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Gül ekstresinin kolinesteraz inhibisyon potansiyelinin belirlenmesi

Year 2018, Volume: 33 Issue: 3, 237 - 240, 18.10.2018
https://doi.org/10.7161/omuanajas.465971

Abstract

Yağ gülü
veya Isparta gülü olarak bilinen Rosa
damascena Mill.
, dünya genelinde kokulu güller arasında kültürü yapılan ve
ekonomik açıdan önemli olan gül türlerinden bir tanesidir. Isparta gülünden
elde edilen uçucu yağ özellikle kozmetik, parfümeri, ilaç ve gıda sanayisinde
kullanılmaktadır. Isparta gülü geleneksel olarak göğüs ve karın ağrılarının
tedavisinde, kalbin güçlendirilmesi, kabızlık, sindirim sorunları ve sinirsel
hastalıkların tedavisinde kullanıldığı bilinmektedir. Alzheimer hastalığının
(AD) patogenezi henüz netleşmemesine rağmen, kabul gören teorilerden biri
"kolinerjik hipotez" olmuştur. Alzheimer hastalarının beyinlerinde
asetilkolin (ACh) ve bütirilkolin (BCh) olarak adlandırılan nöromediyatör
düzeylerinde eksiklik görülmüştür. Sırasıyla ACh ve BCh'yi hidroliz eden temel
enzimler olan asetilkolinesteraz (AChE) ve bütirilkolinesterazın (BChE)
inhibisyonu AD'ye karşı önemli bir tedavi seçeneği haline gelmiştir. Bu
nedenle, AD patogenezinde yer alan anahtar enzimler olan AChE ve BChE aktivitelerini
önleme faaliyetlerini taramak için bir araştırma başlattık. Bu amaçla, gül
suyunun bu enzimler üzerindeki inhibisyon etkilerini inceledik. IC50
değerleri AChE için 0.6227 µg ml-1 BChE için 0.1956 µg ml-1
olarak belirlendi.

References

  • Baydar, H., 2005. Tıbbi, Aromatik ve Keyf Bitkileri(Bilim ve Teknolojisi), Süleyman Demirel Üniversitesi Yayınları, No: 51.
  • Baser, K.H.C. Altintas, A., Kurkcuoglu, M. 2012. “Turkish Rose: A review of the history, ethnobotany and modern uses of rose petals, rose oil, rose water and other rose products”, HerbalGram 96: 40-53.
  • Basiri, A., Murugaiyaha, V., Osman, H., et al. 2013. An expedient, ionic liquid mediated multi-component synthesis of novel piperidone grafted cholinesterase enzymes inhibitors and their molecular modeling study. Eur. J. Med. Chem. 67, 221-229.
  • Darvesh, S., Hopkins, D.A., Geula, C. 2003. Neurobiology of butyrylcholinesterase. Nat. Rev. Neurosci. 4, 131-138.
  • Ellman, G.L., Courtney, D., Andies, V., Featherstone, R.M. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7, 88-95.
  • Howes, M.J., Houghton, P.J. 2003. Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function. Pharmacol. Biochem. Behav. 75(3):513-27.
  • Lambert, J., Heath, S., Even, G., et al. 2009. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease. Nat. Genet., 41, 1094-1099.
  • Massoud, F., Le´ger, G. 2011. Pharmacological treatment of Alzheimer disease. Can. J. Psychiatry. 56, 579-588.
  • Mukherjee, P.K. Kumar, V. Mal, M., Houghton, P.J. 2007. Acetylcholinesterase inhibitors from plants.Phytomedicine, 14 (4), 289-300.
  • Özçelik, H., Muca, B., Özavcı, A.G.M., 2011. Isparta Yağ gülü (Rosa x damascena Mill.) Yağı ve Çiçeklerinin Strese Bağlı Nörolojik ve Psikiyatrik Hastalıklara Etkileri. Biyoloji Bilimleri Araştırma Dergisi. 4,2: 99-105.
  • Özçelik, H., Yildirim, B., Muca, B., 2013. Rosa damascena Mill.’ nın Türkiye’ de Varyasyonu. Suleyman Demirel University Journal of Natural and Applied Science. 17(2), 52-60.
  • Senol, F.S., Orhan, I.E., Kurkcuoglu, M., Khan, M.T.H., Altintas, A., Sener, B., Baser, K.H.C. 2013. A mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.). Food Research International 53; 502-509.
  • Seshadri, S., Fitzpatrick, A.L., Ikram, M.A., et al. 2010. Genome-wide analysis of genetic loci associated with Alzheimer disease. J. Am. Med. Assoc., 303, 1832-1840.
  • Singh, M., Kaur, M., Kukreja, H., et al. 2013. Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection. Eur. J. Med. Chem. 70, 165-188.

