Research Article
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Year 2020, Volume: 1 Issue: 2, 94 - 99, 30.09.2020

Abstract

References

  • Referans1 Rosa MB, Fernandes MDS, Bonjardim LR, Gaviao MBD, Calixto LA, Castelo PM. Evaluation of oral mechanical and gustatory sensitivities and salivary cotinine levels in adult smokers. Acta Odontol Scand. 2020;78(4):256-64.
  • Referans2 Zhang P, Li Y, Fu Y, Huang L, Liu B, Zhang L, et al. Inhibition of Autophagy Signaling via 3-methyladenine Rescued Nicotine-Mediated Cardiac Pathological Effects and Heart Dysfunctions. Int J Biol Sci. 2020;16(8):1349-62.
  • Referans3 Wipfli H. The Tobacco Atlas, Fourth Edition. American Journal of Epidemiology. 2012;176(12):1193-.
  • Referans4 Baker CL, Flores NM, Zou KH, Bruno M, Harrison VJ. Benefits of quitting smoking on work productivity and activity impairment in the United States, the European Union and China. Int J Clin Pract. 2017;71(1).
  • Referans5 Yılmaz H, Ertekin T, Atay E, Nisari M, Susar Güler H, Al Ö, et al. Antioxidant role of melatonin against nicotine's teratogenic effects on embryonic bone development. Iran J Basic Med Sci. 2018;21(8):787-93.
  • Referans6 Altun I, Yuksel KZ. An Experimental Study on the Effects of Smoking in the Perinatal Period and During Lactation on the Intervertebral Disks of Newborns. World Neurosurg. 2017;99:1-5.
  • Referans7 Mayyas F, Aldawod H, Alzoubi KH, Khabour O, Shihadeh A, Eissenberg T. Comparison of the cardiac effects of electronic cigarette aerosol exposure with waterpipe and combustible cigarette smoke exposure in rats. Life Sci. 2020;251:117644.
  • Referans8 Khabour OF, Alzoubi KH, Bani-Ahmad M, Dodin A, Eissenberg T, Shihadeh A. Acute exposure to waterpipe tobacco smoke induces changes in the oxidative and inflammatory markers in mouse lung. Inhal Toxicol. 2012;24(10):667-75.
  • Referans9 Mayyas F, Alzoubi KH. Cardiac effects of cigarette tobacco smoking in rat model of diabetes. Life Sci. 2018;211:279-85.
  • Referans10 Selçuk E, Özrenk K. Erzincan Yöresinde Yetiştirilen Kızılcıkların (Cornus mas L.) Fenolojik ve Pomolojik Özelliklerinin Belirlenmesi. Iğdır Univ. J. Inst. Sci. &Tech. 2011; 1(4) 23-30..pdf>.
  • Referans11 Yarilgac T, Kadim H, Ozturk B. Role of maturity stages and modified-atmosphere packaging on the quality attributes of cornelian cherry fruits (Cornus mas L.) throughout shelf life. J Sci Food Agric. 2019;99(1):421-8.
  • Referans12 Dinda B, Kyriakopoulos AM, Dinda S, Zoumpourlis V, Thomaidis NS, Velegraki A, et al. Cornus mas L. (cornelian cherry), an important European and Asian traditional food and medicine: Ethnomedicine, phytochemistry and pharmacology for its commercial utilization in drug industry. J Ethnopharmacol. 2016;193:670-90.
  • Referans13 Yilmaz S, Alpa S, Gocmen AY, Ulger H, Arslan E, Yay AH, et al. The investigation of the antitumoral effect of Cornus mas L in mice with ehrlich solid tumor. Bratisl Lek Listy. 2020;121(1):22-30.
  • Referans14 Wu R, Feng J, Yang Y, Dai C, Lu A, Li J, et al. Significance of Serum Total Oxidant/Antioxidant Status in Patients with Colorectal Cancer. PLoS One. 2017;12(1):e0170003.
  • Referans15 Yılmaz S, Göçmen AY, Üner AK, Akyüz E, Tokpınar A. The protective role of melatonin against the effect of caffeine on embryonic kidney. Turkısh Bulletın Of Hygıene And Experımental Bıology. 2020:61-70.
  • Referans16 Yılmaz S, Ülger H, Ertekin T, Yay AH, Nisari M, Alpa Ş, Acer N. Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created. Iranian Journal of Basic Medical Sciences. 2019; 22:418-425. doi: 10.22038/ijbms.2019.33623.8019
  • Referans17 Nisari M, Yılmaz S, Ertekin T, Ceylan C, İnanç N, Al Ö, Ülger H. Effects of Curcumin on Lipid Peroxidation and Antioxidant Enzymes in Kidney, Liver, Brain and Testis of Mice Bearing Ehrlich Solid Tumor. 2017, 1, 994; doi:10.3390/proceedings1100994.
  • Referans18 Kantekin ÇÜ, Çakırca M, Yaman F, Göçmen AY. Does the Application of Desflurane at The Same Concentration by Different Flows Change the Oxidative Stress? Animal Experiment. Online Türk Sağlık Bilimleri Dergisi. 2019: 4(4); 492-504.
  • Referans19 Momi N, Ponnusamy MP, Kaur S, Rachagani S, Kunigal SS, Chellappan S, et al. Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through a9 nAChR-mediated MUC4 upregulation. Oncogene 2013;32:1384–95.
  • Referans20 El-Sokkary GH, Cuzzocrea S, Reiter RJ. Effect of chronic nicotine administration on the rat lung and liver: beneficial role of melatonin. Toxicology 2007;239: 60–7.
  • Referans21 Dhouib H, Jallouli M, Draief M, Bouraoui S, El-Fazaa S. Oxidative damage and histopathological changes in lung of rat chronically exposed to nicotine alone or associated to ethanol. Pathologie Biologie 63 (2015) 258–267
  • Referans22 Ferrari, C.K.B., and Torres, E.A.F.S. 2003. Biochemical pharmacology of functional foods and prevention of chronic diseases of aging. Biomed. Pharmacother. 57: 251–260. doi:10.1016/S0753-3322(03)00032-5. PMID:12888262.
  • Referans23 Saad AB, Rjeibi I, Alimi H, Ncib S, Bouhamda T, Zouari. Protective effects of Mentha spicata against nicotine-induced toxicity in liver and erythrocytes of Wistar rats. Appl. Physiol. Nutr. Metab. 43: 77–83 (2018) dx.doi.org/10.1139/apnm-2017-0144.
  • Referans24 Hritcu, L., Ionita, R., Motei, D.E., Babii, C., Stefan, M., and Mihasan, M. 2017. Nicotine versus 6-hydroxy-l-nicotine against chlorisondamine induced memory impairment and oxidative stress in the rat hippocampus. Biomed. Pharmacother. 86: 102–108. doi:10.1016/j.biopha.2016.12.008. PMID:27951416
  • Referans25 Halliwell, B. 2006. Reactive species and antioxidants. Redox biology is a fundamental theme for aerobic life. Plant Physiol. 141: 312–322. doi:10.1104/pp.106. 077073. PMID:16760481.
  • Referans26 Karafakıoglu, Y.S., Dündar, Y., Aslan, R., FI˙dan, A.F., and CI˙gercI˙, I.H. 2009. The effects of tobacco harvesting on oxidant-antioxidants status, some biochemical and hematologic markers in women workers. Res. J. Biol. Sci. 4: 691–696. Khanduja, K.L., and Bhardwaj, A. 2003. Stable free radical scavenging and antiperoxidative properties of reservetrol compared in vitro with some other bioflavonoids. Ind. J. Biochem. Biophys. 40: 416–422. PMID:22900369.
  • Referans27 Karabulut D, Ulusoy HB, Kaynak E, Sönmez MF. Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS. Anatol J Cardiol 2016; 16: 310-5.
  • Referans28 Doğanyiğit Z, Okan A, Kaymak E, Pandır D, Silici S. Investigation of protective effects of apilarnil against lipopolysaccharideinduced liver injury in rats via TLR 4/ HMGB-1/ NF-κB pathway. Biomedicine & Pharmacotherapy 125 (2020) 1099673.

