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The Diagnostic Value of Complete Blood Test Parameters In Acute Appendicitis: We Should Not Only Take Into Account Wbc

Year 2020, Issue: 4, 696 - 700, 01.12.2020

Sönmez Ocak Ömer Faruk Bük Ahmet Burak Çiftci

Abstract

Objective: Appendectomy is the most common urgent surgical procedure but a diagnosis of acute appendicitis still remains challenging. In this retrospective study, we aimed to evaluate the value of the complete blood count CBC test parameters in acute appendicitis.Materials and methods: Data of 131 patients who underwent appendectomy between January 2016 – December 2016 were collected retrospectively. Demographic features, CBC parameters and final histopathological results of the patients were recorded. The patients were divided into two groups according to the final pathological results Group 1: Acute appendicitis group, Group 2: Normal appendices group and were compared in terms of WBC white blood cell , platelet count, hemoglobin level, RDW red cell distribution width , MPV mean platelet volume and NLR neutrophil to lymphocyte ratio values.Results: 13 of 131 patients had normal appendices. WBC, platelet and NLR values were signifcantly higher in Group 1 compared to the Group 2 p

Keywords

Appendicitis red cell distribution width platelets neutrophil lymphocyte

References

  • Seetahal SA, Bolorunduro OB, Sookdeo TC, Oyetunji TA, Greene WR, Frederick W, et al. Negative appendectomy: a 10-year review of a nationally representative sample. Am J Surg 2011;201 4:433–7. [CrossRef]
  • Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 1990;132:910–25. [CrossRef]
  • Raja AS, Wright C, Sodickson AD, Zane RD, Schiff GD, Hanson R, et al. Negative appendectomy rate in the era of CT. an 18-year perspective. Radiology 2010;256:460–5. [CrossRef]
  • Harswick C, Uyenishi AA, Kordick MF, Chan SB. Clinical guidelines, computed tomography scan, and negative appendectomies: a case series. The Am J Emerg Med 2006;24:68–72. [CrossRef]
  • Kotaluoto S, Ukkonen M, Pauniaho SL, Helminen M, Sand J, Rantanen T. Mortality Related to Appendectomy; a Population Based Analysis over Two Decades in Finland. World J Surg 2017;41:64–9. [CrossRef]
  • Andersson MN, Andersson RE. Causes of short-term mortality after appendectomy: a population-based case-controlled study. Ann Surg 2011;254:103–7. [CrossRef]
  • Yang HR, Wang YC, Chung PK, Chen WK, Jeng LB, Chen RJ. Role of leukocyte count, neutrophil percentage, and C-reactive protein in the diagnosis of acute appendicitis in the elderly. Am Surg 2005;71:344–7.
  • Saleem MM, Pervaiz M, Chaudhary IA. Predictive Value of Leukocytosis for Diagnosing Acute Appendicitis. PAFM 2007;67:292.
  • Ulukent SC, Sarıcı IS, Ulutas KT. All CBC parameters in diagnosis of acute appendicitis. Int J Clin Exp Med 2016;9:11871–6.
  • Van Randen A, Bipat S, Zwinderman AH, Ubbink DT, Stoker J, Boermeester MA. Acute appendicitis: meta-analysis of diagnostic performance of CT and graded compression US related to prevalence of disease. Radiology 2008;249:97–106. [CrossRef]
  • Çetinkaya, E, Şenol, K, Saylam B, Tez M. Red cell distribution width to platelet ratio: New and promising prognostic marker in acute pancreatitis. World J Gastroenterol 2004;20:14450–4. [CrossRef]
  • Aktimur R, Cetinkunar S, Yildirim K, Aktimur SH, Ugurlucan M, Ozlem N. Neutrophil-to-lymphocyte ratio as a diagnostic biomarker for the diagnosis of acute mesenteric ischemia. Eur J Trauma Emerg Surg 2016;42:363–8. [CrossRef]
  • Felker GM, Allen LA, Pocock SJ, Shaw LK, McMurray JJV, Pfeffer MA, et al. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 2007;50:40–7. [CrossRef]