Determination of cholinesterase inhibition potential of rose extract

Year 2018, Volume: 33 Issue: 3, 237 - 240, 18.10.2018
https://doi.org/10.7161/omuanajas.465971

Abstract

Rosa Damascena Mill., also known as oil rose
or rose of Isparta, is one of the most important roses among the fragrant roses
in the world. The essential oil obtained from Isparta rose is used especially
in cosmetics, perfumery, pharmaceutical and food industries. Isparta rose is
traditionally used in the treatment of chest and abdominal pain, strengthening
of the heart, constipation, digestive problems and is used in the treatment of
neural diseases. Although pathogenesis of Alzheimer’s disease (AD) has not been
clarified as yet, one of the most accepted theories has been ‘‘cholinergic
hypothesis”. A deficiency in levels of the neuromediators called acetylcholine
(ACh) and butyrylcholine (BCh) has been observed in the brains of AD
patients.  Inhibition of
acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), the main enzymes
which hydrolyze ACh and BCh, respectively, has happen a major treatment option
towards AD. So, we initiated a study to screen their AChE and BChE inhibitory
activities, which are the key enzymes taking place in pathogenesis of AD. For
this purpose, we investigated the effects of rose water on these enzymes. IC50
values were determined as 0.6227 µg ml-1 for AChE and 0.1956 μg/ml
for BChE.

References

  • Baydar, H., 2005. Tıbbi, Aromatik ve Keyf Bitkileri(Bilim ve Teknolojisi), Süleyman Demirel Üniversitesi Yayınları, No: 51.
  • Baser, K.H.C. Altintas, A., Kurkcuoglu, M. 2012. “Turkish Rose: A review of the history, ethnobotany and modern uses of rose petals, rose oil, rose water and other rose products”, HerbalGram 96: 40-53.
  • Basiri, A., Murugaiyaha, V., Osman, H., et al. 2013. An expedient, ionic liquid mediated multi-component synthesis of novel piperidone grafted cholinesterase enzymes inhibitors and their molecular modeling study. Eur. J. Med. Chem. 67, 221-229.
  • Darvesh, S., Hopkins, D.A., Geula, C. 2003. Neurobiology of butyrylcholinesterase. Nat. Rev. Neurosci. 4, 131-138.
  • Ellman, G.L., Courtney, D., Andies, V., Featherstone, R.M. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7, 88-95.
  • Howes, M.J., Houghton, P.J. 2003. Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function. Pharmacol. Biochem. Behav. 75(3):513-27.
  • Lambert, J., Heath, S., Even, G., et al. 2009. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease. Nat. Genet., 41, 1094-1099.
  • Massoud, F., Le´ger, G. 2011. Pharmacological treatment of Alzheimer disease. Can. J. Psychiatry. 56, 579-588.
  • Mukherjee, P.K. Kumar, V. Mal, M., Houghton, P.J. 2007. Acetylcholinesterase inhibitors from plants.Phytomedicine, 14 (4), 289-300.
  • Özçelik, H., Muca, B., Özavcı, A.G.M., 2011. Isparta Yağ gülü (Rosa x damascena Mill.) Yağı ve Çiçeklerinin Strese Bağlı Nörolojik ve Psikiyatrik Hastalıklara Etkileri. Biyoloji Bilimleri Araştırma Dergisi. 4,2: 99-105.
  • Özçelik, H., Yildirim, B., Muca, B., 2013. Rosa damascena Mill.’ nın Türkiye’ de Varyasyonu. Suleyman Demirel University Journal of Natural and Applied Science. 17(2), 52-60.
  • Senol, F.S., Orhan, I.E., Kurkcuoglu, M., Khan, M.T.H., Altintas, A., Sener, B., Baser, K.H.C. 2013. A mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.). Food Research International 53; 502-509.
  • Seshadri, S., Fitzpatrick, A.L., Ikram, M.A., et al. 2010. Genome-wide analysis of genetic loci associated with Alzheimer disease. J. Am. Med. Assoc., 303, 1832-1840.
  • Singh, M., Kaur, M., Kukreja, H., et al. 2013. Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection. Eur. J. Med. Chem. 70, 165-188.
There are 14 citations in total.

