Comparison of Adverse Effects of COVID-19 Vaccines Among Elderly: Pfizer/BioNTech Versus CoronaVac

Hakan Evren; Emine Ünal Evren; Serap Argun Barış; Figen Gülen İnce; Cenk Soydan; Ömür Çınar Elçi; Füsun Yıldız

doi:10.31067/acusaglik.1076933

EN

Comparison of Adverse Effects of COVID-19 Vaccines Among Elderly: Pfizer/BioNTech Versus CoronaVac

Abstract

PURPOSE: The SARS-CoV-2 infection has triggered the Covid-19 pandemic with enormous public health and economic consequences. The safety and efficacy of currently available Covid-19 vaccines have been demonstrated in few studies; however, further information on specific high-risk groups like the elderly with co-morbidities is needed. In this cross-sectional study, we aimed to compare the adverse side effects of two different Covid-19 vaccines (RNA-based Pfizer/BioNTech and inactivated CoronaVac) among the elderly with co-morbidities. MATERIAL AND METHODS: We selected a total of 800 participants 65 years or older who received either one of the vaccines. We collected data on the possible side effects that have been previously attributed to coronavirus vaccination via quantitative telephone interviews. RESULTS: We found that both CoronaVac and Pfizer/BioNTech were safe in adults over 65 years old, even with co-morbidities. The most common side effects were pain on the injection site and fatigue. Adverse effects, particularly allergic reactions, were higher in Pfizer/BioNTech vaccinated group compared to the CoronaVac group. CONCLUSION: In conclusion, even with co-morbidities, both vaccines were well-tolerated among the elderly. As this specific group was largely excluded from the previous trials, we believe that this study may have a contributing impact on vaccine acceptance and health policy decision-making.

Keywords

References

REFERENCES 1. Tangcharoensathien V, Bassett MT, Meng Q, Mills A. Are overwhelmed health systems an inevitable consequence of covid-19? Experiences from China, Thailand, and New York State. bmj. 2021;372
2. Zhang Y, Zeng G, Pan H, et al. Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18–59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial. The Lancet infectious diseases. 2021;21(2):181-192.
3. Malesza M, Wittmann E. Acceptance and intake of COVID-19 vaccines among older Germans. medRxiv. 2021;
4. Baden LR, El Sahly HM, Essink B, et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. New England Journal of Medicine. 2021;384(5):403-416.
5. Ramasamy MN, Minassian AM, Ewer KJ, et al. Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial. The Lancet. 2020;396(10267):1979-1993.
6. Polack FP, Thomas SJ, Kitchin N, et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. New England Journal of Medicine. 2020;383(27):2603-2615.
7. Meo S, Bukhari I, Akram J, Meo A, Klonoff D. COVID-19 vaccines: comparison of biological, pharmacological characteristics and adverse effects of Pfizer/BioNTech and Moderna Vaccines. European Review for Medical and Pharmacological Sciences. 2021;25(3):1663-1669.
8. Li X, Ostropolets A, Makadia R, et al. Characterizing the incidence of adverse events of special interest for COVID-19 vaccines across eight countries: a multinational network cohort study. medRxiv. 2021;

