Abstract
OBJECTIVE: Hepatitis B virus is the most important cause of chronic liver inflammation. Studies showing that platelets have important functions as an inflammatory trigger in cases of chronic inflammation have increased in recent years. Expressed as platelet (PLT) indices; platelet volume (MPV), platelet distribution width (PDW), and platelet percentage (PCT) values; it is one of the important markers that provide information about the function and activation of platelets. In this study, in HBsAg positive and HBsAg negative patients, it is aimed to evaluate the parameters of PLT, MPV, PDW and PCT.
MATERIALS AND METHODS: In this retrospective study, the results of 193 HBsAg positive and 193 HBsAg negative patients who applied to Infectious Diseases Outpatient Clinic of Uşak University Faculty of Medicine Training and Research Hospital were evaluated. The values of PLT, PDW, PCT and MPV parameters were determined using a hemogram device. Student t-test and one- way ANOVA test were used for comparison between the groups. A value of P<0.05 was considered as statistically significant.
RESULTS: In our study, while PLT, PDW, PCT and MPV values were determined as 227.36±69.98 103/mm3, 16.34±1.52%, 0.22±0.62% and 9.74±1.10 fl, respectively, in the HBsAg positive patient group, the same values were determined as 224.95±67.48 103/mm3, 16.16±1.08%, 0.22±0.62%, 9.82±1.20 fl, respectively, (p>0.05, p>0.05, p>0.05 and p>0.05, respectively) in the HBsAg negative patient group. In terms of these values, no statistically significant difference was found between the HBsAg positive patient group and the HBsAg negative patient group. In the correlation analysis performed in all cases (n=386), it can be said that there is a very strong negative correlation between PLT and age, MPV, and PDW (respectively, r=-0.156 p=0.06, r=-0.394 p<0.01, r=-0.467 p< 0.01). It was also determined that there was a strong positive correlation (r=0.915 p<0.01) between PLT and PCT.
CONCLUSION: In this study, there was no significant difference between HBsAg positive patients and HBsAg negative patients in terms of platelet indices. We recommend that studies on this subject be conducted by grouping hepatitis B patients according to different clinical stages.
Keywords
References
- Nassal M. Hepatitis B viruses: reverse transcription a different way. Virus Res. 2008; 134:235-49.
- Zafrin N, Sarkar MAS, Rahman M, Salma U, Mahbub T, Azhar MA. Hepatitis B virus infection: knowledge and awareness among the patients admitted in a tertiary care hospital in Bangladesh. Viral Hepatit Dergisi. 2019; 25(1):6-13.
- Perz JF, Armstrong GL, Farrington LA, Hutin YJ, Bell BP. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol. 2006; 4:529-38.
- Lupberger J, Hildt E. Hepatitis B virus-induced oncogenesis, World J Gastroenterol. 2007;13(1):74-81.
- Yuri GA, Ayvazyan L, Mikhailidis PD, et al. Mean platelet volume: a link between thrombosis and inflammation Current pharmaceutical design. 2011;17(1):47-58.
- Golebiewska EM, Poole AW. Platelet secretion: From haemostasis to wound healing and beyond. Blood reviews. 2015; 29(3):153-62.
- Öztürk Z, Dag M, Kuyumcu M, et al. Could platelet indices be new biomarkers for inflammatory bowel diseases. Eur Rev Med Pharmacol Sci. 2013;17(3):334-41.
- Budak YU, Polat M, Huysal K. The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review. Biochemia medica. 2016;26(2):178-93.
- Celik T, Güler E, Atas Berksoy E, Arslan N. Mean platelet volume as a negative marker of inflammation in children with rotavirus gastroenteritis. Iran J Pediatr. 2014;24(5):617-22.
- Ripoche J. Blood platelets and inflammation: their relationship with liver and digestive diseases. Clin Res Hepatol Gastroenterol. 2011;35(5):353-7.
- Tong H, Song L, Hoan N et al. Soluble MICB protein levels and platelet counts during hepatitis B virus infection and response to hepatocellular carcinoma treatment. BMC Infect Dis 2015;15(1):25.
- Efe S, Asker İ, İnal V. Prognostic significance of critical patients’ platelet indexes in mixed type critical care unit. Yoğun Bakım Derg. 2019;10(1):13−17
- Oncel MY, Ozdemir R, Yurttutan S et al. Mean platelet volume in neonatal sepsis, J Clin Lab Anal. 2012;26(6):493-6.
- Ozdemir R, Karadeniz C, Doksoz O et al. Are mean platelet volume and platelet distribution width useful parameters in children with acute rheumatic carditis? Pediatr Cardiol. 2014;35(1):53-6.
