JİNEKOLOJİ HASTALARINDA SELEKTİF SERATONİN GERİ ALIM İNHİBİTÖRLERİ KULLANMANIN KANAMA ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ
Abstract
Amaç: Çalışmanın amacı SSRİ kullanan ve değişik jinekolojik operasyonlar geçien hastalarda operasyon tipi, kanama miktarı, kan transfüzyon ihtiyacı ve transfüzyon yapılan kan miktarını değerlendirmektir.
Gereç ve yöntem: Jinekolojik operasyon geçiren hastalarda retrospektif değerlendirme yapıldı. SSRİ kullanan ve kullanmayan hastalar peroperatif ve postoperatif hemoglobin, hematokrit, trombosit sayısı, aktive parsiyel tromboplastin zamanı (APTT), INR değeri; kan transfüzyonu ihtiyacı ve transfüze edilen kan miktarı açısından karşılaştırıldı.
Bulgular: Jinekolojik operasyon geçiren hastalarda SSRİ grubundan antidepresan ilaçların kanamada artmaya ve hemoglobin ve hematokrit değerlerinde düşmeye neden olmadığı görüldü. Gruplar arasında kan transfüzyonu ihtiyacı ve miktarı açısından istatistiksel olarak anlamlı fark bulunamadı.
Sonuç: Potansiyel kanama etkisi yüzünden SSRİ'lerinin preoperatif dönemde kullanımının kesilmesine gerek yoktur. Bu hastaları perioperatif dönemde yakın takip edilmesi ve kanama protokolünün dikkatli izlenmesi yeterlidir.
Keywords
selektif seratonin geri alım inhibitörleri intraoperatif kanama jinekolojik orerasyonlar kan transfüzyonu
Supporting Institution
yok
References
- REFERENCES 1. Francisco J. de Abajo. Effects of Selective Serotonin Reuptake Inhibitors on Platelet Function Drugs Aging May 2011; Volume 28, Issue 5, 345–367
- 2. Halperin D, Reber G. Influence of antidepressants on hemostasis. Dialogues Clin Neurosci 2007; 9: 47 –59
- 3. P. Seitz D, M. Bell C, S. Gill S, et al. Risk of Perioperative Blood Transfusions and Postoperative Complications Associated With Serotonergic Antidepressants in Older Adults Undergoing Hip Fracture Surgery Journal of Clinical Psychopharmacology & Volume 33, Number 6
- 4. Lindqvist PG, Nasiell J, Gustafsson LL, Nordstrom L. Selective serotonin reuptake inhibitor use during pregnancy increases the risk of postpartum hemorrhage and anemia: a hospital-based cohort study. J Thromb Haemost 2014; 12: 1986–92. 14.
- 5. Dalton S.O, Johansen C, Mellemkjær L, et al. Use of Selective Serotonin Reuptake Inhibitors and Risk of Upper Gastrointestinal Tract BleedingA Population-Based Cohort Study Arch Intern Med. 2003;163(1):59-64
- 6. Meijer WE, Heerdink ER. Association of Risk of Abnormal Bleeding With Degree of Serotonin Reuptake Inhibition by Antidepressants Arch Intern Med 2004; 164:2367-2370
- 7. Bismuth –Evenzal Y. Decreased serotonin content and reduced agonist-induced aggregation in platelets of patients chronically medicated with SSRI drugs J Affect Disord 2012;136:99-103
- 8. Serebruany VL Selective serotonin reuptake inhibitors and increased bleeding risk: are we missing something? Am J Med 2006 ;119:113-116
- 9. Naesh O, Hindberg I, Bruun AB: Decreased reuptake of serotonin in human platelets after surgery. Clin Physiol 2001; 21:39–4
- 10. M. van Haelst I.M, Egberts T.C.G, J. Doodeman H, et al. Use of Serotonergic Antidepressants and Bleeding Risk in Orthopedic Patients Anesthesiology 2010; 112:631–6
- 11. Serebruany VL, Glassman AH, Malinan AI, et al. Platelet/endothelial biomarkers in depressed patients treated with selective serotonin reuptake inhibitor sertraline after acute coronary events. Circulation. 2003;108(8):939Y944.
