Preeklampsi Hastalarındaki Lipit Profili ile Normal Gebe Hastalardaki Lipit Profilinin Karşılaştırılması
Abstract
Amaç: Preeklamptik gebelerdeki lipit profili ile normal gebelerdeki lipit profilini karşılaştırmak.
Materyal-Metot: Bu çalışma prospektif olarak Harran Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Kliniğinde 2021 Haziran - 2022 Haziran tarihleri arasında hastaneye başvuran 40 ağır preeklamptik, 40 hafif preeklamptik ve 40 sağlıklı gebe hastalardan oluşmuştur. Tüm hastaların yaşı, gebelik ve doğum sayıları, kan basıncı ve nabız değerleri, Vücut Kitle İndeksi(VKİ), kanda total kolesterol, LDL, HDL trigliserit (TG) seviyeleri ve hemogram parametreleri (hemoglobin, hematokrit, WBC, trombosit sayısı ve MPV) değerlendirildi.
Bulgular: Gruplara göre sistolik - diastolik kan basınçları ve nabız değerleri arasında istatistiksel olarak anlamlı fark bulunmuştur (tüm gruplar için p<0.001). Preeklampsi (PE) gruplarında yer alan gebelerin VKİ kontrol grubuna göre daha yüksek olduğu ve gruplara göre VKİ arasında anlamlı fark olduğu ortaya çıkmıştır (p<0.001). Preeklampsili gebelerin total kolesterol, TG ve LDL değerlerinin sağlıklı gebelere göre daha yüksek olduğu, HDL değerlerinin ise sağlıklı gebelere göre daha düşük olduğu belirlenmiştir (p<0.001).
Sonuç: Bu çalışmada PE hastalarındaki lipit profilinin normal gebelerdeki lipit profiline göre daha yüksek çıktığını ve preeklamptik gebelerin daha obez olduğu görülmüştür. Preeklampsili gebelerin lipit profili açısından riskli bir grup olduğu ve doğum sonrası süreçtede takip edilmesi gerektiği sonucuna varılmıştır.
Keywords
References
- 1. Sibai BM, Stella CL. Diagnosis and Management of Atypical Preeclampsia-Eclampsia. American Journal Of Obstetrics and Gynecology 2009; 200(5): 481-488.
- 2. Filipek A, Jurewicz, E. Preeclampsia-A Disease of Pregnant Women. Postepy Biochemii 2018; 64(4): 323-329.
- 3. Bokslag A, Van Weissenbruch M, Mol BW, De Groot, CJ. Preeclampsia; Short And Long-Term Consequences for Mother and Neonate. Early Human Development 2016; 102: 47-50.
- 4. World Health Organization. Geographic Variation in The İncidence of Hypertension in Pregnancy. World Health Or-ganization İnternational Collaborative Study of Hypertensive Disorders of Pregnancy. Am J Obstet Gynecol 1998; 158 (1): 80-83.
- 5. Firoz T, Sanghvi H, Merialdi M, Von Dadelszen, P. Pre-Eclampsia in Low And Middle İncome Countries. Best Practi-ce & Research Clinical Obstetrics & Gynaecology 2011; 25(4): 537-548.
- 6. Wisner K. Gestational Hypertension and Preeclampsia. MCN: The American Journal of Maternal/Child Nursing 2019; 44(3): 170.
- 7. Ma’ayeh M, Costantine, MM. Prevention of Preeclampsia. In Seminars in Fetal and Neonatal Medicine 2020; 25(5): 101-123.
- 8. Al-Jameil N, Khan FA, Khan MF, Tabassum H. A Brief Over-view of Preeclampsia. Journal of Clinical Medicine Research 2014; 6(1):1-7.
- 9. Ramos JGL, Sass N, Costa SHM. Preeclampsia. Revista Brasi-leira de Ginecologia e Obstetrícia 2017; 39: 496-512.
- 10. Peraçoli JC, Borges VTM, Ramos JGL, Cavalli RDC, Costa, SHAM, Oliveira LG, et al. Pre-Eclampsia/Eclampsia. Revista Brasileira de Ginecologia e Obstetrícia 2019; 41: 318-332.
- 11. Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclamp-sia: Pathophysiology, Challenges, and Perspecti-ves. Circulation Research 2019; 124(7): 1094-1112.
- 12. Kanadıkırık F. Preeklamptik Gebelerde Serum Lipid Düzeyi. Göztepe Tıp Dergisi 2002; 17: 99-101.
- 13. Satter N, Clark P, Greer IA, Shepherd J, Packard CJ. Lipopro-tein (A) Levels İn Normal Pregnancy Complicated with Pre-eclampsia. Atherosclerosis 2000; 148:407-411.
- 14. Kılıç N. Preeklampside Lipoprotein (a) Seviyeleri: Bir Pros-pektif Klinik Çalıșma. Kafkas Tıp Bilimleri Dergisi 2012; 2(1): 6-9.
