Research Article
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Year 2023, Volume: 7 Issue: 2, 589 - 600, 31.05.2023

Özlem Uğur Ezgi Karadağ Hasan Oğuz Çetinayak Volkan Semiz Fadime Akman

https://doi.org/10.30621/jbachs.1072283

Abstract

Project Number

No:2018.KB.SAG.052

References

  • 1. Ozturk E. Radyoterapi Alan Baş Ve Boyun Kanserli Hastalarda Yaşam Kalitesi Ve Yaşam Kalitesini Etkileyen Faktorler. Sağlık Bilimleri Enstitusu, İc Hastalıkları Hemşireliği, Yuksek Lisans Tezi, İstanbul Universitesi, 2011.
  • 2. Cancer facts and statistics (internet). Erişim adresi: http://www.cancer.org/research/cancerfactsstatistics/ index. (Erişim tarihi: 12.04.2015).
  • 3. WHO, Cancer statistics Prediction (internet). Erişim adresi: http://globocan.iarc.fr/Pages/burden_sel.aspx. (Erişim tarihi: 04.08.2020).
  • 4. Siegel RL, Miller KD, Jemal A. Cancer statistics, CA Cancer J Clin 2020; 70(1): 7-30.
  • 5. Sağlık Bakanlığı, Turkiye kanser istatistikleri (internet), http://kanser.gov.tr/Dosya/ca_istatistik/2009kanseraporu-1.pdf,(2009) (Erişim tarihi: 11.04.2015).
  • 6. Tufan AN. Allogeneik Hematopoetik Kök Hücre Nakli Sonrası Gelişen Mukozit ile İnsan Lökosit Antijen (HLA) Doku Grubunun İlişkisi. Yayınlanmış Doktora Tezi, 2010.
  • 7. Biswal BM, Zakaria A, Ahmad NM. Topical application of honey in the management of radiation mucositis: a preliminary study, Support Care Cancer 2003; 11(4) :242-8.
  • 8. Rashad UM, Al-Gezawy SM, El-Gezawy E, Azzaz AN. Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer. J Laryngol Otol. 2009; 123(2):223-8, doi: 10.1017/S0022215108002478.
  • 9. Eilers J, Million R. Prevention And Menagement Of Oral Mucositis İn Patients With Cancer, Seminars in Oncology Nursing 2007; 23 (3):201- 212.
  • 10. Ferreira PR, Fleck JF, Diehl A, Barletta D, Braga-Filho A, Barletta A. et al., Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: a double-blind randomized trial, Head Neck 2004; 26(4):313-21.
  • 11. Worthington HV, Clarkson JE, Bryan G, Burness FS, Glenny AM, Littlewood A. et al., Interventions for preventing oral mucositis for patients with cancer receiving treatment, Cochrane Database Syst Rev. 2011, 13(4):1- 276, doi: 10.1002/14651858.CD000978.pub5.
  • 12. Song JJ, Twumasi-Ankrah P, Salcido R. Systematic review and meta-analysis on the use of honey to protect from the effects of radiation-induced oral mucositis, Adv Skin Wound Care 2012; 25(1):23-8, doi: 10.1097/01.ASW.0000410687.14363.a3.
  • 13. Bulut KH, Tüfekçi GF. Honey prevents oral mocositis in children undergoing chemotherapy: A quasi-experimental study with a control group, Complemantary Therapies İn Medicine 2016; 29:132-140. 14. Abdulrhman M, Elbarbary NS, Ahmed D, Amin R. Honey and a mixture of honey, beeswax, and olive oil-propolis extract in treatment of chemotherapy-induced oral mucositis: a randomized controlled pilot study, Pediatr Hematol Oncol. 2012; 29(3):285-92.
  • 15. Bergman A, Yanai J, Weiss J, Bell D, David MP. Acceleration of wound healing by topical application of honey. An animal model, Am J Surg.1983,145(3): 374-6.
  • 16. Molan PC. The potential of honey to promote oral wellness, Gen Dent. 2001;49(6): 584-9.
  • 17. Khanal B, Uppal N. Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study, Int J Oral Maxillofac Surg. 2010, 39(12): 1181- 5, doi:10.1016/j.ijom.2010.05.014.
  • 18. Xu JL, Xia R, Sun ZH, Sun L, Min X, Liu C, et al., Effects of honey use on the management of radio/ chemotherapy-induced mucositis: a meta- analysis of randomized controlled trials, Int. J. Oral Maxillofac. Surg.2016, 45:1618– 1625, doi:1j.ijom.2016.04.023 19. Bahramnezhad F, Nayeri DN, Bassampour SS, Khajeh M, Asgari P. Honey and Radiation-Induced Stomatitis in Patients With Head and Neck Cancer, Iran Red Crescent Med J 2015, 17(10):1-7.
  • 20. Charalambous A, Lambrinou E, Katodritis N, Vomvas D, Raftopoulos V, Georgiou MC et al., The effectiveness of thyme honey for the management of treatment- induced xerostomia in head and neck cancer patients:A feasibility randomized control trial. European Journal of Oncology Nursing 2017, 27:1-8.