- 12. Hergovich N, Aigner M, Eichler HG, et al. Paroxetine decreases platelet serotonin storage and platelet function in human beings. Clin Pharmacol Ther 2000; 68: 435-42
- 13. Mago R, Mahajan R, Thase ME.Medically serious adverse effects of newer antidepressants. Curr Psychiatry Rep 2008; 10(3):249– 257)
- 14. Movig KL, Janssen MW, de Waal Malefijt J, Kabel PJ, Leufkens HG, Egberts AC. Relationship of serotonergic antidepressants and need for blood transfusion in orthopedic surgical patients. Arch Intern Med 2003;163(19):2354–2358
- 15. Book Jeong , Sun Wan Kim et al Use of Serotonergic Antidepressants and Bleeding Risk in Patients Undergoing Surgery Psychosomatics 2014:55:213-220
- 16. Harirchian S, Zoumalan R.A, Rosenberg D.B. Antidepressants and Bleeding Risk After Face-lift Surgery Arch Facial Plast Surg. 2012;14(4):248-252
- 17. Sayadipour A, Mago R, Kepler C.K, et al. Antidepressants and the risk of abnormal bleeding during spinal surgery: a case–control study Eur Spine J 2012; 21:2070–2078
- 18. Gärtner R, Cronin-Fenton D, Hundborg H.H, Pedersen L, Lash T.L, Sørensen H.T, et al. Use of selective serotonin reuptake inhibitors and risk of re-operation due to post-surgical bleeding in breast cancer patients: a Danish populationbased cohort study BMC Surgery 2010; 10:3)6
- 19. Kim SY, Kim JM. Associations between Plasma Cytokines and Depressive Mood in Patients with Breast Cancer Int J Psychiatry Med 2012;43:1-17
- 20. Fava M. Prospective studies of adverse events related to antidepressant discontinuation. J Clin Psychiatry.2006;67(suppl4):14-21.
- 21. Favaro A, GerosaG, Ceforio AL, et al Posttraumatic stress disorder and depression in heart transplantation recipients: the relationship with outcome and adherence to medical treatment Gen Hosp Psychiatry 2011;33:1-7
- 22. Valuck RJ, Orton HD, LibbyAM. Antidepressant discontinuation and risk of suicide attempt: a retrospective,nestedcase-controlstudy. JClinPsychiatry.2009; 70(8):1069-1077
- 23. Cozza KL, Gary H. Wynn. SRIs and Bleeding; Transporters; Metformin and Olanzapine. Psychosomatics 2011; 52:589-592
- 24. Renoir T. Selective serotonine reuptake inhibitor antidepressant treatment discontinuation syndrome: A review of the clinical evidance and the possible mechanisms involved. Front Pharmacol 2013;4:45
- 25. Humpries JE, Wheby MS, et al Fluoxetine and the bleeding time Arch Pathol Labmed 1990;114:727-728
AN EVALUATION OF THE EFFECT OF USING SELECTIVE SERATONIN RE-UPTAKE INHIBITORS ON PERIOPERATIVE BLEEDING IN GYNECOLOGY PATIENTS
Abstract
Aim:The aim of this study was to examine the effects of the use of SSRI by patients in different gynecological operations, through an evaluation of operation type, bleeding amount, requirement for blood and amount of blood transfused.
Material and Methods: A retrospective evaluation was made of patients who underwent gynecological surgery. Patients who were taking and not taking SSRI were compared in respect of preoperative and postoperative hemoglobin, hematocrit, platelet count, activated partial thromboplastin time (APTT), INR values, requirement for blood transfusion, and amount of blood transfused.
Results: The use of antidepressant drugs by gynaecology patients was not seen to increase bleeding and caused no decrease in hemoglobin or hematocrit values. No statistically significant difference was determined between the groups in respect of the requirement and amount of blood transfusions.
Conclusion: There is no need to terminate the use of SSRI because of potential bleeding effects or to evaluate patients in respect of these effects. It can be considered sufficient to monitor these patients closely perioperatively and to carefully follow the bleeding protocol.
Keywords
selective seratonin re-uptake inhibitors intraoperative bleeding gynecologic operations blood transfusion
References
- REFERENCES 1. Francisco J. de Abajo. Effects of Selective Serotonin Reuptake Inhibitors on Platelet Function Drugs Aging May 2011; Volume 28, Issue 5, 345–367
- 2. Halperin D, Reber G. Influence of antidepressants on hemostasis. Dialogues Clin Neurosci 2007; 9: 47 –59
- 3. P. Seitz D, M. Bell C, S. Gill S, et al. Risk of Perioperative Blood Transfusions and Postoperative Complications Associated With Serotonergic Antidepressants in Older Adults Undergoing Hip Fracture Surgery Journal of Clinical Psychopharmacology & Volume 33, Number 6
- 4. Lindqvist PG, Nasiell J, Gustafsson LL, Nordstrom L. Selective serotonin reuptake inhibitor use during pregnancy increases the risk of postpartum hemorrhage and anemia: a hospital-based cohort study. J Thromb Haemost 2014; 12: 1986–92. 14.
