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Paratiroid adenomunu taklit eden paratiroid karsinomu olgusu

Year 2019, Volume: 3 Issue: 3, 265 - 267, 15.03.2019

Semra Demirli Atıcı Değercan Yeşilyurt Dudu Solakoğlu Kahraman Emre Dikmeer Hakan Öğücü Halit Batuhan Demir Gökhan Akbulut

https://doi.org/10.28982/josam.473603

Abstract

Paratiroid karsinomu nadir görülen endokrin tümörlerden biri olup primer hiperparatiroidizmli olgularının %1'ini oluşturmaktadır. Benzer görüntüleme yöntemleri ve benzer klinik bulgular nedeniyle preoperatif paratiroid adenomları ve paratiroid karsinomu ayırt etmek zordur. 70 yaşında kadın hasta, yorgunluk ve yaygın kemik ağrısı şikayeti ile başvurdu. Laboratuvar testleri, artmış parathormon düzeyi, boyun ultrasonografisi ve paratiroid sintigrafisi, primer hiperparatiroidizm ile uyumluydu. Paratiroid adenomunu destekleyen görüntüleme yöntemleri ile hasta paratiroid adenomuna bağlı primer hiperparatiroidi ön tanısı ile opere edildi. Ameliyat sonrası problem saptanmayan hasta, postoperatif beşinci günde sorunsuz bir şekilde taburcu edildi. Postoperatif patoloji paratiroid adenomunda gelişen paratiroid karsinomu olarak rapor edildi. Paratiroid karsinomu ve paratiroid adenomu benzer klinik ve görüntüleme yöntemlerine sahiptir, preoperatif tanı koymak zordur.

Keywords

Hiperkalsemi Primer hiperparatiroidizm Paratiroid adenomu Paratiroid karsinomu

References

  • 1. Shane E. Clinical review 122: Parathyroid carcinoma. J Clin Endocrinol Metab. 2001 Feb;86(2),:485-93.
  • 2. Haven CJ, van Puijenbroek M, Tan MH, Teh BT, Fleuren GJ, van Wezel T, et al. Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroidcarcinomas. Clin Endocrinol. 2007;67:370-6.
  • 3. Wassif WS, Moniz CF, Friedman E, Wong S, Weber G, Nordenskjöld M, Peters TJ, Larsson C. Familial isolated hyperparathyroidism: a distinct genetic entity with an increased risk of parathyroid cancer. J Clin Endocrinol Metab. 1993 Dec;77(6):1485-9.
  • 4. Tamler R, Lewis MS, LiVolsi VA, Genden EM. Parathyroid carcinoma: ultrasonographic and histologic features. Thyroid. 2005 Jul;15(7):744-5.
  • 5. Fernandes JMP, Paiva C, Correia R, Polónia J, Moreira da Costa A. Parathyroid carcinoma: From a case report to a review of the literature. Int J Surg Case Rep. 2018;42:214-217. doi: 10.1016/j.ijscr.2017.11.030.
  • 6. Marcocci C, Cetani F, Rubin MR, Silverberg SJ, Pinchera A, Bilezikian JP. Parathyroidcarcinoma. J Bone MinerRes. 2008;23:1869-80.
  • 7. Spinelli C, Bonadio AG, Berti P, Materazzi G, Miccoli P. Cutaneous spreading of parathyroid carcinoma after fine needle aspiration cytology. J Endocrinol Invest. 2000 Apr;23(4):255-7.
  • 8. Chiofalo MG, Scognamiglio F, Losito S, Lastoria S, Marone U, Pezzullo L. Huge parathyroid carcinoma: clinical considerations and literature review. World J Surg Oncol. 2005 Jun 23;3:39.
  • 9. Koea JB, Shaw JH. Parathyroid cancer: biology and management. Surg Oncol. 1999 Nov;8(3):155-65.
  • 10. Sandelin K, Auer G, Bondeson L, Grimelius L, Farnebo LO. Prognostic factors in parathyroid cancer: a review of 95 cases. World J Surg. 1992 Jul-Aug;16(4):724-31.
  • 11. Givi B, Shah JP. Parathyroid carcinoma. Clin Oncol (R Coll Radiol). 2010 Aug;22(6):498-507.
  • 12. Munson ND, Foote RL, Northcutt RC, Tiegs RD, Fitzpatrick LA, Grant CS, et al. Parathyroid carcinoma: is there a role for adjuvant radiation therapy? Cancer. 2003;98(11):2378–84.