- Akbal A, Gokmen F, Gencer M, Inceer BS, Komurcu E. Mean platelet volume and platelet distribution width can be related to bone mineralization, Osteoporos Int. 2014;25(9): 2291-5.
- World Health Organization. Hepatitis B vaccines. Weekly Epidemiological Record. 2004; 79: 255-263.
- European Association for the Study of the Liver. Clinical Practice Guidelines on the management of hepatitis B virüs infection. J Hepatol. 2017; 67:370-98.
- World Health Organization. Guidelines for The Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection. WHO, Geneva, 2015:1-134.
- Ceylan B, Fincanci M, Yardimci C et al. Can mean platelet volume determine the severity of liver fibrosis or inflammation in patients with chronic hepatitis
- Ceylan B, Mete B, Fincanci M et al. A new model using platelet indices to predict liver fibrosis in patients with chronic hepatitis B infection, Wien Klin Wochenschr. 2013;125:453-60.
- Turhan O, Coban E, Inan D, Yalcin AN. Increased mean platelet volume in chronic hepatitis B patients with inactive disease, Med Sci Monit. 2010;16(4):202-5.
- Şay Coşkun US, Özmen ZC. Evaluation of Platelet İndex and Biochemical Parameters in Patients with Hepatitis B Virus. F.U.Med. J. Health Sci. 2019; 33 (1): 43-46.
- Cho SY, Lee A, Lee HJ, Suh J-T, Park TS. Mean platelet volume in Korean patients with hepatic diseases, Platelets. 2012;23(8):648-649.
- Karabulut N, Mustafa N. Namlı MN. HBsAg pozitif hastaların trombosit indekslerinin değerlendirilmesi. ANKEM Derg. 2015;29(2):73-78.
HBsAg Pozitif Hastaların Trombosit İndekslerinin Değerlendirilmesi /Evaluation of Platelet Indexes of HBsAg Positive Patients
Abstract
ÖZET
AMAÇ: Hepatit B virüsü, kronik karaciğer inflamasyonunun en önemli nedenidir. Trombositlerin, kronik inflamasyon durumlarında inflamatuar tetikleyici olarak önemli fonksiyonlarının olduğunu gösteren çalışmalar son yıllarda artmıştır. Trombosit (PLT) indeksleri olarak ifade edilen; trombosit hacmi (MPV), trombosit dağılım genişliği (PDW) ve trombosit yüzdesi (PCT) değerleri; trombositlerin fonksiyonu ve aktivasyonu hakkında bilgi veren önemli belirteçlerdendir. Bu çalışmada; HBsAg pozitif ve HBsAg negatif hastalarda; PLT, MPV, PDW, PCT parametrelerinin değerlendirilmesi amaçlanmıştır.
GEREÇ-YÖNTEM: Bu retrospektif çalışmada; Uşak Üniversitesi Tıp Fakültesi Eğitim ve Araştırma Hastanesi Enfeksiyon hastalıkları polikliniğine başvurmuş olan 193 HBsAg pozitif ve 193 HBsAg negatif hastanın sonuçları değerlendirilmiştir. PLT, PDW, PCT ve MPV parametrelerinin değerleri hemogram cihazıyla kullanılarak belirlenmiştir. Gruplar arası karşılaştırmada, student t-testi ve one-way ANOVA testi kullanılmıştır. P<0.05 değeri istatistiksel olarak anlamlı kabul edilmiştir.
BULGULAR: Çalışmamız; HBsAg pozitif hasta grubunda; PLT, PDW, PCT ve MPV değerleri sırası ile 227.36±69.98 103/mm3, % 16.34±1.52, % 0.22±0.62 ve 9.74±1.10 fl olarak belirlenirken, HBsAg negatif hasta grubunda ise değerler sırasıyla; 224.95±67.48 103/mm3, %16.16±1.08, % 0.22±0.62, 9.82±1.20 fl olarak tespit edildi (sırasıyla; p>0.05, p>0.05, p>0.05 ve p>0.05). Bu değerler yönünden HBsAg pozitif ve HBsAg negatif hasta grubu arasında istatistiki olarak anlamlı fark tespit edilememiştir.
Tüm olgularda (n=386) yapılan korelasyon analizinde PLT ile yaş, MPV, PDW arasında oldukça güçlü negatif korelasyon (sırası ile, r=-0.156 p=0.006, r=-0.394 p<0.001, r=-0.467 p< 0.001) belirlenmiş olup, PLT ile PCT arasında ise güçlü bir pozitif korelasyonun (r=0.915 p<0.001) olduğu saptanmıştır.
SONUÇ: Bu çalışmada; trombosit indekleri yönünden HBsAg pozitif hastalar ile HBsAg negatif hastalar arasında anlamlı fark tespit edilememiştir. Bu konuyla ilgili çalışmaların hepatit B hastalarını farklı klinik evrelere göre gruplandırarak yapılmasını önermekteyiz.
