Case Report
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A MALE WITH HYPERKERATOSIS OF AREOLA ASSOCIATED WITH CHRONIC ECZEMA

Year 2017, Volume: 1 Issue: 1, 1 - 7, 28.12.2017

Selda Pelin Kartal Cemile Tuğba Eren Altunel Fatma Khurami Murat Alper

Abstract

Hyperkeratosis of the nipple and areola (HNA) is
a rare disorder characterized by verrucous thickening and brown pigmentation of
the nipple and areola. HNA is very rarely seen in men and generally has been
reported to be related to hormonal therapy. Here, we report a male patient who developed verrucous brown
pigmentation on his areola for the last two years and who had no association with
hormonal therapy but with chronic eczema.

Keywords

Hyperkeratosis nipple areola eczema obesity

References

  • 1. Kartal Durmazlar SP, Eskioglu F, Bodur Z. Hyperkeratosis of the nipple and areola: 2 years of remission with low-dose acitretin and topical calcipotriol therapy. J Dermatolog Treat. 2008;19:337-340.
  • 2. Ghanadan A, Balighi K, Khezri S, et al. Nevoid hyperkeratosis of the nipple and/or areola: Treatment with topical steroid. Indian J Dermatol. 2013;58: 408.
  • 3. Chikhalkar SB, Misri R, Kharkar V. Nevoid hyperkeratosis of nipple: nevoid or hormonal? Indian J Dermatol Venereol Leprol. 2006;72:384-386.
  • 4. Schwartz RA. Hyperkeratosis of nipple and areola. Arch Dermatol 1978;14(12): 1844-45.
  • 5. Obayashi H, Tsuchida T, Ikeda S. Hyperkeratosis of the nipple and areola. Rinsho Dermatol. 1998;40:147-150.
  • 6. Kubota Y, Koga T, Nakayama J, et al. Naevoid hyperkeratosis of the nipple and areola in a man. Br J Dermatol. 2000;142:382-384.
  • 7. Brinca A, Cardoso JC, Brites MM, et al. Florid cutaneous papillomatosis and acanthosis nigricans maligna revealing gastric adenocarcinoma. An Bras Dermatol. 2011;86:573-577.
  • 8. Martinez-Garcia E, Taibjee S, Koch D, et al. Vemurafenib-induced hyperkeratosis of the areola treated with topical adapelene. Clin Exp Dermatol. 2016; 41:148-151.
  • 9. Pérez-Izquierdo JM, Vilata JJ, Sánchez JL, et al. Retinoic acid treatment of nipple hyperkeratosis. Arch Dermatol. 1990;126:687-688.
  • 10. Mold DE, Jegasothy BV. Estrogen-induced hyperkeratosis of the nipple. Cutis. 1980; 26:95-96.
  • 11. Alonso-Corral MJ, Garrido-Colmenero C, et al. Nevoid hyperkeratosis of the nipple and the areola. Dermatol Online. J 2016;17;22(2) pii: 13030/qt9bp2r6pt.
  • 12. Kuhlman DS, Hodge SJ, Owen LG. Hyperkeratosis of the nipple and areola. J Am Acad Dermatol. 1985;13:596-598.
  • 13. English JC 3rd, Coots NV. A man with nevoid hyperkeratosis of the areola. Cutis. 1996;57:354-356.
  • 14. Mitxelena J, Ratón JA, Bilbao I, et al. Nevoid hyperkeratosis of the areola in men: response to cryotherapy. Dermatology. 1999;199:73-74.
