Abstract
Amaç: Bu çalışmada benign prostat hiperplazisi (BPH) olan erkeklerde ses analizi yapılarak farklılıkların belirlenmesi ve literatürle tartışılması amaçlandı.
Gereç ve Yöntemler: Çalışmaya üroloji polikliniğine gelerek BPH tanısı alan ve ses analizi için tarafımıza başvuran 77 erkek hasta dahil edildi. Hastaların yaşları, testosteron düzeyleri, prostat spesifik antijen (PSA) düzeyleri, prostat hacimleri (mililitre) kaydedildi. Hastalara uluslararası prostat semptom skorlaması (IPSS) uygulandı. IPSS skorlamasına göre hafif, orta, ağır hastalar; sırasıyla grup 1, grup 2, grup 3 olarak sınıflandırıldı. Ses Engelleme İndeksi-10'un Türkçe versiyonu (VHI-10) hastalara uygulandı ve sonuçlar kaydedildi.
Bulgular: Çalışmaya 77 erkek hasta kabul edildi. Yaş ortalaması 60 idi. Hastaların ortalama prostat hacmi 41,1 ml idi. Hastaların IPSS skoru ortalama 16 idi. Ortalama VHI-10 skorları 9,14 idi. Hastaların ortalama PSA düzeyleri 1,43; testosteron seviyeleri 3.04 idi. F0 Hz (ortalama pitch) değerleri 157,74; jitter yüzdesi değerleri 0,26 anlamına gelir; shimmer % değerleri ortalama 2,42; Ortalama HNR dB değerleri 22,91 idi.
Sonuç: Belki de testosteron yerine birçok yerel faktörün, hormonun ve büyüme faktörünün etkili olduğunu düşünmek daha mantıklı olacaktır.
Keywords
References
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- 2.Lein M, Stephan C, Jung K, et al. Relation of free PSA/total PSA in serum for differentiating between patients with prostatic cancer and benign hyper-plasia of the prostate:which cutoff should be used?. Cancer Invest. 1998; 16(1): 45-9. https://doi.org/10.3109/07357909809039753
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- 4.Nanjundeswaran C, Jacobson BH, Gartner-Schmidt J, et al. Vocal Fatigue Index (VFI): Development and Validation. J Voice. 2015; 29(4): 433-40. https://doi.org/10.1016/j.jvoice.2014.09.012
- 5.Kim JM, Shin SC, Park GC, et al. Effect of sex hormones on extracellular matrix of lamina propria in rat vocal fold. Laryngoscope. 2020; 130(3): 732-40. https://doi.org/10.1002/lary.28086 6.Kilic MA. Evaluation of the patient with voice problem by objective and subjective methods. Curr Pract ORL. 2010; 6(2): 257-65. 7.Nacci A, Fattori B, Basolo F, et al. Sex hormone receptors in vocal fold tissue: a theory about the influence of sex hormones in the larynx. Folia Phoniatr Logop. 2011; 63(2): 77-82. https://doi.org/10.1159/000316136
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- 10.Pedersen MF, Møller S, Krabbe S, et al. Fundamental voice frequency in female puberty measured with electroglottography during continuous speech as a secondary sex characteristic. A comparison between voice, pubertal stages, oestrogens and androgens. Int J Pediatr Otorhinolaryngol. 1990; 20(1):17-24. https://doi.org/10.1016/0165-5876(90)90331-K
- 11.Cler GJ, McKenna VS, Dahl KL, et al. Longitudinal Case Study of Transgender Voice Changes Under Testosterone Hormone Therapy. J Voice. 2020; 34(5): 748-62. https://doi.org/10.1016/j.jvoice.2019.03.006
- 12.Glaser R, York A, Dimitrakakis C. Effect of testosterone therapy on the female voice.Climacteric. 2016; 19(2): 198-203. https://doi.org/10.3109/13697137.2015.1136925
