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Naringin protects against colistin-induced sciatic nerve damage by reducing oxidative stress, apoptosis and inflammation damage

Year 2024, Volume: 41 Issue: 1, 53 - 59, 29.03.2024

Selçuk Yılmaz Sefa Küçükler Hasan Şimşek Serpil Aygörmez Fatih Mehmet Kandemir

Abstract

Colistin is used in treatment against gram-negative bacteria. It causes toxic effects due to oxidative stress in a dose-dependent manner. Naringin is a flavonoid with strong antioxidant properties found naturally in many plants, especially citrus fruits. This study aimed to determine the protective effects of NRG in CLS-induced sciatic nerve injury. Thirty-five male Spraque rats were randomly divided into five groups: control, NRG, CLS, CLS+NRG50, and CLS+NRG100. CLS was administered orally at a 15 mg/kg dose for seven days. NRG was administered orally at 50 or 100 mg/kg doses for seven days. Sciatic nerve tissues were collected and analyzed for oxidative stress markers, inflammation, and apoptosis damage levels by biochemical methods. CLS caused toxic damage in sciatic nerve tissue by increasing lipid peroxidation (MDA) and decreasing antioxidant capacity (SOD, CAT, GPx, and GSH); increasing NF-κB, TNF-α, nNOS release; increasing apoptotic factor (Caspase-3); decreasing HO-1 and nCAM; and inducing 8-OHdG, MAPK and GFAP (p<0.05). NRG, on the other hand, reversed all these changes in sciatic nerve tissue and reduced CLS-induced oxidative stress damage, inflammatory damage and apoptotic damage (p<0.05). These effects were more effective at the 100 mg/kg dose of NRG than at the 50 mg/kg dose (p<0.05). In sciatic nerve tissue, CLS induced sciatic nerve toxicity with increased oxidative stress, inflammation, and apoptotic damage. NRG showed a protective effect against CLS-induced sciatic nerve toxicity.

