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Göz Kuruluğu Şikayetiyle Başvuran Sjögren Sendromlu Hastalarda Anti-HCV Seroprevalansının Araştırılması

Year 2023, Volume: 5 Issue: 2, 95 - 98, 28.06.2023
https://doi.org/10.52827/hititmedj.1253995

Abstract

Amaç: Sjögren Sendromu (SS) esas olarak ekzokrin bezleri tutan ve tükrük ve gözyaşı bezlerinin tutulumu sonucu ağız ve gözlerin kuruluğu ile karakterize sistemik otoimmün bir hastalıktır. Hepatit C virüs (HCV) enfeksiyonu ile SS/sicca sendromu arasında anlamlı bir ilişki vardır. HCV hem SS’nun etyolojisinde suçlanmış hem de sicca sendromu HCV enfeksiyonunun karaciğer dışı belirtilerinden biri olarak gösterilmiştir. Bu çalışmada, Göz Hastalıkları kliniğine başvuran ve SS tanısı alan hastalarda Anti-HCV seroprevalansının araştırılması amaçlanmıştır. Veriler hastane otomasyon sisteminden retrospektif olarak elde edilmiştir.
Bulgular: Şubat 2017 ile Şubat 2023 tarihleri arasındaki göz polikliniğine başvuran ve sjögren sendromu tanısı ile siklosporin reçetelenen toplam 2281 hasta verisi elde edildi. Otomasyon sisteminden bu hastaların 521 tanesinin anti-HCV testi yapıldığı saptandı. Yedi hastada (%1,3) anti-HCV testi pozitif bulundu. Anti-HCV testi pozitif olanların olmayanlara göre yaş ortalamaları anlamlı oranda yüksek bulunurken cinsiyetler arasında fark bulunmadı.
Sonuç: Bu çalışmada kuru göz semptomu olan hastalarda anti-HCV pozitifliği genel populasyonla benzer bulunmuştur. Kuru göz semptomu olan tüm hastaların SS açısından değerlendirilmesi ve HCV enfeksiyonu ile birlikteliği akılda tutularak anti-HCV testlerinin yapılması daha sağlıklı veriler elde edilmesi açısından önemlidir.

References

  • Ramos-Casals M, Brito-Zerón P, Sisó-Almirall A, Bosch X. Primary Sjögren syndrome. BMJ 2012;344.
  • Daniels TE, Fox PC. Salivary and oral components of Sjögren’s syndrome. Rheumatic Disease Clinics of North America 1992;18(3):571-589.
  • Akpek EK, Klimava A, Thorne JE, Martin D, Lekhanont K, Ostrovsky A. Evaluation of patients with dry eye for presence of underlying Sjögren’s syndrome. Cornea 2009;28(5):493.
  • Ramos-Casals M, Font J. Extrahepatic manifestations in patients with chronic hepatitis C virus infection. Current opinion in rheumatology 2005;17(4):447-455.
  • 5. Haddad J, Trinchet J, Pateron D, et al. Lymphocytic sialadenitis of Sjögren’s syndrome associated with chronic hepatitis C virus liver disease. The Lancet 1992;339(8789):321-323. Wang Y, Dou H, Liu G, et al. Hepatitis C virus infection and the risk of Sjögren or sicca syndrome: a meta analysis. Microbiology and immunology 2014;58(12):675-687.
  • Ramos-Casals M, Muñoz S, Medina F, et al. Systemic autoimmune diseases in patients with hepatitis C virus infection: characterization of 1020 cases (The HISPAMEC Registry). The Journal of Rheumatology 2009;36(7):1442-1448.
  • Smith BD, Morgan RL, Beckett GA, et al. Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945–1965. Morbidity and Mortality Weekly Report: Recommendations and Reports 2012;61(4):1-32.
  • Toczylowski K, Bojkiewicz E, Barszcz M, Wozinska-Klepadlo M, Potocka P, Sulik A. Etiology, Clinical Presentation and Incidence of Infectious Meningitis and Encephalitis in Polish Children. J Clin Med 2020;9(8). Epub 2020/07/28.
  • Çeldir M, Kara I, Coşkuner S, et al. Hepatitis C prevalence in Turkey: estimation through meta-analysis: Ilayda Arjen Kara. European Journal of Public Health 2014;24(suppl_2):cku163-032.
  • Brito-Zerón P, Gheitasi H, Retamozo S, et al. How hepatitis C virus modifies the immunological profile of Sjögren syndrome: analysis of 783 patients. Arthritis Research & Therapy 2015;17(1):1-9.
  • Vitali C, Del Papa N. Classification criteria for Sjögren’s syndrome. Sjögren’s Syndrome 2016:47-60.
  • Shiboski S, Shiboski C, Criswell L, et al. American College of Rheumatology classification criteria for Sjögren’s syndrome: a data driven, expert consensus approach in the Sjögren’s International Collaborative Clinical Alliance cohort. Arthritis care & research 2012;64(4):475-487.
  • Ramos-Casals M, Garcia-Carrasco M, Cervera R, et al. Hepatitis C virus infection mimicking primary Sjögren syndrome: a clinical and immunologic description of 35 cases. Medicine 2001;80(1):1-8.