  • 21. Motallebnejad M, Akram S, Moghadamnia A, Moulana Z, S. , The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial, J Contemp Dent Pract. 2008, 9(3):40-7. 22. Dodd JM, Dibble SL, Miasowski C, MacPhail L, Greenspan D, Paul SM, et al., Randomized clinical trial of the effectiveness of 3 commonly used mouthwashes to treat chemotherapy-induced mucositis, Oral surgery oral medicine oral pathology 2000, 90(1):39- 47.
  • 23. Kazemıan A, Kamian S, Aghili M, Hashemi FA, Haddad P. Benzydamine for prophylaxis of radiation-induced oral mucositis in head and neck cancers: a double- blind placebo-controlled randomized clinical trial, European Journal of Cancer Care 2009,18:174–178.
  • 24. Karagözoğlu S, Ulusoy FM. Chemotherapy: the effect of oral cryotherapy on the development of mucositis, J Clin Nursing 2005, 14(6):754-65.
  • 25. İstek E. Kolorektal Kanserli Hastalarda Yorgunluk Düzeyi ve Yorgunluğu Etkileyen Faktörlerin Belirlenmesi, Dokuz Eylül Üniversitesi Sağlık Bilimleri Enstitüsü, Onkoloji Hemşireliği Ana Bilim Dalı 2008, Yüksek Lisans Tezi.
  • 26. Matthews RW, Scully CM, Levers GH. Clinical evaluation of benzydamine, chlorhexidine, and placabo mouthwashes in the management of recurrent apthous stomamtitis, Oral Surgery,Oral Medicine,Oral Pathology 1987, 63 (2):189–191.
  • 27. Kong M, Hwank DS, Yoon SW, Kim J. The effect of clove-based herbal mouthwash on radiation-induced oral mucositis in patients with head and neck cancer: a single-blind randomized preliminary study. Onco Targets Ther. 2016, 9:4533–4538., doi: 10.2147/OTT.S108769
  • 28. Hawley P, Hovan A, McGahan CE, Saunders D. A randomized placebo-controlled trial of manuka honey for radiation-induced oral mucositis. Support Care Cancer 2014, 22 :751–761
  • 29. Co L.J., Mejia B.M.A., Que J.M., Dizon M.J.R., Effectiveness of honey on radiation- induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies: A meta-analysis and systematic review of literatüre. Head Neck 2015; 38(7):1119-28, doi: 10.1002/hed.24431.
  • 30. Jaime CS, Martínez C, García FT, Giner-Boya P, Icart-Isern T, Joan M. et al., Efficacy of Plantago major, chlorhexidine 0.12% and sodium bicarbonate 5% solution in the treatment of oral mucositis in cancer patients with solid tumour: A feasibility randomised triple-blind phase III clinical trial, Eur J Oncol Nurs 2017, 32:40-47, doi: 10.1016/j.ejon.2017.11.006.
  • 31. Guire MCD, Fulton J, Park J, Carlton G, Correa EP, Eilers J. et al, Systematic revieeof basic oral car efor the management of oral mucositis in patients. Support Care Cancer 2013, 22:564- 579.
  • 32. Gibson R, Keed D, Lalla R, Batteman E, Blijlevans E, Fijlstra M. et al., Systemtic review of agents fort he management of gastrointestinal mucositis in cancer patients. Support Care Cancer 2013, 21:313-326.
  • 33. Can G. ( Ed.) Onkoloji Hemşireliğinde Kanıta Dayalı Bakım, İstanbul Konsensusu, Nobel Tıp Kitabevi 2015, İstanbul.
  • 34. Brozozowska A, Golebıowskı P. Acute radiation-induced oral mucositis in patients subjected to radiotherapy due to head and neck cancer, Pol J Public Health 2019, 129(1): 27-30 35. Bossola M. Nutritional Interventions in Head and Neck Cancer Patients Undergoing Chemoradiotherapy: A Narrative Review. Nutrients 2015, 7:265-276.
  • 36. Uğur Ö. Kemoradyoterapi Alan Baş- Boyun Kanserli Hastaların Beslenme Durumlarının Değerlendirilmesi, İzmir Kâtip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi 2019, 4(3):83-89.
  • 37. Kurtuldu E, Miloğlu Ö, Derindağ G, Özdoğan A. Tat Duyusu Bozukluklarına Genel Bakış, Ataürk Üniv. Diş Hek. Fak. Derg. 2018, 28(2): 277- 283. 38. Abendstein H, Nordgren M, Boysen M, Jannert M, Silander E, Ahlner- Elmqvist M, et al., Quality of life and head and neck cancer: a 5 year prospective study. Laryngoscope 2005, 115(12):2183-92, doi: 10.1097/01.MLG.0000181507.69620.14.
  • 39. Alkhouli M, Laflouf M, Alhaddad M. Efficacy of Aloe-Vera Use for Prevention of Chemotherapy-Induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia: A Randomized Controlled Clinical Trial. Compr Child Adolesc Nurs. 2020, 26:1-14. doi: 10.1080/24694193.2020.1727065.