Supporting Institution
Çalışmanın ekonomik maliyeti olmadığı için herhangi bir kurumdan destek alınmamıştır.
References
- Nassal M. Hepatitis B viruses: reverse transcription a different way. Virus Res. 2008; 134:235-49.
- Zafrin N, Sarkar MAS, Rahman M, Salma U, Mahbub T, Azhar MA. Hepatitis B virus infection: knowledge and awareness among the patients admitted in a tertiary care hospital in Bangladesh. Viral Hepatit Dergisi. 2019; 25(1):6-13.
- Perz JF, Armstrong GL, Farrington LA, Hutin YJ, Bell BP. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol. 2006; 4:529-38.
- Lupberger J, Hildt E. Hepatitis B virus-induced oncogenesis, World J Gastroenterol. 2007;13(1):74-81.
- Yuri GA, Ayvazyan L, Mikhailidis PD, et al. Mean platelet volume: a link between thrombosis and inflammation Current pharmaceutical design. 2011;17(1):47-58.
- Golebiewska EM, Poole AW. Platelet secretion: From haemostasis to wound healing and beyond. Blood reviews. 2015; 29(3):153-62.
- Öztürk Z, Dag M, Kuyumcu M, et al. Could platelet indices be new biomarkers for inflammatory bowel diseases. Eur Rev Med Pharmacol Sci. 2013;17(3):334-41.
- Budak YU, Polat M, Huysal K. The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review. Biochemia medica. 2016;26(2):178-93.
- Celik T, Güler E, Atas Berksoy E, Arslan N. Mean platelet volume as a negative marker of inflammation in children with rotavirus gastroenteritis. Iran J Pediatr. 2014;24(5):617-22.
- Ripoche J. Blood platelets and inflammation: their relationship with liver and digestive diseases. Clin Res Hepatol Gastroenterol. 2011;35(5):353-7.
- Tong H, Song L, Hoan N et al. Soluble MICB protein levels and platelet counts during hepatitis B virus infection and response to hepatocellular carcinoma treatment. BMC Infect Dis 2015;15(1):25.
- Efe S, Asker İ, İnal V. Prognostic significance of critical patients’ platelet indexes in mixed type critical care unit. Yoğun Bakım Derg. 2019;10(1):13−17
- Oncel MY, Ozdemir R, Yurttutan S et al. Mean platelet volume in neonatal sepsis, J Clin Lab Anal. 2012;26(6):493-6.
- Ozdemir R, Karadeniz C, Doksoz O et al. Are mean platelet volume and platelet distribution width useful parameters in children with acute rheumatic carditis? Pediatr Cardiol. 2014;35(1):53-6.
- Akbal A, Gokmen F, Gencer M, Inceer BS, Komurcu E. Mean platelet volume and platelet distribution width can be related to bone mineralization, Osteoporos Int. 2014;25(9): 2291-5.
- World Health Organization. Hepatitis B vaccines. Weekly Epidemiological Record. 2004; 79: 255-263.
- European Association for the Study of the Liver. Clinical Practice Guidelines on the management of hepatitis B virüs infection. J Hepatol. 2017; 67:370-98.
- World Health Organization. Guidelines for The Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection. WHO, Geneva, 2015:1-134.
- Ceylan B, Fincanci M, Yardimci C et al. Can mean platelet volume determine the severity of liver fibrosis or inflammation in patients with chronic hepatitis
- Ceylan B, Mete B, Fincanci M et al. A new model using platelet indices to predict liver fibrosis in patients with chronic hepatitis B infection, Wien Klin Wochenschr. 2013;125:453-60.
- Turhan O, Coban E, Inan D, Yalcin AN. Increased mean platelet volume in chronic hepatitis B patients with inactive disease, Med Sci Monit. 2010;16(4):202-5.
- Şay Coşkun US, Özmen ZC. Evaluation of Platelet İndex and Biochemical Parameters in Patients with Hepatitis B Virus. F.U.Med. J. Health Sci. 2019; 33 (1): 43-46.
- Cho SY, Lee A, Lee HJ, Suh J-T, Park TS. Mean platelet volume in Korean patients with hepatic diseases, Platelets. 2012;23(8):648-649.
- Karabulut N, Mustafa N. Namlı MN. HBsAg pozitif hastaların trombosit indekslerinin değerlendirilmesi. ANKEM Derg. 2015;29(2):73-78.
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Original Investigation |
| Authors | |
| Early Pub Date | December 30, 2022 |
| Publication Date | December 30, 2022 |
| Acceptance Date | December 7, 2022 |
| Published in Issue | Year 2022 Volume: 5 Issue: 3 |
