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Year 2011, Volume: 28 Issue: 2, 71 - 78, 19.03.2012

Abstract

References

  • Andersson, K.E. 2002. Bladder activation: afferent mechanisms. Urology. 59, 43-50.
  • Andersson, K.E., Anders, A. 2004. Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev. 84, 935–986.
  • Andersson, K.E. 2010. Detrusor myocyte activity and afferent signaling. Neurourol Urodyn. 29, 97-106.
  • Badawi, J.K, Seja, T., Bross, S. 2008. In vitro effects of the cyclooxygenase inhibitor indomethacin and of the phospholipase-C inhibitor U-73122 on carbachol-induced contractions of porcine detrusor muscle. Fundam Clin. Pharmacol. 22, 667-72.
  • Bjorling, D.E., Saban, M.R., Bruskewitz, R.C., Saban, R.A. 1994. Response of the isolated guinea pig bladder to exogenous and leukotriens. J. Urol. 152, 1281-1286.
  • Bolle, P., Tucci, P. 1998. Response to isoprenalin of rabbit detrusor strips following exposure to NSAIDs. Pharmacol Res. 37, 395-401.
  • Bolle, P., Fidanza S., Tucci P. 1999. Response to isoprenaline of rabbit detrusor muscle following exposure to 5,8,11,14 eicosatetraynoic acid. Role of prostanoids on beta-adrenergic –evoked response. J. Auton Pharmacol. 19, 161-165.
  • Brading A.F., Williams J.H. 1990. Contractile responses of smooth muscle strips from rat and guinea pig urinary bladder to transmural stimula- tion: effects of atropine and alpha,beta-metylene ATP. Br. J. Pharmacol. 99,493-498.
  • Choo, L.K., Mitchelson, F. 1980. The effect of indomethacin and adenosine 5’-triphoshate on the excitatory innervation of the rat urinary bladder. Can. J. Physiol. Pharmacol. 58, 1042-1048.
  • Creed, K.E., Callahan, S.M. 1989. Prostaglandin and neurotransmission at the guinea pig and rabbit urinary bladder. Eur. J. Physiol. 413, 299- 302.
  • de Groat, W. 2006. Integrative control of the lower urinary tract: preclinical perspective. Br. J. Pharmacol. 147, 25–40.
  • Dean, D.M., Downie, J.W. 1978. Interaction of prostaglandins and adenosine 5'-triphosphate in the noncholinergic neurotransmission in rabbit detrusor. Prostaglandins. 16, 245-251.
  • Giglio, D., Tobin, G. 2009. Muscarinic receptor subtypes in the lower urinary tract. Pharmacology. 83, 259-269.
  • Grilli, M., Pizzi, M., Memo, M., Spano, P. 1996. Neuroprotection by aspirin and sodium salicylate through blockade of NF-kB activation. Sci- ence. 274, 1383-1385.
  • Hoyle, C.H.V. 1994. Non-adrenergic, non-cholinergic control of the urinary bladder. World J. Urol. 12, 233-244.
  • Khan, M.A., Thompson, C.S., Mumtaz, F., H., Jeremy, J.Y. 1998. Role of prostaglandins in the urinary bladder: an update. Prostaglandins Leukot Essent Fatty Acids. 59, 415-422.
  • Khattab, M., AL-Shabanah, O., EL-Kashef, H. 2002. Comparative study of the contractile activity evoked by ATP and diadenosine tetraphos- phate in isolated rat urinary bladder ATP- NSAIDs. Pharmacol. Res. 45, 93-99.