Details

Primary Language

English

Subjects

Infectious Diseases

Journal Section

Research Article

Authors

Hakan Evren ^*
0000-0001-8247-8144
Kuzey Kıbrıs Türk Cumhuriyeti

Emine Ünal Evren
0000-0001-9455-0473
Kuzey Kıbrıs Türk Cumhuriyeti

Serap Argun Barış
0000-0002-4429-9441
Türkiye

Figen Gülen İnce
0000-0002-5628-9937
Kuzey Kıbrıs Türk Cumhuriyeti

Cenk Soydan
0000-0003-2772-4220
Kuzey Kıbrıs Türk Cumhuriyeti

Ömür Çınar Elçi
0000-0002-8815-288X
Kuzey Kıbrıs Türk Cumhuriyeti

Füsun Yıldız
0000-0003-4810-7301
Kuzey Kıbrıs Türk Cumhuriyeti

Early Pub Date

June 7, 2023

Publication Date

July 10, 2023

Submission Date

February 24, 2022

Acceptance Date

April 14, 2023

Published in Issue

Year 2023 Volume: 14 Number: 3

DOI

https://doi.org/10.31067/acusaglik.1076933

IZ

https://izlik.org/JA74BN26RZ

Cite

RIS / Bibtex

APA

Evren, H., Ünal Evren, E., Argun Barış, S., Gülen İnce, F., Soydan, C., Elçi, Ö. Ç., & Yıldız, F. (2023). Comparison of Adverse Effects of COVID-19 Vaccines Among Elderly: Pfizer/BioNTech Versus CoronaVac. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 14(3), 353-359. https://doi.org/10.31067/acusaglik.1076933

AMA

1.Evren H, Ünal Evren E, Argun Barış S, et al. Comparison of Adverse Effects of COVID-19 Vaccines Among Elderly: Pfizer/BioNTech Versus CoronaVac. Acibadem Univ Saglik Bilim Derg. 2023;14(3):353-359. doi:10.31067/acusaglik.1076933

Chicago

Evren, Hakan, Emine Ünal Evren, Serap Argun Barış, et al. 2023. “Comparison of Adverse Effects of COVID-19 Vaccines Among Elderly: Pfizer BioNTech Versus CoronaVac”. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 14 (3): 353-59. https://doi.org/10.31067/acusaglik.1076933.

EndNote

Evren H, Ünal Evren E, Argun Barış S, Gülen İnce F, Soydan C, Elçi ÖÇ, Yıldız F (July 1, 2023) Comparison of Adverse Effects of COVID-19 Vaccines Among Elderly: Pfizer/BioNTech Versus CoronaVac. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 14 3 353–359.

IEEE

[1]H. Evren et al., “Comparison of Adverse Effects of COVID-19 Vaccines Among Elderly: Pfizer/BioNTech Versus CoronaVac”, Acibadem Univ Saglik Bilim Derg, vol. 14, no. 3, pp. 353–359, July 2023, doi: 10.31067/acusaglik.1076933.

ISNAD

Evren, Hakan - Ünal Evren, Emine - Argun Barış, Serap - Gülen İnce, Figen - Soydan, Cenk - Elçi, Ömür Çınar - Yıldız, Füsun. “Comparison of Adverse Effects of COVID-19 Vaccines Among Elderly: Pfizer BioNTech Versus CoronaVac”. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 14/3 (July 1, 2023): 353-359. https://doi.org/10.31067/acusaglik.1076933.

JAMA

1.Evren H, Ünal Evren E, Argun Barış S, Gülen İnce F, Soydan C, Elçi ÖÇ, Yıldız F. Comparison of Adverse Effects of COVID-19 Vaccines Among Elderly: Pfizer/BioNTech Versus CoronaVac. Acibadem Univ Saglik Bilim Derg. 2023;14:353–359.

MLA

Evren, Hakan, et al. “Comparison of Adverse Effects of COVID-19 Vaccines Among Elderly: Pfizer BioNTech Versus CoronaVac”. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, vol. 14, no. 3, July 2023, pp. 353-9, doi:10.31067/acusaglik.1076933.

Vancouver

1.Hakan Evren, Emine Ünal Evren, Serap Argun Barış, Figen Gülen İnce, Cenk Soydan, Ömür Çınar Elçi, Füsun Yıldız. Comparison of Adverse Effects of COVID-19 Vaccines Among Elderly: Pfizer/BioNTech Versus CoronaVac. Acibadem Univ Saglik Bilim Derg. 2023 Jul. 1;14(3):353-9. doi:10.31067/acusaglik.1076933

Cited By

Relative effectiveness of COVID-19 vaccine booster doses in people aged 65 and older—a retrospective cohort study in Türkiye

Therapeutic Advances in Vaccines and Immunotherapy

https://doi.org/10.1177/25151355241285375