Research Article
Year 2023,
Volume: 9 Issue: 4, 743 - 752, 04.07.2023
Abstract
References
- 1. Beiske AG, Loge JH, Ronningen A, Svensson E. Pain in Parkinson's disease: prevalence and characteristics. Pain 2009;141:173-7.
- 2. Goetz CG, Tanner CM, Levy M, Wilson RS, Garron DC. Pain in Parkinson's disease. Mov Disord 1986;1:45-9.
- 3. Broetz D, Eicher M, Gasser T, Weller M, Steinbach JP. Radicular and nonradicular back pain in Parkinson's disease: a controlled study. Mov Disord 2007;22:853-6.
- 4. Etchepare F, Rozenberg S, Mirault T, Bonnet A-M, Lecorre C, Agid Y, et al. Back problems in Parkinson’s disease: an underestimated problem. Joint Bone Spine 2006;73:298-302.
- 5. Valkovic P, Minar M, Singliarova H, Harsan J, Hanakova M, Martinkova J, et al. Pain in parkinson s disease: a cross-sectional study of its prevalence, types, and relationship to depression and quality of life. PLoS One 2015;10:e0136541.
- 6. Ford B. Pain in Parkinson's disease. Mov Disord 2010;25 Suppl 1:S98-103.
- 7. Galazky I, Caspari C, Heinze H-J, Frankel J. The prevalence of chronic low back pain and lumbar deformities in patients with Parkinson's disease: implications on spinal surgery. Eur Spine J 2018;27:2847-53.
- 8. Ashour R, Jankovic J. Joint and skeletal deformities in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. Mov Disord 2006;21:1856-63.
- 9. Kim YE, Lee W-W, Yun JY, Yang HJ, Kim H-J, Jeon BS, et al. Musculoskeletal problems in Parkinson's disease: neglected issues. Parkinsonism Relat Disord 2013;19:666-9.
- 10. Kosaka H, Sairyo K, Biyani A, Leaman D, Yeasting R, Higashino K, et al. Pathomechanism of loss of elasticity and hypertrophy of lumbar ligamentum flavum in elderly patients with lumbar spinal canal stenosis. Spine (Phila Pa 1976) 2007;32:2805-11.
- 11. Kolte VS, Khambatta S, Ambiye MV. Thickness of the ligamentum flavum: correlation with age and its asymmetry-an magnetic resonance imaging study. Asian Spine J 2015;9:245-53.
- 12. Safak AA, Is M, Sevinc O, Barut C, Eryoruk N, Erdogmus B, et al. The thickness of the ligamentum flavum in relation to age and gender. Clin Anat 2010;23:79-83.
- 13. Okuda T, Fujimoto Y, Tanaka N, Ishida O, Baba I, Ochi M. Morphological changes of the ligamentum flavum as a cause of nerve root compression. Eur Spine J 2005;14:277-86.
- 14. Hallett M. Parkinson revisited: pathophysiology of motor signs. Adv Neurol 2003;91:19-28.
- 15. Hughes AJ, Daniel SE, Blankson S, Lees AJ. A clinicopathologic study of 100 cases of Parkinson's disease. Arch Neurol 1993;50:140-8.
- 16. Goetz CG, Poewe W, Rascol O, Sampaio C, Stebbins GT, Counsell C, et al. Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations. Mov Disord 2004;19:1020-8.
- 17. Buhmann C, Wrobel N, Grashorn W, Fruendt O, Wesemann K, Diedrich S, et al., Pain in Parkinson disease: a cross-sectional survey of its prevalence, specifics, and therapy. J Neurol 2017;264:758-69.
- 18. Gerdelat-Mas A, Simonetta-Moreau M, Thalamas C, Ory-Magne F, Slaoui T, Rascol O, et al. Levodopa raises objective pain threshold in Parkinson’s disease: a RIII reflex study. J Neurol Neurosurg Psychiatry 2007;78:1140-2.
- 19. Chaudhuri KR, Healy DG, Schapira AH. Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol 2006;5:235-45.
