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Childhood Supratentorial High Grade Glial Tumor

Year 2011, Issue: 4, 235 - 239, 01.12.2011

Gökalp Silav Banu Atalar Elif Ilgaz Aydınlar Özlem Er Aydın Sav İlhan Elmacı

Abstract

Pediatric high grade glial tumors have different cytogenetic and molecular characteristics compared to the adult forms. They also demonstrate different responses to treatment then adult high grade gliomas. Resection of the tumor in a maximal safe manner, additionaly, using modern chemotherapeutic agents and advanced techniques of radiotherapy, provides a better survivalIn this case report, the aim is to enlighten the actual aproach of to pediatric high grade glial tumors and to evaluate the developments of diagnosis and treatment.

Keywords

Glial tumor childhood surgery radiotheraphy chemotheraphy

References

  • Heideman RL, Kuttesch J, Gajjar AJ, Walter AW, Jenkins JJ, Li Y, Sanford RA, Kun LE Supratentorial malignant gliomas in childhood. Cancer 1997;80/3:497-504
  • Dohrmann GJ, Farwell JR, Flannery JT: Astrocytomas in childhood: a population-based study. Surg Neurol 1985;23:64–68
  • Dohrmann GJ, Farwell JR, Flannery JT: Glioblastoma multiforme in children. J Neurosurg 1976;44:442–448
  • Rickert CH, Sträter R, Kaatsch P, Wassmann H, Jürgens H, Dockhorn-Dworniczak B, Paulus W: Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult cases. Am J Pathol 2001;158:1525–1532
  • Finlay JL, Boyett JM, Yates AJ, Wisoff JH, Milstein JM, GeyerJR Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine and prednisone with the eight-drugs-in-1-day regimen. J Clin Oncol 1995;13:112-23
  • Phuphanichh S, Edwards M, Levin V, Vesttnys PS, Vara WM, Davis RL Supratentorial malignant gliomas of clildhood. J Neurosurg 1984;60:495-9
  • Marchese MJ, Chang CH Malignant astrocytic gliomas in children. Cancer 1990; 65:2771-8
  • Al-Mefty O, Al-Rodhan NF, Phillips RL, El-Senossi M, Fox JL. Factors affecting survival of children with malignant gliomas. Neurosurgery 1987; 20: 416-20
  • Dropcho EJ, Wisoff JH, Walker RW, Allen JC. Supratentorial malignant gliomas in childhood: a review of fifty cases. Ann Neurol 1987; 22: 355-64
  • Campbell JW, Pollack IF, Martinez AJ, Shultz B. High-grade astrocytomas in children: radiologically complete resection is associated with an excellent long-term prognosis. Neurosurgery 1996; 38: 258-64
  • Duffner PK, Horowitz ME, Krisher JP, Friedman HS, Burger PC, Cohen ME: Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med 1993; 328: 1725-31
  • Geyer JR, Finlay JL, Boyett JM, Wisoff J, Yates A, Mao L, Packer RJ:. Survival of infants with malignant astrocytomas. Cancer 1995; 75: 1045-50
  • Walker MD, Strike TA, Sheline GE. An analysis of dose-effect relationship in the radiotherapy of malignant gliomas. Int J Radiat Oncol Biol Phys. 1979 Oct;5(10):1725-31.
  • Chang CH, Horton J, Schoenfeld D, Salazer O, Perez-Tamayo R, Kramer S, Weinstein A, Nelson JS, Tsukada Y. Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study. Cancer. 1983 Sep 15;52(6):997-1007.
  • Stupp R, Dietrich PY, Ostermann Kraljevic S, Pica A, Maillard I, Maeder P,Meuli R, Janzer R, Pizzolato G, Miralbell R, Porchet F, Regli L, de Tribolet N,Mirimanoff RO, Leyvraz S. Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide. J Clin Oncol. 2002 Mar 1;20(5):1375-82.
  • Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005 Mar 10;352(10):987-96
  • Lashford LS, Thiesse P, Jouvet A, Jaspan T, Couanet D, Griffiths PD, Doz F, Ironside J, Robson K, Hobson R, Dugan M, Pearson AD, Vassal G, Frappaz D. Temozolomide in Malignant gliomas of childhood: a United Kingdom children’s cancer study group and French society for pediatric oncology intergroup study. J Clin Oncol 2002; 20:4684–4691