The Effect of Honey Therapy on the Management of Oral Mucosites in Head and Neck Cancer Patients with Chemoradiotherapy: A Randomized Controlled Study

Year 2023, Volume: 7 Issue: 2, 589 - 600, 31.05.2023

Özlem Uğur Ezgi Karadağ Hasan Oğuz Çetinayak Volkan Semiz Fadime Akman

https://doi.org/10.30621/jbachs.1072283

Abstract

Purpose: Mucositis management has an important place in the treatment of these cancer patients. Therefore, the aim of our study is to examine the effect of honey treatment on oral mucositis management in patients with head and neck cancer receiving radiotherapy.
Methods: The study was planned as a randomized controlled, single-blind, parallel group study. The study was conducted on 32 patients with 16 patients in each parallel group. Five data collection tools were used to collect the research data. Patient Identification Form , Researcher Mucositis Index, VAS- Pain, Honey Management Monitoring Chart (given to the patients in the treatment group). Oral Care Management Follow-up Form (given to the patients in the control group).
Results: The number of days with mucositis was similar in both parallel groups (Honey Group / Mean ± SD: 14.88 ± 7.36, Bicarbonate Group / Mean ± SD: 14.38 ± 6.33).
Conclusion: Honey application has not been found to be superior to bicarbonate mouthwash on the development and staging of oral mucositis.

Keywords

Head and neck cancer Treatment – ınduced mucositis Pain and change in taste Honey

Supporting Institution

Dokuz Eylül University Scientific Research Projects Coordination Unit .