- 20. Andreadou E, Anagnostouli M, Vasdekis V, Kararizou E, Rentzos M, Kontaxis T, et al. The impact of comorbidity and other clinical and sociodemographic factors on health-related quality of life in Greek patients with Parkinson's disease. Aging Ment Health 2011;15:913-21.
- 21. Bijkerk C, Houwing-Duistermaat JJ, Valkenburg HA, Meulenbelt I, Hofman A, Breeveld FC, et al. Heritabilities of radiologic osteoarthritis in peripheral joints and of disc degeneration of the spine. Arthritis Rheum 1999;42:1729-35.
- 22. Borenstein DG, Balagué F. Low back pain in adolescent and geriatric populations. Rheum Dis Clin North Am 2021;47:149-63.
- 23. Hill AV. Production and absorption of work by muscle. Science 1960;131:897-903.
- 24. O'Connor BL, Palmoski MJ, Brandt K. Neurogenic acceleration of degenerative joint lesions. J Bone Joint Surg Am 1985;67:562-72.
- 25. Wasner G, Deuschl G. Pains in Parkinson disease -- many syndromes under one umbrella. Nat Rev Neurol 2012;8:284-94.
- 26. Jensen RK, Jensen TS, Koes B, Hartvigsen J. Prevalence of lumbar spinal stenosis in general and clinical populations: a systematic review and meta-analysis. Eur Spin J 2020:29:2143-63.
- 27. Andreisek G, Imhof M, Wertli M, Winklhofer S, Pfirrmann CWA, Hodler J, et al; Lumbar Spinal Stenosis Outcomes Study Working Group Zurich. A systematic review of semiquantitative and qualitative radiologic criteria for the diagnosis of lumbar spinal stenosis. Am J Roentgenol 2013;201:W735-46.
- 28. Andreisek G, Deyo RA, Jarvik JG, Porchet F, Winklhofer SFX, Steurer J; LSOS working group. Consensus conference on core radiological parameters to describe lumbar stenosis - an initiative for structured reporting. Eur Radiol 2014;24:3224-32.
- 29. Mamisch N, Brımann M, Hodler J, Held U, Brunner F, Steurer J; Lumbar Spinal Stenosis Outcomes Study Working Group Zurich. Radiologic criteria for the diagnosis of spinal stenosis: results of a Delphi survey. Radiology 2012;264:174-9.
- 30. Altinkaya N, Yildirim T, Demir S, Alkan O, Sarica FB. Factors associated with the thickness of the ligamentum flavum: is ligamentum flavum thickening due to hypertrophy or buckling? Spine (Phila Pa 1976) 2011;36:E1093-7.
- 31. Abbas J, Hamoud K, Masharawi YM, May H, Hay O, Medlej B, et al. Ligamentum flavum thickness in normal and stenotic lumbar spines. Spine (Phila Pa 1976) 2010;35:1225-30.
- 32. Sakamaki T, Sairyo K, Sakai T, Tamura T, Okada Y, Mikami H. Measurements of ligamentum flavum thickening at lumbar spine using MRI. Arch Orthop Trauma Surg 2009;129:1415-9.
Investigation of the relationship between lumbar spine MRI findings and pain in patients who received and did not receive Parkinson's treatment
Abstract
Objectives: Parkinson's disease is a chronic, progressive neurodegenerative disorder. Pain is a common symptom in Parkinson's disease, but the prevalence, characteristics, and documentation of its relationship with Parkinson's disease are insufficient. In this study, it was aimed to evaluate the relationship between lumbar spine magnetic resonance imaging (MRI) findings in patients who received and did not receive Parkinson's treatment.
Methods: The demographic characteristics of patients with diagnosed Parkinson's disease were retrospectively obtained from the records. Their pain was grouped and the Hoehn Yahr stage at the first examination, and the interventional treatments performed were recorded. MRI measurements were made in the axial plane and sagittal plane of the spinal canal, whereas Ligamentum flavum measurements were made on both the right and left sides.