  • Kishii, K-I., Tetsuhiro, H.I.T. 1992. Comparison of contractile mechanisms by carbachol and ATP in detrusor strips of rabbit urinary bladder. Japan. J. Pharmacol. 58, 219-229.
  • Klarskov, P. 1987. Influence of prostaglandins and ketoprofen on contractile responses of human and pig detrusor and trigone muscles in vitro. Pharmacol. Toxicol. 61, 37-41.
  • Kories, C., Cyzborra, C., Fetscher, C., Schneider, T. 2003. Gender comparison of muscarinic receptor expression and function in rat and human urinary bladder:differential regulation of M2 and M3. Naunyn Schmeiderbergs Arch. Pharmacol. 367, 524-531.
  • Lai, H.H., Smith, C.P., Munoz, A., Boone, T.B., Szigeti, G.P., Somogyi, G.T. 2008. Activation of cholinergic receptors blocks non-adrenergic non-cholinergic contractions in the rat urinary bladder. Brain Res. Bull. 77, 420-426.
  • Lluel, P., Barras, M., Palea, S. 2002. Cholinergic and purinergic contribution to the micturition reflex in conscious rats with longterm bladder outlet obstruction. Neurourol. Urodyn. 21, 142–153.
  • Maggi, A.A., Evangelista, S., Grimaldi, G. 1984. Evidence for the involvement of arachidonic acid metabolites in spontaneous and drug-induced contractions of rat urinary bladder. J. Pharmacol. Exp. Ther. 230, 500-513.
  • Naramatsu, M., Yamashita, T., Kokubun, S. 1997. The signalling pathway which causes contraction via P2-purinoceptors in rat urinary bladder smooth muscle. Br. Pharmacol. 122, 558-562.
  • Nile, C.J, de Vente, J., Gillespie, J.I. 2010. Stretch independent regulation of prostaglandin E(2) production within the isolated guinea-piglamina propria. BJU Int.105, 540-548.
  • Picado, C. 2006. Mechanisms of aspirin sensitivity. Curr. Allergy Asthma Rep. 6, 198-202.
  • Schneider, T., Hein, T., Michel, M.C. 2004. Signal transduction underlying carbachol- induced contraction of rat urinary bladder. I. Phospholi- pases and Ca++ sources. J. Pharmacol. Exp. Ther. 308, 47-53.
  • Schröder, A., Levin, R.M., Kogan, B.A. 2001. Aspirin treatment improves bladder function after outlet obstruction in rabbits. Urology. 58, 608–613.
  • Takagi-Matsumoto H., Tsukimi, Y., Tajimi, M. 2004. Effects of NSAIDs on bladder function in normal and cystitis rats:a comparison study of aspirin, indomethacin, and ketoprofen. J. Pharmacol. Sci. 95, 458–465.
  • Tucci, P., Bartocci, C., Bolle, P. 2002. Cyclo-oxygenase- and capsaicin-sensitive afferent fibres affect beta-adrenoceptor –evoked response in the rat urinary bladder. Pharmacol. 64, 57-62.
  • Velasco, C., Angelico, P., Guarneri, L., Leonardi, A., Clarke, D.E. 2001. Effects of the nuclear factor-kappaB inhibitors 2-hydroxy-4-trifluo rom ethylbenzoic acid and aspirin on micturition in rats with normal and inflamed bladder. J. Urol. 66, 1962–1968.
  • Wust, M., Averbeck, B., Reif, S., Brater, M. 2002. Different responses to drugs against overactive bladder in detrusor muscle of pig, guinea pig and mouse. Eur. J. Pharmacol. 454, 59–69.

