Case Report
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A rare cause of precocious puberty: Juvenile granulosa cell tumor

Year 2020, Volume: 4 Issue: 2, 167 - 169, 01.02.2020

Ayşe Özkan Yılmaz Kor Ayşe Selcan Koç Zerrin Özçelik Elif Burcu Aydın

https://doi.org/10.28982/josam.636136

Abstract


Ovarian sex cord-stromal tumors, including granulosa cell tumors are rare, especially in children. They are classified into juvenile and adult types. Juvenile granulosa cell tumors (JGCT) comprise 5% of all granulosa cell tumors. Precocious pseudo-puberty is a common presentation of these tumors, associated with hormonal changes. We report a rare case of JGCT of the ovary in a 4-year-old girl who presented with breast enlargement and alveolar pigmentation for two months. At her examination she had also an abdominal mass. Based on imagining features and laboratory findings, the diagnosis of the mass was unclear. After surgery, histopathological examination revealed JGCT of the left ovary. Although in most of girls with precocious puberty, the etiology is idiopathic, important causes, such as ovarian tumors like JGCTs must be considered.

Keywords

Juvenile granulosa cell tumor Ovary Puberty

References

  • 1. Roth LM. Recent advances in the pathology and classification of ovarian sex cord–stromal tumors. Int J Gynecol Pathol. 2006;25(3):199–215.
  • 2. Young RH, Dickersin GR, Scully RE. Juvenile granulosa cell tumor of the ovary: a clinicopathological analysis of 125 cases. Am J Surg Pathol. 1984;8(8):575–96.
  • 3. Von Allmen D. Malignant lesions of the ovary in childhood. Semin Pediatr Surg. 2005;14:100-5.
  • 4. Cisternino M, Arrigo T, Pasquino AM, Tinelli C, Antoniazzi F, Beduschi L, et al. Etiology and age incidence of precocious puberty in girls: a multicentric study. J Pediatr Endocrinol Metab. 2000;13:695–701.
  • 5. Herman-Giddens M, Sandier A, Friedman N. Sexual precocity in girls. An association with sexual abuse? Am J Dis Child. 1988;142:431–3.
  • 6. Oltmann SC, Garcia N, Barber R, Huang R, Hicks B, Fischer A. Can we preoperatively risk stratify ovarian masses for malignancy? J Pediatr Surg. 2010;45(1):130–4.
  • 7. Pectasides D, Pectasides E, Psyrri A. Granulosa cell tumor of the ovary. Cancer Treat Rev. 2008;34(1):1-12.
  • 8. Brookfield KF, Cheung MC, Koniaris LG, Sola JE, Fischer AC. A population-based analysis of 1037 malignant ovarian tumors in the pediatric population. J Surg Res. 2009;156(1):45–49.
  • 9. Low LCK, Wang Q. Gonadotropin independent precocious puberty. J Pediatr Endocrinol Metab. 1998;11(4):497–507.
  • 10. Gittleman AM, Price AP, Coren C, Akhtar M, Donovan V, Katz DS. Radiology-Pathology Conference: Juvenile granulosa cell tumor. Journal of Clinical Imaging. 2003;27(4):221-4.
  • 11. Laufer MR, Goldstein DP. Benign and malignant ovarian masses. In: Emans SJH, Laufer MR, Goldstein DP, eds. Pediatric and adolescent gynecology. 5th ed. Philadelphia, Pa: Lippincott Williams & Wilkins. 2005; 685.
  • 12. Eugster EA, Palmert MR. Precocious puberty. J Clin Endocrinol Metab. 2006;91:0.
  • 13. Auranen A, Sundström J, Ijäs J, Grénman S. Prognostic factors of ovarian granulosa cell tumor: a study of 35 patients and review of the literature. Int J Gynecol Cancer. 2007;17(5):1011.
  • 14. Crew KD, Cohen MH, Smith DH, Tiersten AD, Feirt NM, Hershman DL. Long natural history of recurrent granulosa cell tumor of the ovary 23 years after initial diagnosis: a case report and review of the literature. Gynecol Oncol. 2005;96(1):235.
  • 15. Elbachiri M, Taleb A, Derrabi N, Bouchbika Z, Benchakroun N, Jouhadi H, et al. Adult-type granulosa cell tumor of the testis: report of a case and review of literature. Pan Afr Med J. 2017;26:198.

