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References
- Riihimäki M, Hemminki A, Fallah M, et al. Metastatic sites and survival in lung cancer. Lung Cancer. 2014;86(1):78-84.
- Ferreira LM, Hebrant A, Dumont JE. Metabolic reprogramming of the tumor. Oncogene. 2012;31(36):3999-4011.
- Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow?. Lancet. 2001;357(9255):539-545.
- Van Cutsem E, Arends J. The causes and consequences of cancer-associated malnutrition. Eur J Oncol Nurs. 2005;9 Suppl 2:51-63.
- McMillan DC, Watson WS, O'Gorman P, Preston T, Scott HR, McArdle CS. Albumin concentrations are primarily determined by the body cell mass and the systemic inflammatory response in cancer patients with weight loss. Nutr Cancer. 2001;39(2):210-213.
- Deme D, Telekes A. Az albumin prognosztikai jelentősége az onkológiában [Prognostic importance of albumin in oncology]. Orv Hetil. 2018;159(3):96-106.
- Fruchtenicht AV, Poziomyck AK, Kabke GB, Loss SH, Antoniazzi JL, Steemburgo T, Moreira LF. Nutritional risk assessment in critically ill cancer patients: systematic review. Rev Bras Ter Intensiva. 2015;27(3):274-283.
- Söyler Y, Öztürk A. The prognostic role of gustave roussy immune (GRIm)-score in metastatic lung adenocarcinoma patients treated with chemotherapy. Ann Clin Anal Med. 2023;14(7):640-645.
- Zhang Y, Kong FF, Zhu ZQ, Shan HX. Controlling Nutritional Status (CONUT) score is a prognostic marker in III-IV NSCLC patients receiving first-line chemotherapy. BMC Cancer. 2023;23(1):225.
- Hung HY, Chen JS, Chien-YuhYeh, et al. Preoperative alkaline phosphatase elevation was associated with poor survival in colorectal cancer patients. Int J Colorectal Dis. 2017;32(12):1775-1778.
- Namikawa T, Ishida N, Tsuda S, et al. Prognostic significance of serum alkaline phosphatase and lactate dehydrogenase levels in patients with unresectable advanced gastric cancer. Gastric Cancer. 2019;22(4):684-691.
- Chan AW, Chan SL, Mo FK, et al. Albumin-to-alkaline phosphatase ratio: a novel prognostic index for hepatocellular carcinoma. Dis Markers. 2015;2015:564057.
- Nie M, Sun P, Chen C, et al. Albumin-to-alkaline phosphatase ratio: a novel prognostic index of overall survival in cisplatin-based chemotherapy-treated patients with metastatic nasopharyngeal carcinoma. J Cancer. 2017;8(5):809-815.
- Zhang L, Zhang H, Yue D, et al. The prognostic value of the preoperative albumin to alkaline phosphatase ratio in patients with non-small cell lung cancer after surgery. Thorac Cancer. 2019;10(7):1581-1589.
- Tan P, Xie N, Ai J, et al. The prognostic significance of Albumin-to-Alkaline Phosphatase Ratio in upper tract urothelial carcinoma. Sci Rep. 2018;8(1):12311.
- Tian G, Li G, Guan L, Yang Y, Li N. Pretreatment albumin-to-alkaline phosphatase ratio as a prognostic indicator in solid cancers: a meta-analysis with trial sequential analysis. Int J Surg. 2020;81:66-73.
- Rami-Porta R, Asamura H, Travis WD, Rusch VW. Lung cancer - major changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017;67(2):138-155.
- Li D, Yu H, Li W. Albumin-to-alkaline phosphatase ratio at diagnosis predicts survival in patients with metastatic non-small-cell lung cancer. Onco Targets Ther. 2019;12:5241-5249.
- Zhou S, Wang H, Jiang W, Yu Q, Zeng A. Prognostic value of pretreatment albumin-to-alkaline phosphatase ratio in extensive-disease small-cell lung cancer: a retrospective cohort study. Cancer Manag Res. 2020;12:2015-2024.
- Zhou S, Jiang W, Wang H, Wei N, Yu Q. Predictive value of pretreatment albumin-to-alkaline phosphatase ratio for overall survival for patients with advanced non-small cell lung cancer. Cancer Med. 2020;9(17):6268-6280.
- Liu X, Li Y, Zhao Q, Jiang H, Ni J, Cai H. Albumin-to-alkaline phosphatase ratio: A novel prognostic index for patients with driver mutation-negative advanced non-small cell lung cancer. Clin Respir J. 2021;15(5):540-549.
Prognostic significance of albumin-to-alkaline phosphatase ratio for overall survival in metastatic lung adenocarcinoma patients
Abstract
Aims: This study aims to determine the prognostic significance of the pretreatment albumin/alkaline phosphatase ratio (AAPR) for overall survival in patients diagnosed with metastatic lung adenocarcinoma (MLA).
Methods: The medical records of 459 patients diagnosed with MLA between 2010 and 2021 were retrospectively reviewed. The AAPR was calculated using blood test results obtained at the time of diagnosis.
Results: The study identified the optimal threshold value for AAPR as 0.314. Patients with a high AAPR (AAPR>0.314) demonstrated significantly longer median survival and overall survival time compared to those with a low AAPR (AAPR ≤ 0.314) (p<0.001). Specifically, the median survival time for the low AAPR group was 2.13±0.29 (95% CI: 1.56-2.70) months, while the high AAPR group had a median survival time of 4.1±0.59 (95% CI: 2.90-5.23) months (p<0.001). The 1-year survival rates were 27.3% and 5.3% for the high and low AAPR groups, respectively (p<0.001). Additionally, an AAPR ≤ 0.314 increased the risk of death by 1.96 times at 1 year.