Non-Steroidal Anti-İnflamatuar İlaçların İzole Sıçan Mesanesi Detrüsör Striplerine Etkisi

Year 2011, Volume: 28 Issue: 2, 71 - 78, 19.03.2012

Abstract

Bu çalışmada farklı gruplardan non-steroidal anti-inflamatuar ilaçların (NSAİİ) mesane kas motilitesinin düzenlenmesine katılan çeşitli fizyolojik mekanizmalar üzerindeki etkileri izole sıçan mesanesi detrusör striplerinde incelendi. Bu amaçla; aspirin, indometazin ve ketoprofen varlığında izole detrusör striplerinin karbakol, isoprenalin ve elektriksel alan stimülasyonu (EAS)’na verdiği yanıtlar değerlendirildi. İn vitro çalışmalar için, mesane detrüsör kasları çıkarılarak organ banyolarına asıldı. Deney protokolünün başlangıcında, detrüsör kaslarının karbakol, isoprenalin ve EAS’ye verdiği yanıtlar kontrol yanıtları kabul edilerek kaydedildi. Daha sonra, bu yanıtlar NSAİİ’lar ile 30 dakika muamelenin (inkübasyon) ardından tekrar alındı. Her bir NSAİİ varlığında mesane bazal tonuslarında meydan gelen değişiklikler de değerlendirildi. Aspirin varlığında mesane bazal tonusu değişmedi. Düşük konsantrasyonlarda aspirin (10-8M ve 10-7M) detrusör striplerinin karbakole verdiği yanıtları anlamlı olarak azalttı, fakat daha yüksek konsantrasyonlarda (10-6-10-4M) kontrol yanıtları ile karşılaştırıldığında anlamlı fark bulunmadı. İsoprenalin yanıtları, aspirin (10-7-10-5M) varlığında değişmedi. Aspirin, sadece en düşük konsantrasyonda (10-7M) EAS’nun yüksek frekanslı yanıtlarını anlamlı olarak azalttı, fakat düşük frekanslı yanıtlarını değiştirmedi. Bununla birlikte, daha yüksek konsantrasyonlarda (10-6M, 10-5M) EAS yanıtları üzerinde etkili bulunmadı. İndometazin varlığında (10-7-10-5M) bazal tonus azaldı. Karbakol ve EAS yanıtları değişmedi. İsoprenalin yanıtları indometazin ile muamelenin ardından doz bağımlı olarak azaldı. Ketoprofen (10-7-10-5M) ile inkübasyon bazal tonusta düşüşe neden oldu ve karbakol yanıtlarını anlamlı olarak artırdı. Sadece en yüksek ketoprofen konsantrasyonu isoprenalin yanıtlarını anlamlı olarak azalttı. Ketoprofen kullanılan dozların hiçbirinde EAS yanıtlarını değiştirmedi. Sonuçlarımız, izole detrüsör striplerinde NSAİİ’lar varlığında karbakol, isoprenalin ve EAS yanıtlarında meydana gelen değişikliklerin temel olarak prostaglandin sentez inhibisyonu ile ilişkili olduğunu göstermektedir. Ancak diğer mekanizmaların katkısı da göz ardı edilmemelidir. Bununla birlikte, farklı gruplardan NSAİİ’ların bu yanıtlar üzerindeki etkileri birbirlerinden farklıdır.

