Bitki Sekonder Metabolitlerinin Sağlık Üzerine Fonksiyonel Etkileri

Taha Gökmen Ülger; Nurcan Yabancı Ayhan

Functional Effects of Plant Secondary Metabolites On Health

Year 2020, Issue: 3, 384 - 390, 01.09.2020

Taha Gökmen Ülger Nurcan Yabancı Ayhan

Abstract

Some types of secondary compounds, which are generally classified into 4 groups as phenolic compounds, terpenes-steroids, alkaloids and organosulfur compounds are critical for both medicine and pharmacy since they show anti-inflammatory, hypoglycemic, hypolipidemic and antioxidant effects, have protective effects against cardiovascular diseases and cancer and have a variety of positive effects on health. It has been revealed that some phenolic compounds have cardioprotective effects by inhibiting the oxidation of lipoproteins, exhibiting hypocholesterolemic effect, reducing atherosclerosis risk, inhibiting platelet aggregation, improving vascular function, protecting the metabolism against inflammation and oxidative stress. Besides, some secondary compounds such as sulfurous compounds and flavonoids have beneficial effects on diabetes-related hyperglycemia and abnormal lipid profile and consequently, may be protective against diabetic neuropathy, diabetic nephropathy, and diabetic retinopathy. Some phenolic compounds and alkaloids have also been shown to demonstrate the anticarcinogenic activity by inhibiting carcinogenesis to DNA, having a protective effect against oxidative DNA damage, normalizing altered cell signaling leading to inhibition of malignant transformation, and inhibiting the growth and metastatic potential of cancer cells. A greater number of secondary metabolites have been discovered thanks to the development of bioreactor technology and the use of plant secondary metabolites has begun to be used more in drug production. However, rather than extract and nutraceutical forms of secondary metabolites, which are effective not only in the treatment of the diseases but also maintaining health and avoiding diseases, it may be more beneficial to consume natural forms of them with fruits and vegetables. The clinical course of a disease can be improved by recommending vegetables and fruits which are rich in secondary metabolites, whose functional activity is known in the medical nutritional recommendations for diseases. Studies evaluating the functional efficacy of different secondary metabolites against diseases may also be useful in terms of patient and disease-specific medical nutrition recommendations

Keywords

Secondary compounds, phenolic compounds, terpenes-steroids, alkaloids, organosulfur compounds

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Bitki Sekonder Metabolitlerinin Sağlık Üzerine Fonksiyonel Etkileri

Year 2020, Issue: 3, 384 - 390, 01.09.2020

Taha Gökmen Ülger Nurcan Yabancı Ayhan

Abstract

Fenolik bileşikler, terpenler-steroidler, alkaloidler ve kükürtlü bileşikler olmak üzere genel olarak dört grupta sınıflandırılan sekonder bileşiklerin bazı türlerinin antiinflamatuar, hipoglisemik, hipolipidemik ve antioksidan etki göstermesi, kardiyovasküler hastalıklar ve kansere karşı koruyucu olması ve sağlık üzerine farklı birtakım olumlu etkileri bulunması dolayısıyla tıp ve eczacılık için büyük önem arz etmektedir. Bazı fenolik bileşiklerin lipoproteinlerin oksidasyonunu önleyerek, hipokolesterolemik etki göstererek, aterosklerozis riskini azaltarak, platelet agregasyonunu inhibe ederek, vasküler fonksiyonu iyileştirerek, inflamasyon ve oksidatif strese karşı koruyarak kardiyoprotektif etki gösterdiği, kükürtlü bileşikler ve flavonoidler gibi bazı sekonder bileşiklerin ise diyabete bağlı olarak görülen hiperglisemi ve bozulmuş lipid profiline karşı yararlı etkilerinin bulunduğu ve bu sayede diyabetik nöropati, diyabetik nefropati, diyabetik retinopatiye karşı koruyucu olabileceği belirtilmiştir. Bazı fenolik bileşikler ve alkaloidlerin de DNA’ya karsinojen bağlanmasını inhibe ederek, oksidatif DNA hasarına karşı koruyarak, malign dönüşümün inhibisyonuna yol açan değiştirilmiş hücre sinyallemesini normalize ederek, kanser hücresinin büyümesini ve metastatik potansiyelini inhibe ederek antikarsinojenik etki gösterdiği belirtilmiştir. Biyoreaktör teknolojisinin gelişimi ile daha fazla sayıda sekonder metabolit keşfedilmiş ve bu sayede ilaç yapımında bitki sekonder metabolitleri daha fazla kullanılmaya başlanmıştır. Fakat yalnızca hastalıkların tedavisinde değil, sağlığın sürdürülmesi ve hastalıklara karşı korunmada da etkili olan sekonder metabolitlerin ekstrakte ve nutrasötik formlarından ziyade meyve ve sebzelerle birlikte doğal formlarının alınması daha yararlı olabilmektedir. Hastalıklara ilişkin tıbbi beslenme önerilerinde de fonksiyonel etkinliği bilinen sekonder metabolitlerin yoğun bulunduğu sebze ve meyvelerin önerilmesiyle hastalığın klinik seyri iyileştirilebilir. Farklı sekonder metabolitlerin hastalıklara karşı fonksiyonel etkinliğinin değerlendirileceği çalışmalar hastaya ve hastalığa özgü tıbbi beslenme önerileri açısından da yararlı olabilir

Keywords

Sekonder bileşikler, fenolik bileşikler, terpenler-steroidler, alkaloidler, kükürtlü bileşikler

