Abstract
Objective: Uterine leiomyomas are the most common benign tumors of reproductive age women with symptoms of bleeding, pain, pressure and consequences on reproduction. Obestatin is a recently discovered secreted peptide encoded by the preproghrelin gene. The role of obestatin in the regulation of metabolism is still under debate. In this article, we investigate the use of biomarker in patients with uterine leiomyoma. Our goal is to study the obestatin as a biomarker for the diagnosis and monitoring of uterine leiomyoma.
Methods: This cross-sectional observational study was conducted between January 2015–June 2015 in outpatient gynecology clinic of Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara. A total of 82 women were recruited as 48 with uterine leiomyoma and 34 healthy controls.The obestatin levels were reviewed prospectively.
Results: The obestatin levels of study group was lower than the control group (1.91±2.64 pg/mL vs. 3.58±4.81 pg/mL, p ꓿.009). The obestatin levels without normal distribution, Mann–Whitney U-test was performed for two independent groups.
Conclusion: Increased obestatin characterized obesity in women, supporting the hypothesis that the imbalance of obestatin may have a role in the pathophysiology of leiomyoma due to obesity. On the other hand, some relevant differences between our data on circulating blood levels of obestatin in normal-weight women who had leiomyoma subjects and those reported in the few studies published so far imply that further extensive research in this new area is needed.
Ethical Statement
Approval was obtained by the institutional review board from Ankara Zekai Tahir Burak Women's Health Training and Research Hospital on 26.11.2014 # 2014/37.
Supporting Institution
None
Thanks
None
References
- Lacquaniti A, Donato V, Chirico V, Buemi A, Buemi M. Obestatin: an interesting but controversial gut hormone. Ann Nutr Metab. 2011;59(2-4):193-9.
- Gargantini E, Grande C, Trovato L, Ghigo E, Granata R. The role of obestatin in glucose and lipid metabolism. Horm Metab Res. 2013 Dec;45(13):1002-8.
- Guyenet SJ, Schwartz MW. Clinical review: Regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity. J Clin Endocrinol Metab. 2012 Mar;97(3):745-55.
- Vicennati V, Genghini S, De Iasio R, Pasqui F, Pagotto U, Pasquali R. Circulating obestatin levels and the ghrelin/obestatin ratio in obese women. Eur J Endocrinol. 2007 Sep;157(3):295-301.
- Seim I, Walpole C, Amorim L, Josh P, Herington A, Chopin L. The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease. Mol Cell Endocrinol. 2011 Jun 20;340(1):111-7.
- Buttram VC Jr, Reiter RC. Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril. 1981 Oct;36(4):433-45.
- Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake. Science. 2005 Nov 11;310(5750):996-9.
- Markowska A, Ziolkowska A, Nowinka K, Malendowicz LK. Elevated blood active ghrelin and normal total ghrelin and obestatin concentrations in uterine leiomyoma. Eur J Gynaecol Oncol. 2009;30(3):281-4.
- Ren XL, Zhou XD, Zhang J, He GB, Han ZH, Zheng MJ, Li L, Yu M, Wang L. Extracorporeal ablation of uterine fibroids with high-intensity focused ultrasound: imaging and histopathologic evaluation. J Ultrasound Med. 2007 Feb;26(2):201-12.
- Granata R, Volante M, Settanni F, Gauna C, Ghé C, Annunziata M, Deidda B, Gesmundo I, Abribat T, van der Lely AJ, Muccioli G, Ghigo E, Papotti M. Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats. J Mol Endocrinol. 2010 Jul;45(1):9-17. doi: 10.1677/JME-09-0141.
- Alloatti G, Arnoletti E, Bassino E, Penna C, Perrelli MG, Ghé C, Muccioli G. Obestatin affords cardioprotection to the ischemic-reperfused isolated rat heart and inhibits apoptosis in cultures of similarly stressed cardiomyocytes. Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H470-81.
Abstract
Amaç: Uterin leiomyomlar üreme çağındaki kadınlarda kanama, ağrı, baskı ve üreme üzerine etkileri gibi semptomlarla en sık görülen iyi huylu tümörlerdir. Obestatin, preproghrelin geni tarafından kodlanan, yakın zamanda keşfedilen salgılanan bir peptiddir. Obestatinin metabolizmanın düzenlenmesindeki rolü halen tartışılmaktadır. Bu yazıda uterin leiyomiyomlu hastalarda biyobelirteçlerin kullanımını araştırdık. Amacımız obestatin’i uterus leiomyomunun tanısı ve takibi için bir biyobelirteç olarak incelemektir.