Results: Twenty-six patients were included in the study. The average age was 73.5. Notably, 57.7% of patients were not diagnosed with Parkinson's disease prior to admission, while the Hoehn Yahr stage mostly comprised Stage 2 with 53.8%. Additionally, low back, waist, and hip pain was observed in 84.6% (n = 22), whereas 61.5% (n = 16) of patients experienced radicular pain. Epidural injections accounted for 33.2%. On lumbar MRI, the most narrow spinal segment on axial measurement was shown to be L4-L5. The axial spinal canal measurement of the Hoehn Yahr 1 group was observed to be significantly lower than the Hoehn Yahr 2 group.
Conclusions: Optimal management for lumbar pain that increases with age is currently inadequate. There is a need to conduct larger studies on pain complaints, which is one of the frequently experienced non-motor symptoms in Parkinson's disease, as well as the interventional methods applied.
Keywords
References
- 1. Beiske AG, Loge JH, Ronningen A, Svensson E. Pain in Parkinson's disease: prevalence and characteristics. Pain 2009;141:173-7.
- 2. Goetz CG, Tanner CM, Levy M, Wilson RS, Garron DC. Pain in Parkinson's disease. Mov Disord 1986;1:45-9.
- 3. Broetz D, Eicher M, Gasser T, Weller M, Steinbach JP. Radicular and nonradicular back pain in Parkinson's disease: a controlled study. Mov Disord 2007;22:853-6.
- 4. Etchepare F, Rozenberg S, Mirault T, Bonnet A-M, Lecorre C, Agid Y, et al. Back problems in Parkinson’s disease: an underestimated problem. Joint Bone Spine 2006;73:298-302.
- 5. Valkovic P, Minar M, Singliarova H, Harsan J, Hanakova M, Martinkova J, et al. Pain in parkinson s disease: a cross-sectional study of its prevalence, types, and relationship to depression and quality of life. PLoS One 2015;10:e0136541.
- 6. Ford B. Pain in Parkinson's disease. Mov Disord 2010;25 Suppl 1:S98-103.
- 7. Galazky I, Caspari C, Heinze H-J, Frankel J. The prevalence of chronic low back pain and lumbar deformities in patients with Parkinson's disease: implications on spinal surgery. Eur Spine J 2018;27:2847-53.
- 8. Ashour R, Jankovic J. Joint and skeletal deformities in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. Mov Disord 2006;21:1856-63.
- 9. Kim YE, Lee W-W, Yun JY, Yang HJ, Kim H-J, Jeon BS, et al. Musculoskeletal problems in Parkinson's disease: neglected issues. Parkinsonism Relat Disord 2013;19:666-9.
- 10. Kosaka H, Sairyo K, Biyani A, Leaman D, Yeasting R, Higashino K, et al. Pathomechanism of loss of elasticity and hypertrophy of lumbar ligamentum flavum in elderly patients with lumbar spinal canal stenosis. Spine (Phila Pa 1976) 2007;32:2805-11.
- 11. Kolte VS, Khambatta S, Ambiye MV. Thickness of the ligamentum flavum: correlation with age and its asymmetry-an magnetic resonance imaging study. Asian Spine J 2015;9:245-53.
- 12. Safak AA, Is M, Sevinc O, Barut C, Eryoruk N, Erdogmus B, et al. The thickness of the ligamentum flavum in relation to age and gender. Clin Anat 2010;23:79-83.
- 13. Okuda T, Fujimoto Y, Tanaka N, Ishida O, Baba I, Ochi M. Morphological changes of the ligamentum flavum as a cause of nerve root compression. Eur Spine J 2005;14:277-86.
- 14. Hallett M. Parkinson revisited: pathophysiology of motor signs. Adv Neurol 2003;91:19-28.
- 15. Hughes AJ, Daniel SE, Blankson S, Lees AJ. A clinicopathologic study of 100 cases of Parkinson's disease. Arch Neurol 1993;50:140-8.
- 16. Goetz CG, Poewe W, Rascol O, Sampaio C, Stebbins GT, Counsell C, et al. Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations. Mov Disord 2004;19:1020-8.
- 17. Buhmann C, Wrobel N, Grashorn W, Fruendt O, Wesemann K, Diedrich S, et al., Pain in Parkinson disease: a cross-sectional survey of its prevalence, specifics, and therapy. J Neurol 2017;264:758-69.
