Düşük Serum D Vitamin Düzeylerine Parathormon Yanıtını Etkileyen Faktörler

Tuğba Aydın

Factors Affecting Parathormone Response To Low Serum Vitamin D Levels

Year 2020, Issue: 4, 706 - 710, 01.12.2020

Tuğba Aydın

Abstract

Objective: The aim of the study is to determine the factors affecting parathormone PTH response induced in patients with low serum 25 OH vitamin D levels.Materials and methods: This is a retrospective descriptive study. The patients whom serum 25 OH vitamin D and PTH levels were examined together were included in our study in Istanbul in Physical Therapy Rehabilitation Education and Research Hospital between 2015 and 2019. Patients with 25 OH vitamin D values lower than 30 ng/mL were included in the study. The patients 17 years and under; the patients with abnormal creatinine, albumin, calcium and phosphorus levels and the patients with PTH levels lower than 12 pg/mL were excluded from the study. Age, sex, seasonal hospital admission, serum 25 OH vitamin D and PTH levels were examined.Results: The mean age of the 334 patients included in the study was 49.1±17.7 years. The mean serum 25 OH vitamin D level was 14.5±7.6 ng/mL and the mean PTH level was 49.3±26.5 pg/mL. 34.4% of the patients had severe 25 OH vitamin D deficiency, 37.4% of the patients had 25 OH vitamin D deficiency and 28.1% of the patients had 25 OH vitamin D insufficiency. Hyperparathyroidism was found in 6.3% of all cases. Hyperparathyroidism was found to be significantly more frequent in patients with severe 25 OH vitamin D deficiency. There was a negative correlation between serum PTH and 25 OH vitamin D levels. There was a positive correlation between age and serum PTH levels. There was no relationship with 25 OH vitamin D level, gender and seasonal distribution.Conclusion: Low 25 OH vitamin D induced PTH elevation is not only dependent on vitamin D levels, but also age. PTH levels were found to be higher in patients with low vitamin D while age increased

Keywords

25 OH vitamin D, parathyroid hormone, parathormone response

References

Türkiye Endokrin ve Metabolizma Derneği. Osteoporoz ve Metabolik Kemik Hastalıkları Tanı ve Tedavi Kılavuzu 9. Baskı. Ankara: Miki Matbaacılık; 2018.
Khundmiri SJ, Murray RD, Lederer E. PTH and Vitamin D. Compr Physiol 201615;6:561–601. [CrossRef]
Yavuz D, Mete T, Yavuz R, Altunoğlu A. D Vitamini, Kalsiyum & Mineral Metabolizması, D Vitaminin İskelet Dışı Etkileri ve Kronik Böbrek Yetmezliğinde Nutrisyonel D Vitamini Kullanımı. Ankara Med J 2014;14:162–71. [CrossRef]
Wright NC, Chen L, Niu J, Neogi T, Javiad K, Nevitt MA, et al. Defining physiologically “normal” vitamin D in African Americans. Osteoporos Int 2012;23:2283–91. [CrossRef]
Valcour A, Blocki F, Hawkins DM, Rao SD. Effects of age and serum 25-OH-vitamin D on serum parathyroid hormone levels. J Clin Endocrinol Metab 2012;97:3989–95. [CrossRef]
Lotito A, Teramoto M, Cheung M, Becker K, Sukumar D. Serum Parathyroid Hormone Responses to Vitamin D Supplementation in Overweight/Obese Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Nutrients 2017;9:241. [CrossRef]
Sahota O, Mundey MK, San P, Godber IM, Lawson N, Hosking DJ. The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis. Bone 2004;35:312–9. [CrossRef]
Özdemir O. Serum 25(OH) Vitamin D Düzeyi Düşük Olan Kadınlarda Paratiroid Hormon Yanıtının Değerlendirilmesi. Turk Med J 2008;2:124–7. https://www.journalagent.com/ttd/pdfs/ TTD_2_3_124_127.pdf
Vurgun E, Evliyaoğlu O, Vardar M. Assessment of vitamin D deficiency level by the physiological response of parathyroid hormone in Turkish adults. Turk J Biochem 2018;43:502–9. [CrossRef]
Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S, Meunier P. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporosis Int 1997;7:439–43. [CrossRef]
Di Monaco M, Castiglioni C, Vallero F, Di Monaco R, Tappero R. Parathyroid hormone response to severe vitamin D deficiency is sex associated: an observational study of 571 hip fracture inpatients. J Nutr Health Aging 2013;17:180–4. [CrossRef]
Khazaei Z, Khazaei S, Beigrezaei S, Nasri H. Vitamin D deficiency in healthy people and its relationship with gender and age. J Parathyroid Dis 2018;6:16–8. [CrossRef]
Bozkurt S, Alkan BM, Yildiz F, Gümüş S, Sezer N, Ardiçoğlu Ö, Akkuş S. Age, Sex, and Seasonal Variations in the Serum Vitamin D3 Levels in a Local Turkish Population. Arch Rheumatol 2014;29:14–19. [CrossRef]