- 15. Ephraim RK, Doe PA, Amoah S, Antoh, EO. Lipid Profile and High Maternal Body Mass İndex İs Associated with Preec-lampsia: A Case-Control Study of The Cape Coast Metropo-lis. Annals Of Medical And Health Sciences Research 2014; 4(5): 746-750.
- 16. Lima VJD, Andrade CRD, Ruschi GE, Sass N. Serum Lipid Levels in Pregnancies Complicated By Preeclampsia. Sao Paulo Medical Journal 2011; 129: 73-76.
- 17. Bayhan G, Koçyigit Y, Atamer A, Atamer Y, Akkus, Z. Poten-tial Atherogenic Roles of Lipids, Lipoprotein (A) and Lipid Pe-roxidation in Preeclampsia. Gynecological Endocrinology 2005; 21(1): 1-6.
- 18. Aziz R, Mahboob T. Pre-Eclampsia and Lipid Profile. Pakistan Journal Of Medical Sciences 2007; 23(5): 751-754.
- 19. Tesfa E, Nibret E, Munshea A. Maternal Lipid Profile and Risk of Pre-Eclampsia in African Pregnant Women: A Systematic Review And Meta-Analysis. Plos One 2020; 15(12): e0243538.
- 20. Ambad R, Dhok, A. The Association of Lipid Profile and Uric Acid Levels in Normotensive, Preeclamptic Pregnancy–A Hospital-Based Study. Journal of Datta Meghe Institute Of Medical Sciences University 2020; 15(1): 21-25.
- 21. Saputra NPK, Lipoeto NI, Machmud R. Analyses of Nutrients and Body Mass İndex As Risk Factor For Preeclampsia. The Journal of Obstetrics and Gynecology of India 2017; 67(6): 409-413.
- 22. Getahun D, Ananth CV, Oyelese Y, Chavez MR, Kirby RS, Smulian JC. Primary Preeclampsia in The Second Pregnancy: Effects of Changes in Prepregnancy Body Mass İndex Between Pregnancies. Obstetrics & Gynecology 2007; 110(6): 1319-1325.
- 23. Sween LK, Althouse AD, Roberts JM. Early-Pregnancy Per-cent Body Fat in Relation to Preeclampsia Risk in Obese Women. American Journal Of Obstetrics And Gynecology 2015; 212(1): 84-e1.
- 24. O'Brien TE, Ray JG, Chan WS. Maternal Body Mass İndex and The Risk Of Preeclampsia: A Systematic Overview. Epidemio-logy 2003; 14(3): 368-374.
Abstract
Background: To compare the lipid profile of preeclamptic pregnant women with the lipid profile of normal pregnant women.
Materials and Methods: This study consisted of 40 severe preeclamptic, 40 mild preeclamptic, and 40 healthy pregnant patients who were prospectively admitted to the hospital in Harran University Faculty of Medicine, Department of Obstetrics and Gynecology between June 2021 and June 2022. Age, pregnancy and delivery numbers, blood pressure and pulse values, Body Mass Index (BMI), blood total cholesterol, LDL, HDL triglycer-ide (TG) levels and hemogram parameters (Hemoglobin, Hematocrit, WBC, Platelet count and MPV) of all patients were evaluated.he study was planned as descriptive cross-sectional. The attitudes of the students studying at the Faculty of medicine towards scientific research were questioned. In the study, the ‘’Attitude Scale Towards Scientific Research ‘’ was used.
Results: A statistically significant difference was found between systolic - diastolic blood pressures and heart rate values according to the groups (p<0.001 for all groups). It was found that the BMI of the pregnant women in the preeclampsia (PE) groups was higher than the control group and there was a significant difference between the BMIs according to the groups (p<0.001). It was determined that total cholesterol, TG and LDL values of pregnant women with preeclampsia were higher than healthy pregnant women, and HDL values were lower than healthy pregnant women (p<0.001).
Conclusions: In this study, it was observed that the lipid profile in PE patients was higher than the lipid profile in normal pregnant women, and preeclamptic pregnant women were more obese. It was concluded that pregnant women with preeclampsia are a risky group in terms of lipid profile and should be followed up in the postpartum period.
Key Words: Pregnant, Lipid profile, Preeclampsia, Body mass index
References
- 1. Sibai BM, Stella CL. Diagnosis and Management of Atypical Preeclampsia-Eclampsia. American Journal Of Obstetrics and Gynecology 2009; 200(5): 481-488.
- 2. Filipek A, Jurewicz, E. Preeclampsia-A Disease of Pregnant Women. Postepy Biochemii 2018; 64(4): 323-329.
- 3. Bokslag A, Van Weissenbruch M, Mol BW, De Groot, CJ. Preeclampsia; Short And Long-Term Consequences for Mother and Neonate. Early Human Development 2016; 102: 47-50.
- 4. World Health Organization. Geographic Variation in The İncidence of Hypertension in Pregnancy. World Health Or-ganization İnternational Collaborative Study of Hypertensive Disorders of Pregnancy. Am J Obstet Gynecol 1998; 158 (1): 80-83.