- 13.Jost L, Fuchs M, Loeffler M, et al. Associations of Sex Hormones and Anthropometry with the Speaking Voice Profile in the Adult General Popu-lation. J Voice. 2018; 32(3): 261-72. https://doi.org/10.1016/j.jvoice.2017.06.011
- 14.Huang G, Pencina KM, Coady JA, et al. Functional Voice Testing Detects Early Changes in Vocal Pitch in Women During Testosterone Administra-tion. J Clin Endocrinol Metab. 2015; 100(6): 2254-60. https://doi.org/10.1210/jc.2015-1669
- 15.Akcam T, Bolu E, Merati AL, et al. Voice Changes after Androgen Thera-py for Hypogonadotrophic Hypogonadism. Laryngoscope. 2004; 114(9): 1587-91. https://doi.org/10.1097/00005537-200409000-00016
- 16.Hamdan A, Tabet G, Fakhri G, et al. Effect of Hormonal Replacement Therapy on Voice. J Voice. 2018; 32(1): 116-21. https://doi.org/10.1016/j.jvoice.2017.02.019
- 17.Wolters TLC, Roerink SHPP, Drenthen LCA, et al. Voice Characteristics in Patients with Acromegaly during Treatment. J Voice. 2020; S0892-1997(19)30444-8.
- 18.Aydin K, Turkyilmaz D, Ozturk B, et al. Voice characteristics of acro-megaly. Eur Arch Otorhinolaryngol. 2013; 270(4): 1391. https://doi.org/10.1007/s00405-013-2369-4
Abstract
Aim: In this study, we aimed to determine the differences by performing voice analysis in men with benign pros-tatic hyperplasia (BPH) and discussing it with the literature
Methods: The study included 77 male patients who came to the urology outpatient clinic and were diagnosed with BPH and consult to us for voice analysis. Patients' ages, testosterone, prostate specific antigen (PSA) levels, prostate volumes (milliliters) were recorded. International prostate symptom scoring (IPSS) was applied to the patients. Mild, moderate, severe patients according to IPSS scoring; were classify as group 1, group 2, group 3, respectively. Voice Handicap Index-10 Turkish version (VHI-10) was realized to the patients and the results were saved.
Results: 77 male patients were accepted to the study. The average age was 60. The mean prostate volume of the patients was 41.1 ml. The IPSS score of the patients was 16 on average. The mean VHI-10 scores were 9.14. The mean PSA levels of the patients were 1.43; testosterone levels were 3.04. F0 Hz (mean pitch) values were 157.74; jitter % values mean 0.26; shimmer % values mean 2.42; The mean HNR dB values were 22.91.
Conclusions: Maybe it would be more logical to think that many local factors, hormones and growth factors are efficient in place of a testosterone.
Keywords: Benign prostatic hyperplasia, voice, analysis, frequency
References
- 1.Logozzi M, Angelini DF, Giuliani A, et al. Increased Plasmatic Levels of PSA-Expressing Exosomes Distinguish Prostate Cancer Patients from Be-nign Prostatic Hyperplasia: A Prospective Study. Cancers (Basel). 2019; 11(10): 1449. https://doi.org/10.3390/cancers11101449
- 2.Lein M, Stephan C, Jung K, et al. Relation of free PSA/total PSA in serum for differentiating between patients with prostatic cancer and benign hyper-plasia of the prostate:which cutoff should be used?. Cancer Invest. 1998; 16(1): 45-9. https://doi.org/10.3109/07357909809039753
- 3.Kilic MA, Okur E, Yildirim I, et al. Reliability and validity of the Turkish version of the Voice Handicap Index. Kulak Burun Bogaz Ihtis Derg. 2008; 18(3): 139-47.