  • 15. Bayramgurler D, Bilen N, Apaydın R, Ercin C. Nevoid hyperkeratosis of the nipple and areola: treatment of two patients with topical calcipotriol. J Am Acad Dermatol. 2002;46:131-133.
  • 16. Boussemart L, Routier E, Mateus C, et al. Prospective study of cutaneous side-effects associated with the BRAF inhibitor vemurafenib: a study of 42 patients. Ann Oncol. 2013;24:1691-1697.
  • 17. Frigerio M, Santi V, Di Micoli A, et al. Hyperkeratosis of nipple skin during sorafenib treatment. Dig Liver Dis. 2009;41:611.
  • 18. Allegue F, Soria C, Rocamora A, et al. Hyperkeratosis of the nipple and areola in a patient with cutaneous T-cell lymphoma. Int J Dermatol. 1990;29:519-520.
  • 19. Ahn SK, Chung J, Soo Lee W, et al. Hyperkeratosis of the nipple and areola simultaneously developing with cutaneous T-cell lymphoma. J Am Acad Dermatol. 1995;32:124-125.
  • 20. Polat Ekinci A, Ozturk Sari S, Buyukbabani N, et al. The Dilemma of coexisting nevoid hyperkeratosis of the nipple and areola in mycosis fungoides: A report of three cases. Dermatopathology (Basel). 2015;17:61-66.
  • 21. Roustan G, Yus ES, Simón A. Nevoid hyperkeratosis of the areola with histopathological features mimicking mycosis fungoides. Eur J Dermatol. 2002;12: 79-81.
  • 22. Rosman IS, Hepper DM, Lind AC, et al. Nevoid hyperkeratosis of the areola misinterpreted as mycosis fungoides. J Cutan Pathol. 2012;39:545-548.
  • 23. Yalçın B, Gur G, Tabanlıoğlu-Onan D, et al. Mycosis fungoides mimicking nevoid hyperkeratosis of the nipple and areola in an adolescent. Turk J Pediatr. 2014;56:565-567.
  • 24. Guevara-Gutiérrez E, Tarango-Martínez VM, Sandoval-Tress C, et al.Unilateral nevoid hyperkeratosis of the nipple and areola treated with topical calcitriol. Actas Dermosifiliogr. 2008;99:500-501.
  • 25. Tsai KY, Hsu HC. Successful treatment of topical tretinoin cream in a patient with unilateral nevoid hyperkeratosis of nipple and areola. Dermatol Sinica. 2009;27:128-131.
  • 26. Kavak A, Parlak AH, Aydogan I,et al. Hyperkeratosis of the nipple and areola in a patient with chronic mucocutaneous candidiasis. J Dermatol. 2006;33:510-511.
  • 27. Lee HW, Chang SE, Lee MW, et al. Hyperkeratosis of the nipple associated with acanthosis nigricans: treatment with topical calcipotriol. J Am Acad Dermatol. 2005;52:529-530.
  • 28. Ayaz T, Baydur Şahin S, Şahin OZ. Relation of Acanthosis nigricans to metabolic syndrome in overweight and obese women. Metab Syndr Relat Disord. 2014;12:320-323.
  • 29. Lee HW, Suh HS, Choi JC, et al. Hyperkeratosis of the nipple and areola as a sign of malignant acanthosis nigricans. Clin Exp Dermatol. 2005;30:721-722.
  • 30. Katoh N. Future perspectives in the treatment of atopic dermatitis. J Dermatol. 2009; 36:367-376.