References

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8. Mohammed MS, Osman WJ, Garelnabi EA, Osman Z, Osman B, Khalid HS, Mohamed MA. Secondary metabolites as antiinflammatory agents. J Phytopharmacol 2014;3:275–85. http:// www.phytopharmajournal.com/Vol3_Issue4_09.pdf
9. Souto AL, Tavares JF, Da Silva MS, Diniz MF, De Athayde-Filho PF, Barbosa FJM. Anti-inflammatory activity of alkaloids: an update from 2000 to 2010. Molecules 2011;16:8515–34. [CrossRef]
10. De las Heras B, Hortelano S. Molecular basis of the anti-inflammatory effects of terpenoids. Inflamm Allergy Drug Targets 2009;8:28–39. [CrossRef]
11. Mandegary A, Pournamdari M, Sharififar F, Pournourmohammadi S, Fardiar R, Shooli S. Alkaloid and flavonoid rich fractions of fenugreek seeds (Trigonella foenum-graecum L.) with antinociceptive and anti-inflammatory effects. Food Chem Toxicol 2012;50:2503–7. [CrossRef]
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13. Rotelli AE, Guardia T, Juárez AO, de la Rocha NE, Pelzer LE. Comparative study of flavonoids in experimental models of inflammation. Pharmacol Res 2003;48:601–6. [CrossRef]
14. Paradkar PN, Blum PS, Berhow MA, Baumann H, Kuo SM. Dietary isoflavones suppress endotoxin-induced inflammatory reaction in liver and intestine. Cancer Lett 2004;215:21–8. [CrossRef]
15. Fang SC, Hsu CL, Yen GC. Anti-inflammatory effects of phenolic compounds isolated from the fruits of Artocarpus heterophyllus. J Agric Food Chem 2008;56:4463–8. [CrossRef]
16. American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2014;37:S81–90. [CrossRef]
17. Malviya N, Jain S, Malviya S. Antidiabetic potential of medicinal plants. Acta Pol Pharm 2010;67:113–8. https://www.ptfarm.pl/pub/ File/Acta_Poloniae/2010/2/113.pdf
18. Vinayagam R, Xu B. Antidiabetic properties of dietary flavonoids: a cellular mechanism review. Nutr Metab (Lond) 2015;12:60. [CrossRef]
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21. Akiyama S, Katsumata SI, Suzuki K, Nakaya Y, Ishimi Y, Uehara M. Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes. Biosci Biotechnol Biochem 2009;73:2779–82. [CrossRef ]
22. Kakadiya J, Mulani H, Shah N. Protective effect of hesperidin on cardiovascular complication in experimentally induced myocardial infarction in diabetes in rats. J Basic Clin Pharm 2010;1:85–91. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979178/
23. Prasath GS, Subramanian SP. Modulatory effects of fisetin, a bioflavonoid, on hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in hepatic and renal tissues in streptozotocin-induced diabetic rats. Eur J Pharmacol 2011;668:492– 6. [CrossRef]
24. Niture NT, Ansari AA, Naik SR. Anti-hyperglycemic activity of rutin in streptozotocin-induced diabetic rats: an effect mediated through cytokines, antioxidants and lipid biomarkers. Indian J Exp Biol 2014;52:720–7.
25. Prasath GS, Subramanian SP. Antihyperlipidemic Effect of Fisetin, a Bioflavonoid of Strawberries, Studied in Streptozotocin‐Induced Diabetic Rats. J Biochem Mol Toxicol 2014;28:442–9. [CrossRef]
26. Sendrayaperumal V, Iyyam Pillai S, Subramanian S. Design, synthesis and characterization of zinc-morin, a metal flavonol complex and evaluation of its antidiabetic potential in HFD-STZ induced type 2 diabetes in rats. Chem Biol Interact 2014;219:9–17. [CrossRef]
27. Cho KW, Lee OH, Banz WJ, Moustaid-Moussa N, Shay NF, Kim YC. Daidzein and the daidzein metabolite, equol, enhance adipocyte differentiation and PPARγ transcriptional activity. J Nutr Biochem 2010;21:841–7. [CrossRef]
28. Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559–65. [CrossRef]
29. Shi Y, Liang XC, Zhang H, Wu QL, Qu L, Sun Q. Quercetin protects rat dorsal root ganglion neurons against high glucose-induced injury in vitro through Nrf-2/HO-1 activation and NF-κB inhibition. Acta Pharmacol Sin 2013;34:1140–8. [CrossRef]
30. Hao LN, Wang M, Ma JL, Yang T. Puerarin decreases apoptosis of retinal pigment epithelial cells in diabetic rats by reducing peroxynitrite level and iNOS expression. Sheng Li Xue Bao 2012;64:199–206. http://www.actaps.com.cn/qikan/manage/wenzhang/2012-2-13. pdf
31. Ayepola OR, Cerf ME, Brooks NL, Oguntibeju OO. Kolaviron, a biflavonoid complex of Garcinia kola seeds modulates apoptosis by suppressing oxidative stress and inflammation in diabetes-induced nephrotoxic rats. Phytomedicine 2014;21:1785–93. [CrossRef]
32. Bao L, Zhang Z, Dai X, Ding Y, Jiang Y, Li Y, Li Y. Effects of grape seed proanthocyanidin extract on renal injury in type 2 diabetic rats. Mol Med Rep 2015;11:645–52. [CrossRef]
33. Park CH, Noh JS, Fujii H, Roh SS, Song YO, Choi JS, et al. Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic db/db mice. Drug discoveries & therapeutics 2015;9, 13–22. [CrossRef]
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Details

Primary Language	Turkish
Journal Section	Collection
Authors	Taha Gökmen Ülger Nurcan Yabancı Ayhan
Publication Date	September 1, 2020
Published in Issue	Year 2020Issue: 3

Cite

EndNote	Ülger TG, Yabancı Ayhan N (September 1, 2020) Bitki Sekonder Metabolitlerinin Sağlık Üzerine Fonksiyonel Etkileri. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 3 384–390.

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