Details

Primary Language Turkish
Journal Section Agricultural Biotechnology
Authors

Esra Şentürk

Murat Şentürk

Publication Date October 18, 2018
Acceptance Date October 13, 2018
Published in Issue Year 2018 Volume: 33 Issue: 3

Cite

APA Şentürk, E., & Şentürk, M. (2018). Gül ekstresinin kolinesteraz inhibisyon potansiyelinin belirlenmesi. Anadolu Tarım Bilimleri Dergisi, 33(3), 237-240. https://doi.org/10.7161/omuanajas.465971
AMA Şentürk E, Şentürk M. Gül ekstresinin kolinesteraz inhibisyon potansiyelinin belirlenmesi. ANAJAS. October 2018;33(3):237-240. doi:10.7161/omuanajas.465971
Chicago Şentürk, Esra, and Murat Şentürk. “Gül Ekstresinin Kolinesteraz Inhibisyon Potansiyelinin Belirlenmesi”. Anadolu Tarım Bilimleri Dergisi 33, no. 3 (October 2018): 237-40. https://doi.org/10.7161/omuanajas.465971.
EndNote Şentürk E, Şentürk M (October 1, 2018) Gül ekstresinin kolinesteraz inhibisyon potansiyelinin belirlenmesi. Anadolu Tarım Bilimleri Dergisi 33 3 237–240.
IEEE E. Şentürk and M. Şentürk, “Gül ekstresinin kolinesteraz inhibisyon potansiyelinin belirlenmesi”, ANAJAS, vol. 33, no. 3, pp. 237–240, 2018, doi: 10.7161/omuanajas.465971.
ISNAD Şentürk, Esra - Şentürk, Murat. “Gül Ekstresinin Kolinesteraz Inhibisyon Potansiyelinin Belirlenmesi”. Anadolu Tarım Bilimleri Dergisi 33/3 (October 2018), 237-240. https://doi.org/10.7161/omuanajas.465971.
JAMA Şentürk E, Şentürk M. Gül ekstresinin kolinesteraz inhibisyon potansiyelinin belirlenmesi. ANAJAS. 2018;33:237–240.
MLA Şentürk, Esra and Murat Şentürk. “Gül Ekstresinin Kolinesteraz Inhibisyon Potansiyelinin Belirlenmesi”. Anadolu Tarım Bilimleri Dergisi, vol. 33, no. 3, 2018, pp. 237-40, doi:10.7161/omuanajas.465971.
Vancouver Şentürk E, Şentürk M. Gül ekstresinin kolinesteraz inhibisyon potansiyelinin belirlenmesi. ANAJAS. 2018;33(3):237-40.
Online ISSN: 1308-8769