Abstract
Obesity is a major risk factor for chronic disease such as metabolic syndrome, dyslipidemia, type 2 diabetes mellitus and cardiovascular disease. In recent years, despite advances in understanding the molecular basis of obesity, drugs used against obesity have side effects and lack of physiological specificity. MicroRNAs miRNAs are short ~ 22 nt , noncoded and endogenous RNA molecules and binding to mRNA 3 ‘untranslated region of many genes regulated post-transcriptional. A miRNA has many target genes. In the future, miRNAs will help in early diagnosis of chronic diseases and will provide new therapeutic targets. The miRNA in obesity have been reported in the regulation of lipid metabolism. In this review, adipocyte biology and the relation between obesity, miRNA biogenesis, regulation, function and role in the regulation of lipid metabolism in obesity will be focused
Keywords
References
- Klop B, Elte JW, Cabezas MC. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients. 2013;5:1218-40.
- McGregor RA, Choi MS. microRNAs in the regulation of adipogenesis and obesity. Curr Mol Med. 2011;11:304-16.
- Ge Q, Brichard S, Yi X et al. microRNAs as a new mechanism regulating adipose tissue inflammation in obesity and as a novel therapeutic strategy in the metabolic syndrome. J Immunol Res. 2014;2014:987285.
- Fuentes E, Fuentes F, Vilahur G et al. Mechanisms of chronic state of inflammation as mediators that link obese adipose tissue and metabolic syndrome. Mediators Inflamm. 2013;2013:136584.
- Xie H, Lim B, Lodish HF. MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes. 2009;58:1050-57.
- Moore KJ, Rayner KJ, Suárez Y et al. The role of microRNAs in cholesterol efflux and hepatic lipid metabolism. Annu Rev Nutr. 2011;31:49-63.
- Fernández-Hernando C, Suárez Y, Rayner KJ et al. MicroRNAs in lipid metabolism. Curr Opin Lipidol. 2011;22:86-92.
- Flowers E, Froelicher ES, Aouizerat BE. MicroRNA regulation of lipid metabolism. Metabolism. 2013;62:12-20.
- Novák J, Bienertová-Vašků J, Kára T et al. MicroRNAs involved in the lipid metabolism and their possible implications for atherosclerosis development and treatment. Mediators Inflamm. 2014;2014:275867.
- Moore KJ, Rayner KJ, Suárez Y et al. microRNAs and cholesterol metabolism. Trends Endocrinol Metab. 2010;21:699-706.
- MicroRNA modulation of lipid metabolism and oxidative stress in
- cardiometabolic diseases. Free Radic Biol Med. 2013;64:31-9.
- Lin Q, Gao Z, Alarcon RM et al. A role of miR-27 in the regulation of adipogenesis. FEBS J. 2009;276:2348-58.
- Gao W, He HW, Wang ZM et al. Plasma levels of lipometabolism- related miR-122 and miR-370 are increased in patients with hyperlipidemia and associated with coronary artery disease. Lipids Health Dis. 2012;11:55.
- Son YH, Ka S, Kim Ay et al. Regulation of Adipocyte Differentiation via MicroRNAs. Endocrinol Metab (Seoul). 2014;29:122-35.
- Esau C, Davis S, Murray SF et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab. 2006;3:87-98.
- Heneghan HM, Miller N, Kerin MJ. Role of microRNAs in obesity and the metabolic syndrome. Obes Rev. 2010;11:354-61.
- Takanabe R, Ono K, Abe Y et al. Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet. Biochem Biophys Res Commun. 2008;376:728-32.
- Canfrán-Duque A, Ramírez CM, Goedeke L et al. microRNAs and HDL life cycle. Cardiovasc Res. 2014;103:414-22.
- Jordan SD, Krüger M, Willmes DM et al. Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nat Cell Biol. 2011;13:434-46.
- Williams MD, Mitchell GM. MicroRNAs in insulin resistance and obesity. Exp Diabetes Res 2012;2012: 484696.
- Viesti A, Collares R, Salgado W Jr, Pretti da Cunha Tirapelli D, dos Santos JS. The expression of LEP, LEPR, IGF1 and IL10 in obesity and the relationship with microRNAs. PLoS ONE 2014; 9: e93512.
