Case Report
Year 2024,
Volume: 10 Issue: 1 - January 2024, 149 - 153, 04.01.2024
Abstract
Ewing sarcoma (ES) is a malignant soft tissue tumor that consists of undifferentiated neuroectodermal cells. The anatomical sites of ES are commonly the pelvis and long bones. Metastasis is the cause of the most prevalent pulmonary ES. The primary lung origin of ES is extremely uncommon. Here, we report a rare case of primary pulmonary ES diagnosed from cytology and biopsy material. A chest X-ray revealed a lesion with a 9 × 7.5 cm diameter in the pericardiac area of the right lung. Clinical and radiological examinations (computed tomography and positron emission tomography) demonstrated that the lesion was a primary lesion. No distant metastasis was detected. Bronchoscopy-guided fine-needle aspiration and cytological analysis of the lesion revealed uniformly shaped small round cell morphology. Immunohistochemistry performed on the cell block produced positive results for CD99 and FLI-1. These immunohistochemical findings support the ES diagnosis.
References
- 1. Sohn AJ, Lang B, McCarroll M, Agarwal A. Primary pulmonary Ewing sarcoma/peripheral primitive neuroectodermal tumor. Proc (Bayl Univ Med Cent). 2020;33(4):646-648. doi: 10.1080/08998280.2020.1798723.
- 2. Wu HH, Wingfield-Digby J, Jifon G. Primary Ewing sarcoma of the lung: a challenging case. J R Coll Physicians Edinb. 2020;50(2):141-143. doi: 10.4997/JRCPE.2020.212.
- 3. Dharmalingam P, Nargund A, MukundaPai M, Patil Okaly GV. Primary Ewing sarcoma of the lung diagnosed on cytology: case report with review of literature. Diagn Cytopathol. 2020;48(11):1098-1101. doi: 10.1002/dc.24458.
- 4. Hammar S, Bockus D, Remington F, Cooper L. The unusual spectrum of neuroendocrine lung neoplasms. Ultrastruct Pathol. 1989;13(5-6):515-560. doi: 10.3109/01913128909074534.
- 5. Fan YH, Ma HX, Guo SP, Chen Y, Zhang SP. Application of anlotinib combined with neoadjuvant chemotherapy in primary EWS/PNET of lung: a case report. Front Oncol. 2022;12:822469. doi: 10.3389/fonc.2022.822469.
- 6. Zhang J, Dong A, Cui Y, Wang Y. FDG PET/CT in a case of primary pulmonary Ewing sarcoma. Clin Nucl Med. 2019;44(8):666-668. doi: 10.1097/RLU.0000000000002659.
- 7. Öztürk S, Kurtulus Ozturk E, Isiksalan Ozbulbul N, Acu B, Dundar E. Primary Extraosseous Ewing's Sarcoma of the Lung: Radiologic and Pathologic correlation. Cureus. 2021;13(5):e14830. doi: 10.7759/cureus.14830.
- 8. Mizuguchi K, Minato H, Onishi H, Mitani Y, Kawai J. Cytopathological findings of primary pulmonary Ewing family of tumors with EWSR1 translocation: a case report. Thorac Cancer. 2016;7(5):602-606. doi: 10.1111/1759-7714.12347.
- 9. Andrew F, Nielsen GP (eds.). Bone and Tissue Pathology: A Volume in the Foundations in Diagnostic Pathology Series. 2nd ed. Elsevier Health Sciences, 2022.
Year 2024,
Volume: 10 Issue: 1 - January 2024, 149 - 153, 04.01.2024
Abstract
Supporting Institution
YOK
Thanks
YOK
References
- 1. Sohn AJ, Lang B, McCarroll M, Agarwal A. Primary pulmonary Ewing sarcoma/peripheral primitive neuroectodermal tumor. Proc (Bayl Univ Med Cent). 2020;33(4):646-648. doi: 10.1080/08998280.2020.1798723.
- 2. Wu HH, Wingfield-Digby J, Jifon G. Primary Ewing sarcoma of the lung: a challenging case. J R Coll Physicians Edinb. 2020;50(2):141-143. doi: 10.4997/JRCPE.2020.212.
- 3. Dharmalingam P, Nargund A, MukundaPai M, Patil Okaly GV. Primary Ewing sarcoma of the lung diagnosed on cytology: case report with review of literature. Diagn Cytopathol. 2020;48(11):1098-1101. doi: 10.1002/dc.24458.
- 4. Hammar S, Bockus D, Remington F, Cooper L. The unusual spectrum of neuroendocrine lung neoplasms. Ultrastruct Pathol. 1989;13(5-6):515-560. doi: 10.3109/01913128909074534.
- 5. Fan YH, Ma HX, Guo SP, Chen Y, Zhang SP. Application of anlotinib combined with neoadjuvant chemotherapy in primary EWS/PNET of lung: a case report. Front Oncol. 2022;12:822469. doi: 10.3389/fonc.2022.822469.
- 6. Zhang J, Dong A, Cui Y, Wang Y. FDG PET/CT in a case of primary pulmonary Ewing sarcoma. Clin Nucl Med. 2019;44(8):666-668. doi: 10.1097/RLU.0000000000002659.
- 7. Öztürk S, Kurtulus Ozturk E, Isiksalan Ozbulbul N, Acu B, Dundar E. Primary Extraosseous Ewing's Sarcoma of the Lung: Radiologic and Pathologic correlation. Cureus. 2021;13(5):e14830. doi: 10.7759/cureus.14830.
- 8. Mizuguchi K, Minato H, Onishi H, Mitani Y, Kawai J. Cytopathological findings of primary pulmonary Ewing family of tumors with EWSR1 translocation: a case report. Thorac Cancer. 2016;7(5):602-606. doi: 10.1111/1759-7714.12347.
- 9. Andrew F, Nielsen GP (eds.). Bone and Tissue Pathology: A Volume in the Foundations in Diagnostic Pathology Series. 2nd ed. Elsevier Health Sciences, 2022.
There are 9 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Pathology |
| Journal Section | Case Reports |
| Authors | |
| Early Pub Date | October 9, 2023 |
| Publication Date | January 4, 2024 |
| Submission Date | August 11, 2023 |
| Acceptance Date | October 7, 2023 |
| Published in Issue | Year 2024 Volume: 10 Issue: 1 - January 2024 |
e-ISSN: 2149-3189
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