Abstract
References
- Duraker N, Caynak Z, Türköz K. Perineural invasion has no prognostic value in patients with invasive breast carcinoma. The Breast 2006; 15: 629-34.
- Yao D, Wang Z, Cai H, et al. Relationship between red cell distribution width and prognosis in patients with breast cancer after operation: a retrospective cohort study. Biosci Rep 2019; 39: BSR20190740.
- Tungsukruthai S, Petpiroon N, Chanvorachote P. Molecular mechanisms of breast cancer metastasis and potential anti-metastatic compounds. Anticancer Res 2018; 38: 2607-18.
- Raghunath A, Desai K, Ahluwalia MS. Current treatment options for breast cancer brain metastases. Curr Treat Options Oncol 2019; 20: 1-18.
- Förhécz Z, Gombos T, Borgulya G, et al. Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J 2009; 158: 659-66.
- Demir A, Yarali N, Fisgin T, et al. Most reliable indices in differentiation between thalassemia trait and iron deficiency anemia. Pediatr Int 2002; 44: 612-6.
- Gunebakmaz O, Kaya MG, Duran M, et al. Red blood cell distribution width in ‘non-dippers’ versus ‘dippers’. Cardiology 2012; 123: 154-9.
- Nishizaki Y, Yamagami S, Suzuki H, et al. Red blood cell distribution width as an effective tool for detecting fatal heart failure in super-elderly patients. Intern Med 2012; 51: 2271-6.
- Karabulut A, Uzunlar B. Correlation between red cell distribution width and coronary ectasia in the acute myocardial infarction. SAGE Publications Sage CA: Los Angeles, CA; 2012.
- Chiba T, Marusawa H, Ushijima T. Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation. Gastroenterology 2012; 143: 550-63.
- Mladenova D, Kohonen-Corish MR. Mouse models of inflammatory bowel disease-insights into the mechanisms of inflammation-associated colorectal cancer. In Vivo 2012; 26: 627-46.
- Periša V, Zibar L, Sinčić-Petričević J, et al. Red blood cell distribution width as a simple negative prognostic factor in patients with diffuse large B-cell lymphoma: a retrospective study. Croat Med J 2015; 56: 334-43.
- Ay S, Eryilmaz MA, Aksoy N, et al. Is early detection of colon cancer possible with red blood cell distribution width? Asian Pac J Cancer Prev 2015; 16: 753-6.
- Riedl J, Posch F, Königsbrügge O, et al. Red cell distribution width and other red blood cell parameters in patients with cancer: association with risk of venous thromboembolism and mortality. PLoS One 2014; 9: e111440.
- Koma Y, Onishi A, Matsuoka H, et al. Increased red blood cell distribution width associates with cancer stage and prognosis in patients with lung cancer. PLoS One 2013; 8: e80240.
- Abakay O, Tanrikulu AC, Palanci Y, et al. The value of inflammatory parameters in the prognosis of malignant mesothelioma. J Int Med Res 2014; 42: 554-65.
- Lee H, Kong S-Y, Sohn JY, et al. Elevated red blood cell distribution width as a simple prognostic factor in patients with symptomatic multiple myeloma. Biomed Res Int 2014; 2014: 145619.
- Yoo Y-C, Park S, Kim H-J, et al. Preoperative routine laboratory markers for predicting postoperative recurrence and death in patients with breast cancer. J Clin Med 2021; 10: 2610.
- Koh C, Bhoo-Pathy N, Ng K, et al. Utility of pre-treatment neutrophil–lymphocyte ratio and platelet–lymphocyte ratio as prognostic factors in breast cancer. Br J Cancer 2015; 113: 150-8.
- Sun H, Yin C-Q, Liu Q, et al. Clinical significance of routine blood test-associated inflammatory index in breast cancer patients. Med Sci Monit 2017; 23: 5090-5.
- Wang H, Naghavi M, Allen C, et al. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016; 388: 1459-544.
- Warwick R, Mediratta N, Shackcloth M, et al. Preoperative red cell distribution width in patients undergoing pulmonary resections for non-small-cell lung cancer. Eur J Cardiothorac Surg 2014; 45: 108-13.
- Albayrak S, Zengin K, Tanik S, et al. Red cell distribution width as a predictor of prostate cancer progression. Asian Pac J Cancer Prev 2014; 15: 7781-4.
- Kust D, Lucijanic M, Urch K, et al. Clinical and prognostic significance of anisocytosis measured as a red cell distribution width in patients with colorectal cancer. Int J Med 2017; 110: 361-7.
- Yazici P, Demir U, Bozkurt E, et al. The role of red cell distribution width in the prognosis of patients with gastric cancer. Cancer Biomark 2017; 18: 19-25.
