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Evaluation of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume in Inactive Hepatitis B Carriers

Year 2015, Volume: 6 Issue: 22, 8 - 13, 24.07.2015
https://doi.org/10.17944/mkutfd.75063

Abstract

Aim: The aim of this study was to investigate the neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) levels in children with inactive hepatitis B virus (HBV) carriers and to evaluate the possible association between NLR, MPV and inflammation status in HBV infection.

Material and Method: Thirty inactive HBV carrier children and 32 age and gender matched healthy controls were enrolled as study group. Complete blood count parameters including white blood count, absolute neutrophil count and lymphocyte count, neutrophil to lymphocyte ratio and mean platelet volume were assessed in both study and the control groups.

Results: There was no significant difference in the mean age of inactive HBV carriers (11.9±3.4 years) and the control subjects (11.0±2.7 years) (p=0.25).  No significant differences were found in NLR (2.90±3.24 and 1.74±0.87, respectively, p=0.82) and MPV levels (7.9±1.0fL and 8.0±1.2fL, respectively, p=0.86) between inactive HBV carriers and the controls. MPV was found to be inversely correlated with platelet count in both patients and the control groups (r=-0.44, p=0.01; r=-0.36, p=0.04, respectively). A positive correlation was found between NLR and MPV (r=0.41, p=0.03) in patient group.

Conclusion: NLR and MPV levels were not different in inactive HBV carrier children compared to the controls. Our results suggest that NLR and MPV values may not be appropriate for determining of chronicity and inflammation status in chronic HBV infection.

Key words: Hepatitis B, chronic, neutrophil to lymphocyte ratio, mean platelet volume

References

  • Sokal EM, Paganelli M, Wirth S, Socha P, Vajro P, Lacaille F, Kelly D, Mieli-Vergani G, European Society of Pediatric Gastroenterology H, Nutrition. Management of chronic hepatitis B in childhood: ESPGHAN clinical practice guidelines: consensus of an expert panel on behalf of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition. Journal of Hepatology 2013;59:814-29.
  • Celikbilek M, Dogan S, Gursoy S, Zararsiz G, Yurci A, Ozbakir O, Guven K, Yucesoy M. Noninvasive assessment of liver damage in chronic hepatitis B. World Journal of Hepatology 2013;5:439-45.
  • Yilmaz B, Aydin H, Can G, Senturk Z, Ustuner B, Yilmaz H, Ozturkler M, Roach EC, Korkmaz U, Kurt M, Celebi A, Senturk O, Hulagu S. The relationship between fibrosis level and blood neutrophil to lymphocyte ratio in inactive hepatitis B carriers. European Journal of Gastroenterology & Hepatology 2014;26:1325-28.
  • Liu H, Zhang H, Wan G, Sang Y, Chang Y, Wang X, Zeng H. Neutrophil-lymphocyte ratio: a novel predictor for short-term prognosis in acute-on-chronic hepatitis B liver failure. Journal of Viral Hepatitis 2014;21:499-507.
  • Xiao GQ, Liu C, Liu DL, Yang JY, Yan LN. Neutrophil-lymphocyte ratio predicts the prognosis of patients with hepatocellular carcinoma after liver transplantation. World Journal of Gastroenterology: WJG 2013;19:8398-407.
  • Hu Y, Lou Y, Chen Y, Mao W. Evaluation of mean platelet volume in patients with hepatitis B virus infection. International Journal of Clinical and Experimental Medicine 2014;7:4207-213.
  • Ozer S, Yilmaz R, Sonmezgoz E, Karaaslan E, Taskin S, Butun I, Demir O. Simple markers for subclinical inflammation in patients with Familial Mediterranean Fever. Medical Science Monitor : İnternational medical journal of experimental and clinical research 2015;21:298-303.
  • Chen L, Lou Y, Chen Y, Yang J. Prognostic value of the neutrophil-to-lymphocyte ratio in patients with acute-on-chronic liver failure. International Journal of Clinical Practice 2014;68:1034-40.
  • Han L, Han T, Nie C, Zhang Q, Cai J. Elevated mean platelet volume is associated with poor short term outcomes in hepatitis B virus-related acute-on-chronic liver failure patients. Clinics and Research in Hepatology and Gastroenterology 2014.
  • Karagoz E, Ulcay A, Tanoglu A, Kara M, Turhan V, Erdem H, Oncul O, Gorenek L. Clinical usefulness of mean platelet volume and red blood cell distribution width to platelet ratio for predicting the severity of hepatic fibrosis in chronic hepatitis B virus patients. European Journal of Gastroenterology & Hepatology 2014;26:1320-24.
  • Qi XT, Wan F, Lou Y, Ye B, Wu D. The mean platelet volume is a potential biomarker for cirrhosis in chronic hepatitis B virus infected patients. Hepato-gastroenterology 2014;61:456-59.
  • Ceylan B, Mete B, Fincanci M, Aslan T, Akkoyunlu Y, Ozgunes N, Colak O, Gunduz A, Senates E, Ozaras R, Inci A, Tabak F. A new model using platelet indices to predict liver fibrosis in patients with chronic hepatitis B infection. Wiener Klinische Wochenschrift 2013;125:453-60.