  • Verschuur AC, Grill J, Lelouch-Tubiana A, Couanet D, Kalifa C, Vassal G Temozolomide in pediatric high-grade glioma: a key for combination therapy? Br J Cancer 2004; 91:425–429
  • Broniscer A, Iacono L, Chintagumpala M, Fouladi M, Wallace D, Bowers DC, Stewart C, Krasin MJ, Gajjar A. Role of temozolomide after radiotherapy for newly diagnosed diffuse brainstem glioma in children: results of a multiinstitutional study (SJHG-98) Cancer 2005; 103:133–139
  • Fulton DS, Urtasun RC, Scott-Brown I, Johnson ES, Mielke B, Curry B, Huyser-Wierenga D, Hanson J, Feldstein M: Increasing radiationdose intensity using hyperfractionation in patients with malignant glioma. Final report of a prospective phase I-II dose response study. J Neuro-oncol 1992;14:63–72
  • Packer RJ, Boyett JM, Zimmerman RA, Rorke LB, Kaplan AM, Albright AL, Selch MT, Finlay JL, Hammond GD, Wara WM: Hyperfractionated radiation therapy (72 Gy) for children with brainstem gliomas. A Children’s Cancer Group Phase I/II Trial. Cancer 1993; 72:1414–1421
  • Sposto R, Ertel IJ, Jenkin RD, Boesel CP, Venes JL, Ortega JA, Evans AE, Wara W, Hammond D: The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: results of a randomized trial. A report from the Childrens Cancer Study Group. J Neurooncol 1989; 7:165–177
  • Campbell JW, Pollack IF, Martinez AJ, Shultz B: High-grade astrocytomas in children: Radiologically complete resection is associated with an excellent long-term prognosis. Neurosurgery 38:258–264, 1996
  • Wisoff JH, Boyett JM, Berger MS, Brant C, Li H, Yates AJ, McGuire-Cullen P, Turski PA, Sutton LN, Allen JC, Packer RJ, Finlay JL: Current neurosurgical management and the impact of the extent of resection in the treatment of malignant gliomas of childhood: a report of the Children’s Cancer Group trial no. CCG-945. J Neurosurg 1998;89:52–59
  • Pollack IF, Finkelstein SD, Burnham J, Holmes EJ, Hamilton RL, Yates AJ, Finlay JL, Sposto R: Age and TP53 mutation frequency in childhood gliomas: results in a multiinstitutional cohort. Cancer Res 2001; 61:7404–7407
  • Pollack IF, Finkelstein SD, Woods J, Burnham J, Holmes EJ, Hamilton RL, Yates AJ, Boyett JM, Finlay JL, Sposto R: Expression of p53 and prognosis in childhood malignant gliomas. N Engl J Med 2002;346:420–427
  • Pollack IF, Hamilton RL, Burnham J, Holmes EJ, Finkelstein SD, Sposto R, Yates AJ, Boyett JM, Finlay JL: The impact of proliferation index on outcome in childhood malignant gliomas:results in a multi-institutional cohort. Neurosurgery 2002;50:1238–1245
  • Seiz M, Krafft U, Freyschlag CF, Weiss C, Schmieder K, Lohr F, Wenz F, Thomé C, Tuettenberg J.J: Long-term adjuvant administration of temozolomide in patients with glioblastoma multiforme: experience of a single institution. Cancer Res Clin Oncol. 2010 Nov;136(11):1691-5
  • Jain RK. Antiangiogenic therapy for cancer: current and emerging concepts. Oncology (Williston Park) 2005;19:7–16
  • Kerbel RS. Tumor angiogenesis. N Engl J Med. 2008;358:2039–2049
  • Vredenburgh JJ, Desjardins A, Herndon JE, 2nd, Marcello J, Reardon DA, Quinn JA, Rich JN, Sathornsumetee S, Gururangan S, Sampson J, Wagner M, Bailey L, Bigner DD, Friedman AH, Friedman HS. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol. 2007;25:4722–4729
  • Phuphanich S, Edwards MS, Levin VA, Vestnys PS, Wara WM, Davis RL, Wilson CB: Supratentorial malignant gliomas of childhood. Results of treatment with radiation therapy and chemotherapy. J Neurosurg 1984; 60 495–499

