Abstract
Amaç:
Serebrovasküler hastalıkların kardiyak fonksiyonlar üzerine negatif etkileri
olduğu bilinmektedir. Ek olarak, inme kliniğinde uzun dönem izlemde en sık ve en önemli ölüm nedeni kardiyak
disfonksiyondur. Bu çalışmanın amacı hemorajik inmeli hastalarda kardiyak enzim
ve inflamasyon belirteçlerinin değişimini incelemek ve bu belirteçlerin inme
prognozuna etklerini araştırmaktır.
Materyal ve Metot: Bu
çalışmaya intraserebral hematom (ISH)
tanısı ile yatırılan ve hastalığın başlangıcının ilk 24 saati içinde
olan 53 hasta ile 48 kontrol dahil edildi. Her iki grubun da 1., 5. ve 10. gün
kreatinin kinaz (CK), kreatinin kinaz myokardiyal band (CKMB), troponin-I
(Trop-I), C reaktif protein (CRP) ve lökosit değerleri incelendi.
Bulgular: Çalışmaya dâhil edilen 53 hasta ile 48 kontrol
grubu arasında yaş açısından anlamlı farklılık tespit edilmedi (P=0.062). 1.gün
CK, CRP ve lökosit değerleri ile 5. ve 10 gün
CRP ve lökosit değerleri, ISH grubunda kontrol grubuna göre anlamlı
olarak daha yüksek idi. Bununla beraber, ISH grubunda CK-MB ve troponin
değerlerinin giderek azaldığı, CRP değerlerinin ise giderek arttığı tespit
edildi. 53 kişilik hasta grubunun 13 tanesi takipte exitus oldu. Yaşayan
hastalar ile karşılaştırıldığında, exitus olan hastalarda 1. gün CK, CRP ve
lökosit, 5. gün CK, CK-MB ve CRP ile 10. gün CK, CK-MB ve troponin değerleri
anlamlı olarak daha yüksek idi.
Sonuç:
Çalışmamızda, intraserebral hematom tanılı hastalarda CK-MB ve
troponin değerlerinde 1.günden itibaren bir azalma olduğunu, CRP değerlerinde
ise 1. günden itibaren bir artma olduğunu tespit ettik. Ek olarak, exitus olan
hastalarda kardiyak enzim ve inflamatuvar belirteçlerin daha yüksek olduğunu
tespit ettik. Dolayısıyla hemorajik
inmeli hastalarda myokardiyal hasarın ve inflamasyonun erken dönemde
tanınmasının, morbidite ve mortaliteyi büyük ölçüde azaltabileceğini
düşünüyoruz.
References
- 1. Albertson M, Sharma J. Stroke: current concepts. S D Med. 2014;11(67):455-465.
- 2.Liu Q, Ding Y, Yan P, Zhang JH, Lei H. Electrocardiographic abnormalities in patients with intracerebral hemorrhage. Acta Neurochir Suppl. 2011;111:353-6.
- 3. Arab D, Yahia AM, Qureshi AI. Cardiovascular manifestations of acute intracranial lesions: pathophysiology, manifestations, and treatment. J Intensive Care Med. 2003;3(18):119-29.
- 4. Hays A, Diringer MN. Elevated troponin levels are associated with higher mortality following intracerebral hemorrhage. Neurology. 2006; 9(66):1330-4
- 5. Apak I, Iltumur K, Tamam Y, Kaya N. Serum cardiac troponin T levels as an indicator of myocardial injury in ischemic and hemorrhagic stroke patients. Tohoku J Exp Med. 2005;2(205): 93-101.
- 6. Michael J. Aminof. Manifestations of Acute Neurologial Lesions. Neurology And General Medicine 4th Edition; 2007.
- 7.Liang XM, Chen J, Zhang T, Liu J, Jiang XJ, Xu ZQ. Cerebral hemorrhage increases plasma concentrations of noradrenalin and creatine kinase MB fraction with induction of cardiomyocyte damage in rats. Cell Biochem Biophys. 2014;3(70):1807-11.
- 8.Maramattom BV, Manno EM, Fulgham JR, Jaffe AS, Wijdicks EF. Clinical importance of cardiac troponin release and cardiac abnormalities in patients with supratentorial cerebral hemorrhages. Mayo Clin Proc. 2006;2(81):192-6
- 9. Tobias SL, Bookatz BJ, Diamond TH. Myocardial damage and electrocardiographic cahanges in acute cerebrovascular hemorrhage; A report of three cases and review. Heart Lung 1987;16(5):521-526
- 10.Wıllıam P. Cheshıre, Jr, Clıfford BS. The insular cortex and cardiac response to stroke: Neurology . 2006;3(66):1296-1297
- 11. Wybraniec M, Mizia-Stec K, Krzych L. Stress cardiomyopathy: yet another type of neurocardiogenic injury: 'stress cardiomyopathy'.Cardiovasc Pathol. 2014;3(23):113-20.