A case of parathyroid carcinoma mimicking parathyroid adenoma

Year 2019, Volume: 3 Issue: 3, 265 - 267, 15.03.2019

Semra Demirli Atıcı Değercan Yeşilyurt Dudu Solakoğlu Kahraman Emre Dikmeer Hakan Öğücü Halit Batuhan Demir Gökhan Akbulut

https://doi.org/10.28982/josam.473603

Abstract

Parathyroid carcinoma is one of the rare endocrine tumors and constitutes 1% of the cases with primary hyperparathyroidism. Because of similar imaging modalities and similar clinical findings, it is difficult to distinguish between preoperative parathyroid adenomas and parathyroid carcinoma. A 70-year-old female patient presented with fatigue and generalized bone pain. Her laboratory tests, neck and parathyroid scintigraphy were compatible with primary hyperparathyroidism with a significantly elevated level of parathormone. With the imaging methods which supported parathyroid adenoma, the patient was operated with a presumptive diagnosis of primary hyperparathyroidism due to parathyroid adenoma. The postoperative course was unremarkable and she was discharged on the postoperative fifth day. Postoperative pathology was reported as parathyroid carcinoma developed in a parathyroid adenoma. Parathyroid carcinoma and parathyroid adenoma have similar clinically and imaging methods, it is difficult to diagnose preoperatively.

Keywords

Hypercalcemia Primary hyperparathyroidism Parathyroid adenoma Parathyroid carcinoma

References

  • 1. Shane E. Clinical review 122: Parathyroid carcinoma. J Clin Endocrinol Metab. 2001 Feb;86(2),:485-93.
  • 2. Haven CJ, van Puijenbroek M, Tan MH, Teh BT, Fleuren GJ, van Wezel T, et al. Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroidcarcinomas. Clin Endocrinol. 2007;67:370-6.
  • 3. Wassif WS, Moniz CF, Friedman E, Wong S, Weber G, Nordenskjöld M, Peters TJ, Larsson C. Familial isolated hyperparathyroidism: a distinct genetic entity with an increased risk of parathyroid cancer. J Clin Endocrinol Metab. 1993 Dec;77(6):1485-9.
  • 4. Tamler R, Lewis MS, LiVolsi VA, Genden EM. Parathyroid carcinoma: ultrasonographic and histologic features. Thyroid. 2005 Jul;15(7):744-5.
  • 5. Fernandes JMP, Paiva C, Correia R, Polónia J, Moreira da Costa A. Parathyroid carcinoma: From a case report to a review of the literature. Int J Surg Case Rep. 2018;42:214-217. doi: 10.1016/j.ijscr.2017.11.030.
  • 6. Marcocci C, Cetani F, Rubin MR, Silverberg SJ, Pinchera A, Bilezikian JP. Parathyroidcarcinoma. J Bone MinerRes. 2008;23:1869-80.
  • 7. Spinelli C, Bonadio AG, Berti P, Materazzi G, Miccoli P. Cutaneous spreading of parathyroid carcinoma after fine needle aspiration cytology. J Endocrinol Invest. 2000 Apr;23(4):255-7.
  • 8. Chiofalo MG, Scognamiglio F, Losito S, Lastoria S, Marone U, Pezzullo L. Huge parathyroid carcinoma: clinical considerations and literature review. World J Surg Oncol. 2005 Jun 23;3:39.
  • 9. Koea JB, Shaw JH. Parathyroid cancer: biology and management. Surg Oncol. 1999 Nov;8(3):155-65.
  • 10. Sandelin K, Auer G, Bondeson L, Grimelius L, Farnebo LO. Prognostic factors in parathyroid cancer: a review of 95 cases. World J Surg. 1992 Jul-Aug;16(4):724-31.
  • 11. Givi B, Shah JP. Parathyroid carcinoma. Clin Oncol (R Coll Radiol). 2010 Aug;22(6):498-507.
  • 12. Munson ND, Foote RL, Northcutt RC, Tiegs RD, Fitzpatrick LA, Grant CS, et al. Parathyroid carcinoma: is there a role for adjuvant radiation therapy? Cancer. 2003;98(11):2378–84.
There are 12 citations in total.

