Amaç: Salusinler, insan plazmasında alfa ve beta formlarında bulunan peptit hormon yapısında potansiyel biyobelirteçlerdir. Vasküler dolaşımdaki salusin beta düzeyinin aterosklerozda ve ilişkili kardiyovasküler hastalıklarda arttığı bilinmektedir. İlk defa bu çalışmada Non-ST Elevasyonlu Miyokard İnfarktüsü (NSTEMİ) hastalarında, koroner arter hastalığının tanısı ve tedavisinde potansiyel bir biyobelirteç olan salusin betanın araştırılmasını amaçladık. Yöntem: NSTEMİ grubundaki gönüllülerden yatış ve taburculuk gününde, kontrol grubundaki sağlıklı gönüllülerden ise poliklinik başvurusunda salusin beta düzeyi ölçümü için kan örneği alınmıştır. Bulgular: Analiz sonucunda salusin beta düzeyi NSTEMİ grubunda kontrol grubuna göre daha yüksek saptanmasına rağmen, iki grup arasında salusin beta düzeyleri açısından anlamlı bir farklılık saptanmadı (p=0.833). NSTEMİ grubunda yatış gününe kıyasla taburculuk günü ölçülen salusin beta düzeyinde düşüş saptanmasına rağmen, iki grup arasında istatistiksel anlamlı bir farklılık saptanmamıştır (p=0.059). Sonuç: Gerçekleştirdiğimiz prospektif çalışmada NSTEMİ hastalarında salusin beta düzeyi sağlıklı popülasyon grubuna kıyasla artmış olmakla birlikte; istatistiksel olarak anlamlı bir artış saptanmamıştır. Bununla birlikte akut koroner sendrom hastalarında salusin betanın koroner arter hastalığındaki rolü ile ilgili çalışmalar nadirdir. Elde ettiğimiz bulguların gelecekteki salusin çalışmaları için temel oluşturacağını, koroner arter hastalığının tanısı ve tedavisinde yol gösterici olabileceğini düşünmekteyiz.
Mersin Üniversitesi Bilimsel Araştırma Projeleri Birimi
2020-1-TP3-4029
Aim: Salusins are potential biomarkers in the structure of peptide hormones found in human plasma in the alpha and beta forms. Salusin-beta levels are known to increase in the vascular circulation in atherosclerosis and associated cardiovascular disease. In this study, we aimed to investigate salusin-beta, a potential biomarker for the diagnosis and treatment of coronary artery disease, for the first time in patients with Non-ST Elevation Myocardial İnfarction(NSTEMI). Method: Blood samples were collected for salusin-beta level measurement from the subjects in the NSTEMI group at initial hospitalization and at discharge, while samples were obtained from the healthy subjects in the control group at the time of outpatient clinic admission. Results: Despite a higher salusin-beta level being observed in the NSTEMI group compared to the control group, there was no significant difference in salusin-beta levels between the two groups (p=0.833). Although a decrease in salusin-beta levels was detected on discharge day compared to initial hospitalization in the NSTEMI group, no statistically significant difference was found between the two groups (p=0.059). Conclusion: In our prospective study, although the salusin beta levels in NSTEMI patients was found to be increased compared to the healthy population group; no statistically significant increase was detected. However, studies regarding the role of salusin beta in coronary artery disease in acute coronary syndrome patients are rare. We believe that our findings will provide a basis for future studies on salusin and it may guide the diagnosis and treatment of coronary artery disease.
2020-1-TP3-4029
Primary Language | Turkish |
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Subjects | Surgery (Other), Health Care Administration |
Journal Section | Articles |
Authors | |
Project Number | 2020-1-TP3-4029 |
Early Pub Date | April 5, 2024 |
Publication Date | April 30, 2024 |
Submission Date | May 29, 2023 |
Acceptance Date | September 18, 2023 |
Published in Issue | Year 2024 Volume: 17 Issue: 1 |
MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.
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