Çocukluk Çağı Supratentorial Yüksek Dereceli Glial Tümör: Olgu Sunumu

Year 2011, Issue: 4, 235 - 239, 01.12.2011

Gökalp Silav Banu Atalar Elif Ilgaz Aydınlar Özlem Er Aydın Sav İlhan Elmacı

Abstract

Pediatrik yüksek dereceli glial tümörler erişkinlerde ortaya çıkan eşdeğerlerine göre belirgin sitogenetik ve moleküler farklılıklar gösterirler. Adjuvan tedavilere verdikleri yanıtlar açısından da erişkin yüksek dereceli glial tümörlerden farklıdırlar. Maksimum güvenli tümör rezeksiyonu içeren cerrahi tedavi, hastaların yaşam sürelerinin uzamasını sağlamaktadır. Ayrıca, modern kemoterapi ajanları ve radyoterapideki gelişimlerde uygulanabilecek tedavilerin sınırlarını genişletmiştir. Bu olgu sunumu ile çocukluk çağı yüksek dereceli glial tümörlere güncel yaklaşımın irdelenmesi, tanı ve tedavide ortaya çıkan gelişmelerin değerlendirilmesi amaçlanmıştır

Keywords

Glial tümör çocukluk çağı cerrahi tedavi radyoterapi kemoterapi

References

  • Heideman RL, Kuttesch J, Gajjar AJ, Walter AW, Jenkins JJ, Li Y, Sanford RA, Kun LE Supratentorial malignant gliomas in childhood. Cancer 1997;80/3:497-504
  • Dohrmann GJ, Farwell JR, Flannery JT: Astrocytomas in childhood: a population-based study. Surg Neurol 1985;23:64–68
  • Dohrmann GJ, Farwell JR, Flannery JT: Glioblastoma multiforme in children. J Neurosurg 1976;44:442–448
  • Rickert CH, Sträter R, Kaatsch P, Wassmann H, Jürgens H, Dockhorn-Dworniczak B, Paulus W: Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult cases. Am J Pathol 2001;158:1525–1532
  • Finlay JL, Boyett JM, Yates AJ, Wisoff JH, Milstein JM, GeyerJR Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine and prednisone with the eight-drugs-in-1-day regimen. J Clin Oncol 1995;13:112-23
  • Phuphanichh S, Edwards M, Levin V, Vesttnys PS, Vara WM, Davis RL Supratentorial malignant gliomas of clildhood. J Neurosurg 1984;60:495-9
  • Marchese MJ, Chang CH Malignant astrocytic gliomas in children. Cancer 1990; 65:2771-8
  • Al-Mefty O, Al-Rodhan NF, Phillips RL, El-Senossi M, Fox JL. Factors affecting survival of children with malignant gliomas. Neurosurgery 1987; 20: 416-20
  • Dropcho EJ, Wisoff JH, Walker RW, Allen JC. Supratentorial malignant gliomas in childhood: a review of fifty cases. Ann Neurol 1987; 22: 355-64
  • Campbell JW, Pollack IF, Martinez AJ, Shultz B. High-grade astrocytomas in children: radiologically complete resection is associated with an excellent long-term prognosis. Neurosurgery 1996; 38: 258-64
  • Duffner PK, Horowitz ME, Krisher JP, Friedman HS, Burger PC, Cohen ME: Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med 1993; 328: 1725-31
  • Geyer JR, Finlay JL, Boyett JM, Wisoff J, Yates A, Mao L, Packer RJ:. Survival of infants with malignant astrocytomas. Cancer 1995; 75: 1045-50
  • Walker MD, Strike TA, Sheline GE. An analysis of dose-effect relationship in the radiotherapy of malignant gliomas. Int J Radiat Oncol Biol Phys. 1979 Oct;5(10):1725-31.
  • Chang CH, Horton J, Schoenfeld D, Salazer O, Perez-Tamayo R, Kramer S, Weinstein A, Nelson JS, Tsukada Y. Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study. Cancer. 1983 Sep 15;52(6):997-1007.
  • Stupp R, Dietrich PY, Ostermann Kraljevic S, Pica A, Maillard I, Maeder P,Meuli R, Janzer R, Pizzolato G, Miralbell R, Porchet F, Regli L, de Tribolet N,Mirimanoff RO, Leyvraz S. Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide. J Clin Oncol. 2002 Mar 1;20(5):1375-82.
  • Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005 Mar 10;352(10):987-96
  • Lashford LS, Thiesse P, Jouvet A, Jaspan T, Couanet D, Griffiths PD, Doz F, Ironside J, Robson K, Hobson R, Dugan M, Pearson AD, Vassal G, Frappaz D. Temozolomide in Malignant gliomas of childhood: a United Kingdom children’s cancer study group and French society for pediatric oncology intergroup study. J Clin Oncol 2002; 20:4684–4691