- 5. Dalton S.O, Johansen C, Mellemkjær L, et al. Use of Selective Serotonin Reuptake Inhibitors and Risk of Upper Gastrointestinal Tract BleedingA Population-Based Cohort Study Arch Intern Med. 2003;163(1):59-64
- 6. Meijer WE, Heerdink ER. Association of Risk of Abnormal Bleeding With Degree of Serotonin Reuptake Inhibition by Antidepressants Arch Intern Med 2004; 164:2367-2370
- 7. Bismuth –Evenzal Y. Decreased serotonin content and reduced agonist-induced aggregation in platelets of patients chronically medicated with SSRI drugs J Affect Disord 2012;136:99-103
- 8. Serebruany VL Selective serotonin reuptake inhibitors and increased bleeding risk: are we missing something? Am J Med 2006 ;119:113-116
- 9. Naesh O, Hindberg I, Bruun AB: Decreased reuptake of serotonin in human platelets after surgery. Clin Physiol 2001; 21:39–4
- 10. M. van Haelst I.M, Egberts T.C.G, J. Doodeman H, et al. Use of Serotonergic Antidepressants and Bleeding Risk in Orthopedic Patients Anesthesiology 2010; 112:631–6
- 11. Serebruany VL, Glassman AH, Malinan AI, et al. Platelet/endothelial biomarkers in depressed patients treated with selective serotonin reuptake inhibitor sertraline after acute coronary events. Circulation. 2003;108(8):939Y944.
- 12. Hergovich N, Aigner M, Eichler HG, et al. Paroxetine decreases platelet serotonin storage and platelet function in human beings. Clin Pharmacol Ther 2000; 68: 435-42
- 13. Mago R, Mahajan R, Thase ME.Medically serious adverse effects of newer antidepressants. Curr Psychiatry Rep 2008; 10(3):249– 257)
- 14. Movig KL, Janssen MW, de Waal Malefijt J, Kabel PJ, Leufkens HG, Egberts AC. Relationship of serotonergic antidepressants and need for blood transfusion in orthopedic surgical patients. Arch Intern Med 2003;163(19):2354–2358
- 15. Book Jeong , Sun Wan Kim et al Use of Serotonergic Antidepressants and Bleeding Risk in Patients Undergoing Surgery Psychosomatics 2014:55:213-220
- 16. Harirchian S, Zoumalan R.A, Rosenberg D.B. Antidepressants and Bleeding Risk After Face-lift Surgery Arch Facial Plast Surg. 2012;14(4):248-252
- 17. Sayadipour A, Mago R, Kepler C.K, et al. Antidepressants and the risk of abnormal bleeding during spinal surgery: a case–control study Eur Spine J 2012; 21:2070–2078
- 18. Gärtner R, Cronin-Fenton D, Hundborg H.H, Pedersen L, Lash T.L, Sørensen H.T, et al. Use of selective serotonin reuptake inhibitors and risk of re-operation due to post-surgical bleeding in breast cancer patients: a Danish populationbased cohort study BMC Surgery 2010; 10:3)6
- 19. Kim SY, Kim JM. Associations between Plasma Cytokines and Depressive Mood in Patients with Breast Cancer Int J Psychiatry Med 2012;43:1-17
- 20. Fava M. Prospective studies of adverse events related to antidepressant discontinuation. J Clin Psychiatry.2006;67(suppl4):14-21.
- 21. Favaro A, GerosaG, Ceforio AL, et al Posttraumatic stress disorder and depression in heart transplantation recipients: the relationship with outcome and adherence to medical treatment Gen Hosp Psychiatry 2011;33:1-7
- 22. Valuck RJ, Orton HD, LibbyAM. Antidepressant discontinuation and risk of suicide attempt: a retrospective,nestedcase-controlstudy. JClinPsychiatry.2009; 70(8):1069-1077
- 23. Cozza KL, Gary H. Wynn. SRIs and Bleeding; Transporters; Metformin and Olanzapine. Psychosomatics 2011; 52:589-592
- 24. Renoir T. Selective serotonine reuptake inhibitor antidepressant treatment discontinuation syndrome: A review of the clinical evidance and the possible mechanisms involved. Front Pharmacol 2013;4:45
- 25. Humpries JE, Wheby MS, et al Fluoxetine and the bleeding time Arch Pathol Labmed 1990;114:727-728
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | April 1, 2021 |
| Submission Date | December 20, 2020 |
| Acceptance Date | January 13, 2021 |
| Published in Issue | Year 2021 Volume: 18 Issue: 1 |
