynamics predict mortality in patients with pneumococcal pneumonia. J. Infect. 2011;62:314–316. (PMID: 21281676)
- 6- Hahn W.H, Song J.H, Kim H, Park S. Is procalcitonin to C-reactive protein ratio useful for the detection of late onset neonatal sepsis? J. Matern. Fetal. Neonatal. Med. 2018;31:822–826. (PMID: 28277917)
- 7- Fairclough E, Cairns E, Hamilton J, Kelly C. Evaluation of a modified early warning system for acute medical admissions and comparison with C-reactive p rotein/albumin ratio as a predictor of patient outcome. Clinical Medicine. 2009;9(1):30–33. (PMID: 19271597)
- 8- Aw D, Silva AB, Palmer DB. Immunosenescence: emerging challenges for an ageing population. Immunology. 2007;120:435–446. (PMID: 17313487)
- 9- Imam Z, Odish F, Gill I, O'Connor D, Armstrong J, Vanood A, Ibironke O, Hanna A, Ranski A, Halalau A. Olde et al. Older age and comorbidity are independent mortality predictors in a large cohort of 1305 COVID-19 patients in Michigan, United States. J Intern Med. 2020 Oct;288(4):469-476. (PMID: 32498135)
- 10- Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020 Mar 28; 395(10229):1054-1062. (PMID: 32171076)
- 11- Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020 Apr 28; 323(16):1574-1581. (PMID: 32250385)
- 12- Liu F, Li L, Xu M, Wu J, Luo D, Zhu Y et al. Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19. J Clin Virol. 2020 Jun;127:104370. doi: 10.1016/j.jcv.2020.104370. (PMID: 32344321)
- 13- Li X, Wang L, Yan S, Yang F, Xiang L, Zhu J, et al. Clinical characteristics of 25 death cases with COVID-19: A retrospective review of medical records in a single medical center, Wuhan, China. Int J Infect Dis. 2020 May;94:128-132. (PMID: 32251805)
- 14- Pan F, Yang L, Li Y, Liang B, Li L, Ye T, et al. Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study. Int J Med Sci. 2020; 17(9):1281-1292. (PMID: 32547323)
- 15- Chen W, Zheng KI, Liu S, Yan Z, Xu C, Qiao Z. Plasma CRP level is positively associated with the severity of COVID-19. Ann Clin Microbiol Antimicrob. 2020 May 15; 19(1):18. (PMID: 32414383)
- 16- Violi F, Cangemi R, Romiti GF, Ceccarelli G, Oliva A, Alessandri F, et al. Is Albumin Predictor of Mortality in COVID-19? Antioxid Redox Signal. 2021 Jul 10; 35(2):139-142. (PMID: 32524832)
- 17- Kalyon S, Gültop F, Şimşek F, Adaş M. Relationships of the neutrophil-lymphocyte and CRP-albumin ratios with the duration of hospitalization and fatality in geriatric patients with COVID-19. J Int Med Res. 2021 Sep;49(9):3000605211046112. (PMID: 34581218)
Abstract
Purpose: The aim of our study was to determine whether C-reactive protein/albumin is an age-related marker in Covid-19 pneumonia.
Materials and Methods: We performed a retrospective research on 296 patients (166 male/130 female) with Covid-19 pneumonia. The participants were divided into two groups as <65 and ≥65 years of age. The need of intensive care unit, pulse steroid requirement and mortality rates were all compared using the The C-reactive protein/albumin ratio.
Results: The C-reactive protein/albumin was found to be high in patients over the age of 65 as well as those under the age of 65 who were admitted to the intensive care unit and was found to be significant in demonstrating mortality in patients aged 65 and over. According to univariate analysis, the C-reactive protein/albumin ratio was statistically significant for the risk of intensive care admission in both patients under 65 and over 65 years of age (OR:1.515 and OR:1.357, respectively). According to multivariate analysis, the CRP/albumin ratio was statistically significant for the risk of intensive care admission, only in patients over the age of 65 (OR:1.209).
Conclusion: The increased C-reactive protein/albumin levels are thought to be useful in predicting the severity of Covid-19, hospitalisation time, and mortality rates. This variable can be calculated and used to predict the clinical course of Covid-19 pneumonia without regard to age.