Effect of Cornus Mas L. Extract on Organs in Rats Given Nicotine

Year 2020, Volume: 1 Issue: 2, 94 - 99, 30.09.2020

Abstract

Nicotine plays an important role in oxidative stress formation. For this purpose, to reveal the antioxidant effect of cornelian cherry plant, the effects of nicotine-induced oxidative stress.
28 adult Wistar Albino (180-220 g) male rats were used in the study. Rats were divided into four groups as control group (n = 6), cornelian cherry group (n = 7), nicotine group (n = 7) and nicotine + cornelian cherry group (n = 8). While nicotine extract was applied to the experimental group, cornelian cherry extract was applied to the treatment group as well as nicotine. TBARS, SOD, GSH, GSSG, TOS, TAS, Redox potential values were measured by spectrophotometric analysis in lung, brain, kidney, heart and liver tissues. OSI and GSH / GSSG values were calculated as TOS / TAS and GSH / GSSG rates, respectively.
When the experimental groups are examined, it is seen that there is a significant difference between the nicotine-treated group and the other groups (p <0.05). Its effect on lung, brain, kidney, heart and liver tissues is seen biochemically. Especially when the TAS value is examined, a significant difference is observed in the Nicotine group compared to other groups (p <0.05).
Cornelian cherry is understood to be an important plant with antioxidant properties against nicotine by increasing TAS level against oxidative stress formation.