- 4.Nanjundeswaran C, Jacobson BH, Gartner-Schmidt J, et al. Vocal Fatigue Index (VFI): Development and Validation. J Voice. 2015; 29(4): 433-40. https://doi.org/10.1016/j.jvoice.2014.09.012
- 5.Kim JM, Shin SC, Park GC, et al. Effect of sex hormones on extracellular matrix of lamina propria in rat vocal fold. Laryngoscope. 2020; 130(3): 732-40. https://doi.org/10.1002/lary.28086 6.Kilic MA. Evaluation of the patient with voice problem by objective and subjective methods. Curr Pract ORL. 2010; 6(2): 257-65. 7.Nacci A, Fattori B, Basolo F, et al. Sex hormone receptors in vocal fold tissue: a theory about the influence of sex hormones in the larynx. Folia Phoniatr Logop. 2011; 63(2): 77-82. https://doi.org/10.1159/000316136
- 8.Ouyoung LM, Villegas BC, Liu C, et al. Effects of Resonance Voice Therapy on Hormone-Related Vocal Disorders in Professional Singers: A Pilot Study. Clin Med Insights Ear Nose Throat. 2018; 11:1179550618786934. https://doi.org/10.1177/1179550618786934
- 9.Kravos A, Hočevar-Boltežar I, et al. Serum levels of sex hormones in males with Reinke's edema. Eur Arch Otorhinolaryngol. 2013; 270(1): 233-8. https://doi.org/10.1007/s00405-012-2156-7
- 10.Pedersen MF, Møller S, Krabbe S, et al. Fundamental voice frequency in female puberty measured with electroglottography during continuous speech as a secondary sex characteristic. A comparison between voice, pubertal stages, oestrogens and androgens. Int J Pediatr Otorhinolaryngol. 1990; 20(1):17-24. https://doi.org/10.1016/0165-5876(90)90331-K
- 11.Cler GJ, McKenna VS, Dahl KL, et al. Longitudinal Case Study of Transgender Voice Changes Under Testosterone Hormone Therapy. J Voice. 2020; 34(5): 748-62. https://doi.org/10.1016/j.jvoice.2019.03.006
- 12.Glaser R, York A, Dimitrakakis C. Effect of testosterone therapy on the female voice.Climacteric. 2016; 19(2): 198-203. https://doi.org/10.3109/13697137.2015.1136925
- 13.Jost L, Fuchs M, Loeffler M, et al. Associations of Sex Hormones and Anthropometry with the Speaking Voice Profile in the Adult General Popu-lation. J Voice. 2018; 32(3): 261-72. https://doi.org/10.1016/j.jvoice.2017.06.011
- 14.Huang G, Pencina KM, Coady JA, et al. Functional Voice Testing Detects Early Changes in Vocal Pitch in Women During Testosterone Administra-tion. J Clin Endocrinol Metab. 2015; 100(6): 2254-60. https://doi.org/10.1210/jc.2015-1669
- 15.Akcam T, Bolu E, Merati AL, et al. Voice Changes after Androgen Thera-py for Hypogonadotrophic Hypogonadism. Laryngoscope. 2004; 114(9): 1587-91. https://doi.org/10.1097/00005537-200409000-00016
- 16.Hamdan A, Tabet G, Fakhri G, et al. Effect of Hormonal Replacement Therapy on Voice. J Voice. 2018; 32(1): 116-21. https://doi.org/10.1016/j.jvoice.2017.02.019
- 17.Wolters TLC, Roerink SHPP, Drenthen LCA, et al. Voice Characteristics in Patients with Acromegaly during Treatment. J Voice. 2020; S0892-1997(19)30444-8.
- 18.Aydin K, Turkyilmaz D, Ozturk B, et al. Voice characteristics of acro-megaly. Eur Arch Otorhinolaryngol. 2013; 270(4): 1391. https://doi.org/10.1007/s00405-013-2369-4
Details
| Primary Language | English |
|---|---|
| Subjects | Otorhinolaryngology |
| Journal Section | Articles |
| Authors | |
| Publication Date | December 31, 2023 |
| Acceptance Date | September 15, 2023 |
| Published in Issue | Year 2023 Volume: 6 Issue: 3 |
