Research Article
Year 2021,
Volume: 14 Issue: 3, 346 - 350, 30.09.2021
Abstract
Günümüzde alkol alımı sindirim sistemi hastalıkları başta olmak üzere birçok hastalığın önemli bir etkenidir. Dopamin agonistlerinin alkol kaynaklı hasarlar üzerinde iyileşmeye yardımcı olduğunun bilinmesine karşın, bupropionun etanol kaynaklı değişen biyokimyasal parametreler üzerindeki etkileri tam olarak açıklığa kavuşturulmamıştır. Bu çalışma etanol uygulaması ile değişen bazı biyokimyasal parametreler üzerinde bupropionun etkisini değerlendirmek için gerçekleştirildi. Çalışmada ratlara haftada iki kez dört hafta süreyle % 56 etanol uygulaması yapıldı ve sonrasında bupropion 30 ve 60 mg/kg dozlarda yedi gün süreyle oral olarak uygulandı. Çalışma sonunda bupropionun etanol ile değişen aspartat aminotransferaz (AST), alanin aminotransferaz (ALT), alkalin fosfataz (ALP), üre, kreatinin, total protein ve glukoz değerlerini tersine çevirdiği belirlendi. Çalışma bulguları alkol uygulaması ile değişen biyokimyasal parametreleri bupropionun etkili bir şekilde iyileştirdiğini göstermiştir.
Keywords
References
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- Andersen O, Bergsaker-Aspoy J, Halvorsen L, Giercksky K. Doxepin in the treatment of duodenal ulcer. A doubleblind clinical study comparing doxepin and placebo. Scand J Gastroenterol. 1984; 19:923-925.
- Behrman SW. Management of complicated peptic ulcer disease. Arch Surg. 2005; 140(2):201-208.
- Costello MR, Mandelkern MA, Shoptaw S, Shulenberger S, Baker SK, Abrams AL, Xia C, London ED, Brody AL. Effects of treatment for tobacco dependence on resting cerebral glucose metabolism. Neuropsychopharmacology. 2010 Feb;35(3):605-12. .
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- Ozbayer C, Kurt H, Ozdemir Z, Tuncel T, Saadat SM, Burukoglu D, Senturk H, Degirmenci I, Gunes HV. Gastroprotective, cytoprotective and antioxidant effects of Oleum cinnamomi on ethanol induced damage. Cytotechnology. 2014; 66(3), 431-441.
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- Rachdaoui N, Sebastian BM, Nagy LE. Chronic ethanol feeding impairs endothelin-1-stimulated glucose uptake via decreased G alpha 11 expression in rat adipocytes. Am J Physiol Endocrinol Metab. 2003;285(2):E303-10.
- Saravanan R, Viswanathan P, Pugalendi KV. Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats. Life Sci. 2006 Jan 11;78(7):713-8.
- Sharpe PC, McBride R, Archbold GPR. Biochemical markers of alcohol abuse. QJM. 1996; 89(2), 137-144.
- Shrivastava RK, Siegal H, Lawlor R, Shah BK, Dayican G. Doxepin therapy for duodenal ulcer: a controlled trial in patients who failed to respond to cimetidine. Clin Ther. 1985; 7(3):319-26.
- Tahir M, Sultana S. Chrysin modulates ethanol metabolism in Wistar rats: a promising role against organ toxicities. Alcohol Alcohol. 2011;46(4):383-92.
Year 2021,
Volume: 14 Issue: 3, 346 - 350, 30.09.2021
Abstract
Today, alcohol intake is a significant factor in many diseases primarily digestive system disorders. Despite dopamine agonists for helping to heal on alcohol-induced damages was known, the effects of bupropion on ethanol-induced varying biochemical parameters were not clarified completely. This study was conducted to assess the effects of bupropion on some changing biochemical parameters due to ethanol treatment. Rats were administered with 56% ethanol twice a week for four weeks and then bupropion was orally administered in doses of 30 and 60 mg/kg for 7 days. At the end of the study, it was found that bupropion reversed the values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea, creatinine, total protein, and glucose changed by ethanol. Study findings proved that bupropion improved effectively the changed biochemical parameters due to alcohol administration.
Keywords
References
- Abuohashish HM, Ahmed MM, Al-Rejaie SS, Eltahir KE. The antidepressant bupropion exerts alleviating properties in an ovariectomized osteoporotic rat model. Acta Pharmacol Sin. 2015; 36(2):209-20.
- Ahmed B, Alam T, Varshney M, Khan SA. Hepatoprotective activity of two plants belonging to the Apiaceae and the Euphorbiaceae family. J Ethnopharmacol. 2002 Mar;79(3):313-6.
- Aihara T, Nakamura E, Amagase K, Tomita K., Fujishita F, Furutani K, Okabe S. Pharmacological control of gastric acid secretion for the treatment of acidrelated peptic disease: past, present, and future. Pharmacol. Therap. 2003; 98(1):109-27.
