Year 2006,
Volume: 19 Issue: 3, 116 - 120, 26.06.2015
Abstract
-
Keywords
References
- 1. Parker C, Milosevic M, Panzarella T, Banerjee D, Jewett M, Catton C, et al. The prognostic significance of the tumor infiltrating lymphocyte count in stage 1 testicular seminoma managed by surveillance. Eur J Cancer 2002; 38 (15):2014-9.
- 2. Hsu YJ, Pai L, Chen YC, Ho CL, Kao WY, Chao TY. Extragonadal germ cell tumors in Taiwan: an analysis of treatment results of 59 patients. Cancer 2002; 95:766– 74.
- 3. El Abbadi N, Maagili MR, Arkha Y, Amarti A, Bellakhdar F. Cerebellar primary germinom. Case report. Neurochirurgie 2002; 48:351-4.
- 4. Wolden SL, Wara WM, Larson DA, Prados MD, Edwards MSB, Sneed PK. Radiation therapy for primary intracranial germ-cell tumors. Int J Radiat Oncol Biol Phys. 1995; 32:943–47.
- 5. Nakagawa Y, Perentes E, Ross GW, Ross AN, Rubinstein LJ. immunohistochemical differences between intracranial germinomas and their gonadal equivalents. An immunoperoxidase study of germ cell tumors with epithelial membrane antigen, cytokeratin, and vimentin. J Pathol. 1988; 156(1):67-72.
- 6. Bentley AJ, Parkinson MC, Harding BN, Bains RM, Lantos PL. A comparative morphological and immunohistochemical study of testicular seminomas and intracranial germinomas. Histopathology. 1990;17(5):443-9.
- 7. Tekkok IH, Sav A. Aggressive spinal germinom with ascending metastases. J Neurooncol. 2005;75(2):135– 41.
- 8. Martinazzi M, Zampieri A, Martinazzi S, Crivelli F, Mauri MF, Calandra C.Proliferative activity of stage I testicular neoplasms: evaluation by image analysis of immunoreactive MIB-1. Pathologica. 1998; 90(6):783-7.
- 9. Hattab EM, Tu PH, Wilson JD, Cheng L. OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. Am J Surg Pathol. 2005 ;29(3):368- 71.
- 10. Bailey D, Marks A, Stratis M, Baumal R. Immunohistochemical staining of germ cell tumors and intratubular malignant germ cells of the testis using antibody to placental alkaline phosphatase and a monoclonal anti-seminoma antibody. Mod Pathol. 1991; 4(2):167-71.
- 11. Midi A, Bozkurt S, Yapıcıer Ö, Sav A.. Langerhans Cell Histiocytosis and Intracranial Germinoma: Are Immunohistology Techniques Helpful in Distinguishing Two Entities?. Journal oj Neurological Sciences (Türkish) . 2006; 23 (3): 209-214
- 12. Bell DA, Flotte TJ, Bhan AK. Immunohistochemical characterization of seminoma and its inflammatory cell infiltrate. Hum Pathol. 1987; 18(5):511-20.
- 13. Grobholz R, Verbeke CS, Schleger C, Kohrmann KU, Hein B, Wolf G,et al. Expression of MAGE antigens and analysis of the inflammatory T-cell infiltrate in human seminoma. Urol Res. 2000; 28(6):398-403.
TESTİS SEMİNOMU VE İNTRAKRANYAL GERMİNOMUN İMMÜNHİSTOKİMYASAL VE HİSTOMORFOLOJİK ÖZELLİKLERİNİN KARŞILAŞTIRILMASI
Abstract
Amaç: Kranyal germinom, testis seminomu ve over disgerminomu histolojik olarak benzer özelliklere sahip ancak farklı lokalizasyonlarda yerleşen tümörlerdir. Bu çalışmada testis seminomu ile kranyal germinomlar tümör içerisindeki lenfosit ve eozinofillerin oranı, Ki–67, PLAP, vimentin immünhistokimyasal boyanma özellikleri bakımından karşılaştırılmıştır.
Gereç ve Yöntem: M.Ü. Nörolojik Bilimler Enstitüsünde 1995–2002 yılları arasında tanı almış 10 adet intrakranyal germinom ve 2 adet testis seminomuyla Marmara Üniversitesi Tıp. Fakültesi Patoloji Anabilim Dalı’nda 1998–2003 yılları arasında tanı almış 6 adet testis seminomu olgusu çalışma kapsamına alınmıştır. Olgulara PLAP, vimentin, Ki–67, tümör içerisindeki lenfosit yoğunluğunu saptamak için CD45 immünhistokimyasal boyamalar yapılmıştır.