References

  • Referans1 Rosa MB, Fernandes MDS, Bonjardim LR, Gaviao MBD, Calixto LA, Castelo PM. Evaluation of oral mechanical and gustatory sensitivities and salivary cotinine levels in adult smokers. Acta Odontol Scand. 2020;78(4):256-64.
  • Referans2 Zhang P, Li Y, Fu Y, Huang L, Liu B, Zhang L, et al. Inhibition of Autophagy Signaling via 3-methyladenine Rescued Nicotine-Mediated Cardiac Pathological Effects and Heart Dysfunctions. Int J Biol Sci. 2020;16(8):1349-62.
  • Referans3 Wipfli H. The Tobacco Atlas, Fourth Edition. American Journal of Epidemiology. 2012;176(12):1193-.
  • Referans4 Baker CL, Flores NM, Zou KH, Bruno M, Harrison VJ. Benefits of quitting smoking on work productivity and activity impairment in the United States, the European Union and China. Int J Clin Pract. 2017;71(1).
  • Referans5 Yılmaz H, Ertekin T, Atay E, Nisari M, Susar Güler H, Al Ö, et al. Antioxidant role of melatonin against nicotine's teratogenic effects on embryonic bone development. Iran J Basic Med Sci. 2018;21(8):787-93.
  • Referans6 Altun I, Yuksel KZ. An Experimental Study on the Effects of Smoking in the Perinatal Period and During Lactation on the Intervertebral Disks of Newborns. World Neurosurg. 2017;99:1-5.
  • Referans7 Mayyas F, Aldawod H, Alzoubi KH, Khabour O, Shihadeh A, Eissenberg T. Comparison of the cardiac effects of electronic cigarette aerosol exposure with waterpipe and combustible cigarette smoke exposure in rats. Life Sci. 2020;251:117644.
  • Referans8 Khabour OF, Alzoubi KH, Bani-Ahmad M, Dodin A, Eissenberg T, Shihadeh A. Acute exposure to waterpipe tobacco smoke induces changes in the oxidative and inflammatory markers in mouse lung. Inhal Toxicol. 2012;24(10):667-75.
  • Referans9 Mayyas F, Alzoubi KH. Cardiac effects of cigarette tobacco smoking in rat model of diabetes. Life Sci. 2018;211:279-85.
  • Referans10 Selçuk E, Özrenk K. Erzincan Yöresinde Yetiştirilen Kızılcıkların (Cornus mas L.) Fenolojik ve Pomolojik Özelliklerinin Belirlenmesi. Iğdır Univ. J. Inst. Sci. &Tech. 2011; 1(4) 23-30..pdf>.
  • Referans11 Yarilgac T, Kadim H, Ozturk B. Role of maturity stages and modified-atmosphere packaging on the quality attributes of cornelian cherry fruits (Cornus mas L.) throughout shelf life. J Sci Food Agric. 2019;99(1):421-8.
  • Referans12 Dinda B, Kyriakopoulos AM, Dinda S, Zoumpourlis V, Thomaidis NS, Velegraki A, et al. Cornus mas L. (cornelian cherry), an important European and Asian traditional food and medicine: Ethnomedicine, phytochemistry and pharmacology for its commercial utilization in drug industry. J Ethnopharmacol. 2016;193:670-90.
  • Referans13 Yilmaz S, Alpa S, Gocmen AY, Ulger H, Arslan E, Yay AH, et al. The investigation of the antitumoral effect of Cornus mas L in mice with ehrlich solid tumor. Bratisl Lek Listy. 2020;121(1):22-30.
  • Referans14 Wu R, Feng J, Yang Y, Dai C, Lu A, Li J, et al. Significance of Serum Total Oxidant/Antioxidant Status in Patients with Colorectal Cancer. PLoS One. 2017;12(1):e0170003.
  • Referans15 Yılmaz S, Göçmen AY, Üner AK, Akyüz E, Tokpınar A. The protective role of melatonin against the effect of caffeine on embryonic kidney. Turkısh Bulletın Of Hygıene And Experımental Bıology. 2020:61-70.
  • Referans16 Yılmaz S, Ülger H, Ertekin T, Yay AH, Nisari M, Alpa Ş, Acer N. Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created. Iranian Journal of Basic Medical Sciences. 2019; 22:418-425. doi: 10.22038/ijbms.2019.33623.8019