- 18. Gerdelat-Mas A, Simonetta-Moreau M, Thalamas C, Ory-Magne F, Slaoui T, Rascol O, et al. Levodopa raises objective pain threshold in Parkinson’s disease: a RIII reflex study. J Neurol Neurosurg Psychiatry 2007;78:1140-2.
- 19. Chaudhuri KR, Healy DG, Schapira AH. Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol 2006;5:235-45.
- 20. Andreadou E, Anagnostouli M, Vasdekis V, Kararizou E, Rentzos M, Kontaxis T, et al. The impact of comorbidity and other clinical and sociodemographic factors on health-related quality of life in Greek patients with Parkinson's disease. Aging Ment Health 2011;15:913-21.
- 21. Bijkerk C, Houwing-Duistermaat JJ, Valkenburg HA, Meulenbelt I, Hofman A, Breeveld FC, et al. Heritabilities of radiologic osteoarthritis in peripheral joints and of disc degeneration of the spine. Arthritis Rheum 1999;42:1729-35.
- 22. Borenstein DG, Balagué F. Low back pain in adolescent and geriatric populations. Rheum Dis Clin North Am 2021;47:149-63.
- 23. Hill AV. Production and absorption of work by muscle. Science 1960;131:897-903.
- 24. O'Connor BL, Palmoski MJ, Brandt K. Neurogenic acceleration of degenerative joint lesions. J Bone Joint Surg Am 1985;67:562-72.
- 25. Wasner G, Deuschl G. Pains in Parkinson disease -- many syndromes under one umbrella. Nat Rev Neurol 2012;8:284-94.
- 26. Jensen RK, Jensen TS, Koes B, Hartvigsen J. Prevalence of lumbar spinal stenosis in general and clinical populations: a systematic review and meta-analysis. Eur Spin J 2020:29:2143-63.
- 27. Andreisek G, Imhof M, Wertli M, Winklhofer S, Pfirrmann CWA, Hodler J, et al; Lumbar Spinal Stenosis Outcomes Study Working Group Zurich. A systematic review of semiquantitative and qualitative radiologic criteria for the diagnosis of lumbar spinal stenosis. Am J Roentgenol 2013;201:W735-46.
- 28. Andreisek G, Deyo RA, Jarvik JG, Porchet F, Winklhofer SFX, Steurer J; LSOS working group. Consensus conference on core radiological parameters to describe lumbar stenosis - an initiative for structured reporting. Eur Radiol 2014;24:3224-32.
- 29. Mamisch N, Brımann M, Hodler J, Held U, Brunner F, Steurer J; Lumbar Spinal Stenosis Outcomes Study Working Group Zurich. Radiologic criteria for the diagnosis of spinal stenosis: results of a Delphi survey. Radiology 2012;264:174-9.
- 30. Altinkaya N, Yildirim T, Demir S, Alkan O, Sarica FB. Factors associated with the thickness of the ligamentum flavum: is ligamentum flavum thickening due to hypertrophy or buckling? Spine (Phila Pa 1976) 2011;36:E1093-7.
- 31. Abbas J, Hamoud K, Masharawi YM, May H, Hay O, Medlej B, et al. Ligamentum flavum thickness in normal and stenotic lumbar spines. Spine (Phila Pa 1976) 2010;35:1225-30.
- 32. Sakamaki T, Sairyo K, Sakai T, Tamura T, Okada Y, Mikami H. Measurements of ligamentum flavum thickening at lumbar spine using MRI. Arch Orthop Trauma Surg 2009;129:1415-9.
There are 32 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences, Geriatrics and Gerontology, Neurosciences, Neurology and Neuromuscular Diseases |
| Journal Section | Original Articles |
| Authors | |
| Early Pub Date | June 1, 2023 |
| Publication Date | July 4, 2023 |
| Submission Date | November 21, 2021 |
| Acceptance Date | March 7, 2023 |
| Published in Issue | Year 2023 Volume: 9 Issue: 4 |
e-ISSN: 2149-3189
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