Keywords

Apoptosis Colistin Naringin Oxidative stress Sciatic nerve

References

  • Aksu EH, Kandemir FM, Küçükler S, Mahamadu A. Improvement in colistin-induced reproductive damage, apoptosis, and autophagy in testes via reducing oxidative stress by chrysin. J Biochem Mol Toxicol. 2018 Nov;32(11):e22201.
  • Aksu EH, Kandemir FM, Küçükler S. The effects of hesperidin on colistin-induced reproductive damage, autophagy, and apoptosis by reducing oxidative stress. Andrologia. 2021 Mar;53(2):e13900.
  • Çelik H, Kandemir FM, Caglayan C, Özdemir S, Çomaklı S, Kucukler S, et al. Neuroprotective effect of rutin against colistin-induced oxidative stress, inflammation and apoptosis in rat brain associated with the CREB/BDNF expressions. Mol Biol Rep. 2020 Mar;47(3):2023-2034.
  • Dai C, Li J, Lin W, Li G, Sun M, Wang F, et al. Electrophysiology and ultrastructural changes in mouse sciatic nerve associated with colistin sulfate exposure. Toxicol Mech Methods. 2012 Oct;22(8):592-6. Dai C, Li J, Li J. New insight in colistin induced neurotoxicity with the mitochondrial dysfunction in mice central nervous tissues. Exp Toxicol Pathol. 2013 Sep;65(6):941-8.
  • Dai C, Tang S, Biao X, Xiao X, Chen C, Li J. Colistin induced peripheral neurotoxicity involves mitochondrial dysfunction and oxidative stress in mice. Mol Biol Rep. 2019 Apr;46(2):1963-1972.
  • Caglayan C, Kandemir FM, Ayna A, Gür C, Küçükler S, Darendelioğlu E. Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway. Metab Brain Dis. 2022 Aug;37(6):1931-1940.
  • Varışlı B, Caglayan C, Kandemir FM, Gür C, Ayna A, Genç A, et al. Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress in rats. Mol Biol Rep. 2023 Jan;50(1):433-442.
  • Ghanbari-Movahed M, Jackson G, Farzaei MH, Bishayee A. A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies. Front Pharmacol. 2021 Mar 29;12:639840.
  • Akintunde JK, Akintola TE, Adenuga GO, Odugbemi ZA, Adetoye RO, Akintunde OG. Naringin attenuates Bisphenol-A mediated neurotoxicity in hypertensive rats by abrogation of cerebral nucleotide depletion, oxidative damage and neuroinflammation. Neurotoxicology. 2020 Dec;81:18-33.
  • Kaur G, Prakash A. Involvement of the nitric oxide signaling in modulation of naringin against intranasal manganese and intracerbroventricular β-amyloid induced neurotoxicity in rats. J Nutr Biochem. 2020 Feb;76:108255.
  • Garabadu D, Agrawal N. Naringin Exhibits Neuroprotection Against Rotenone-Induced Neurotoxicity in Experimental Rodents. Neuromolecular Med. 2020 Jun;22(2):314-330.
  • Semis HS, Kandemir FM, Caglayan C, Kaynar O, Genc A, Arıkan SM. Protective effect of naringin against oxaliplatin-induced peripheral neuropathy in rats: A behavioral and molecular study. J Biochem Mol Toxicol. 2022 Sep;36(9):e23121.
  • Temel Y, Çağlayan C, Ahmed BM, Kandemir FM, Çiftci M. The effects of chrysin and naringin on cyclophosphamide-induced erythrocyte damage in rats: biochemical evaluation of some enzyme activities in vivo and in vitro. Naunyn Schmiedebergs Arch Pharmacol. 2021 Apr;394(4):645-654.
  • Semis HS, Kandemir FM, Kaynar O, Dogan T, Arikan SM. The protective effects of hesperidin against paclitaxel-induced peripheral neuropathy in rats. Life Sci. 2021 Dec 15;287:120104.
  • Placer ZA, Cushman LL, Johnson BC. Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem. 1966; 16(2):359-64.
  • Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1988; 34(3):497-500.
  • Aebi H. Catalase in vitro. Methods Enzymol. 1984; 105:121-26.
  • Lawrence RA, Burk RF. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun. 1976; 71(4):952-58.
  • Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 1968; 25(1):192-205.
  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193(1):265-75.
  • Hanedan B, Ozkaraca M, Kirbas A, Kandemir FM, Aktas MS, Kilic K, et al. Investigation of the effects of hesperidin and chrysin on renal injury induced by colistin in rats. Biomed Pharmacother. 2018 Dec;108:1607-1616.
  • Akaras N, Abuc OO, Koc K, Bal T, Geyikoglu F, Atilay H, et al. (1 → 3)-β-d-glucan enhances the toxicity induced by Bortezomib in rat testis. J Food Biochem. 2020 Mar;44(3):e13155.