Abstract
Obezite Metabolik Sedrom, dislipidemi, Tip 2 Diabetes Mellitus ve kardiovasküler hastalık gibi kronik hastalıklar için major risk faktörüdür. Son yıllarda obezitenin moleküler temelinin anlaşılmasında ilerlemelere rağmen, obezite’ye karşı kullanılan ilaçlar fizyolojik spesifite eksikliğine ve yan etkilere sahiptir. MicroRNA’lar miRNA , kısa ~22 nt , kodlanamayan endojen RNA molekülleridir ve mRNA’nın 3’ untranslated bölgesine bağlanarak birçok geni transkripsiyon sonrası düzenler. Bir miRNA birçok hedeflere sahiptir. Gelecekte miRNA’lar kronik hastalıklarının erken teşhisine yardımcı olacak ve yeni terapötik hedefler sağlayacaktır. miRNA’lar obezitede lipid metabolizması düzenlenmesinde bildirilmiştir. Bu derlemede adiposit biyolojisi ve obezite ile arasındaki ilgi, miRNA biyogenezi, düzenlenmesi, fonksiyonları ve obezitede lipid metabolizmasının düzenlenmesindeki rolü incelenecektir
Keywords
References
- Klop B, Elte JW, Cabezas MC. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients. 2013;5:1218-40.
- McGregor RA, Choi MS. microRNAs in the regulation of adipogenesis and obesity. Curr Mol Med. 2011;11:304-16.
- Ge Q, Brichard S, Yi X et al. microRNAs as a new mechanism regulating adipose tissue inflammation in obesity and as a novel therapeutic strategy in the metabolic syndrome. J Immunol Res. 2014;2014:987285.
- Fuentes E, Fuentes F, Vilahur G et al. Mechanisms of chronic state of inflammation as mediators that link obese adipose tissue and metabolic syndrome. Mediators Inflamm. 2013;2013:136584.
- Xie H, Lim B, Lodish HF. MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes. 2009;58:1050-57.
- Moore KJ, Rayner KJ, Suárez Y et al. The role of microRNAs in cholesterol efflux and hepatic lipid metabolism. Annu Rev Nutr. 2011;31:49-63.
- Fernández-Hernando C, Suárez Y, Rayner KJ et al. MicroRNAs in lipid metabolism. Curr Opin Lipidol. 2011;22:86-92.
- Flowers E, Froelicher ES, Aouizerat BE. MicroRNA regulation of lipid metabolism. Metabolism. 2013;62:12-20.
- Novák J, Bienertová-Vašků J, Kára T et al. MicroRNAs involved in the lipid metabolism and their possible implications for atherosclerosis development and treatment. Mediators Inflamm. 2014;2014:275867.
- Moore KJ, Rayner KJ, Suárez Y et al. microRNAs and cholesterol metabolism. Trends Endocrinol Metab. 2010;21:699-706.
- MicroRNA modulation of lipid metabolism and oxidative stress in
- cardiometabolic diseases. Free Radic Biol Med. 2013;64:31-9.
- Lin Q, Gao Z, Alarcon RM et al. A role of miR-27 in the regulation of adipogenesis. FEBS J. 2009;276:2348-58.
- Gao W, He HW, Wang ZM et al. Plasma levels of lipometabolism- related miR-122 and miR-370 are increased in patients with hyperlipidemia and associated with coronary artery disease. Lipids Health Dis. 2012;11:55.
- Son YH, Ka S, Kim Ay et al. Regulation of Adipocyte Differentiation via MicroRNAs. Endocrinol Metab (Seoul). 2014;29:122-35.
- Esau C, Davis S, Murray SF et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab. 2006;3:87-98.
- Heneghan HM, Miller N, Kerin MJ. Role of microRNAs in obesity and the metabolic syndrome. Obes Rev. 2010;11:354-61.
- Takanabe R, Ono K, Abe Y et al. Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet. Biochem Biophys Res Commun. 2008;376:728-32.
- Canfrán-Duque A, Ramírez CM, Goedeke L et al. microRNAs and HDL life cycle. Cardiovasc Res. 2014;103:414-22.
- Jordan SD, Krüger M, Willmes DM et al. Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nat Cell Biol. 2011;13:434-46.
- Williams MD, Mitchell GM. MicroRNAs in insulin resistance and obesity. Exp Diabetes Res 2012;2012: 484696.
- Viesti A, Collares R, Salgado W Jr, Pretti da Cunha Tirapelli D, dos Santos JS. The expression of LEP, LEPR, IGF1 and IL10 in obesity and the relationship with microRNAs. PLoS ONE 2014; 9: e93512.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Collection |
| Authors | |
| Publication Date | June 1, 2016 |
| Published in Issue | Year 2016Issue: 2 |