  • Hampole CV, Mehrotra AK, Thenappan T, Gomberg-Maitland M, Shah SJ. Usefulness of red cell distribution width as a prognostic marker in pulmonary hypertension. Am J Cardiol 2009;104:868–72. [CrossRef]
  • Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 2008;117:163–8. [CrossRef]
  • Ani C, Ovbiagele B. Elevated red blood cell distribution width predicts mortality in persons with known stroke. J Neurol Sci 2009;277:103–8. [CrossRef]
  • Malandrino N, Wu WC, Taveira TH, Whitlatch HB, Smith RJ. Association between red blood cell distribution width and macrovascular and microvascular complications in diabetes. Diabetologia 2012;55:226– 35. [CrossRef]
  • Senol K, Saylam B, Kocaay F, Tez M. Red cell distribution width as a predictor of mortality in acute pancreatitis. Am J Emerg Med 2013;31:687–9. [CrossRef]
  • Narci H, Turk E, Karagulle E, Togan T, Karabulut K. The role of red cell distribution width in the diagnosis of acute appendicitis: A retrospective case-controlled study. World J Emerg Surg 2013;8:46. [CrossRef]
  • Toktas O, Aslan M. Mean platelet volume, red cell distribution width, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in the diagnosis of acute appendicitis. East J Med 2017;22:5–9. [CrossRef]
  • Bozlu G, Taskinlar H, Unal S, Alakaya M, Naycı A, Kuyucu N. Diagnostic value of red blood cell distribution width in pediatric acute appendicitis. Pediatr Int 2016;58:202–5. [CrossRef]
  • Tanrikulu CS, Tanrikulu Y, Sabuncuoglu MZ, Karamercan MA, Akkapulu N, Coskun F. Mean platelet volume and red cell distribution width as a diagnostic marker in acute appendicitis. Iran Red Crescent Med J 2014;16:e10211. [CrossRef]
  • Albayrak Y, Albayrak A, Albayrak F, Yildirim R, Aylu B, Uyanik A, et al. Mean platelet volume: a new predictor in confirming acute appendicitis diagnosis. Clin Appl Thromb Hemost 2011;17:362–6. [CrossRef]
  • Fan Z, Pan J, Zhang Y, Wang Z, Zhu M, Yang B, et al. Mean platelet volume and platelet distribution width as markers in the diagnosis of acute gangrenous appendicitis. Dis Markers 2015;2015:542013. [CrossRef]
  • Erdem H, Aktimur R, Cetinkunar S, Reyhan E, Gokler C, Irkorucu O, Sozen S. Evaluation of mean platelet volume as a diagnostic biomarker in acute appendicitis. Int J Clin Exp Med 2015;8:1291–5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358583/
  • Narcı H, Turk E, Karagulle E, Togan T, Karabulut K. The role of mean platelet volume in the diagnosis of acute appendicitis: a retrospective case-controlled study. Iran Red Crescent Med J 2013;15:e11934. [CrossRef]
  • Uyanik B, Kavalci C, Arslan ED, Yilmaz F, Aslan O, Dede S, Bakir F. Role of mean platelet volume in diagnosis of childhood acute appendicitis. Emerg Med Int 2012;2012:823095. [CrossRef]
  • Kahramanca S, Ozgehan G, Seker D, Gokce E I, Seker G, Tunç G, et al. Neutrophil-to-lymphocyte ratio as a predictor of acute appendicitis. Ulus Travma Acil Cerrahi Derg 2014;20:19–22. [CrossRef]
  • Goodman DA, Goodman CB, Monk JS. Use of the neutrophil: lymphocyte ratio in the diagnosis of appendicitis. Am Surg 1995;61:257–9.
  • Markar SR, Karthikesalingam A, Falzon A, Kan Y. The diagnostic value of neutrophil: lymphocyte ratio in adults with suspected acute appendicitis. Acta Chir Belg 2010;110:543–7. [CrossRef]
  • Weyrich AS, Lindemann S, Zimmerman GA. The evolving role of platelets in inflammation. J Thromb Haemost 2003;1:1897–105. [CrossRef]
  • Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest 2005;115:3378–84. [CrossRef]
  • Zarbock A, Polanowska-Grabowska RK, Ley K. Platelet-neutrophil- interactions: linking hemostasis and inflammation. Blood Rev 2007;21:99–111. [CrossRef]