Conclusion: The AAPR was significantly reduced in MLA patients, making it a significant biomarker for forecasting prognosis and directing treatment options for these patients.
Keywords
Metastatic Lung Adenocarcinoma Albumin-to-Alkaline Phosphatase Ratio prognostic factor survival
Project Number
-
References
- Riihimäki M, Hemminki A, Fallah M, et al. Metastatic sites and survival in lung cancer. Lung Cancer. 2014;86(1):78-84.
- Ferreira LM, Hebrant A, Dumont JE. Metabolic reprogramming of the tumor. Oncogene. 2012;31(36):3999-4011.
- Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow?. Lancet. 2001;357(9255):539-545.
- Van Cutsem E, Arends J. The causes and consequences of cancer-associated malnutrition. Eur J Oncol Nurs. 2005;9 Suppl 2:51-63.
- McMillan DC, Watson WS, O'Gorman P, Preston T, Scott HR, McArdle CS. Albumin concentrations are primarily determined by the body cell mass and the systemic inflammatory response in cancer patients with weight loss. Nutr Cancer. 2001;39(2):210-213.
- Deme D, Telekes A. Az albumin prognosztikai jelentősége az onkológiában [Prognostic importance of albumin in oncology]. Orv Hetil. 2018;159(3):96-106.
- Fruchtenicht AV, Poziomyck AK, Kabke GB, Loss SH, Antoniazzi JL, Steemburgo T, Moreira LF. Nutritional risk assessment in critically ill cancer patients: systematic review. Rev Bras Ter Intensiva. 2015;27(3):274-283.
- Söyler Y, Öztürk A. The prognostic role of gustave roussy immune (GRIm)-score in metastatic lung adenocarcinoma patients treated with chemotherapy. Ann Clin Anal Med. 2023;14(7):640-645.
- Zhang Y, Kong FF, Zhu ZQ, Shan HX. Controlling Nutritional Status (CONUT) score is a prognostic marker in III-IV NSCLC patients receiving first-line chemotherapy. BMC Cancer. 2023;23(1):225.
- Hung HY, Chen JS, Chien-YuhYeh, et al. Preoperative alkaline phosphatase elevation was associated with poor survival in colorectal cancer patients. Int J Colorectal Dis. 2017;32(12):1775-1778.
- Namikawa T, Ishida N, Tsuda S, et al. Prognostic significance of serum alkaline phosphatase and lactate dehydrogenase levels in patients with unresectable advanced gastric cancer. Gastric Cancer. 2019;22(4):684-691.
- Chan AW, Chan SL, Mo FK, et al. Albumin-to-alkaline phosphatase ratio: a novel prognostic index for hepatocellular carcinoma. Dis Markers. 2015;2015:564057.
- Nie M, Sun P, Chen C, et al. Albumin-to-alkaline phosphatase ratio: a novel prognostic index of overall survival in cisplatin-based chemotherapy-treated patients with metastatic nasopharyngeal carcinoma. J Cancer. 2017;8(5):809-815.
- Zhang L, Zhang H, Yue D, et al. The prognostic value of the preoperative albumin to alkaline phosphatase ratio in patients with non-small cell lung cancer after surgery. Thorac Cancer. 2019;10(7):1581-1589.
- Tan P, Xie N, Ai J, et al. The prognostic significance of Albumin-to-Alkaline Phosphatase Ratio in upper tract urothelial carcinoma. Sci Rep. 2018;8(1):12311.
- Tian G, Li G, Guan L, Yang Y, Li N. Pretreatment albumin-to-alkaline phosphatase ratio as a prognostic indicator in solid cancers: a meta-analysis with trial sequential analysis. Int J Surg. 2020;81:66-73.
- Rami-Porta R, Asamura H, Travis WD, Rusch VW. Lung cancer - major changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017;67(2):138-155.
- Li D, Yu H, Li W. Albumin-to-alkaline phosphatase ratio at diagnosis predicts survival in patients with metastatic non-small-cell lung cancer. Onco Targets Ther. 2019;12:5241-5249.
- Zhou S, Wang H, Jiang W, Yu Q, Zeng A. Prognostic value of pretreatment albumin-to-alkaline phosphatase ratio in extensive-disease small-cell lung cancer: a retrospective cohort study. Cancer Manag Res. 2020;12:2015-2024.
- Zhou S, Jiang W, Wang H, Wei N, Yu Q. Predictive value of pretreatment albumin-to-alkaline phosphatase ratio for overall survival for patients with advanced non-small cell lung cancer. Cancer Med. 2020;9(17):6268-6280.
- Liu X, Li Y, Zhao Q, Jiang H, Ni J, Cai H. Albumin-to-alkaline phosphatase ratio: A novel prognostic index for patients with driver mutation-negative advanced non-small cell lung cancer. Clin Respir J. 2021;15(5):540-549.
Details
| Primary Language | English |
|---|---|
| Subjects | Chest Diseases |
| Journal Section | Original Article |
| Authors | |
| Project Number | - |
| Early Pub Date | October 28, 2023 |
| Publication Date | October 29, 2023 |
| Published in Issue | Year 2023 Volume: 6 Issue: 6 |
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