Project Number

No:2018.KB.SAG.052

Thanks

Thank you to all the participants

References

  • 1. Ozturk E. Radyoterapi Alan Baş Ve Boyun Kanserli Hastalarda Yaşam Kalitesi Ve Yaşam Kalitesini Etkileyen Faktorler. Sağlık Bilimleri Enstitusu, İc Hastalıkları Hemşireliği, Yuksek Lisans Tezi, İstanbul Universitesi, 2011.
  • 2. Cancer facts and statistics (internet). Erişim adresi: http://www.cancer.org/research/cancerfactsstatistics/ index. (Erişim tarihi: 12.04.2015).
  • 3. WHO, Cancer statistics Prediction (internet). Erişim adresi: http://globocan.iarc.fr/Pages/burden_sel.aspx. (Erişim tarihi: 04.08.2020).
  • 4. Siegel RL, Miller KD, Jemal A. Cancer statistics, CA Cancer J Clin 2020; 70(1): 7-30.
  • 5. Sağlık Bakanlığı, Turkiye kanser istatistikleri (internet), http://kanser.gov.tr/Dosya/ca_istatistik/2009kanseraporu-1.pdf,(2009) (Erişim tarihi: 11.04.2015).
  • 6. Tufan AN. Allogeneik Hematopoetik Kök Hücre Nakli Sonrası Gelişen Mukozit ile İnsan Lökosit Antijen (HLA) Doku Grubunun İlişkisi. Yayınlanmış Doktora Tezi, 2010.
  • 7. Biswal BM, Zakaria A, Ahmad NM. Topical application of honey in the management of radiation mucositis: a preliminary study, Support Care Cancer 2003; 11(4) :242-8.
  • 8. Rashad UM, Al-Gezawy SM, El-Gezawy E, Azzaz AN. Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer. J Laryngol Otol. 2009; 123(2):223-8, doi: 10.1017/S0022215108002478.
  • 9. Eilers J, Million R. Prevention And Menagement Of Oral Mucositis İn Patients With Cancer, Seminars in Oncology Nursing 2007; 23 (3):201- 212.
  • 10. Ferreira PR, Fleck JF, Diehl A, Barletta D, Braga-Filho A, Barletta A. et al., Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: a double-blind randomized trial, Head Neck 2004; 26(4):313-21.
  • 11. Worthington HV, Clarkson JE, Bryan G, Burness FS, Glenny AM, Littlewood A. et al., Interventions for preventing oral mucositis for patients with cancer receiving treatment, Cochrane Database Syst Rev. 2011, 13(4):1- 276, doi: 10.1002/14651858.CD000978.pub5.
  • 12. Song JJ, Twumasi-Ankrah P, Salcido R. Systematic review and meta-analysis on the use of honey to protect from the effects of radiation-induced oral mucositis, Adv Skin Wound Care 2012; 25(1):23-8, doi: 10.1097/01.ASW.0000410687.14363.a3.
  • 13. Bulut KH, Tüfekçi GF. Honey prevents oral mocositis in children undergoing chemotherapy: A quasi-experimental study with a control group, Complemantary Therapies İn Medicine 2016; 29:132-140. 14. Abdulrhman M, Elbarbary NS, Ahmed D, Amin R. Honey and a mixture of honey, beeswax, and olive oil-propolis extract in treatment of chemotherapy-induced oral mucositis: a randomized controlled pilot study, Pediatr Hematol Oncol. 2012; 29(3):285-92.
  • 15. Bergman A, Yanai J, Weiss J, Bell D, David MP. Acceleration of wound healing by topical application of honey. An animal model, Am J Surg.1983,145(3): 374-6.
  • 16. Molan PC. The potential of honey to promote oral wellness, Gen Dent. 2001;49(6): 584-9.
  • 17. Khanal B, Uppal N. Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study, Int J Oral Maxillofac Surg. 2010, 39(12): 1181- 5, doi:10.1016/j.ijom.2010.05.014.
  • 18. Xu JL, Xia R, Sun ZH, Sun L, Min X, Liu C, et al., Effects of honey use on the management of radio/ chemotherapy-induced mucositis: a meta- analysis of randomized controlled trials, Int. J. Oral Maxillofac. Surg.2016, 45:1618– 1625, doi:1j.ijom.2016.04.023 19. Bahramnezhad F, Nayeri DN, Bassampour SS, Khajeh M, Asgari P. Honey and Radiation-Induced Stomatitis in Patients With Head and Neck Cancer, Iran Red Crescent Med J 2015, 17(10):1-7.
  • 20. Charalambous A, Lambrinou E, Katodritis N, Vomvas D, Raftopoulos V, Georgiou MC et al., The effectiveness of thyme honey for the management of treatment- induced xerostomia in head and neck cancer patients:A feasibility randomized control trial. European Journal of Oncology Nursing 2017, 27:1-8.