Bulgular ve Sonuç: Germinom olgularının yaş aralığı 9–30 olup ortalama yaş 17 dir. Seminom olgularının yaş aralığı 15–49 olup ortalama yaş 32,6’dır. Çalışmamızda kranyal germinom ve seminomlarda tümör içi lenfosit ve eozinofil varlığı yanısıra PLAP ve vimentin immünhistokimyasal boyanma özellikleri bakımından istatistiksel olarak anlamlı fark bulunmamıştır. MIB-1 (Ki-67) proliferasyon indeksi seminomda %44, germinomda %25 olarak bulunmuştur ve fark istatistiksel olarak anlamlıdır.
Anahtar Kelimeler: Cranial germinoma, Testicular seminoma, Lymphocite, Eosinophils, Ki-67, PLAP
References
- 1. Parker C, Milosevic M, Panzarella T, Banerjee D, Jewett M, Catton C, et al. The prognostic significance of the tumor infiltrating lymphocyte count in stage 1 testicular seminoma managed by surveillance. Eur J Cancer 2002; 38 (15):2014-9.
- 2. Hsu YJ, Pai L, Chen YC, Ho CL, Kao WY, Chao TY. Extragonadal germ cell tumors in Taiwan: an analysis of treatment results of 59 patients. Cancer 2002; 95:766– 74.
- 3. El Abbadi N, Maagili MR, Arkha Y, Amarti A, Bellakhdar F. Cerebellar primary germinom. Case report. Neurochirurgie 2002; 48:351-4.
- 4. Wolden SL, Wara WM, Larson DA, Prados MD, Edwards MSB, Sneed PK. Radiation therapy for primary intracranial germ-cell tumors. Int J Radiat Oncol Biol Phys. 1995; 32:943–47.
- 5. Nakagawa Y, Perentes E, Ross GW, Ross AN, Rubinstein LJ. immunohistochemical differences between intracranial germinomas and their gonadal equivalents. An immunoperoxidase study of germ cell tumors with epithelial membrane antigen, cytokeratin, and vimentin. J Pathol. 1988; 156(1):67-72.
- 6. Bentley AJ, Parkinson MC, Harding BN, Bains RM, Lantos PL. A comparative morphological and immunohistochemical study of testicular seminomas and intracranial germinomas. Histopathology. 1990;17(5):443-9.
- 7. Tekkok IH, Sav A. Aggressive spinal germinom with ascending metastases. J Neurooncol. 2005;75(2):135– 41.
- 8. Martinazzi M, Zampieri A, Martinazzi S, Crivelli F, Mauri MF, Calandra C.Proliferative activity of stage I testicular neoplasms: evaluation by image analysis of immunoreactive MIB-1. Pathologica. 1998; 90(6):783-7.
- 9. Hattab EM, Tu PH, Wilson JD, Cheng L. OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. Am J Surg Pathol. 2005 ;29(3):368- 71.
- 10. Bailey D, Marks A, Stratis M, Baumal R. Immunohistochemical staining of germ cell tumors and intratubular malignant germ cells of the testis using antibody to placental alkaline phosphatase and a monoclonal anti-seminoma antibody. Mod Pathol. 1991; 4(2):167-71.
- 11. Midi A, Bozkurt S, Yapıcıer Ö, Sav A.. Langerhans Cell Histiocytosis and Intracranial Germinoma: Are Immunohistology Techniques Helpful in Distinguishing Two Entities?. Journal oj Neurological Sciences (Türkish) . 2006; 23 (3): 209-214
- 12. Bell DA, Flotte TJ, Bhan AK. Immunohistochemical characterization of seminoma and its inflammatory cell infiltrate. Hum Pathol. 1987; 18(5):511-20.
- 13. Grobholz R, Verbeke CS, Schleger C, Kohrmann KU, Hein B, Wolf G,et al. Expression of MAGE antigens and analysis of the inflammatory T-cell infiltrate in human seminoma. Urol Res. 2000; 28(6):398-403.
There are 13 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | June 26, 2015 |
| Published in Issue | Year 2006 Volume: 19 Issue: 3 |