Puberte prekoksun nadir bir nedeni: Juvenil granüloza hücreli tümör

Year 2020, Volume: 4 Issue: 2, 167 - 169, 01.02.2020

Ayşe Özkan Yılmaz Kor Ayşe Selcan Koç Zerrin Özçelik Elif Burcu Aydın

https://doi.org/10.28982/josam.636136

Abstract


Granüloza hücreli tümörleri içeren over seks kord stromal tümörleri, özellikle çocuklarda nadir görülen tümörlerdir. Juvenil ve yetişkin tip olarak iki gruba ayrılırlar. Juvenil granüloza hücreli tümörler (JGHT) tüm granüloza hücreli tümörlerin % 5’ini içerir. Yalancı puberte prekoks, hormonal değişiklikler ile ilişkili bu tümörlerin en sık görülen bulgusudur. Biz burada 2 aydır meme büyümesi ve alveoler pigmentasyon şikayeti ile başvuran, 4 yaşındaki bir kız çocuğunda görülen nadir bir JGHT olgusunu bildirdik. Muayenesinde abdominal kitlesi de mevcuttu. Görüntüleme ve laboratuvar bulguları ile kitlenin tanısı belirsizdi. Operasyon sonrası histopatolojik tanı sol overin JGHT’ ü olarak konuldu. Puberte prekoksu olan kızların çoğunda etyoloji idiyopatik olsa da JGHT de içeren bazı over tümörleri gibi önemli nedenler göz önünde bulundurulmalıdır.

Keywords

Juvenil granüloza hücreli tümör Over Puberte

References

  • 1. Roth LM. Recent advances in the pathology and classification of ovarian sex cord–stromal tumors. Int J Gynecol Pathol. 2006;25(3):199–215.
  • 2. Young RH, Dickersin GR, Scully RE. Juvenile granulosa cell tumor of the ovary: a clinicopathological analysis of 125 cases. Am J Surg Pathol. 1984;8(8):575–96.
  • 3. Von Allmen D. Malignant lesions of the ovary in childhood. Semin Pediatr Surg. 2005;14:100-5.
  • 4. Cisternino M, Arrigo T, Pasquino AM, Tinelli C, Antoniazzi F, Beduschi L, et al. Etiology and age incidence of precocious puberty in girls: a multicentric study. J Pediatr Endocrinol Metab. 2000;13:695–701.
  • 5. Herman-Giddens M, Sandier A, Friedman N. Sexual precocity in girls. An association with sexual abuse? Am J Dis Child. 1988;142:431–3.
  • 6. Oltmann SC, Garcia N, Barber R, Huang R, Hicks B, Fischer A. Can we preoperatively risk stratify ovarian masses for malignancy? J Pediatr Surg. 2010;45(1):130–4.
  • 7. Pectasides D, Pectasides E, Psyrri A. Granulosa cell tumor of the ovary. Cancer Treat Rev. 2008;34(1):1-12.
  • 8. Brookfield KF, Cheung MC, Koniaris LG, Sola JE, Fischer AC. A population-based analysis of 1037 malignant ovarian tumors in the pediatric population. J Surg Res. 2009;156(1):45–49.
  • 9. Low LCK, Wang Q. Gonadotropin independent precocious puberty. J Pediatr Endocrinol Metab. 1998;11(4):497–507.
  • 10. Gittleman AM, Price AP, Coren C, Akhtar M, Donovan V, Katz DS. Radiology-Pathology Conference: Juvenile granulosa cell tumor. Journal of Clinical Imaging. 2003;27(4):221-4.
  • 11. Laufer MR, Goldstein DP. Benign and malignant ovarian masses. In: Emans SJH, Laufer MR, Goldstein DP, eds. Pediatric and adolescent gynecology. 5th ed. Philadelphia, Pa: Lippincott Williams & Wilkins. 2005; 685.
  • 12. Eugster EA, Palmert MR. Precocious puberty. J Clin Endocrinol Metab. 2006;91:0.
  • 13. Auranen A, Sundström J, Ijäs J, Grénman S. Prognostic factors of ovarian granulosa cell tumor: a study of 35 patients and review of the literature. Int J Gynecol Cancer. 2007;17(5):1011.
  • 14. Crew KD, Cohen MH, Smith DH, Tiersten AD, Feirt NM, Hershman DL. Long natural history of recurrent granulosa cell tumor of the ovary 23 years after initial diagnosis: a case report and review of the literature. Gynecol Oncol. 2005;96(1):235.
  • 15. Elbachiri M, Taleb A, Derrabi N, Bouchbika Z, Benchakroun N, Jouhadi H, et al. Adult-type granulosa cell tumor of the testis: report of a case and review of literature. Pan Afr Med J. 2017;26:198.
There are 15 citations in total.