Details

Primary Language English
Subjects Surgery
Journal Section Case report
Authors

Semra Demirli Atıcı 0000-0002-8287-067X

Değercan Yeşilyurt This is me 0000-0001-6938-2076

Dudu Solakoğlu Kahraman This is me 0000-0002-4126-5326

Emre Dikmeer This is me 0000-0001-9442-0273

Hakan Öğücü This is me 0000-0003-4089-1162

Halit Batuhan Demir 0000-0002-2746-7941

Gökhan Akbulut

Publication Date March 15, 2019
Published in Issue Year 2019 Volume: 3 Issue: 3

Cite

APA Demirli Atıcı, S., Yeşilyurt, D., Solakoğlu Kahraman, D., Dikmeer, E., et al. (2019). A case of parathyroid carcinoma mimicking parathyroid adenoma. Journal of Surgery and Medicine, 3(3), 265-267. https://doi.org/10.28982/josam.473603
AMA Demirli Atıcı S, Yeşilyurt D, Solakoğlu Kahraman D, Dikmeer E, Öğücü H, Demir HB, Akbulut G. A case of parathyroid carcinoma mimicking parathyroid adenoma. J Surg Med. March 2019;3(3):265-267. doi:10.28982/josam.473603
Chicago Demirli Atıcı, Semra, Değercan Yeşilyurt, Dudu Solakoğlu Kahraman, Emre Dikmeer, Hakan Öğücü, Halit Batuhan Demir, and Gökhan Akbulut. “A Case of Parathyroid Carcinoma Mimicking Parathyroid Adenoma”. Journal of Surgery and Medicine 3, no. 3 (March 2019): 265-67. https://doi.org/10.28982/josam.473603.
EndNote Demirli Atıcı S, Yeşilyurt D, Solakoğlu Kahraman D, Dikmeer E, Öğücü H, Demir HB, Akbulut G (March 1, 2019) A case of parathyroid carcinoma mimicking parathyroid adenoma. Journal of Surgery and Medicine 3 3 265–267.
IEEE S. Demirli Atıcı, “A case of parathyroid carcinoma mimicking parathyroid adenoma”, J Surg Med, vol. 3, no. 3, pp. 265–267, 2019, doi: 10.28982/josam.473603.
ISNAD Demirli Atıcı, Semra et al. “A Case of Parathyroid Carcinoma Mimicking Parathyroid Adenoma”. Journal of Surgery and Medicine 3/3 (March 2019), 265-267. https://doi.org/10.28982/josam.473603.
JAMA Demirli Atıcı S, Yeşilyurt D, Solakoğlu Kahraman D, Dikmeer E, Öğücü H, Demir HB, Akbulut G. A case of parathyroid carcinoma mimicking parathyroid adenoma. J Surg Med. 2019;3:265–267.
MLA Demirli Atıcı, Semra et al. “A Case of Parathyroid Carcinoma Mimicking Parathyroid Adenoma”. Journal of Surgery and Medicine, vol. 3, no. 3, 2019, pp. 265-7, doi:10.28982/josam.473603.
Vancouver Demirli Atıcı S, Yeşilyurt D, Solakoğlu Kahraman D, Dikmeer E, Öğücü H, Demir HB, Akbulut G. A case of parathyroid carcinoma mimicking parathyroid adenoma. J Surg Med. 2019;3(3):265-7.
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