  • Thayumanavan G, Jeyabalan S, Fuloria S, Sekar M, Ravi M, Selvaraj LK, et al. Silibinin and Naringenin against Bisphenol A-Induced Neurotoxicity in Zebrafish Model-Potential Flavonoid Molecules for New Drug Design, Development, and Therapy for Neurological Disorders. Molecules. 2022 Apr 15;27(8):2572.
  • Kandemir FM, Kucukler S, Caglayan C, Gur C, Batil AA, Gülçin İ. Therapeutic effects of silymarin and naringin on methotrexate‐induced nephrotoxicity in rats: Biochemical evaluation of anti‐inflammatory, antiapoptotic, and antiautophagic properties. J. Food Biochem. 2017; 41(5), e12398.
  • Sagliyan A, Benzer F, Kandemir FM, Gunay C, Han MC, Ozkaraca M. Beneficial effects of oral administrations of grape seed extract on healing of surgically induced skin wounds in rabbits. Revue Méd. Vét. 2012;163(1):11-17.
  • Ömür AD, Kandemir FM, Yıldırım BA, Akman O, Şenocak EA, Eldutar E, et al. Protective effect of dandelion (Taraxacum officinale) extract Against gentamicin-induced reproductive damage in male rats. Kafkas Univ. Vet. Fak. 2016;22:929-936.
  • Ileriturk M, Kandemir O, Akaras N, Simsek H, Genc A, Kandemir FM. Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress. Reprod Toxicol. 2023 Jun;118:108369.
  • Ileritürk M., Kandemir Ö. Protective Effect of Rutin on Malathion-induced Gastric Toxicity: Evaluation of Oxidative Stress, Inflammation and Apoptosis. F.U. Vet. J. Health Sci. 2023;37(2):139-145
  • Şimşek H, Akaras N, Gür C, Küçükler S, Kandemir FM. Beneficial effects of Chrysin on Cadmium-induced nephrotoxicity in rats: Modulating the levels of Nrf2/HO-1, RAGE/NLRP3, and Caspase-3/Bax/Bcl-2 signaling pathways. Gene. 2023 Jul 30;875:147502.
  • Gur C, Akarsu SA, Akaras N, Tuncer SC, Kandemir FM. Carvacrol reduces abnormal and dead sperm counts by attenuating sodium arsenite-induced oxidative stress, inflammation, apoptosis, and autophagy in the testicular tissues of rats. Environ Toxicol. 2023; 38(6):1265-76.
  • Simsek H, Akaras N. Acacetin ameliorates acetylsalicylic acid-induced gastric ulcer in rats by interfering with oxidative stress, inflammation, and apoptosis. Int J Med Biochem 2023; 6(2):96-103.
  • Akaras N. , Kandemir F. M. , Şimşek H. , Gür C. , Aygörmez S. Antioxidant, Antiinflammatory, and Antiapoptotic Effects of Rutin in Spleen Toxicity Induced by Sodium Valproate in Rats. TJNS. 2023; 12(2): 138-144.
  • Yardım A, Kucukler S, Özdemir S, Çomaklı S, Caglayan C, Kandemir FM, et al. Silymarin alleviates docetaxel-induced central and peripheral neurotoxicity by reducing oxidative stress, inflammation and apoptosis in rats. Gene. 2021 Feb 15;769:145239.
  • Celik H, Kucukler S, Ozdemir S, Comakli S, Gur C, Kandemir FM, et al. Lycopene protects against central and peripheral neuropathy by inhibiting oxaliplatin-induced ATF-6 pathway, apoptosis, inflammation and oxidative stress in brains and sciatic tissues of rats. Neurotoxicology. 2020 Sep;80:29-40.
  • Yardım A, Kandemir FM, Çomaklı S, Özdemir S, Caglayan C, Kucukler S, et al. Protective Effects of Curcumin Against Paclitaxel-Induced Spinal Cord and Sciatic Nerve Injuries in Rats. Neurochem Res. 2021 Feb;46(2):379-395.
  • Gur C, Kandemir FM, Caglayan C, Satıcı E. Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2/HO-1 and caspase-3/Bax/Bcl-2 signaling pathways. Chem Biol Interact. 2022 Sep 25;365:110073.
  • Akcılar R, Akcılar A, Koçak C, Koçak FE, Bayat Z, Şimşek H, et al. Effects of Ukrain on intestinal apoptosis caused by ischemia-reperfusion injury in rats. Int J Clin Exp Med. 2015 Dec 15;8(12):22158-66.
  • Akaras N, Bal T, Atilay H, Selli J, Halici MB. Protective effects of agomelatine on testicular damage caused by bortezomib. Biotech Histochem. 2017;92(8):552-559.
  • Şimşek H, Demiryürek Ş, Demir T, Atabay HD, Çeribasi AO, Bayraktar R, et al. Assessment of expressions of Bcl-XL, b-FGF, Bmp-2, Caspase-3, PDGFR-α, Smad1 and TGF-β1 genes in a rat model of lung ischemia/reperfusion. Iran J Basic Med Sci. 2016 Feb;19(2):209-14.

