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Uzman Görüşü: Yaşlılarda Metformin Kullanımı ve B12 Vitamin Eksikliği

Year 2019, Volume: 2 Issue: 1, 27 - 29, 30.04.2019

Abstract

Wong Chit Wa ve ark. bakım evinde kalan yaşlılarda
metformin kullanımının B12 vitamini eksikliği ile ilişkili olup olmadığını
araştırdıkları çalışmada metformin kullanımının B12 vitamini eksikliği riskinin
ve ciddiyetinin artmasına yol açtığını bulunmuştur. Bu çalışmada serum B12
konsantrasyonunun <150 pmol / L olan olgular vitamin B12 eksikliği olarak
değerlendirilmiş olup kişilerin klinikleri hakkında bilgi verilmemiştir. Serum
B12 konsantrasyonunun 150 pmol / L'nin altında seçilmesi, B12 eksikliğini
teşhis etmek için yeterli değildir. B12 vitamini eksikliğini teşhis etmek için
klinik başvuru, fonksiyonel testler, intrakorpusküler vitamin B12 düzeyi ve B12
vitaminini etkileyen komorbiditeler değerlendirilmelidir.

References

  • 1) Wong, C. W., Leung, C. S., Leung, C. P., Cheng, J. N., (2018). Association of metformin use with vitamin B12 deficiency in the institutionalized elderly. Archives of Gerontology an Geriatrics, 79, 57-62
  • 2) Devalia, V., Hamilton, M. S., Molloy, A.M., (2014). British Committee for Standards in Haematology. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol, 166, 496.
  • 3) Matchar, D. B., McCrory, D.C., Millington, D.S., Feussner, J. R., (1994). Performance of the serum cobalamin assay for diagnosis of cobalamin deficiency. Am J Med Sci, 308, 276.
  • 4) Lu, W.R., Defilippi, J., Braun, A., (2013). Unleash metformin: reconsideration of the contraindication in patients with renal impairment. Ann Pharmacother 47:1488-1497
  • 5) Van Loon, S. L., Wilbik, A. M., Kaymak, U., van den Heuvel E. R., Scharnhorst, V., Boer, A. K., (2018). Improved testing for vitamin B12 deficiency: correcting MMA for eGFR reduces the number of patients classified as vitamin B12 deficient. Ann Clin Biochem, 55, 685
  • 6) Obeid, R., Jung, J., Falk, J., Herrmann, W., Geisel, J., Friesenhahn-Ochs, B., Lammert, F., Fassbender, K., Kostopoulos, P., 2013. Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes. Biochimi, 95, 1056

Expert Opinion on Association of Metformin Use and Vitamin B12 Deficiency in Older Adults

Year 2019, Volume: 2 Issue: 1, 27 - 29, 30.04.2019

Abstract

Wong Chit Wa et al., in which they aimed to investigate whether metformin use is associated with vitamin B12 deficiency in the institutionalized elderly, and found that metformin use lead to an increased risk and severity of vitamin B12 deficiency. In this study vitamin B12 deficiency was diagnosed if the serum vitamin B12 concentration was <150 pmol/L and the clinical presentation of cases defined as vitamin B12 deficient was not mentioned. Selecting serum vitamin B12 concentration below 150 pmol/L is not enough to diagnose B12 deficiency. Clinical presentation, functional tests, intracorpuscular vitamin B12 levels and the comorbidities which have effect on vitamin B12 should be evaluated to diagnose vitamin B12 deficiency.

References

  • 1) Wong, C. W., Leung, C. S., Leung, C. P., Cheng, J. N., (2018). Association of metformin use with vitamin B12 deficiency in the institutionalized elderly. Archives of Gerontology an Geriatrics, 79, 57-62
  • 2) Devalia, V., Hamilton, M. S., Molloy, A.M., (2014). British Committee for Standards in Haematology. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol, 166, 496.
  • 3) Matchar, D. B., McCrory, D.C., Millington, D.S., Feussner, J. R., (1994). Performance of the serum cobalamin assay for diagnosis of cobalamin deficiency. Am J Med Sci, 308, 276.
  • 4) Lu, W.R., Defilippi, J., Braun, A., (2013). Unleash metformin: reconsideration of the contraindication in patients with renal impairment. Ann Pharmacother 47:1488-1497
  • 5) Van Loon, S. L., Wilbik, A. M., Kaymak, U., van den Heuvel E. R., Scharnhorst, V., Boer, A. K., (2018). Improved testing for vitamin B12 deficiency: correcting MMA for eGFR reduces the number of patients classified as vitamin B12 deficient. Ann Clin Biochem, 55, 685
  • 6) Obeid, R., Jung, J., Falk, J., Herrmann, W., Geisel, J., Friesenhahn-Ochs, B., Lammert, F., Fassbender, K., Kostopoulos, P., 2013. Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes. Biochimi, 95, 1056
There are 6 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Articles
Authors

Fatma Sena Dost Günay

Ahmet Turan Işık

Publication Date April 30, 2019
Submission Date April 3, 2019
Acceptance Date April 30, 2019
Published in Issue Year 2019 Volume: 2 Issue: 1

Cite

APA Dost Günay, F. S., & Işık, A. T. (2019). Expert Opinion on Association of Metformin Use and Vitamin B12 Deficiency in Older Adults. Geriatrik Bilimler Dergisi, 2(1), 27-29.
AMA Dost Günay FS, Işık AT. Expert Opinion on Association of Metformin Use and Vitamin B12 Deficiency in Older Adults. JoGS. April 2019;2(1):27-29.
Chicago Dost Günay, Fatma Sena, and Ahmet Turan Işık. “Expert Opinion on Association of Metformin Use and Vitamin B12 Deficiency in Older Adults”. Geriatrik Bilimler Dergisi 2, no. 1 (April 2019): 27-29.
EndNote Dost Günay FS, Işık AT (April 1, 2019) Expert Opinion on Association of Metformin Use and Vitamin B12 Deficiency in Older Adults. Geriatrik Bilimler Dergisi 2 1 27–29.
IEEE F. S. Dost Günay and A. T. Işık, “Expert Opinion on Association of Metformin Use and Vitamin B12 Deficiency in Older Adults”, JoGS, vol. 2, no. 1, pp. 27–29, 2019.
ISNAD Dost Günay, Fatma Sena - Işık, Ahmet Turan. “Expert Opinion on Association of Metformin Use and Vitamin B12 Deficiency in Older Adults”. Geriatrik Bilimler Dergisi 2/1 (April 2019), 27-29.
JAMA Dost Günay FS, Işık AT. Expert Opinion on Association of Metformin Use and Vitamin B12 Deficiency in Older Adults. JoGS. 2019;2:27–29.
MLA Dost Günay, Fatma Sena and Ahmet Turan Işık. “Expert Opinion on Association of Metformin Use and Vitamin B12 Deficiency in Older Adults”. Geriatrik Bilimler Dergisi, vol. 2, no. 1, 2019, pp. 27-29.
Vancouver Dost Günay FS, Işık AT. Expert Opinion on Association of Metformin Use and Vitamin B12 Deficiency in Older Adults. JoGS. 2019;2(1):27-9.

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