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Is Gamma-Glutamyl Transferase Elevation Associated With Cardiac Failure In Infants With Ventricular Septal Defect?

Year 2020, Issue: 2, 284 - 288, 01.06.2020

Abstract

Purpose/Aim: Ventricular septal defect VSD which is the most common cause of congenital heart defects in children, can lead to heart failure 6–8 weeks after birth due to the decrease in the pulmonary vascular resistance. The clinical features of cardiac failure can be subtle during the infant period, so the laboratory parameters can help the diagnosis and the follow-up. The relation between gamma-glutamyl transferase GGT and cardiac failure is reported in adults. Herein, we aimed to evaluate the relationship between liver enzymes especially GGT levels and cardiac failure developing due to VSD in pediatric patients

References

  • 1. Bernstein D. Congenital heart disease. In: Behrman RE, Kliegman RM, Jenson HB, editors. Nelson Textbook of Pediatrics, 17th ed. Philadelphia: Saunders; 2004. p.1499–554.
  • 2. Hoffman JIE, Kaplan S, Liberthson RR. Prevalence of congenital heart disease. Am Heart J 2004;147:425–39. [CrossRef]
  • 3. Zan S, Yapıcıoğlu H, Erdem S, Özlü F, Satar M, Özbarlas N ve ark. Çukurova Üniversitesi Tıp Fakültesi Hastanesi yenidoğan yoğun bakım ünitelerinde son beş yılda izlenen konjenital kalp hastalarının retrospektif incelenmesi. Çocuk Sağlığı ve Hastalıkları Derg 2015;58:7–16. http://www.cshd.org.tr/uploads/pdf_CSH_554.pdf
  • 4. Ekici F, Ünal S, Dablan S, Alpan N, Çevik B, Vidinlisan S. Yenidoğan yoğun bakım ünitesindeki 119 bebeğin klinik ve ekokardiyografik değerlendirilmesi. Türkiye Çocuk Hastalıkları Derg 2010;4:22–9. https://dergipark.org.tr/tr/download/article-file/689238
  • 5. Azak E, Ünsal H, Kibar AE, Çetin İİ. Çocuklarda Konjestif Kalp Yetersizliği. Türkiye Çocuk Hastalıkları Dergisi 2016;3:223–32. [CrossRef]
  • 6. Masarone D, Valente F, Rubino M, Vastarella R, Gravino R, Rea A, et al. Pediatric Heart Failure: A Practical Guide to Diagnosis and Management. Pediatr Neonatol 2017;58:303–12. [CrossRef]
  • 7. Ko KH, Lee JH, Choi BM, Lee JH, Yoo KH, Son CS, Lee JW. Utility of the rapid B-type natriuretic peptide assay for detection of cardiovascular problems in newborn infants with respiratory difficulties. Neonatalogy 2008;94:16–21. [CrossRef]
  • 8. Auslender M. Pathophysiology of pediatric heart failure. Progress Pediatr Cardiol 2000;11:175–84. [CrossRef]
  • 9. O’Laughlin MP. Congestive heart failure in children. Pediatr Clin North Am 1999;46:263–73. [CrossRef]
  • 10. Jayaprasad N. Heart Failure in Children. Heart Views 2016;17:92–9. [CrossRef]
  • 11. Ess M, Mussner-Seeber C, Mariacher S, Lorsbach-Koehler A, Pachinger O, Frick M, et al. Gammaglutamyltransferase rather than total bilirubin predicts outcome in chronic heart failure. J Card Fail 2011;17:577–84. [CrossRef]
  • 12. Onat A, Can G, Ornek E, Çiçek G, Ayhan E, Doğan Y. Serum gammaglutamyltransferase: Independent predictor of risk of diabetes, hypertension, metabolic syndrome, and coronary disease. Obesity 2012;20:842–8. [CrossRef]
  • 13. Sen N, Ozlu MF, Basar N, Ozcan F, Güngör O, Turak O, et al. Relationship between elevated serum gammaglutamyltransferase activity and slow coronary flow. Arch Turk Soc Cardiol 2009;37:168–73. https://www.journalagent.com/tkd/ pdfs/TKDA_37_3_168_173.pdf
  • 14. Poelzl G, Eberl C, Achrainer H, Doerler J, Pachinger O, Frick M, Ulmer H. Prevalence and prognostic significance of elevated gamma-glutamyltransferase in chronic heart failure. Circ Heart Fail 2009;2:294–302. [CrossRef]
  • 15. Cabrera-Abreu JC, Green A. Gamma-glutamyl trasferase: value of its measurement in pediatrics. Ann Clin Biochem 2002;39:22–5. [CrossRef]
  • 16. van Deursen VM, Damman K, Hillege HL, van Beek AP, van Veldhuisen DJ, Voors AA. Abnormal liver function in relation to hemodynamic profile in heart failure patients. J Card Fail 2010;16:84–90. [CrossRef]

Ventriküler Septal Defekti Olan Bebeklerde Gama-Glutamil Transferaz Yüksekliği Kalp Yetersizliği ile İlişkili midir?