Year 2024, Volume: 41 Issue: 1, 53 - 59, 29.03.2024

Selçuk Yılmaz Sefa Küçükler Hasan Şimşek Serpil Aygörmez Fatih Mehmet Kandemir

Abstract

References

  • Aksu EH, Kandemir FM, Küçükler S, Mahamadu A. Improvement in colistin-induced reproductive damage, apoptosis, and autophagy in testes via reducing oxidative stress by chrysin. J Biochem Mol Toxicol. 2018 Nov;32(11):e22201.
  • Aksu EH, Kandemir FM, Küçükler S. The effects of hesperidin on colistin-induced reproductive damage, autophagy, and apoptosis by reducing oxidative stress. Andrologia. 2021 Mar;53(2):e13900.
  • Çelik H, Kandemir FM, Caglayan C, Özdemir S, Çomaklı S, Kucukler S, et al. Neuroprotective effect of rutin against colistin-induced oxidative stress, inflammation and apoptosis in rat brain associated with the CREB/BDNF expressions. Mol Biol Rep. 2020 Mar;47(3):2023-2034.
  • Dai C, Li J, Lin W, Li G, Sun M, Wang F, et al. Electrophysiology and ultrastructural changes in mouse sciatic nerve associated with colistin sulfate exposure. Toxicol Mech Methods. 2012 Oct;22(8):592-6. Dai C, Li J, Li J. New insight in colistin induced neurotoxicity with the mitochondrial dysfunction in mice central nervous tissues. Exp Toxicol Pathol. 2013 Sep;65(6):941-8.
  • Dai C, Tang S, Biao X, Xiao X, Chen C, Li J. Colistin induced peripheral neurotoxicity involves mitochondrial dysfunction and oxidative stress in mice. Mol Biol Rep. 2019 Apr;46(2):1963-1972.
  • Caglayan C, Kandemir FM, Ayna A, Gür C, Küçükler S, Darendelioğlu E. Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway. Metab Brain Dis. 2022 Aug;37(6):1931-1940.
  • Varışlı B, Caglayan C, Kandemir FM, Gür C, Ayna A, Genç A, et al. Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress in rats. Mol Biol Rep. 2023 Jan;50(1):433-442.
  • Ghanbari-Movahed M, Jackson G, Farzaei MH, Bishayee A. A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies. Front Pharmacol. 2021 Mar 29;12:639840.
  • Akintunde JK, Akintola TE, Adenuga GO, Odugbemi ZA, Adetoye RO, Akintunde OG. Naringin attenuates Bisphenol-A mediated neurotoxicity in hypertensive rats by abrogation of cerebral nucleotide depletion, oxidative damage and neuroinflammation. Neurotoxicology. 2020 Dec;81:18-33.
  • Kaur G, Prakash A. Involvement of the nitric oxide signaling in modulation of naringin against intranasal manganese and intracerbroventricular β-amyloid induced neurotoxicity in rats. J Nutr Biochem. 2020 Feb;76:108255.
  • Garabadu D, Agrawal N. Naringin Exhibits Neuroprotection Against Rotenone-Induced Neurotoxicity in Experimental Rodents. Neuromolecular Med. 2020 Jun;22(2):314-330.
  • Semis HS, Kandemir FM, Caglayan C, Kaynar O, Genc A, Arıkan SM. Protective effect of naringin against oxaliplatin-induced peripheral neuropathy in rats: A behavioral and molecular study. J Biochem Mol Toxicol. 2022 Sep;36(9):e23121.
  • Temel Y, Çağlayan C, Ahmed BM, Kandemir FM, Çiftci M. The effects of chrysin and naringin on cyclophosphamide-induced erythrocyte damage in rats: biochemical evaluation of some enzyme activities in vivo and in vitro. Naunyn Schmiedebergs Arch Pharmacol. 2021 Apr;394(4):645-654.
  • Semis HS, Kandemir FM, Kaynar O, Dogan T, Arikan SM. The protective effects of hesperidin against paclitaxel-induced peripheral neuropathy in rats. Life Sci. 2021 Dec 15;287:120104.
  • Placer ZA, Cushman LL, Johnson BC. Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem. 1966; 16(2):359-64.
  • Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1988; 34(3):497-500.
  • Aebi H. Catalase in vitro. Methods Enzymol. 1984; 105:121-26.
  • Lawrence RA, Burk RF. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun. 1976; 71(4):952-58.
  • Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 1968; 25(1):192-205.
  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193(1):265-75.
  • Hanedan B, Ozkaraca M, Kirbas A, Kandemir FM, Aktas MS, Kilic K, et al. Investigation of the effects of hesperidin and chrysin on renal injury induced by colistin in rats. Biomed Pharmacother. 2018 Dec;108:1607-1616.
