Abstract
Myasthenia gravis is an autoimmune disease often characterized by circulating antibodies that block acetylcholine receptors at the postsynaptic neuromuscular junction. The resulting modified neuromuscular transmission leads to increase sensivity in the administration of neuromuscular blocking drugs NMD in case of surgery. Sugammadex is a new selective nondepolarizing muscle relaxant-binding agent designed to reverse the effect of steroidal muscle relaxants like rocuronium. We report a successful use of the sugammadex in a 8 year old male patient with myasthenia gravis to reverse rocuronium-induced neuromuscular block
Keywords
References
- Book WJ.Abel M, Eisenkraft JB.Anesthesia and neuromusculer disease.Anestesiol Clin North Am 1996;14:515-42.
- Hirch NP.Neuromusculer Junction in health and disease.Br J Anaesth 2007;99:132-8.
- Ceremuga TE, Yao XL, McCabe JT. Etiology,mechanism,and anesthesia implications of autoimmune myasthenia gravis.AANA J 2002;70:301-10.PMid:12242929.
- Erkal H, Özyurt Y, Arıkan z. Myastenia gravis ve Anestezi: Olgu sunumu.Bakırköy Tıp Dergisi 2006;2:141-3.
- Unterbuchner C,Fink H,Blobner M. The use of sugammadex in patient with myastenia gravis.Anaesthesia 2010;65:302-5.
- Suzuki T, Masaki G, Ogawa S . Neostigmine induced reversal of vecuronium in normal weight, overweight and obese female patients. Br J Anaesth 2006;97: 160-3.
- Nitahara K, Sugi Y, Higa K, Shono S, Hamada T. Neuromusculer effects of sevoflurane in myastenia gravis patients.Br J Anesth 2007;98:337-41.
- Booij LHDJ:Cyclodextrins and the emergence of sugammadex. Anaesthesia 2009;64(Suppl.1):31-37.
Timektomi Yapılan Miyastenia Gravisli Bir Olguda Nöromüsküler Bloğun Çevrilmesinde Sugammadeks Kullanımı
Abstract
Miyastenia gravis, postsinaptik nöromuskuler kavşakta asetil-kolin reseptörlerine karşı antikor oluşumu ile karakterize otoimmün bir hastalıktır. Bu hastaların cerrahisinde, noromuskuler iletideki değişime bağlı olarak kas gevşetici ajanlara karşı aşırı duyarlılık görülebilir. Sugammadeks, roküronyum gibi steroid yapılı nondepolarizan kas gevşeticileri seçici şekilde bağlayarak, etkilerini kaldırmak üzere tasarlanmış yeni bir ilaçtır. Bu çalışmada roküronyum kullanılmış 8 yaşında miyastenia gravisli erkek hastanın kas gücünün geri döndürülmesinde sugammadeks kullanımını bildirdik
Keywords
References
- Book WJ.Abel M, Eisenkraft JB.Anesthesia and neuromusculer disease.Anestesiol Clin North Am 1996;14:515-42.
- Hirch NP.Neuromusculer Junction in health and disease.Br J Anaesth 2007;99:132-8.
- Ceremuga TE, Yao XL, McCabe JT. Etiology,mechanism,and anesthesia implications of autoimmune myasthenia gravis.AANA J 2002;70:301-10.PMid:12242929.
- Erkal H, Özyurt Y, Arıkan z. Myastenia gravis ve Anestezi: Olgu sunumu.Bakırköy Tıp Dergisi 2006;2:141-3.
- Unterbuchner C,Fink H,Blobner M. The use of sugammadex in patient with myastenia gravis.Anaesthesia 2010;65:302-5.
- Suzuki T, Masaki G, Ogawa S . Neostigmine induced reversal of vecuronium in normal weight, overweight and obese female patients. Br J Anaesth 2006;97: 160-3.
- Nitahara K, Sugi Y, Higa K, Shono S, Hamada T. Neuromusculer effects of sevoflurane in myastenia gravis patients.Br J Anesth 2007;98:337-41.
- Booij LHDJ:Cyclodextrins and the emergence of sugammadex. Anaesthesia 2009;64(Suppl.1):31-37.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | December 1, 2012 |
| Published in Issue | Year 2012Issue: 4 |