İnaktif Hepatit B Taşıyıcılarında Nötrofil Lenfosit Oranı ve Ortalama Trombosit Hacminin Değerlendirilmesi

Year 2015, Volume: 6 Issue: 22, 8 - 13, 24.07.2015
https://doi.org/10.17944/mkutfd.75063

Abstract

Amaç: Bu çalışmanın amacı inaktif Hepatit B virüs (HBV) taşıyıcılarında nötrofil lenfosit oranı (NLO) ile ortalama trombosit hacmi (MPV) değerlerini araştırmak ve HBV enfeksiyonunda NLO ve MPV ile inflamasyon durumu arasındaki ilişkiyi değerlendirmektir. 

Gereç ve Yöntem: Otuz inaktif hepatit B virüs taşıyıcısı ve yaş ve cinsiyet yönünden hasta grubu ile uyumlu 32 sağlıklı çocuk kontrol grubuna dahil edildi. Hem çalışma hem de kontrol grubunda beyaz küre sayısı, mutlak nötrofil ve mutlak lenfosit sayısı, NLO ve MPV’yi içeren tam kan sayımı parametreleri değerlendirildi.

Bulgular: İnaktif HBV taşıyıcılar (11.9±3.4 yaş) ile kontrol grubu (11.0±2.7 yaş) arasında yaş ortalamaları yönünden fark yoktu (p=0.25). İnaktif HBV taşıyıcılar ile kontrol grubu arasında NLO (sırasıyla 2.90±3.24 ve 1.74±0.87, p=0.82) ve MPV değerleri (sırasıyla 7.9±1.0 fL ve 8.0±1.2 fL, p=0,86) yönünden de fark saptanmadı. Hem hasta hem de kontrol grubunda MPV ile trombosit sayısı arasında negatif korelasyon saptandı (sırasıyla r=-0.44, p=0.01; r=-0.36, p=0.04). Hasta grubunda MPV ile NLO arasında pozitif korelasyon saptandı (r=0.41, p=0.03).

Sonuç: İnaktif HBV taşıyıcılar ile kontroller karşılaştırıldığında NLO ve MPV değerleri farklı değildi. Bizim sonuçlarımız kronik HBV infeksiyonunda kronikleşme ve inflamasyon durumunun belirlenmesinde NLO ve MPV değerlerinin uygun olmayabileceğini düşündürmektedir.