  • 21. Motallebnejad M, Akram S, Moghadamnia A, Moulana Z, S. , The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial, J Contemp Dent Pract. 2008, 9(3):40-7. 22. Dodd JM, Dibble SL, Miasowski C, MacPhail L, Greenspan D, Paul SM, et al., Randomized clinical trial of the effectiveness of 3 commonly used mouthwashes to treat chemotherapy-induced mucositis, Oral surgery oral medicine oral pathology 2000, 90(1):39- 47.
  • 23. Kazemıan A, Kamian S, Aghili M, Hashemi FA, Haddad P. Benzydamine for prophylaxis of radiation-induced oral mucositis in head and neck cancers: a double- blind placebo-controlled randomized clinical trial, European Journal of Cancer Care 2009,18:174–178.
  • 24. Karagözoğlu S, Ulusoy FM. Chemotherapy: the effect of oral cryotherapy on the development of mucositis, J Clin Nursing 2005, 14(6):754-65.
  • 25. İstek E. Kolorektal Kanserli Hastalarda Yorgunluk Düzeyi ve Yorgunluğu Etkileyen Faktörlerin Belirlenmesi, Dokuz Eylül Üniversitesi Sağlık Bilimleri Enstitüsü, Onkoloji Hemşireliği Ana Bilim Dalı 2008, Yüksek Lisans Tezi.
  • 26. Matthews RW, Scully CM, Levers GH. Clinical evaluation of benzydamine, chlorhexidine, and placabo mouthwashes in the management of recurrent apthous stomamtitis, Oral Surgery,Oral Medicine,Oral Pathology 1987, 63 (2):189–191.
  • 27. Kong M, Hwank DS, Yoon SW, Kim J. The effect of clove-based herbal mouthwash on radiation-induced oral mucositis in patients with head and neck cancer: a single-blind randomized preliminary study. Onco Targets Ther. 2016, 9:4533–4538., doi: 10.2147/OTT.S108769
  • 28. Hawley P, Hovan A, McGahan CE, Saunders D. A randomized placebo-controlled trial of manuka honey for radiation-induced oral mucositis. Support Care Cancer 2014, 22 :751–761
  • 29. Co L.J., Mejia B.M.A., Que J.M., Dizon M.J.R., Effectiveness of honey on radiation- induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies: A meta-analysis and systematic review of literatüre. Head Neck 2015; 38(7):1119-28, doi: 10.1002/hed.24431.
  • 30. Jaime CS, Martínez C, García FT, Giner-Boya P, Icart-Isern T, Joan M. et al., Efficacy of Plantago major, chlorhexidine 0.12% and sodium bicarbonate 5% solution in the treatment of oral mucositis in cancer patients with solid tumour: A feasibility randomised triple-blind phase III clinical trial, Eur J Oncol Nurs 2017, 32:40-47, doi: 10.1016/j.ejon.2017.11.006.
  • 31. Guire MCD, Fulton J, Park J, Carlton G, Correa EP, Eilers J. et al, Systematic revieeof basic oral car efor the management of oral mucositis in patients. Support Care Cancer 2013, 22:564- 579.
  • 32. Gibson R, Keed D, Lalla R, Batteman E, Blijlevans E, Fijlstra M. et al., Systemtic review of agents fort he management of gastrointestinal mucositis in cancer patients. Support Care Cancer 2013, 21:313-326.
  • 33. Can G. ( Ed.) Onkoloji Hemşireliğinde Kanıta Dayalı Bakım, İstanbul Konsensusu, Nobel Tıp Kitabevi 2015, İstanbul.
  • 34. Brozozowska A, Golebıowskı P. Acute radiation-induced oral mucositis in patients subjected to radiotherapy due to head and neck cancer, Pol J Public Health 2019, 129(1): 27-30 35. Bossola M. Nutritional Interventions in Head and Neck Cancer Patients Undergoing Chemoradiotherapy: A Narrative Review. Nutrients 2015, 7:265-276.
  • 36. Uğur Ö. Kemoradyoterapi Alan Baş- Boyun Kanserli Hastaların Beslenme Durumlarının Değerlendirilmesi, İzmir Kâtip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi 2019, 4(3):83-89.
  • 37. Kurtuldu E, Miloğlu Ö, Derindağ G, Özdoğan A. Tat Duyusu Bozukluklarına Genel Bakış, Ataürk Üniv. Diş Hek. Fak. Derg. 2018, 28(2): 277- 283. 38. Abendstein H, Nordgren M, Boysen M, Jannert M, Silander E, Ahlner- Elmqvist M, et al., Quality of life and head and neck cancer: a 5 year prospective study. Laryngoscope 2005, 115(12):2183-92, doi: 10.1097/01.MLG.0000181507.69620.14.
  • 39. Alkhouli M, Laflouf M, Alhaddad M. Efficacy of Aloe-Vera Use for Prevention of Chemotherapy-Induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia: A Randomized Controlled Clinical Trial. Compr Child Adolesc Nurs. 2020, 26:1-14. doi: 10.1080/24694193.2020.1727065.
There are 34 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Özlem Uğur 0000-0002-1020-9962