Gereç ve Yöntem: Bu kesitsel gözlemsel çalışma Ocak 2015-Haziran 2015 tarihleri arasında Ankara Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi Kadın Hastalıkları Polikliniği’nde gerçekleştirildi. Çalışmaya 48’i uterin leiyomiyomlu ve 34’ü sağlıklı kontrol olmak üzere toplam 82 kadın dahil edildi. Obestatin düzeyleri prospektif olarak incelendi.
Bulgular: Normal dağılım göstermeyen obestatin düzeyleri için iki bağımsız gruba Mann-Whitney U-testi uygulandı. Sonuçlar bu istatistik metod sonrası elde edilmiştir. Çalışma grubunun obestatin düzeyleri kontrol grubuna göre daha düşüktü (1.91±2.64 pg/mL vs. 3.58±4.81 pg/mL, p ꓿ 0.009).
Sonuç: Kadınlarda obestatin ile karakterize obezitenin artması, obestatin dengesizliğinin obeziteye bağlı leiomyomun patofizyolojisinde rol oynayabileceği hipotezini desteklemektedir. Öte yandan, leiomyoma hastası olan normal kilolu kadınlarda dolaşımdaki obestatin düzeylerine ilişkin verilerimizle şu ana kadar yayınlanan birkaç çalışmada bildirilenler arasındaki bazı anlamlı farklılıklar, bu yeni alanda daha kapsamlı araştırmalara ihtiyaç olduğunu ima etmektedir.
Ethical Statement
Ankara Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi'nden kurumsal inceleme kurulundan 26.11.2014 # 2014/37 onay alındı.
Supporting Institution
Yok
Thanks
Yok
References
- Lacquaniti A, Donato V, Chirico V, Buemi A, Buemi M. Obestatin: an interesting but controversial gut hormone. Ann Nutr Metab. 2011;59(2-4):193-9.
- Gargantini E, Grande C, Trovato L, Ghigo E, Granata R. The role of obestatin in glucose and lipid metabolism. Horm Metab Res. 2013 Dec;45(13):1002-8.
- Guyenet SJ, Schwartz MW. Clinical review: Regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity. J Clin Endocrinol Metab. 2012 Mar;97(3):745-55.
- Vicennati V, Genghini S, De Iasio R, Pasqui F, Pagotto U, Pasquali R. Circulating obestatin levels and the ghrelin/obestatin ratio in obese women. Eur J Endocrinol. 2007 Sep;157(3):295-301.
- Seim I, Walpole C, Amorim L, Josh P, Herington A, Chopin L. The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease. Mol Cell Endocrinol. 2011 Jun 20;340(1):111-7.
- Buttram VC Jr, Reiter RC. Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril. 1981 Oct;36(4):433-45.
- Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake. Science. 2005 Nov 11;310(5750):996-9.
- Markowska A, Ziolkowska A, Nowinka K, Malendowicz LK. Elevated blood active ghrelin and normal total ghrelin and obestatin concentrations in uterine leiomyoma. Eur J Gynaecol Oncol. 2009;30(3):281-4.
- Ren XL, Zhou XD, Zhang J, He GB, Han ZH, Zheng MJ, Li L, Yu M, Wang L. Extracorporeal ablation of uterine fibroids with high-intensity focused ultrasound: imaging and histopathologic evaluation. J Ultrasound Med. 2007 Feb;26(2):201-12.
- Granata R, Volante M, Settanni F, Gauna C, Ghé C, Annunziata M, Deidda B, Gesmundo I, Abribat T, van der Lely AJ, Muccioli G, Ghigo E, Papotti M. Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats. J Mol Endocrinol. 2010 Jul;45(1):9-17. doi: 10.1677/JME-09-0141.
- Alloatti G, Arnoletti E, Bassino E, Penna C, Perrelli MG, Ghé C, Muccioli G. Obestatin affords cardioprotection to the ischemic-reperfused isolated rat heart and inhibits apoptosis in cultures of similarly stressed cardiomyocytes. Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H470-81.
Details
| Primary Language | English |
|---|---|
| Subjects | Obstetrics and Gynaecology |
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 28, 2023 |
| Submission Date | December 3, 2023 |
| Acceptance Date | December 6, 2023 |
| Published in Issue | Year 2023 Volume: 5 Issue: 4 |