Year 2020, Issue: 2, 284 - 288, 01.06.2020

Abstract

Amaç: Doğuştan kalp hastalıkları içinde en sık görüleni olan ventriküler septal defekt VSD doğumdan 6–8 hafta sonra pulmoner vasküler direncinde azalmasıyla birlikte kalp yetersizliğine neden olabilir. Kalp yetersizliği klinik bulguları özellikle bebeklerde silik olabilir. Bu nedenle tanısı ve takibinde laboratuvar değerlerinden faydalanılır. Yetişkin hastalarda gama-glutamil transferaz GGT ile kalp yetersizliği arasında ilişki gösterilmiştir. Biz de bu çalışma ile VSD nedeniyle kalp yetersizliği gelişen hastalarda karaciğer enzimlerini, özellikle GGT düzeyini değerlendirmeyi amaçladık

References

  • 1. Bernstein D. Congenital heart disease. In: Behrman RE, Kliegman RM, Jenson HB, editors. Nelson Textbook of Pediatrics, 17th ed. Philadelphia: Saunders; 2004. p.1499–554.
  • 2. Hoffman JIE, Kaplan S, Liberthson RR. Prevalence of congenital heart disease. Am Heart J 2004;147:425–39. [CrossRef]
  • 3. Zan S, Yapıcıoğlu H, Erdem S, Özlü F, Satar M, Özbarlas N ve ark. Çukurova Üniversitesi Tıp Fakültesi Hastanesi yenidoğan yoğun bakım ünitelerinde son beş yılda izlenen konjenital kalp hastalarının retrospektif incelenmesi. Çocuk Sağlığı ve Hastalıkları Derg 2015;58:7–16. http://www.cshd.org.tr/uploads/pdf_CSH_554.pdf
  • 4. Ekici F, Ünal S, Dablan S, Alpan N, Çevik B, Vidinlisan S. Yenidoğan yoğun bakım ünitesindeki 119 bebeğin klinik ve ekokardiyografik değerlendirilmesi. Türkiye Çocuk Hastalıkları Derg 2010;4:22–9. https://dergipark.org.tr/tr/download/article-file/689238
  • 5. Azak E, Ünsal H, Kibar AE, Çetin İİ. Çocuklarda Konjestif Kalp Yetersizliği. Türkiye Çocuk Hastalıkları Dergisi 2016;3:223–32. [CrossRef]
  • 6. Masarone D, Valente F, Rubino M, Vastarella R, Gravino R, Rea A, et al. Pediatric Heart Failure: A Practical Guide to Diagnosis and Management. Pediatr Neonatol 2017;58:303–12. [CrossRef]
  • 7. Ko KH, Lee JH, Choi BM, Lee JH, Yoo KH, Son CS, Lee JW. Utility of the rapid B-type natriuretic peptide assay for detection of cardiovascular problems in newborn infants with respiratory difficulties. Neonatalogy 2008;94:16–21. [CrossRef]
  • 8. Auslender M. Pathophysiology of pediatric heart failure. Progress Pediatr Cardiol 2000;11:175–84. [CrossRef]
  • 9. O’Laughlin MP. Congestive heart failure in children. Pediatr Clin North Am 1999;46:263–73. [CrossRef]
  • 10. Jayaprasad N. Heart Failure in Children. Heart Views 2016;17:92–9. [CrossRef]
  • 11. Ess M, Mussner-Seeber C, Mariacher S, Lorsbach-Koehler A, Pachinger O, Frick M, et al. Gammaglutamyltransferase rather than total bilirubin predicts outcome in chronic heart failure. J Card Fail 2011;17:577–84. [CrossRef]
  • 12. Onat A, Can G, Ornek E, Çiçek G, Ayhan E, Doğan Y. Serum gammaglutamyltransferase: Independent predictor of risk of diabetes, hypertension, metabolic syndrome, and coronary disease. Obesity 2012;20:842–8. [CrossRef]
  • 13. Sen N, Ozlu MF, Basar N, Ozcan F, Güngör O, Turak O, et al. Relationship between elevated serum gammaglutamyltransferase activity and slow coronary flow. Arch Turk Soc Cardiol 2009;37:168–73. https://www.journalagent.com/tkd/ pdfs/TKDA_37_3_168_173.pdf
  • 14. Poelzl G, Eberl C, Achrainer H, Doerler J, Pachinger O, Frick M, Ulmer H. Prevalence and prognostic significance of elevated gamma-glutamyltransferase in chronic heart failure. Circ Heart Fail 2009;2:294–302. [CrossRef]
  • 15. Cabrera-Abreu JC, Green A. Gamma-glutamyl trasferase: value of its measurement in pediatrics. Ann Clin Biochem 2002;39:22–5. [CrossRef]
  • 16. van Deursen VM, Damman K, Hillege HL, van Beek AP, van Veldhuisen DJ, Voors AA. Abnormal liver function in relation to hemodynamic profile in heart failure patients. J Card Fail 2010;16:84–90. [CrossRef]
There are 16 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Fatih Aygün

Ahmet İrdem

Publication Date June 1, 2020
Published in Issue Year 2020Issue: 2

Cite

EndNote Aygün F, İrdem A (June 1, 2020) Ventriküler Septal Defekti Olan Bebeklerde Gama-Glutamil Transferaz Yüksekliği Kalp Yetersizliği ile İlişkili midir?. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 2 284–288.