References

  • Andersson, K.E. 2002. Bladder activation: afferent mechanisms. Urology. 59, 43-50.
  • Andersson, K.E., Anders, A. 2004. Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev. 84, 935–986.
  • Andersson, K.E. 2010. Detrusor myocyte activity and afferent signaling. Neurourol Urodyn. 29, 97-106.
  • Badawi, J.K, Seja, T., Bross, S. 2008. In vitro effects of the cyclooxygenase inhibitor indomethacin and of the phospholipase-C inhibitor U-73122 on carbachol-induced contractions of porcine detrusor muscle. Fundam Clin. Pharmacol. 22, 667-72.
  • Bjorling, D.E., Saban, M.R., Bruskewitz, R.C., Saban, R.A. 1994. Response of the isolated guinea pig bladder to exogenous and leukotriens. J. Urol. 152, 1281-1286.
  • Bolle, P., Tucci, P. 1998. Response to isoprenalin of rabbit detrusor strips following exposure to NSAIDs. Pharmacol Res. 37, 395-401.
  • Bolle, P., Fidanza S., Tucci P. 1999. Response to isoprenaline of rabbit detrusor muscle following exposure to 5,8,11,14 eicosatetraynoic acid. Role of prostanoids on beta-adrenergic –evoked response. J. Auton Pharmacol. 19, 161-165.
  • Brading A.F., Williams J.H. 1990. Contractile responses of smooth muscle strips from rat and guinea pig urinary bladder to transmural stimula- tion: effects of atropine and alpha,beta-metylene ATP. Br. J. Pharmacol. 99,493-498.
  • Choo, L.K., Mitchelson, F. 1980. The effect of indomethacin and adenosine 5’-triphoshate on the excitatory innervation of the rat urinary bladder. Can. J. Physiol. Pharmacol. 58, 1042-1048.
  • Creed, K.E., Callahan, S.M. 1989. Prostaglandin and neurotransmission at the guinea pig and rabbit urinary bladder. Eur. J. Physiol. 413, 299- 302.
  • de Groat, W. 2006. Integrative control of the lower urinary tract: preclinical perspective. Br. J. Pharmacol. 147, 25–40.
  • Dean, D.M., Downie, J.W. 1978. Interaction of prostaglandins and adenosine 5'-triphosphate in the noncholinergic neurotransmission in rabbit detrusor. Prostaglandins. 16, 245-251.
  • Giglio, D., Tobin, G. 2009. Muscarinic receptor subtypes in the lower urinary tract. Pharmacology. 83, 259-269.
  • Grilli, M., Pizzi, M., Memo, M., Spano, P. 1996. Neuroprotection by aspirin and sodium salicylate through blockade of NF-kB activation. Sci- ence. 274, 1383-1385.
  • Hoyle, C.H.V. 1994. Non-adrenergic, non-cholinergic control of the urinary bladder. World J. Urol. 12, 233-244.
  • Khan, M.A., Thompson, C.S., Mumtaz, F., H., Jeremy, J.Y. 1998. Role of prostaglandins in the urinary bladder: an update. Prostaglandins Leukot Essent Fatty Acids. 59, 415-422.
  • Khattab, M., AL-Shabanah, O., EL-Kashef, H. 2002. Comparative study of the contractile activity evoked by ATP and diadenosine tetraphos- phate in isolated rat urinary bladder ATP- NSAIDs. Pharmacol. Res. 45, 93-99.
  • Kishii, K-I., Tetsuhiro, H.I.T. 1992. Comparison of contractile mechanisms by carbachol and ATP in detrusor strips of rabbit urinary bladder. Japan. J. Pharmacol. 58, 219-229.
  • Klarskov, P. 1987. Influence of prostaglandins and ketoprofen on contractile responses of human and pig detrusor and trigone muscles in vitro. Pharmacol. Toxicol. 61, 37-41.
  • Kories, C., Cyzborra, C., Fetscher, C., Schneider, T. 2003. Gender comparison of muscarinic receptor expression and function in rat and human urinary bladder:differential regulation of M2 and M3. Naunyn Schmeiderbergs Arch. Pharmacol. 367, 524-531.
  • Lai, H.H., Smith, C.P., Munoz, A., Boone, T.B., Szigeti, G.P., Somogyi, G.T. 2008. Activation of cholinergic receptors blocks non-adrenergic non-cholinergic contractions in the rat urinary bladder. Brain Res. Bull. 77, 420-426.
  • Lluel, P., Barras, M., Palea, S. 2002. Cholinergic and purinergic contribution to the micturition reflex in conscious rats with longterm bladder outlet obstruction. Neurourol. Urodyn. 21, 142–153.
  • Maggi, A.A., Evangelista, S., Grimaldi, G. 1984. Evidence for the involvement of arachidonic acid metabolites in spontaneous and drug-induced contractions of rat urinary bladder. J. Pharmacol. Exp. Ther. 230, 500-513.
  • Naramatsu, M., Yamashita, T., Kokubun, S. 1997. The signalling pathway which causes contraction via P2-purinoceptors in rat urinary bladder smooth muscle. Br. Pharmacol. 122, 558-562.
  • Nile, C.J, de Vente, J., Gillespie, J.I. 2010. Stretch independent regulation of prostaglandin E(2) production within the isolated guinea-piglamina propria. BJU Int.105, 540-548.
  • Picado, C. 2006. Mechanisms of aspirin sensitivity. Curr. Allergy Asthma Rep. 6, 198-202.
  • Schneider, T., Hein, T., Michel, M.C. 2004. Signal transduction underlying carbachol- induced contraction of rat urinary bladder. I. Phospholi- pases and Ca++ sources. J. Pharmacol. Exp. Ther. 308, 47-53.
  • Schröder, A., Levin, R.M., Kogan, B.A. 2001. Aspirin treatment improves bladder function after outlet obstruction in rabbits. Urology. 58, 608–613.
  • Takagi-Matsumoto H., Tsukimi, Y., Tajimi, M. 2004. Effects of NSAIDs on bladder function in normal and cystitis rats:a comparison study of aspirin, indomethacin, and ketoprofen. J. Pharmacol. Sci. 95, 458–465.
  • Tucci, P., Bartocci, C., Bolle, P. 2002. Cyclo-oxygenase- and capsaicin-sensitive afferent fibres affect beta-adrenoceptor –evoked response in the rat urinary bladder. Pharmacol. 64, 57-62.
  • Velasco, C., Angelico, P., Guarneri, L., Leonardi, A., Clarke, D.E. 2001. Effects of the nuclear factor-kappaB inhibitors 2-hydroxy-4-trifluo rom ethylbenzoic acid and aspirin on micturition in rats with normal and inflamed bladder. J. Urol. 66, 1962–1968.
  • Wust, M., Averbeck, B., Reif, S., Brater, M. 2002. Different responses to drugs against overactive bladder in detrusor muscle of pig, guinea pig and mouse. Eur. J. Pharmacol. 454, 59–69.
There are 32 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Internal Medical Sciences
Authors