  • Akaras N, Abuc OO, Koc K, Bal T, Geyikoglu F, Atilay H, et al. (1 → 3)-β-d-glucan enhances the toxicity induced by Bortezomib in rat testis. J Food Biochem. 2020 Mar;44(3):e13155.
  • Thayumanavan G, Jeyabalan S, Fuloria S, Sekar M, Ravi M, Selvaraj LK, et al. Silibinin and Naringenin against Bisphenol A-Induced Neurotoxicity in Zebrafish Model-Potential Flavonoid Molecules for New Drug Design, Development, and Therapy for Neurological Disorders. Molecules. 2022 Apr 15;27(8):2572.
  • Kandemir FM, Kucukler S, Caglayan C, Gur C, Batil AA, Gülçin İ. Therapeutic effects of silymarin and naringin on methotrexate‐induced nephrotoxicity in rats: Biochemical evaluation of anti‐inflammatory, antiapoptotic, and antiautophagic properties. J. Food Biochem. 2017; 41(5), e12398.
  • Sagliyan A, Benzer F, Kandemir FM, Gunay C, Han MC, Ozkaraca M. Beneficial effects of oral administrations of grape seed extract on healing of surgically induced skin wounds in rabbits. Revue Méd. Vét. 2012;163(1):11-17.
  • Ömür AD, Kandemir FM, Yıldırım BA, Akman O, Şenocak EA, Eldutar E, et al. Protective effect of dandelion (Taraxacum officinale) extract Against gentamicin-induced reproductive damage in male rats. Kafkas Univ. Vet. Fak. 2016;22:929-936.
  • Ileriturk M, Kandemir O, Akaras N, Simsek H, Genc A, Kandemir FM. Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress. Reprod Toxicol. 2023 Jun;118:108369.
  • Ileritürk M., Kandemir Ö. Protective Effect of Rutin on Malathion-induced Gastric Toxicity: Evaluation of Oxidative Stress, Inflammation and Apoptosis. F.U. Vet. J. Health Sci. 2023;37(2):139-145
  • Şimşek H, Akaras N, Gür C, Küçükler S, Kandemir FM. Beneficial effects of Chrysin on Cadmium-induced nephrotoxicity in rats: Modulating the levels of Nrf2/HO-1, RAGE/NLRP3, and Caspase-3/Bax/Bcl-2 signaling pathways. Gene. 2023 Jul 30;875:147502.
  • Gur C, Akarsu SA, Akaras N, Tuncer SC, Kandemir FM. Carvacrol reduces abnormal and dead sperm counts by attenuating sodium arsenite-induced oxidative stress, inflammation, apoptosis, and autophagy in the testicular tissues of rats. Environ Toxicol. 2023; 38(6):1265-76.
  • Simsek H, Akaras N. Acacetin ameliorates acetylsalicylic acid-induced gastric ulcer in rats by interfering with oxidative stress, inflammation, and apoptosis. Int J Med Biochem 2023; 6(2):96-103.
  • Akaras N. , Kandemir F. M. , Şimşek H. , Gür C. , Aygörmez S. Antioxidant, Antiinflammatory, and Antiapoptotic Effects of Rutin in Spleen Toxicity Induced by Sodium Valproate in Rats. TJNS. 2023; 12(2): 138-144.
  • Yardım A, Kucukler S, Özdemir S, Çomaklı S, Caglayan C, Kandemir FM, et al. Silymarin alleviates docetaxel-induced central and peripheral neurotoxicity by reducing oxidative stress, inflammation and apoptosis in rats. Gene. 2021 Feb 15;769:145239.
  • Celik H, Kucukler S, Ozdemir S, Comakli S, Gur C, Kandemir FM, et al. Lycopene protects against central and peripheral neuropathy by inhibiting oxaliplatin-induced ATF-6 pathway, apoptosis, inflammation and oxidative stress in brains and sciatic tissues of rats. Neurotoxicology. 2020 Sep;80:29-40.
  • Yardım A, Kandemir FM, Çomaklı S, Özdemir S, Caglayan C, Kucukler S, et al. Protective Effects of Curcumin Against Paclitaxel-Induced Spinal Cord and Sciatic Nerve Injuries in Rats. Neurochem Res. 2021 Feb;46(2):379-395.
  • Gur C, Kandemir FM, Caglayan C, Satıcı E. Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2/HO-1 and caspase-3/Bax/Bcl-2 signaling pathways. Chem Biol Interact. 2022 Sep 25;365:110073.
  • Akcılar R, Akcılar A, Koçak C, Koçak FE, Bayat Z, Şimşek H, et al. Effects of Ukrain on intestinal apoptosis caused by ischemia-reperfusion injury in rats. Int J Clin Exp Med. 2015 Dec 15;8(12):22158-66.
  • Akaras N, Bal T, Atilay H, Selli J, Halici MB. Protective effects of agomelatine on testicular damage caused by bortezomib. Biotech Histochem. 2017;92(8):552-559.
  • Şimşek H, Demiryürek Ş, Demir T, Atabay HD, Çeribasi AO, Bayraktar R, et al. Assessment of expressions of Bcl-XL, b-FGF, Bmp-2, Caspase-3, PDGFR-α, Smad1 and TGF-β1 genes in a rat model of lung ischemia/reperfusion. Iran J Basic Med Sci. 2016 Feb;19(2):209-14.
There are 39 citations in total.