Anahtar kelimeler: Hepatit B, kronisite, nötrofil-lenfosit oranı, ortalama trombosit hacmi

References

  • Sokal EM, Paganelli M, Wirth S, Socha P, Vajro P, Lacaille F, Kelly D, Mieli-Vergani G, European Society of Pediatric Gastroenterology H, Nutrition. Management of chronic hepatitis B in childhood: ESPGHAN clinical practice guidelines: consensus of an expert panel on behalf of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition. Journal of Hepatology 2013;59:814-29.
  • Celikbilek M, Dogan S, Gursoy S, Zararsiz G, Yurci A, Ozbakir O, Guven K, Yucesoy M. Noninvasive assessment of liver damage in chronic hepatitis B. World Journal of Hepatology 2013;5:439-45.
  • Yilmaz B, Aydin H, Can G, Senturk Z, Ustuner B, Yilmaz H, Ozturkler M, Roach EC, Korkmaz U, Kurt M, Celebi A, Senturk O, Hulagu S. The relationship between fibrosis level and blood neutrophil to lymphocyte ratio in inactive hepatitis B carriers. European Journal of Gastroenterology & Hepatology 2014;26:1325-28.
  • Liu H, Zhang H, Wan G, Sang Y, Chang Y, Wang X, Zeng H. Neutrophil-lymphocyte ratio: a novel predictor for short-term prognosis in acute-on-chronic hepatitis B liver failure. Journal of Viral Hepatitis 2014;21:499-507.
  • Xiao GQ, Liu C, Liu DL, Yang JY, Yan LN. Neutrophil-lymphocyte ratio predicts the prognosis of patients with hepatocellular carcinoma after liver transplantation. World Journal of Gastroenterology: WJG 2013;19:8398-407.
  • Hu Y, Lou Y, Chen Y, Mao W. Evaluation of mean platelet volume in patients with hepatitis B virus infection. International Journal of Clinical and Experimental Medicine 2014;7:4207-213.
  • Ozer S, Yilmaz R, Sonmezgoz E, Karaaslan E, Taskin S, Butun I, Demir O. Simple markers for subclinical inflammation in patients with Familial Mediterranean Fever. Medical Science Monitor : İnternational medical journal of experimental and clinical research 2015;21:298-303.
  • Chen L, Lou Y, Chen Y, Yang J. Prognostic value of the neutrophil-to-lymphocyte ratio in patients with acute-on-chronic liver failure. International Journal of Clinical Practice 2014;68:1034-40.
  • Han L, Han T, Nie C, Zhang Q, Cai J. Elevated mean platelet volume is associated with poor short term outcomes in hepatitis B virus-related acute-on-chronic liver failure patients. Clinics and Research in Hepatology and Gastroenterology 2014.
  • Karagoz E, Ulcay A, Tanoglu A, Kara M, Turhan V, Erdem H, Oncul O, Gorenek L. Clinical usefulness of mean platelet volume and red blood cell distribution width to platelet ratio for predicting the severity of hepatic fibrosis in chronic hepatitis B virus patients. European Journal of Gastroenterology & Hepatology 2014;26:1320-24.
  • Qi XT, Wan F, Lou Y, Ye B, Wu D. The mean platelet volume is a potential biomarker for cirrhosis in chronic hepatitis B virus infected patients. Hepato-gastroenterology 2014;61:456-59.
  • Ceylan B, Mete B, Fincanci M, Aslan T, Akkoyunlu Y, Ozgunes N, Colak O, Gunduz A, Senates E, Ozaras R, Inci A, Tabak F. A new model using platelet indices to predict liver fibrosis in patients with chronic hepatitis B infection. Wiener Klinische Wochenschrift 2013;125:453-60.
There are 12 citations in total.

Details

Primary Language Turkish
Journal Section Original Articles
Authors

Unal Uluca

Velat Sen

Ali Gunes

İlhan Tan This is me

Fesih Aktar

Ercan Cubuk This is me

Muhammed Sabaz This is me

Publication Date July 24, 2015
Submission Date April 4, 2015
Published in Issue Year 2015 Volume: 6 Issue: 22

Cite

Vancouver Uluca U, Sen V, Gunes A, Tan İ, Aktar F, Cubuk E, Sabaz M. İnaktif Hepatit B Taşıyıcılarında Nötrofil Lenfosit Oranı ve Ortalama Trombosit Hacminin Değerlendirilmesi. mkutfd. 2015;6(22):8-13.