Details

Primary Language English
Subjects Oncology and Carcinogenesis
Journal Section Case report
Authors

Ayşe Özkan 0000-0003-1181-8169

Yılmaz Kor This is me 0000-0003-1645-5416

Ayşe Selcan Koç 0000-0003-1973-0719

Zerrin Özçelik This is me 0000-0003-3728-0846

Elif Burcu Aydın This is me 0000-0003-0935-5345

Publication Date February 1, 2020
Published in Issue Year 2020 Volume: 4 Issue: 2

Cite

APA Özkan, A., Kor, Y., Koç, A. S., Özçelik, Z., et al. (2020). A rare cause of precocious puberty: Juvenile granulosa cell tumor. Journal of Surgery and Medicine, 4(2), 167-169. https://doi.org/10.28982/josam.636136
AMA Özkan A, Kor Y, Koç AS, Özçelik Z, Aydın EB. A rare cause of precocious puberty: Juvenile granulosa cell tumor. J Surg Med. February 2020;4(2):167-169. doi:10.28982/josam.636136
Chicago Özkan, Ayşe, Yılmaz Kor, Ayşe Selcan Koç, Zerrin Özçelik, and Elif Burcu Aydın. “A Rare Cause of Precocious Puberty: Juvenile Granulosa Cell Tumor”. Journal of Surgery and Medicine 4, no. 2 (February 2020): 167-69. https://doi.org/10.28982/josam.636136.
EndNote Özkan A, Kor Y, Koç AS, Özçelik Z, Aydın EB (February 1, 2020) A rare cause of precocious puberty: Juvenile granulosa cell tumor. Journal of Surgery and Medicine 4 2 167–169.
IEEE A. Özkan, Y. Kor, A. S. Koç, Z. Özçelik, and E. B. Aydın, “A rare cause of precocious puberty: Juvenile granulosa cell tumor”, J Surg Med, vol. 4, no. 2, pp. 167–169, 2020, doi: 10.28982/josam.636136.
ISNAD Özkan, Ayşe et al. “A Rare Cause of Precocious Puberty: Juvenile Granulosa Cell Tumor”. Journal of Surgery and Medicine 4/2 (February 2020), 167-169. https://doi.org/10.28982/josam.636136.
JAMA Özkan A, Kor Y, Koç AS, Özçelik Z, Aydın EB. A rare cause of precocious puberty: Juvenile granulosa cell tumor. J Surg Med. 2020;4:167–169.
MLA Özkan, Ayşe et al. “A Rare Cause of Precocious Puberty: Juvenile Granulosa Cell Tumor”. Journal of Surgery and Medicine, vol. 4, no. 2, 2020, pp. 167-9, doi:10.28982/josam.636136.
Vancouver Özkan A, Kor Y, Koç AS, Özçelik Z, Aydın EB. A rare cause of precocious puberty: Juvenile granulosa cell tumor. J Surg Med. 2020;4(2):167-9.
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