- 12. Dziedzic T. Clinical Significance of Acute Phase Reaction in Stroke Patients. Front Biosci. 2008;1(13):2922-7
- 13.Ay H, Arsava EM, Sarıbaş O. Creatine Kinase-MB Elevation After Stroke is not Cardiac in Origin: Stroke 2002;1(33):286-289
- 14. Collinson PO, Stubbs PJ, Kessler AC. Multicentre Evaluation Of Routine Immunoassay Of Troponin T Study. Multicentre evaluation of the diagnostic value of cardiac troponin T, CK-MB mass, and myoglobin for assessing patients with suspected acute coronary syndromes in routine clinical practice. Heart. 2003;3(89):280-6.
- 15.Norris JW, Hachinski VC, Myers MG, Callow J. Serum cardiac enzymes in stroke. Stroke. 1979; 5(10):548-53
- 16.Lang K, Borner A, Figulla HR. Comparision of biochemical markers fort he detection of minimal myocardial injury: superior sensitivity of cardiac troponin t elisa. J İntern Med 2000;247:119-123
- 17. Garrett MC, Komotar RJ, Starke RM, Doshi D, Otten ML, Connolly ES. Elevated troponin levels are predictive of mortality in surgical intracerebral hemorrhage patients. Neurocrit Care. 2010;2(12):199-203.
- 18. Xu M, Lin J, Wang D, Liu M, Hao Z, Lei C. Cardiac troponin and cerebral herniation in acute intracerebral hemorrhage. Brain Behav.2017;7(6):e00697.
- 19. Morotti A, Phuah CL, Anderson CD, Jessel MJ, Schwab K, Ayres AM, et al. Leukocyte Count and Intracerebral Hemorrhage Expansion. Stroke. 2016;47(6):1473-8.
- 20.Hjalmarsson C, Bergfeldt L, Bokemark L, Manhem K, Andersson B. Electrocardiographic abnormalities and elevated cTNT at admission for intracerebral hemorrhage: predictors for survival? Ann Noninvasive Electrocardiol. 2013;5(18):441-9.
- 21. Katsanos AH, Korantzopoulos P, Tsivgoulis G, Kyritsis AP, Kosmidou M, Giannopoulos S.Electrocardiographic abnormalities and cardiac arrhythmias in structural brain lesions. nt J Cardiol. 2013;2(167):328-34.
Abstract
Background: Cerebrovascular diseases are known to have
negative effects on cardiac functions. In addition, cardiac dysfunction is the
most common and most important cause of death in the stroke clinic during
long-term follow-up. The aim of this study was to investigate the changes in
cardiac enzyme and inflammation markers in patients with hemorrhagic stroke and
to investigate the effects of these markers on stroke prognosis.
Methods: This study included 53 patients and 48 controls who were hospitalized
for intracerebral hematoma (ICH) and were within the first 24 hours of the
onset of the disease.
Creatinine kinase (CK), creatinine kinase myocardial band (CKMB), troponin-I
(Trop-I), C-reactive protein (CRP) and leukocyte values of both groups were evaluated on the 1st, 5th
and 10th days.
Results: There were no significant differences in age
between 53 patients and 48 control groups (68.50 ± 10.22 versus 71.70 ± 6.02, P
= 0.062). CK, CRP and leukocyte values on day 1 and CRP and leukocyte values on day 5 and 10 were significantly higher in
the ICH group than in the control group. However, CK-MB and Troponin levels
decreased and CRP values increased gradually in ICH group. Thirteen
patients of 53 patients died during follow-up. Compared with the surviving
patients, CK, CRP and leukocytes on day 1, CK, CK-MB and CRP on day 5 and CK,
CK-MB and Troponin on day 10 were significantly higher in patients with exitus.
Conclusions: In
our study, we found a decrease in CK-MB and troponin values from day 1 and an increase in CRP values from day 1 in patients with intracerebral
hematoma. In addition, we found
that cardiac enzymes and inflammatory markers were higher in patients with
exitus.
Therefore, we believe that early recognition of myocardial damage and
inflammation in hemorrhagic stroke patients may significantly reduce morbidity
and mortality.
References
- 1. Albertson M, Sharma J. Stroke: current concepts. S D Med. 2014;11(67):455-465.
- 2.Liu Q, Ding Y, Yan P, Zhang JH, Lei H. Electrocardiographic abnormalities in patients with intracerebral hemorrhage. Acta Neurochir Suppl. 2011;111:353-6.