Year 2017, Volume: 1 Issue: 1, 1 - 7, 28.12.2017

Selda Pelin Kartal Cemile Tuğba Eren Altunel Fatma Khurami Murat Alper

Abstract

References

  • 1. Kartal Durmazlar SP, Eskioglu F, Bodur Z. Hyperkeratosis of the nipple and areola: 2 years of remission with low-dose acitretin and topical calcipotriol therapy. J Dermatolog Treat. 2008;19:337-340.
  • 2. Ghanadan A, Balighi K, Khezri S, et al. Nevoid hyperkeratosis of the nipple and/or areola: Treatment with topical steroid. Indian J Dermatol. 2013;58: 408.
  • 3. Chikhalkar SB, Misri R, Kharkar V. Nevoid hyperkeratosis of nipple: nevoid or hormonal? Indian J Dermatol Venereol Leprol. 2006;72:384-386.
  • 4. Schwartz RA. Hyperkeratosis of nipple and areola. Arch Dermatol 1978;14(12): 1844-45.
  • 5. Obayashi H, Tsuchida T, Ikeda S. Hyperkeratosis of the nipple and areola. Rinsho Dermatol. 1998;40:147-150.
  • 6. Kubota Y, Koga T, Nakayama J, et al. Naevoid hyperkeratosis of the nipple and areola in a man. Br J Dermatol. 2000;142:382-384.
  • 7. Brinca A, Cardoso JC, Brites MM, et al. Florid cutaneous papillomatosis and acanthosis nigricans maligna revealing gastric adenocarcinoma. An Bras Dermatol. 2011;86:573-577.
  • 8. Martinez-Garcia E, Taibjee S, Koch D, et al. Vemurafenib-induced hyperkeratosis of the areola treated with topical adapelene. Clin Exp Dermatol. 2016; 41:148-151.
  • 9. Pérez-Izquierdo JM, Vilata JJ, Sánchez JL, et al. Retinoic acid treatment of nipple hyperkeratosis. Arch Dermatol. 1990;126:687-688.
  • 10. Mold DE, Jegasothy BV. Estrogen-induced hyperkeratosis of the nipple. Cutis. 1980; 26:95-96.
  • 11. Alonso-Corral MJ, Garrido-Colmenero C, et al. Nevoid hyperkeratosis of the nipple and the areola. Dermatol Online. J 2016;17;22(2) pii: 13030/qt9bp2r6pt.
  • 12. Kuhlman DS, Hodge SJ, Owen LG. Hyperkeratosis of the nipple and areola. J Am Acad Dermatol. 1985;13:596-598.
  • 13. English JC 3rd, Coots NV. A man with nevoid hyperkeratosis of the areola. Cutis. 1996;57:354-356.
  • 14. Mitxelena J, Ratón JA, Bilbao I, et al. Nevoid hyperkeratosis of the areola in men: response to cryotherapy. Dermatology. 1999;199:73-74.
  • 15. Bayramgurler D, Bilen N, Apaydın R, Ercin C. Nevoid hyperkeratosis of the nipple and areola: treatment of two patients with topical calcipotriol. J Am Acad Dermatol. 2002;46:131-133.
  • 16. Boussemart L, Routier E, Mateus C, et al. Prospective study of cutaneous side-effects associated with the BRAF inhibitor vemurafenib: a study of 42 patients. Ann Oncol. 2013;24:1691-1697.
  • 17. Frigerio M, Santi V, Di Micoli A, et al. Hyperkeratosis of nipple skin during sorafenib treatment. Dig Liver Dis. 2009;41:611.
  • 18. Allegue F, Soria C, Rocamora A, et al. Hyperkeratosis of the nipple and areola in a patient with cutaneous T-cell lymphoma. Int J Dermatol. 1990;29:519-520.
  • 19. Ahn SK, Chung J, Soo Lee W, et al. Hyperkeratosis of the nipple and areola simultaneously developing with cutaneous T-cell lymphoma. J Am Acad Dermatol. 1995;32:124-125.
  • 20. Polat Ekinci A, Ozturk Sari S, Buyukbabani N, et al. The Dilemma of coexisting nevoid hyperkeratosis of the nipple and areola in mycosis fungoides: A report of three cases. Dermatopathology (Basel). 2015;17:61-66.
  • 21. Roustan G, Yus ES, Simón A. Nevoid hyperkeratosis of the areola with histopathological features mimicking mycosis fungoides. Eur J Dermatol. 2002;12: 79-81.
  • 22. Rosman IS, Hepper DM, Lind AC, et al. Nevoid hyperkeratosis of the areola misinterpreted as mycosis fungoides. J Cutan Pathol. 2012;39:545-548.
  • 23. Yalçın B, Gur G, Tabanlıoğlu-Onan D, et al. Mycosis fungoides mimicking nevoid hyperkeratosis of the nipple and areola in an adolescent. Turk J Pediatr. 2014;56:565-567.
  • 24. Guevara-Gutiérrez E, Tarango-Martínez VM, Sandoval-Tress C, et al.Unilateral nevoid hyperkeratosis of the nipple and areola treated with topical calcitriol. Actas Dermosifiliogr. 2008;99:500-501.
  • 25. Tsai KY, Hsu HC. Successful treatment of topical tretinoin cream in a patient with unilateral nevoid hyperkeratosis of nipple and areola. Dermatol Sinica. 2009;27:128-131.
  • 26. Kavak A, Parlak AH, Aydogan I,et al. Hyperkeratosis of the nipple and areola in a patient with chronic mucocutaneous candidiasis. J Dermatol. 2006;33:510-511.
  • 27. Lee HW, Chang SE, Lee MW, et al. Hyperkeratosis of the nipple associated with acanthosis nigricans: treatment with topical calcipotriol. J Am Acad Dermatol. 2005;52:529-530.
  • 28. Ayaz T, Baydur Şahin S, Şahin OZ. Relation of Acanthosis nigricans to metabolic syndrome in overweight and obese women. Metab Syndr Relat Disord. 2014;12:320-323.
  • 29. Lee HW, Suh HS, Choi JC, et al. Hyperkeratosis of the nipple and areola as a sign of malignant acanthosis nigricans. Clin Exp Dermatol. 2005;30:721-722.
  • 30. Katoh N. Future perspectives in the treatment of atopic dermatitis. J Dermatol. 2009; 36:367-376.
There are 30 citations in total.