- 5. Firoz T, Sanghvi H, Merialdi M, Von Dadelszen, P. Pre-Eclampsia in Low And Middle İncome Countries. Best Practi-ce & Research Clinical Obstetrics & Gynaecology 2011; 25(4): 537-548.
- 6. Wisner K. Gestational Hypertension and Preeclampsia. MCN: The American Journal of Maternal/Child Nursing 2019; 44(3): 170.
- 7. Ma’ayeh M, Costantine, MM. Prevention of Preeclampsia. In Seminars in Fetal and Neonatal Medicine 2020; 25(5): 101-123.
- 8. Al-Jameil N, Khan FA, Khan MF, Tabassum H. A Brief Over-view of Preeclampsia. Journal of Clinical Medicine Research 2014; 6(1):1-7.
- 9. Ramos JGL, Sass N, Costa SHM. Preeclampsia. Revista Brasi-leira de Ginecologia e Obstetrícia 2017; 39: 496-512.
- 10. Peraçoli JC, Borges VTM, Ramos JGL, Cavalli RDC, Costa, SHAM, Oliveira LG, et al. Pre-Eclampsia/Eclampsia. Revista Brasileira de Ginecologia e Obstetrícia 2019; 41: 318-332.
- 11. Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclamp-sia: Pathophysiology, Challenges, and Perspecti-ves. Circulation Research 2019; 124(7): 1094-1112.
- 12. Kanadıkırık F. Preeklamptik Gebelerde Serum Lipid Düzeyi. Göztepe Tıp Dergisi 2002; 17: 99-101.
- 13. Satter N, Clark P, Greer IA, Shepherd J, Packard CJ. Lipopro-tein (A) Levels İn Normal Pregnancy Complicated with Pre-eclampsia. Atherosclerosis 2000; 148:407-411.
- 14. Kılıç N. Preeklampside Lipoprotein (a) Seviyeleri: Bir Pros-pektif Klinik Çalıșma. Kafkas Tıp Bilimleri Dergisi 2012; 2(1): 6-9.
- 15. Ephraim RK, Doe PA, Amoah S, Antoh, EO. Lipid Profile and High Maternal Body Mass İndex İs Associated with Preec-lampsia: A Case-Control Study of The Cape Coast Metropo-lis. Annals Of Medical And Health Sciences Research 2014; 4(5): 746-750.
- 16. Lima VJD, Andrade CRD, Ruschi GE, Sass N. Serum Lipid Levels in Pregnancies Complicated By Preeclampsia. Sao Paulo Medical Journal 2011; 129: 73-76.
- 17. Bayhan G, Koçyigit Y, Atamer A, Atamer Y, Akkus, Z. Poten-tial Atherogenic Roles of Lipids, Lipoprotein (A) and Lipid Pe-roxidation in Preeclampsia. Gynecological Endocrinology 2005; 21(1): 1-6.
- 18. Aziz R, Mahboob T. Pre-Eclampsia and Lipid Profile. Pakistan Journal Of Medical Sciences 2007; 23(5): 751-754.
- 19. Tesfa E, Nibret E, Munshea A. Maternal Lipid Profile and Risk of Pre-Eclampsia in African Pregnant Women: A Systematic Review And Meta-Analysis. Plos One 2020; 15(12): e0243538.
- 20. Ambad R, Dhok, A. The Association of Lipid Profile and Uric Acid Levels in Normotensive, Preeclamptic Pregnancy–A Hospital-Based Study. Journal of Datta Meghe Institute Of Medical Sciences University 2020; 15(1): 21-25.
- 21. Saputra NPK, Lipoeto NI, Machmud R. Analyses of Nutrients and Body Mass İndex As Risk Factor For Preeclampsia. The Journal of Obstetrics and Gynecology of India 2017; 67(6): 409-413.
- 22. Getahun D, Ananth CV, Oyelese Y, Chavez MR, Kirby RS, Smulian JC. Primary Preeclampsia in The Second Pregnancy: Effects of Changes in Prepregnancy Body Mass İndex Between Pregnancies. Obstetrics & Gynecology 2007; 110(6): 1319-1325.
- 23. Sween LK, Althouse AD, Roberts JM. Early-Pregnancy Per-cent Body Fat in Relation to Preeclampsia Risk in Obese Women. American Journal Of Obstetrics And Gynecology 2015; 212(1): 84-e1.
- 24. O'Brien TE, Ray JG, Chan WS. Maternal Body Mass İndex and The Risk Of Preeclampsia: A Systematic Overview. Epidemio-logy 2003; 14(3): 368-374.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Research Article |
| Authors | |
| Early Pub Date | August 29, 2023 |
| Publication Date | August 31, 2023 |
| Submission Date | February 27, 2023 |
| Acceptance Date | July 14, 2023 |
| Published in Issue | Year 2023 Volume: 20 Issue: 2 |
Harran Üniversitesi Tıp Fakültesi Dergisi / Journal of Harran University Medical Faculty