  • Referans17 Nisari M, Yılmaz S, Ertekin T, Ceylan C, İnanç N, Al Ö, Ülger H. Effects of Curcumin on Lipid Peroxidation and Antioxidant Enzymes in Kidney, Liver, Brain and Testis of Mice Bearing Ehrlich Solid Tumor. 2017, 1, 994; doi:10.3390/proceedings1100994.
  • Referans18 Kantekin ÇÜ, Çakırca M, Yaman F, Göçmen AY. Does the Application of Desflurane at The Same Concentration by Different Flows Change the Oxidative Stress? Animal Experiment. Online Türk Sağlık Bilimleri Dergisi. 2019: 4(4); 492-504.
  • Referans19 Momi N, Ponnusamy MP, Kaur S, Rachagani S, Kunigal SS, Chellappan S, et al. Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through a9 nAChR-mediated MUC4 upregulation. Oncogene 2013;32:1384–95.
  • Referans20 El-Sokkary GH, Cuzzocrea S, Reiter RJ. Effect of chronic nicotine administration on the rat lung and liver: beneficial role of melatonin. Toxicology 2007;239: 60–7.
  • Referans21 Dhouib H, Jallouli M, Draief M, Bouraoui S, El-Fazaa S. Oxidative damage and histopathological changes in lung of rat chronically exposed to nicotine alone or associated to ethanol. Pathologie Biologie 63 (2015) 258–267
  • Referans22 Ferrari, C.K.B., and Torres, E.A.F.S. 2003. Biochemical pharmacology of functional foods and prevention of chronic diseases of aging. Biomed. Pharmacother. 57: 251–260. doi:10.1016/S0753-3322(03)00032-5. PMID:12888262.
  • Referans23 Saad AB, Rjeibi I, Alimi H, Ncib S, Bouhamda T, Zouari. Protective effects of Mentha spicata against nicotine-induced toxicity in liver and erythrocytes of Wistar rats. Appl. Physiol. Nutr. Metab. 43: 77–83 (2018) dx.doi.org/10.1139/apnm-2017-0144.
  • Referans24 Hritcu, L., Ionita, R., Motei, D.E., Babii, C., Stefan, M., and Mihasan, M. 2017. Nicotine versus 6-hydroxy-l-nicotine against chlorisondamine induced memory impairment and oxidative stress in the rat hippocampus. Biomed. Pharmacother. 86: 102–108. doi:10.1016/j.biopha.2016.12.008. PMID:27951416
  • Referans25 Halliwell, B. 2006. Reactive species and antioxidants. Redox biology is a fundamental theme for aerobic life. Plant Physiol. 141: 312–322. doi:10.1104/pp.106. 077073. PMID:16760481.
  • Referans26 Karafakıoglu, Y.S., Dündar, Y., Aslan, R., FI˙dan, A.F., and CI˙gercI˙, I.H. 2009. The effects of tobacco harvesting on oxidant-antioxidants status, some biochemical and hematologic markers in women workers. Res. J. Biol. Sci. 4: 691–696. Khanduja, K.L., and Bhardwaj, A. 2003. Stable free radical scavenging and antiperoxidative properties of reservetrol compared in vitro with some other bioflavonoids. Ind. J. Biochem. Biophys. 40: 416–422. PMID:22900369.
  • Referans27 Karabulut D, Ulusoy HB, Kaynak E, Sönmez MF. Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS. Anatol J Cardiol 2016; 16: 310-5.
  • Referans28 Doğanyiğit Z, Okan A, Kaymak E, Pandır D, Silici S. Investigation of protective effects of apilarnil against lipopolysaccharideinduced liver injury in rats via TLR 4/ HMGB-1/ NF-κB pathway. Biomedicine & Pharmacotherapy 125 (2020) 1099673.
There are 28 citations in total.

Details

Primary Language English
Subjects Anatomy
Journal Section Research Articles
Authors

Seher Yilmaz

Adem Tokpınar

Şükrü Ateş

Ünal Öztekin 0000-0001-9568-9442

Serife Alpa

Yeşim Göçmen

Publication Date September 30, 2020
Submission Date June 24, 2020
Published in Issue Year 2020 Volume: 1 Issue: 2

Cite

EndNote Yilmaz S, Tokpınar A, Ateş Ş, Öztekin Ü, Alpa S, Göçmen Y (September 1, 2020) Effect of Cornus Mas L. Extract on Organs in Rats Given Nicotine. New Trends in Medicine Sciences 1 2 94–99.