AKUT APANDISIT TANISINDA TAM KAN SAYIMI PARAMETRELERININ TANISAL DEĞERI: SADECE BEYAZ KÜRE DEĞERINI DIKKATE ALMAMALIYIZ

Year 2020, Issue: 4, 696 - 700, 01.12.2020

Sönmez Ocak Ömer Faruk Bük Ahmet Burak Çiftci

Abstract

Amaç: Appendektomi en sık yapılan acil cerrahi girişim olmasına rağmen akut apandisit tanısını koymakta zorluklar görülebilmektedir. Bu retrospektif çalışmada tam kan sayımı TKS parametrelerinin akut apandisit tanısındaki öneminin araştırması hedeflenmiştir.Gereç ve Yöntem: Ocak 2016-Aralık 2016 yılları arasında appendektomi uygulanan 131 hastanın verileri retrospektif olarak incelenmiştir. Hastaların demografik özellikleri, TKS parametreleri ve histopatolojik inceleme sonuçları kaydedilmiştir. Hastalar patoloji sonuçlarına göre iki gruba ayrılmıştır Grup 1: akut apandisit grubu, Grup 2: normal appendiks grubu . İki grubun beyaz küre, trombosit, hemoglobulin seviyeleri ile RDW red cell distribution width , MPV mean platelet volume ve NLR nötrofil/lenfosit oranı değerleri karşılaştırılmıştır.Sonuçlar: Yüz otuz bir hastanın 13’ü normal appendikse sahipti. Beyaz küre, platelet ve NLR değerleri Grup 1’de anlamlı olarak daha yüksek bulundu p