  • Verschuur AC, Grill J, Lelouch-Tubiana A, Couanet D, Kalifa C, Vassal G Temozolomide in pediatric high-grade glioma: a key for combination therapy? Br J Cancer 2004; 91:425–429
  • Broniscer A, Iacono L, Chintagumpala M, Fouladi M, Wallace D, Bowers DC, Stewart C, Krasin MJ, Gajjar A. Role of temozolomide after radiotherapy for newly diagnosed diffuse brainstem glioma in children: results of a multiinstitutional study (SJHG-98) Cancer 2005; 103:133–139
  • Fulton DS, Urtasun RC, Scott-Brown I, Johnson ES, Mielke B, Curry B, Huyser-Wierenga D, Hanson J, Feldstein M: Increasing radiationdose intensity using hyperfractionation in patients with malignant glioma. Final report of a prospective phase I-II dose response study. J Neuro-oncol 1992;14:63–72
  • Packer RJ, Boyett JM, Zimmerman RA, Rorke LB, Kaplan AM, Albright AL, Selch MT, Finlay JL, Hammond GD, Wara WM: Hyperfractionated radiation therapy (72 Gy) for children with brainstem gliomas. A Children’s Cancer Group Phase I/II Trial. Cancer 1993; 72:1414–1421
  • Sposto R, Ertel IJ, Jenkin RD, Boesel CP, Venes JL, Ortega JA, Evans AE, Wara W, Hammond D: The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: results of a randomized trial. A report from the Childrens Cancer Study Group. J Neurooncol 1989; 7:165–177
  • Campbell JW, Pollack IF, Martinez AJ, Shultz B: High-grade astrocytomas in children: Radiologically complete resection is associated with an excellent long-term prognosis. Neurosurgery 38:258–264, 1996
  • Wisoff JH, Boyett JM, Berger MS, Brant C, Li H, Yates AJ, McGuire-Cullen P, Turski PA, Sutton LN, Allen JC, Packer RJ, Finlay JL: Current neurosurgical management and the impact of the extent of resection in the treatment of malignant gliomas of childhood: a report of the Children’s Cancer Group trial no. CCG-945. J Neurosurg 1998;89:52–59
  • Pollack IF, Finkelstein SD, Burnham J, Holmes EJ, Hamilton RL, Yates AJ, Finlay JL, Sposto R: Age and TP53 mutation frequency in childhood gliomas: results in a multiinstitutional cohort. Cancer Res 2001; 61:7404–7407
  • Pollack IF, Finkelstein SD, Woods J, Burnham J, Holmes EJ, Hamilton RL, Yates AJ, Boyett JM, Finlay JL, Sposto R: Expression of p53 and prognosis in childhood malignant gliomas. N Engl J Med 2002;346:420–427
  • Pollack IF, Hamilton RL, Burnham J, Holmes EJ, Finkelstein SD, Sposto R, Yates AJ, Boyett JM, Finlay JL: The impact of proliferation index on outcome in childhood malignant gliomas:results in a multi-institutional cohort. Neurosurgery 2002;50:1238–1245
  • Seiz M, Krafft U, Freyschlag CF, Weiss C, Schmieder K, Lohr F, Wenz F, Thomé C, Tuettenberg J.J: Long-term adjuvant administration of temozolomide in patients with glioblastoma multiforme: experience of a single institution. Cancer Res Clin Oncol. 2010 Nov;136(11):1691-5
  • Jain RK. Antiangiogenic therapy for cancer: current and emerging concepts. Oncology (Williston Park) 2005;19:7–16
  • Kerbel RS. Tumor angiogenesis. N Engl J Med. 2008;358:2039–2049
  • Vredenburgh JJ, Desjardins A, Herndon JE, 2nd, Marcello J, Reardon DA, Quinn JA, Rich JN, Sathornsumetee S, Gururangan S, Sampson J, Wagner M, Bailey L, Bigner DD, Friedman AH, Friedman HS. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol. 2007;25:4722–4729
  • Phuphanich S, Edwards MS, Levin VA, Vestnys PS, Wara WM, Davis RL, Wilson CB: Supratentorial malignant gliomas of childhood. Results of treatment with radiation therapy and chemotherapy. J Neurosurg 1984; 60 495–499
There are 32 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

Gökalp Silav

Banu Atalar

Elif Ilgaz Aydınlar

Özlem Er

Aydın Sav

İlhan Elmacı

Publication Date December 1, 2011
Published in Issue Year 2011Issue: 4

Cite

EndNote Silav G, Atalar B, Aydınlar EI, Er Ö, Sav A, Elmacı İ (December 1, 2011) Çocukluk Çağı Supratentorial Yüksek Dereceli Glial Tümör: Olgu Sunumu. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 4 235–239.