Details

Journal Section Case Reports
Authors

Selda Pelin Kartal This is me

Cemile Tuğba Eren Altunel This is me

Fatma Khurami This is me

Murat Alper

Publication Date December 28, 2017
Published in Issue Year 2017 Volume: 1 Issue: 1

Cite

APA Kartal, S. P., Eren Altunel, C. T., Khurami, F., Alper, M. (2017). A MALE WITH HYPERKERATOSIS OF AREOLA ASSOCIATED WITH CHRONIC ECZEMA. DOD Clinical Case Reports, 1(1), 1-7.
AMA Kartal SP, Eren Altunel CT, Khurami F, Alper M. A MALE WITH HYPERKERATOSIS OF AREOLA ASSOCIATED WITH CHRONIC ECZEMA. DODCR. December 2017;1(1):1-7.
Chicago Kartal, Selda Pelin, Cemile Tuğba Eren Altunel, Fatma Khurami, and Murat Alper. “A MALE WITH HYPERKERATOSIS OF AREOLA ASSOCIATED WITH CHRONIC ECZEMA”. DOD Clinical Case Reports 1, no. 1 (December 2017): 1-7.
EndNote Kartal SP, Eren Altunel CT, Khurami F, Alper M (December 1, 2017) A MALE WITH HYPERKERATOSIS OF AREOLA ASSOCIATED WITH CHRONIC ECZEMA. DOD Clinical Case Reports 1 1 1–7.
IEEE S. P. Kartal, C. T. Eren Altunel, F. Khurami, and M. Alper, “A MALE WITH HYPERKERATOSIS OF AREOLA ASSOCIATED WITH CHRONIC ECZEMA”, DODCR, vol. 1, no. 1, pp. 1–7, 2017.
ISNAD Kartal, Selda Pelin et al. “A MALE WITH HYPERKERATOSIS OF AREOLA ASSOCIATED WITH CHRONIC ECZEMA”. DOD Clinical Case Reports 1/1 (December 2017), 1-7.
JAMA Kartal SP, Eren Altunel CT, Khurami F, Alper M. A MALE WITH HYPERKERATOSIS OF AREOLA ASSOCIATED WITH CHRONIC ECZEMA. DODCR. 2017;1:1–7.
MLA Kartal, Selda Pelin et al. “A MALE WITH HYPERKERATOSIS OF AREOLA ASSOCIATED WITH CHRONIC ECZEMA”. DOD Clinical Case Reports, vol. 1, no. 1, 2017, pp. 1-7.
Vancouver Kartal SP, Eren Altunel CT, Khurami F, Alper M. A MALE WITH HYPERKERATOSIS OF AREOLA ASSOCIATED WITH CHRONIC ECZEMA. DODCR. 2017;1(1):1-7.