Ezgi Karadağ 0000-0001-8001-387X

Hasan Oğuz Çetinayak 0000-0002-8823-8341

Volkan Semiz 0000-0003-0283-1599

Fadime Akman 0000-0001-6260-0165

Project Number No:2018.KB.SAG.052
Publication Date May 31, 2023
Submission Date May 13, 2022
Published in Issue Year 2023 Volume: 7 Issue: 2

Cite

APA Uğur, Ö., Karadağ, E., Çetinayak, H. O., Semiz, V., et al. (2023). The Effect of Honey Therapy on the Management of Oral Mucosites in Head and Neck Cancer Patients with Chemoradiotherapy: A Randomized Controlled Study. Journal of Basic and Clinical Health Sciences, 7(2), 589-600. https://doi.org/10.30621/jbachs.1072283
AMA Uğur Ö, Karadağ E, Çetinayak HO, Semiz V, Akman F. The Effect of Honey Therapy on the Management of Oral Mucosites in Head and Neck Cancer Patients with Chemoradiotherapy: A Randomized Controlled Study. JBACHS. May 2023;7(2):589-600. doi:10.30621/jbachs.1072283
Chicago Uğur, Özlem, Ezgi Karadağ, Hasan Oğuz Çetinayak, Volkan Semiz, and Fadime Akman. “The Effect of Honey Therapy on the Management of Oral Mucosites in Head and Neck Cancer Patients With Chemoradiotherapy: A Randomized Controlled Study”. Journal of Basic and Clinical Health Sciences 7, no. 2 (May 2023): 589-600. https://doi.org/10.30621/jbachs.1072283.
EndNote Uğur Ö, Karadağ E, Çetinayak HO, Semiz V, Akman F (May 1, 2023) The Effect of Honey Therapy on the Management of Oral Mucosites in Head and Neck Cancer Patients with Chemoradiotherapy: A Randomized Controlled Study. Journal of Basic and Clinical Health Sciences 7 2 589–600.
IEEE Ö. Uğur, E. Karadağ, H. O. Çetinayak, V. Semiz, and F. Akman, “The Effect of Honey Therapy on the Management of Oral Mucosites in Head and Neck Cancer Patients with Chemoradiotherapy: A Randomized Controlled Study”, JBACHS, vol. 7, no. 2, pp. 589–600, 2023, doi: 10.30621/jbachs.1072283.
ISNAD Uğur, Özlem et al. “The Effect of Honey Therapy on the Management of Oral Mucosites in Head and Neck Cancer Patients With Chemoradiotherapy: A Randomized Controlled Study”. Journal of Basic and Clinical Health Sciences 7/2 (May 2023), 589-600. https://doi.org/10.30621/jbachs.1072283.
JAMA Uğur Ö, Karadağ E, Çetinayak HO, Semiz V, Akman F. The Effect of Honey Therapy on the Management of Oral Mucosites in Head and Neck Cancer Patients with Chemoradiotherapy: A Randomized Controlled Study. JBACHS. 2023;7:589–600.
MLA Uğur, Özlem et al. “The Effect of Honey Therapy on the Management of Oral Mucosites in Head and Neck Cancer Patients With Chemoradiotherapy: A Randomized Controlled Study”. Journal of Basic and Clinical Health Sciences, vol. 7, no. 2, 2023, pp. 589-00, doi:10.30621/jbachs.1072283.
Vancouver Uğur Ö, Karadağ E, Çetinayak HO, Semiz V, Akman F. The Effect of Honey Therapy on the Management of Oral Mucosites in Head and Neck Cancer Patients with Chemoradiotherapy: A Randomized Controlled Study. JBACHS. 2023;7(2):589-600.
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