- Sousa R, Gonçalves C, Guerra IC, et al. Increased red cell distribution width in Fanconi anemia: a novel marker of stress erythropoiesis. Orphanet J Rare Dis 2016; 11: 1-10.
- Seretis C, Seretis F, Lagoudianakis E, et al. Is red cell distribution width a novel biomarker of breast cancer activity? Data from a pilot study. J Clin Med Res 2013; 5: 121-6.
- Daniel AR, Hagan CR, Lange CA. Progesterone receptor action: defining a role in breast cancer. Expert Rev Endocrinol Metab 2011; 6: 359-69.
- Jafari SH, Jahanmir A, Bahramvand Y, et al. Association of Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2 Expression with Breast Cancer Metastasis in Iran. Iran J Med Sci 2022; 47: 40-47.
- Huang D-P, Ma R-M, Xiang Y-Q. Utility of red cell distribution width as a prognostic factor in young breast cancer patients. Medicine 2016; 95: e3430.
- Prat A, Cheang MCU, Martín M, et al. Prognostic significance of progesterone receptor–positive tumor cells within immunohistochemically defined luminal A breast cancer. J Clin Oncol 2013; 31: 203-9.
- Purdie C, Quinlan P, Jordan L, et al. Progesterone receptor expression is an independent prognostic variable in early breast cancer: a population-based study. Br J Cancer 2014; 110: 565-72.
- Karak SG, Quatrano N, Buckley J, et al. Prevalence and significance of perineural invasion in invasive breast carcinoma. Conn Med 2010; 74: 17-21.
- Koca E, Kuzan TY, Dizdar O, et al. Outcomes of locally advanced breast cancer patients with≥ 10 positive axillary lymph nodes. Med Oncol 2013; 30: 615.
Abstract
Objective: In this study, we aimed to assess the relationship between preoperative red cell distribution width (RDW) and the clinicopathological stage and prognosis of disease in patients operated for invasive epithelial breast cancer (BC).
Material and Method: This retrospective cross-sectional study was conducted between January 2010 and January 2015 at a tertiary hospital in Turkey. A total of 280 patients who underwent surgery for histologically diagnosed invasive epithelial BC were included in the study.
Results: The mean age of the patients was 53.31±12.58 years. The median follow-up time was 83 (IQR: 56.5–102) months. According to the results we found, there was a statistically significant positive correlation between progesterone receptor (PR) negativity and RDW values (p=0.015). In addition, the RDW values of patients with perineural invasion (PNI) were found to be significantly higher than those without (p=0.036).
Conclusion: When the results of our study are evaluated together with prior reports, it can be said that higher preoperative RDW is associated with poor prognosis. When RDW is evaluated together with other possible prognostic factors, such as PNI and PR status, it has the potential to be a new, easily applicable and accurate marker to assess prognosis in patients with invasive epithelial BC.
Keywords
Breast cancer red cell distribution width (RDW) progesterone receptor perineural invasion overall survival
References
- Duraker N, Caynak Z, Türköz K. Perineural invasion has no prognostic value in patients with invasive breast carcinoma. The Breast 2006; 15: 629-34.
- Yao D, Wang Z, Cai H, et al. Relationship between red cell distribution width and prognosis in patients with breast cancer after operation: a retrospective cohort study. Biosci Rep 2019; 39: BSR20190740.
- Tungsukruthai S, Petpiroon N, Chanvorachote P. Molecular mechanisms of breast cancer metastasis and potential anti-metastatic compounds. Anticancer Res 2018; 38: 2607-18.
- Raghunath A, Desai K, Ahluwalia MS. Current treatment options for breast cancer brain metastases. Curr Treat Options Oncol 2019; 20: 1-18.
- Förhécz Z, Gombos T, Borgulya G, et al. Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J 2009; 158: 659-66.
- Demir A, Yarali N, Fisgin T, et al. Most reliable indices in differentiation between thalassemia trait and iron deficiency anemia. Pediatr Int 2002; 44: 612-6.
- Gunebakmaz O, Kaya MG, Duran M, et al. Red blood cell distribution width in ‘non-dippers’ versus ‘dippers’. Cardiology 2012; 123: 154-9.
- Nishizaki Y, Yamagami S, Suzuki H, et al. Red blood cell distribution width as an effective tool for detecting fatal heart failure in super-elderly patients. Intern Med 2012; 51: 2271-6.
- Karabulut A, Uzunlar B. Correlation between red cell distribution width and coronary ectasia in the acute myocardial infarction. SAGE Publications Sage CA: Los Angeles, CA; 2012.
- Chiba T, Marusawa H, Ushijima T. Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation. Gastroenterology 2012; 143: 550-63.
- Mladenova D, Kohonen-Corish MR. Mouse models of inflammatory bowel disease-insights into the mechanisms of inflammation-associated colorectal cancer. In Vivo 2012; 26: 627-46.
