A Retrospective Study on Insulin Resistance in Adults with Autoimmune Thyroiditis in Turkish Population: a Clinical and Molecular Docking Study
Abstract
Background/Purpose: This study aims to retrospectively analyze existing data to assess the prevalence and intensity of insulin resistance among adults with autoimmune thyroiditis, a condition marked by the body's immune response against its thyroid gland, including Hashimoto's thyroiditis. Insulin resistance, characterized by the body's inadequate response to insulin, complicates blood sugar regulation. This research seeks to explore historical health records of individuals diagnosed with autoimmune thyroiditis to identify potential correlations with insulin resistance.
Methods: Our approach involves a comprehensive review of previous medical records, with a focus on evaluating insulin levels, HbA1c values (an indicator of blood sugar regulation), and other pertinent health markers in patients with autoimmune thyroiditis. Data analysis was conducted using SPSS version 26, a software extensively employed in social sciences for statistical computations. The distribution normality was verified through the Shapiro-Wilks test and Box Plot diagrams. Correlation between variables was determined using either Pearson or Spearman's correlation analysis.
Results: Our statistical analysis uncovered a significant correlation between higher Insulin Resistance (HOMA-IR) scores and increased levels of blood glucose and insulin, with p-values indicating strong positive relationships (p<0.01 for both variables). Additionally, a moderate positive correlation was observed between Insulin Resistance (HOMA-IR) scores and both HbA1c levels and HbA1c (IFCC) measurements, reinforcing the association between insulin resistance and long-term glucose regulation markers.
Conclusion: The findings from this study illuminate the extent and impact of insulin resistance among those with autoimmune thyroiditis, highlighting the potential for these insights to revolutionize diagnosis and treatment paradigms. By establishing a clearer understanding of these associations, our goal is to improve clinical strategies, setting the stage for further research that could lead to enhanced treatment outcomes for individuals grappling with these health challenges.
References
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Abstract
References
- 1- Ragusa F, Fallahi P, Elia G, et al. Hashimotos’ thyroiditis: Epidemiology, pathogenesis, clinic and therapy. Best Pract Res Clin Endocrinol Metab. 2019;33(6): 101367.
- 2- Aslan ES, & Savaş Gur. Evaluation and epigenetic impact of B12, vitamin D, folic acid and anemia in Hashimoto's thyroiditis: a clinical and molecular docking study. J Health Sci Med, 2023;6(4): 705-712.
- 3- Miteva MZ, Nonchev BI, Orbetzova MM, et al. Vitamin D and autoimmune thyroid diseases-a review. Folio Med. 2020;62(2):223-229.
- 4- Sawicka-Gutaj N, Gruszczyński D, Zawalna N, et al. Microbiota alterations in patients with autoimmune thyroid diseases: a systematic review. Int. J. Mol. Sci. 2022;23(21), 13450.
- 5- Vargas-Uricoechea, H. Molecular mechanisms in autoimmune thyroid disease. Cells, 2023;12(6), 918.
- 6- Kiguradze T, Bruins FM, Guido N, et al. Evidence for the association of Hashimoto's thyroiditis with psoriasis: a cross‐sectional retrospective study. Int. J. Dermatol. 2017;56(5), 553-556.
- 7- Tang S, Yang M, Zhang D, et al. Clinical characteristics and follow-up of 19 children with Hashimoto’s thyroiditis aged below 3 years: a single-center retrospective analysis. Front Endocrinol, 2021;12, 737527.
- 8- Ferrari SM, Fallahi P, Elia G, et al. Novel therapies for thyroid autoimmune diseases: An update. Best Pract Res Clin Endocrinol Metab. 2020;34(1), 101366.
- 9- Khan, T., Ali, M., Khan, A., et al. Anticancer plants: a review of the active phytochemicals, applications in animal models, and regulatory aspects. Biomolecules. 2020;10, 47–57. https://doi.org/10.3390/ biom10010047.
- 10- Tuorkey Muobarak J., Cancer Therapy with Phytochemicals: Present and Future Perspectives. Biomed. and Environ. Sci. 2015;28(11), 808-819, https://doi.org/10.1016/S0895-3988 (15)30111-2.
- 11- Atmaca U, Kaya R, Karaman HS, et al. Synthesis of oxazolidinone from enantiomerically enriched allylic alcohols and determination of their molecular docking and biologic activities. Bioorganic chem. 2019; 88:102980.
- 12- Schrödinger. Schrödinger. 2024-1. New York: Schrödinger, LLC; 2024.
- 13- Schrödinger. LigPrep. 2024-1. Schrödinger, LLC, New york; 2024.
- 14- Graceffa G, Patrone R, Vieni S, et al. Association between Hashimoto’s thyroiditis and papillary thyroid carcinoma: a retrospective analysis of 305 patients. BMC Endocr Disord, 2019;19, 1-6.
- 15- Eom YS, Wilson JR, & Bernet, VJ. Links between thyroid disorders and glucose homeostasis. Diabetes Metab J, 2022;46(2), 239.
- 16- Mikulska AA, Karaźniewicz-Łada M, Filipowicz D, et al. Metabolic characteristics of hashimoto’s thyroiditis patients and the role of microelements and diet in the disease management—An overview. Int J Mol Sci, 2022;23(12), 6580.
- 17- Bektaş A, Ulusoy M, Özsarı L, et al. The Effects of Gluten on Weight Gain, Hematological, Biochemical, and Various Endocrinological Parameters. Turk J Gastroenterol, 2024;35(3), 178-185.
- 18- Ece A. Computer-aided drug design. BioMed Central; 2023; p. 1-3.
- 19- Friesner RA, Banks JL, Murphy RB, et al. Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. J of med chem. 2004; 25;47(7):1739-1749 DOI: 10.1021/jm0306430.
Details
| Primary Language | English |
|---|---|
| Subjects | Bioinformatics and Computational Biology (Other), Biochemistry and Cell Biology (Other) |
| Journal Section | Clinical Research |
| Authors | |
| Early Pub Date | December 10, 2024 |
| Publication Date | |
| Submission Date | May 31, 2024 |
| Acceptance Date | September 26, 2024 |
| Published in Issue | Year 2025Issue: Kabul Edilen Makaleler |