Duygu Baş

Süleyman Bilge

Yüksel Kesim

Publication Date March 19, 2012
Submission Date March 8, 2011
Published in Issue Year 2011 Volume: 28 Issue: 2

Cite

APA Baş, D., Bilge, S., & Kesim, Y. (2012). Non-Steroidal Anti-İnflamatuar İlaçların İzole Sıçan Mesanesi Detrüsör Striplerine Etkisi. Journal of Experimental and Clinical Medicine, 28(2), 71-78.
AMA Baş D, Bilge S, Kesim Y. Non-Steroidal Anti-İnflamatuar İlaçların İzole Sıçan Mesanesi Detrüsör Striplerine Etkisi. J. Exp. Clin. Med. March 2012;28(2):71-78.
Chicago Baş, Duygu, Süleyman Bilge, and Yüksel Kesim. “Non-Steroidal Anti-İnflamatuar İlaçların İzole Sıçan Mesanesi Detrüsör Striplerine Etkisi”. Journal of Experimental and Clinical Medicine 28, no. 2 (March 2012): 71-78.
EndNote Baş D, Bilge S, Kesim Y (March 1, 2012) Non-Steroidal Anti-İnflamatuar İlaçların İzole Sıçan Mesanesi Detrüsör Striplerine Etkisi. Journal of Experimental and Clinical Medicine 28 2 71–78.
IEEE D. Baş, S. Bilge, and Y. Kesim, “Non-Steroidal Anti-İnflamatuar İlaçların İzole Sıçan Mesanesi Detrüsör Striplerine Etkisi”, J. Exp. Clin. Med., vol. 28, no. 2, pp. 71–78, 2012.
ISNAD Baş, Duygu et al. “Non-Steroidal Anti-İnflamatuar İlaçların İzole Sıçan Mesanesi Detrüsör Striplerine Etkisi”. Journal of Experimental and Clinical Medicine 28/2 (March 2012), 71-78.
JAMA Baş D, Bilge S, Kesim Y. Non-Steroidal Anti-İnflamatuar İlaçların İzole Sıçan Mesanesi Detrüsör Striplerine Etkisi. J. Exp. Clin. Med. 2012;28:71–78.
MLA Baş, Duygu et al. “Non-Steroidal Anti-İnflamatuar İlaçların İzole Sıçan Mesanesi Detrüsör Striplerine Etkisi”. Journal of Experimental and Clinical Medicine, vol. 28, no. 2, 2012, pp. 71-78.
Vancouver Baş D, Bilge S, Kesim Y. Non-Steroidal Anti-İnflamatuar İlaçların İzole Sıçan Mesanesi Detrüsör Striplerine Etkisi. J. Exp. Clin. Med. 2012;28(2):71-8.