- Periša V, Zibar L, Sinčić-Petričević J, et al. Red blood cell distribution width as a simple negative prognostic factor in patients with diffuse large B-cell lymphoma: a retrospective study. Croat Med J 2015; 56: 334-43.
- Ay S, Eryilmaz MA, Aksoy N, et al. Is early detection of colon cancer possible with red blood cell distribution width? Asian Pac J Cancer Prev 2015; 16: 753-6.
- Riedl J, Posch F, Königsbrügge O, et al. Red cell distribution width and other red blood cell parameters in patients with cancer: association with risk of venous thromboembolism and mortality. PLoS One 2014; 9: e111440.
- Koma Y, Onishi A, Matsuoka H, et al. Increased red blood cell distribution width associates with cancer stage and prognosis in patients with lung cancer. PLoS One 2013; 8: e80240.
- Abakay O, Tanrikulu AC, Palanci Y, et al. The value of inflammatory parameters in the prognosis of malignant mesothelioma. J Int Med Res 2014; 42: 554-65.
- Lee H, Kong S-Y, Sohn JY, et al. Elevated red blood cell distribution width as a simple prognostic factor in patients with symptomatic multiple myeloma. Biomed Res Int 2014; 2014: 145619.
- Yoo Y-C, Park S, Kim H-J, et al. Preoperative routine laboratory markers for predicting postoperative recurrence and death in patients with breast cancer. J Clin Med 2021; 10: 2610.
- Koh C, Bhoo-Pathy N, Ng K, et al. Utility of pre-treatment neutrophil–lymphocyte ratio and platelet–lymphocyte ratio as prognostic factors in breast cancer. Br J Cancer 2015; 113: 150-8.
- Sun H, Yin C-Q, Liu Q, et al. Clinical significance of routine blood test-associated inflammatory index in breast cancer patients. Med Sci Monit 2017; 23: 5090-5.
- Wang H, Naghavi M, Allen C, et al. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016; 388: 1459-544.
- Warwick R, Mediratta N, Shackcloth M, et al. Preoperative red cell distribution width in patients undergoing pulmonary resections for non-small-cell lung cancer. Eur J Cardiothorac Surg 2014; 45: 108-13.
- Albayrak S, Zengin K, Tanik S, et al. Red cell distribution width as a predictor of prostate cancer progression. Asian Pac J Cancer Prev 2014; 15: 7781-4.
- Kust D, Lucijanic M, Urch K, et al. Clinical and prognostic significance of anisocytosis measured as a red cell distribution width in patients with colorectal cancer. Int J Med 2017; 110: 361-7.
- Yazici P, Demir U, Bozkurt E, et al. The role of red cell distribution width in the prognosis of patients with gastric cancer. Cancer Biomark 2017; 18: 19-25.
- Sousa R, Gonçalves C, Guerra IC, et al. Increased red cell distribution width in Fanconi anemia: a novel marker of stress erythropoiesis. Orphanet J Rare Dis 2016; 11: 1-10.
- Seretis C, Seretis F, Lagoudianakis E, et al. Is red cell distribution width a novel biomarker of breast cancer activity? Data from a pilot study. J Clin Med Res 2013; 5: 121-6.
- Daniel AR, Hagan CR, Lange CA. Progesterone receptor action: defining a role in breast cancer. Expert Rev Endocrinol Metab 2011; 6: 359-69.
- Jafari SH, Jahanmir A, Bahramvand Y, et al. Association of Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2 Expression with Breast Cancer Metastasis in Iran. Iran J Med Sci 2022; 47: 40-47.
- Huang D-P, Ma R-M, Xiang Y-Q. Utility of red cell distribution width as a prognostic factor in young breast cancer patients. Medicine 2016; 95: e3430.
- Prat A, Cheang MCU, Martín M, et al. Prognostic significance of progesterone receptor–positive tumor cells within immunohistochemically defined luminal A breast cancer. J Clin Oncol 2013; 31: 203-9.
- Purdie C, Quinlan P, Jordan L, et al. Progesterone receptor expression is an independent prognostic variable in early breast cancer: a population-based study. Br J Cancer 2014; 110: 565-72.
- Karak SG, Quatrano N, Buckley J, et al. Prevalence and significance of perineural invasion in invasive breast carcinoma. Conn Med 2010; 74: 17-21.
- Koca E, Kuzan TY, Dizdar O, et al. Outcomes of locally advanced breast cancer patients with≥ 10 positive axillary lymph nodes. Med Oncol 2013; 30: 615.
Details
| Primary Language | English |
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| Subjects | Health Care Administration |
| Journal Section | Original Article |
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| Publication Date | July 20, 2022 |
| Published in Issue | Year 2022 Volume: 5 Issue: 4 |
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