- Andersen O, Bergsaker-Aspoy J, Halvorsen L, Giercksky K. Doxepin in the treatment of duodenal ulcer. A doubleblind clinical study comparing doxepin and placebo. Scand J Gastroenterol. 1984; 19:923-925.
- Behrman SW. Management of complicated peptic ulcer disease. Arch Surg. 2005; 140(2):201-208.
- Costello MR, Mandelkern MA, Shoptaw S, Shulenberger S, Baker SK, Abrams AL, Xia C, London ED, Brody AL. Effects of treatment for tobacco dependence on resting cerebral glucose metabolism. Neuropsychopharmacology. 2010 Feb;35(3):605-12. .
- Dedeoğlu E, Bayram B, Kızıler AU, Dedeoğlu B. Generalized tonic-clonic seizure induced by the extended- release bupropion hydrochloride formulation. Bulletin Clinical Psychopharm. 2011; 21(4), 362-363.
- el-Dakhakhny M, Abdel el-Latif HA, Ammon HP. Different effects of the antidepressant drugs imipramine, maprotiline and bupropion on insulin secretion from mouse pancreatic islets. Arzneimittelforschung. 1996 Jul;46(7):667-9.
- Fisher SJ, Swaan PW, Eddington ND. The ethanol metabolite acetaldehyde increases paracellular drug permeability in vitro and oral bioavailability in vivo. J Pharm Exp Therap. 2010; 332(1), 326-333.
- Fowman DT. The effect of ethanol and its metabolites on carbohydrate, protein and lipid metabolism. Ann Clin Lab Sci. 1988;18: 181-189.
- Halvorson MR, Campbell JL, Sprague G, Slater K, Noffsinger JK, Peterson CM. Comparative evaluation of the clinical utility of three markers of ethanol intake: the effect of gender. Alcohol Clin Exp Res. 1993;17(2):225-9.
- Hamed MA. Metabolic Profile of Rats after One Hour of Intoxication with a Single Oral Dose of Ethanol. J Pharm Toxicol. 2011; 6:158-165.
- Handa RK, DeJoseph MR, Singh LD, Hawkins RA, Singh SP. Glucose transporters and glucose utilization in rat brain after acute ethanol administration. Metab Brain Dis. 2000; 15(3):211-22.
- Jensen SA, Almdal TP, Vilstrup H. Acute in vivo effects of low ethanol concentration on the capacity of urea synthesis in rats. Alcohol Clin Exp Res. 1991;15(1):90-3.
- Ji W, Liang K, An R, Wang X. Baicalin protects against ethanol-induced chronic gastritis in rats by inhibiting Akt/NF-κB pathway. Life Sci. 2019; 239, 117064.
- Mokuda O, Tanaka H, Hayashi T, Ooka H, Okazaki R, Sakamoto Y. Ethanol stimulates glycogenolysis and inhibits both glycogenesis via gluconeogenesis and from exogenous glucose in perfused rat liver. Ann Nutr Metab. 2004; 48(4):276-80.
- Ozbayer C, Kurt H, Ozdemir Z, Tuncel T, Saadat SM, Burukoglu D, Senturk H, Degirmenci I, Gunes HV. Gastroprotective, cytoprotective and antioxidant effects of Oleum cinnamomi on ethanol induced damage. Cytotechnology. 2014; 66(3), 431-441.
- Peterson K. Biomarkers for alcohol use and abuse--a summary. Alcohol Res Health. 2004-2005;28(1):30-7.
- Rachdaoui N, Sebastian BM, Nagy LE. Chronic ethanol feeding impairs endothelin-1-stimulated glucose uptake via decreased G alpha 11 expression in rat adipocytes. Am J Physiol Endocrinol Metab. 2003;285(2):E303-10.
- Saravanan R, Viswanathan P, Pugalendi KV. Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats. Life Sci. 2006 Jan 11;78(7):713-8.
- Sharpe PC, McBride R, Archbold GPR. Biochemical markers of alcohol abuse. QJM. 1996; 89(2), 137-144.
- Shrivastava RK, Siegal H, Lawlor R, Shah BK, Dayican G. Doxepin therapy for duodenal ulcer: a controlled trial in patients who failed to respond to cimetidine. Clin Ther. 1985; 7(3):319-26.
- Tahir M, Sultana S. Chrysin modulates ethanol metabolism in Wistar rats: a promising role against organ toxicities. Alcohol Alcohol. 2011;46(4):383-92.
There are 23 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Journal Section | RESEARCH ARTICLE |
| Authors | |
| Publication Date | September 30, 2021 |
| Acceptance Date | August 26, 2021 |
| Published in Issue | Year 2021 Volume: 14 Issue: 3 |
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