Investigation of Anti-HCV Seroprevalence In Patients With Sjögren's Syndrome Presenting With The Comlaint of Dry Eye

Year 2023, Volume: 5 Issue: 2, 95 - 98, 28.06.2023
https://doi.org/10.52827/hititmedj.1253995

Abstract

Objective: Sjögren's Syndrome (SS) is a systemic autoimmune disease that mainly involves the exocrine glands and is characterized by dry mouth and eyes as a result of involvement of the salivary and lacrimal glands. There is a significant relationship between hepatitis C virus (HCV) infection and SS/sicca syndrome. HCV has been implicated in the etiology of SS and sicca syndrome has been shown as one of the extrahepatic manifestations of HCV infection. In this study, it was aimed to investigate the anti-HCV seroprevalence in patients who applied to the Ophthalmology clinic and were diagnosed with SS. The data were obtained retrospectively from the hospital automation system. It was determined from the automation system that 521 of these patients were tested for anti-HCV. Anti-HCV test was positive in seven patients (1.3%). While the mean age of those with positive anti-HCV test was found to be significantly higher than those who did not, there was no difference between genders.
Conclusion: In this study, anti-HCV positivity was found to be similar to the general population in patients with dry eye symptoms.
Results: Data of 2281 patients who applied to the eye outpatient clinic between February 2017 and February 2023 and were prescribed cyclosporine with the diagnosis of Sjögren's syndrome were obtained. It is important to evaluate all patients with dry eye symptoms in terms of SS and to perform anti-HCV tests, keeping in mind its association with HCV infection, in order to obtain more reliable data.

References

  • Ramos-Casals M, Brito-Zerón P, Sisó-Almirall A, Bosch X. Primary Sjögren syndrome. BMJ 2012;344.
  • Daniels TE, Fox PC. Salivary and oral components of Sjögren’s syndrome. Rheumatic Disease Clinics of North America 1992;18(3):571-589.
  • Akpek EK, Klimava A, Thorne JE, Martin D, Lekhanont K, Ostrovsky A. Evaluation of patients with dry eye for presence of underlying Sjögren’s syndrome. Cornea 2009;28(5):493.
  • Ramos-Casals M, Font J. Extrahepatic manifestations in patients with chronic hepatitis C virus infection. Current opinion in rheumatology 2005;17(4):447-455.
  • 5. Haddad J, Trinchet J, Pateron D, et al. Lymphocytic sialadenitis of Sjögren’s syndrome associated with chronic hepatitis C virus liver disease. The Lancet 1992;339(8789):321-323. Wang Y, Dou H, Liu G, et al. Hepatitis C virus infection and the risk of Sjögren or sicca syndrome: a meta analysis. Microbiology and immunology 2014;58(12):675-687.
  • Ramos-Casals M, Muñoz S, Medina F, et al. Systemic autoimmune diseases in patients with hepatitis C virus infection: characterization of 1020 cases (The HISPAMEC Registry). The Journal of Rheumatology 2009;36(7):1442-1448.
  • Smith BD, Morgan RL, Beckett GA, et al. Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945–1965. Morbidity and Mortality Weekly Report: Recommendations and Reports 2012;61(4):1-32.
  • Toczylowski K, Bojkiewicz E, Barszcz M, Wozinska-Klepadlo M, Potocka P, Sulik A. Etiology, Clinical Presentation and Incidence of Infectious Meningitis and Encephalitis in Polish Children. J Clin Med 2020;9(8). Epub 2020/07/28.
  • Çeldir M, Kara I, Coşkuner S, et al. Hepatitis C prevalence in Turkey: estimation through meta-analysis: Ilayda Arjen Kara. European Journal of Public Health 2014;24(suppl_2):cku163-032.
  • Brito-Zerón P, Gheitasi H, Retamozo S, et al. How hepatitis C virus modifies the immunological profile of Sjögren syndrome: analysis of 783 patients. Arthritis Research & Therapy 2015;17(1):1-9.
  • Vitali C, Del Papa N. Classification criteria for Sjögren’s syndrome. Sjögren’s Syndrome 2016:47-60.
  • Shiboski S, Shiboski C, Criswell L, et al. American College of Rheumatology classification criteria for Sjögren’s syndrome: a data driven, expert consensus approach in the Sjögren’s International Collaborative Clinical Alliance cohort. Arthritis care & research 2012;64(4):475-487.
  • Ramos-Casals M, Garcia-Carrasco M, Cervera R, et al. Hepatitis C virus infection mimicking primary Sjögren syndrome: a clinical and immunologic description of 35 cases. Medicine 2001;80(1):1-8.
There are 13 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Research Articles
Authors

Esmeray Mutlu Yılmaz 0000-0003-2569-7601

Gokhan Ozgur 0000-0003-1759-9753

Publication Date June 28, 2023
Submission Date February 21, 2023
Acceptance Date May 25, 2023
Published in Issue Year 2023 Volume: 5 Issue: 2

Cite

AMA Mutlu Yılmaz E, Ozgur G. Göz Kuruluğu Şikayetiyle Başvuran Sjögren Sendromlu Hastalarda Anti-HCV Seroprevalansının Araştırılması. Hitit Medical Journal. June 2023;5(2):95-98. doi:10.52827/hititmedj.1253995