Keywords

Apandisit RDW platelet nötrofil lenfosit

References

  • Seetahal SA, Bolorunduro OB, Sookdeo TC, Oyetunji TA, Greene WR, Frederick W, et al. Negative appendectomy: a 10-year review of a nationally representative sample. Am J Surg 2011;201 4:433–7. [CrossRef]
  • Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 1990;132:910–25. [CrossRef]
  • Raja AS, Wright C, Sodickson AD, Zane RD, Schiff GD, Hanson R, et al. Negative appendectomy rate in the era of CT. an 18-year perspective. Radiology 2010;256:460–5. [CrossRef]
  • Harswick C, Uyenishi AA, Kordick MF, Chan SB. Clinical guidelines, computed tomography scan, and negative appendectomies: a case series. The Am J Emerg Med 2006;24:68–72. [CrossRef]
  • Kotaluoto S, Ukkonen M, Pauniaho SL, Helminen M, Sand J, Rantanen T. Mortality Related to Appendectomy; a Population Based Analysis over Two Decades in Finland. World J Surg 2017;41:64–9. [CrossRef]
  • Andersson MN, Andersson RE. Causes of short-term mortality after appendectomy: a population-based case-controlled study. Ann Surg 2011;254:103–7. [CrossRef]
  • Yang HR, Wang YC, Chung PK, Chen WK, Jeng LB, Chen RJ. Role of leukocyte count, neutrophil percentage, and C-reactive protein in the diagnosis of acute appendicitis in the elderly. Am Surg 2005;71:344–7.
  • Saleem MM, Pervaiz M, Chaudhary IA. Predictive Value of Leukocytosis for Diagnosing Acute Appendicitis. PAFM 2007;67:292.
  • Ulukent SC, Sarıcı IS, Ulutas KT. All CBC parameters in diagnosis of acute appendicitis. Int J Clin Exp Med 2016;9:11871–6.
  • Van Randen A, Bipat S, Zwinderman AH, Ubbink DT, Stoker J, Boermeester MA. Acute appendicitis: meta-analysis of diagnostic performance of CT and graded compression US related to prevalence of disease. Radiology 2008;249:97–106. [CrossRef]
  • Çetinkaya, E, Şenol, K, Saylam B, Tez M. Red cell distribution width to platelet ratio: New and promising prognostic marker in acute pancreatitis. World J Gastroenterol 2004;20:14450–4. [CrossRef]
  • Aktimur R, Cetinkunar S, Yildirim K, Aktimur SH, Ugurlucan M, Ozlem N. Neutrophil-to-lymphocyte ratio as a diagnostic biomarker for the diagnosis of acute mesenteric ischemia. Eur J Trauma Emerg Surg 2016;42:363–8. [CrossRef]
  • Felker GM, Allen LA, Pocock SJ, Shaw LK, McMurray JJV, Pfeffer MA, et al. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 2007;50:40–7. [CrossRef]
  • Hampole CV, Mehrotra AK, Thenappan T, Gomberg-Maitland M, Shah SJ. Usefulness of red cell distribution width as a prognostic marker in pulmonary hypertension. Am J Cardiol 2009;104:868–72. [CrossRef]
  • Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 2008;117:163–8. [CrossRef]
  • Ani C, Ovbiagele B. Elevated red blood cell distribution width predicts mortality in persons with known stroke. J Neurol Sci 2009;277:103–8. [CrossRef]
  • Malandrino N, Wu WC, Taveira TH, Whitlatch HB, Smith RJ. Association between red blood cell distribution width and macrovascular and microvascular complications in diabetes. Diabetologia 2012;55:226– 35. [CrossRef]
  • Senol K, Saylam B, Kocaay F, Tez M. Red cell distribution width as a predictor of mortality in acute pancreatitis. Am J Emerg Med 2013;31:687–9. [CrossRef]
  • Narci H, Turk E, Karagulle E, Togan T, Karabulut K. The role of red cell distribution width in the diagnosis of acute appendicitis: A retrospective case-controlled study. World J Emerg Surg 2013;8:46. [CrossRef]
  • Toktas O, Aslan M. Mean platelet volume, red cell distribution width, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in the diagnosis of acute appendicitis. East J Med 2017;22:5–9. [CrossRef]
  • Bozlu G, Taskinlar H, Unal S, Alakaya M, Naycı A, Kuyucu N. Diagnostic value of red blood cell distribution width in pediatric acute appendicitis. Pediatr Int 2016;58:202–5. [CrossRef]
  • Tanrikulu CS, Tanrikulu Y, Sabuncuoglu MZ, Karamercan MA, Akkapulu N, Coskun F. Mean platelet volume and red cell distribution width as a diagnostic marker in acute appendicitis. Iran Red Crescent Med J 2014;16:e10211. [CrossRef]
  • Albayrak Y, Albayrak A, Albayrak F, Yildirim R, Aylu B, Uyanik A, et al. Mean platelet volume: a new predictor in confirming acute appendicitis diagnosis. Clin Appl Thromb Hemost 2011;17:362–6. [CrossRef]
  • Fan Z, Pan J, Zhang Y, Wang Z, Zhu M, Yang B, et al. Mean platelet volume and platelet distribution width as markers in the diagnosis of acute gangrenous appendicitis. Dis Markers 2015;2015:542013. [CrossRef]
  • Erdem H, Aktimur R, Cetinkunar S, Reyhan E, Gokler C, Irkorucu O, Sozen S. Evaluation of mean platelet volume as a diagnostic biomarker in acute appendicitis. Int J Clin Exp Med 2015;8:1291–5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358583/
  • Narcı H, Turk E, Karagulle E, Togan T, Karabulut K. The role of mean platelet volume in the diagnosis of acute appendicitis: a retrospective case-controlled study. Iran Red Crescent Med J 2013;15:e11934. [CrossRef]
  • Uyanik B, Kavalci C, Arslan ED, Yilmaz F, Aslan O, Dede S, Bakir F. Role of mean platelet volume in diagnosis of childhood acute appendicitis. Emerg Med Int 2012;2012:823095. [CrossRef]
  • Kahramanca S, Ozgehan G, Seker D, Gokce E I, Seker G, Tunç G, et al. Neutrophil-to-lymphocyte ratio as a predictor of acute appendicitis. Ulus Travma Acil Cerrahi Derg 2014;20:19–22. [CrossRef]
  • Goodman DA, Goodman CB, Monk JS. Use of the neutrophil: lymphocyte ratio in the diagnosis of appendicitis. Am Surg 1995;61:257–9.
  • Markar SR, Karthikesalingam A, Falzon A, Kan Y. The diagnostic value of neutrophil: lymphocyte ratio in adults with suspected acute appendicitis. Acta Chir Belg 2010;110:543–7. [CrossRef]
  • Weyrich AS, Lindemann S, Zimmerman GA. The evolving role of platelets in inflammation. J Thromb Haemost 2003;1:1897–105. [CrossRef]
  • Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest 2005;115:3378–84. [CrossRef]
  • Zarbock A, Polanowska-Grabowska RK, Ley K. Platelet-neutrophil- interactions: linking hemostasis and inflammation. Blood Rev 2007;21:99–111. [CrossRef]
There are 33 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Sönmez Ocak

Ömer Faruk Bük

Ahmet Burak Çiftci

Publication Date December 1, 2020
Published in Issue Year 2020Issue: 4

Cite

EndNote Ocak S, Bük ÖF, Çiftci AB (December 1, 2020) The Diagnostic Value of Complete Blood Test Parameters In Acute Appendicitis: We Should Not Only Take Into Account Wbc. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 4 696–700.