- 3. Arab D, Yahia AM, Qureshi AI. Cardiovascular manifestations of acute intracranial lesions: pathophysiology, manifestations, and treatment. J Intensive Care Med. 2003;3(18):119-29.
- 4. Hays A, Diringer MN. Elevated troponin levels are associated with higher mortality following intracerebral hemorrhage. Neurology. 2006; 9(66):1330-4
- 5. Apak I, Iltumur K, Tamam Y, Kaya N. Serum cardiac troponin T levels as an indicator of myocardial injury in ischemic and hemorrhagic stroke patients. Tohoku J Exp Med. 2005;2(205): 93-101.
- 6. Michael J. Aminof. Manifestations of Acute Neurologial Lesions. Neurology And General Medicine 4th Edition; 2007.
- 7.Liang XM, Chen J, Zhang T, Liu J, Jiang XJ, Xu ZQ. Cerebral hemorrhage increases plasma concentrations of noradrenalin and creatine kinase MB fraction with induction of cardiomyocyte damage in rats. Cell Biochem Biophys. 2014;3(70):1807-11.
- 8.Maramattom BV, Manno EM, Fulgham JR, Jaffe AS, Wijdicks EF. Clinical importance of cardiac troponin release and cardiac abnormalities in patients with supratentorial cerebral hemorrhages. Mayo Clin Proc. 2006;2(81):192-6
- 9. Tobias SL, Bookatz BJ, Diamond TH. Myocardial damage and electrocardiographic cahanges in acute cerebrovascular hemorrhage; A report of three cases and review. Heart Lung 1987;16(5):521-526
- 10.Wıllıam P. Cheshıre, Jr, Clıfford BS. The insular cortex and cardiac response to stroke: Neurology . 2006;3(66):1296-1297
- 11. Wybraniec M, Mizia-Stec K, Krzych L. Stress cardiomyopathy: yet another type of neurocardiogenic injury: 'stress cardiomyopathy'.Cardiovasc Pathol. 2014;3(23):113-20.
- 12. Dziedzic T. Clinical Significance of Acute Phase Reaction in Stroke Patients. Front Biosci. 2008;1(13):2922-7
- 13.Ay H, Arsava EM, Sarıbaş O. Creatine Kinase-MB Elevation After Stroke is not Cardiac in Origin: Stroke 2002;1(33):286-289
- 14. Collinson PO, Stubbs PJ, Kessler AC. Multicentre Evaluation Of Routine Immunoassay Of Troponin T Study. Multicentre evaluation of the diagnostic value of cardiac troponin T, CK-MB mass, and myoglobin for assessing patients with suspected acute coronary syndromes in routine clinical practice. Heart. 2003;3(89):280-6.
- 15.Norris JW, Hachinski VC, Myers MG, Callow J. Serum cardiac enzymes in stroke. Stroke. 1979; 5(10):548-53
- 16.Lang K, Borner A, Figulla HR. Comparision of biochemical markers fort he detection of minimal myocardial injury: superior sensitivity of cardiac troponin t elisa. J İntern Med 2000;247:119-123
- 17. Garrett MC, Komotar RJ, Starke RM, Doshi D, Otten ML, Connolly ES. Elevated troponin levels are predictive of mortality in surgical intracerebral hemorrhage patients. Neurocrit Care. 2010;2(12):199-203.
- 18. Xu M, Lin J, Wang D, Liu M, Hao Z, Lei C. Cardiac troponin and cerebral herniation in acute intracerebral hemorrhage. Brain Behav.2017;7(6):e00697.
- 19. Morotti A, Phuah CL, Anderson CD, Jessel MJ, Schwab K, Ayres AM, et al. Leukocyte Count and Intracerebral Hemorrhage Expansion. Stroke. 2016;47(6):1473-8.
- 20.Hjalmarsson C, Bergfeldt L, Bokemark L, Manhem K, Andersson B. Electrocardiographic abnormalities and elevated cTNT at admission for intracerebral hemorrhage: predictors for survival? Ann Noninvasive Electrocardiol. 2013;5(18):441-9.
- 21. Katsanos AH, Korantzopoulos P, Tsivgoulis G, Kyritsis AP, Kosmidou M, Giannopoulos S.Electrocardiographic abnormalities and cardiac arrhythmias in structural brain lesions. nt J Cardiol. 2013;2(167):328-34.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Research Article |
| Authors | |
| Publication Date | August 29, 2019 |
| Submission Date | February 15, 2019 |
| Acceptance Date | August 3, 2019 |
| Published in Issue | Year 2019 Volume: 16 Issue: 2 |
Harran Üniversitesi Tıp Fakültesi Dergisi / Journal of Harran University Medical Faculty