Keywords
Project Number
YOK
References
- 1- Lia T, Lub H and Zhangc W. Clinical observation and management of COVID-19 patients; Emerging Microbes and Infections 2020; 9: 687–690. (PMID: 32208840)
- 2- Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020; 395: 507-513. (PMID: 32007143)
- 3- Feketea GM, Vlacha V. The Diagnostic Significance of Usual Biochemical Parameters in Coronavirus Disease 19 (COVID-19): Albumin to Globulin Ratio and CRP to Albumin Ratio; Front Med (Lausanne) 2020;7:566591.3. (PMID: 33224959)
- 4- Pepys M.B, Hirschfield G.M. C-reactive protein: a critical update. J. Clin. Invest. 2013;111:1805–1812. (PMID: 12813013)
- 5- Mooiweer E, Luijk B, Bonten M.J, Ekkelenkamp M.B. C-Reactive protein levels but not CRP dynamics predict mortality in patients with pneumococcal pneumonia. J. Infect. 2011;62:314–316. (PMID: 21281676)
- 6- Hahn W.H, Song J.H, Kim H, Park S. Is procalcitonin to C-reactive protein ratio useful for the detection of late onset neonatal sepsis? J. Matern. Fetal. Neonatal. Med. 2018;31:822–826. (PMID: 28277917)
- 7- Fairclough E, Cairns E, Hamilton J, Kelly C. Evaluation of a modified early warning system for acute medical admissions and comparison with C-reactive p rotein/albumin ratio as a predictor of patient outcome. Clinical Medicine. 2009;9(1):30–33. (PMID: 19271597)
- 8- Aw D, Silva AB, Palmer DB. Immunosenescence: emerging challenges for an ageing population. Immunology. 2007;120:435–446. (PMID: 17313487)
- 9- Imam Z, Odish F, Gill I, O'Connor D, Armstrong J, Vanood A, Ibironke O, Hanna A, Ranski A, Halalau A. Olde et al. Older age and comorbidity are independent mortality predictors in a large cohort of 1305 COVID-19 patients in Michigan, United States. J Intern Med. 2020 Oct;288(4):469-476. (PMID: 32498135)
- 10- Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020 Mar 28; 395(10229):1054-1062. (PMID: 32171076)
- 11- Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020 Apr 28; 323(16):1574-1581. (PMID: 32250385)
- 12- Liu F, Li L, Xu M, Wu J, Luo D, Zhu Y et al. Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19. J Clin Virol. 2020 Jun;127:104370. doi: 10.1016/j.jcv.2020.104370. (PMID: 32344321)
- 13- Li X, Wang L, Yan S, Yang F, Xiang L, Zhu J, et al. Clinical characteristics of 25 death cases with COVID-19: A retrospective review of medical records in a single medical center, Wuhan, China. Int J Infect Dis. 2020 May;94:128-132. (PMID: 32251805)
- 14- Pan F, Yang L, Li Y, Liang B, Li L, Ye T, et al. Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study. Int J Med Sci. 2020; 17(9):1281-1292. (PMID: 32547323)
- 15- Chen W, Zheng KI, Liu S, Yan Z, Xu C, Qiao Z. Plasma CRP level is positively associated with the severity of COVID-19. Ann Clin Microbiol Antimicrob. 2020 May 15; 19(1):18. (PMID: 32414383)
- 16- Violi F, Cangemi R, Romiti GF, Ceccarelli G, Oliva A, Alessandri F, et al. Is Albumin Predictor of Mortality in COVID-19? Antioxid Redox Signal. 2021 Jul 10; 35(2):139-142. (PMID: 32524832)
- 17- Kalyon S, Gültop F, Şimşek F, Adaş M. Relationships of the neutrophil-lymphocyte and CRP-albumin ratios with the duration of hospitalization and fatality in geriatric patients with COVID-19. J Int Med Res. 2021 Sep;49(9):3000605211046112. (PMID: 34581218)
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Research |
| Authors | |
| Project Number | YOK |
| Publication Date | September 30, 2022 |
| Acceptance Date | August 3, 2022 |
| Published in Issue | Year 2022 Volume: 47 Issue: 3 |