Details

Primary Language English
Subjects Orthopaedics
Journal Section Research Article
Authors

Selçuk Yılmaz 0000-0003-2508-8558

Sefa Küçükler 0000-0002-8222-5515

Hasan Şimşek 0000-0001-5573-4923

Serpil Aygörmez 0000-0002-5675-5096

Fatih Mehmet Kandemir 0000-0002-8490-2479

Publication Date March 29, 2024
Submission Date September 24, 2023
Acceptance Date February 25, 2024
Published in Issue Year 2024 Volume: 41 Issue: 1

Cite

APA Yılmaz, S., Küçükler, S., Şimşek, H., Aygörmez, S., et al. (2024). Naringin protects against colistin-induced sciatic nerve damage by reducing oxidative stress, apoptosis and inflammation damage. Journal of Experimental and Clinical Medicine, 41(1), 53-59.
AMA Yılmaz S, Küçükler S, Şimşek H, Aygörmez S, Kandemir FM. Naringin protects against colistin-induced sciatic nerve damage by reducing oxidative stress, apoptosis and inflammation damage. J. Exp. Clin. Med. March 2024;41(1):53-59.
Chicago Yılmaz, Selçuk, Sefa Küçükler, Hasan Şimşek, Serpil Aygörmez, and Fatih Mehmet Kandemir. “Naringin Protects Against Colistin-Induced Sciatic Nerve Damage by Reducing Oxidative Stress, Apoptosis and Inflammation Damage”. Journal of Experimental and Clinical Medicine 41, no. 1 (March 2024): 53-59.
EndNote Yılmaz S, Küçükler S, Şimşek H, Aygörmez S, Kandemir FM (March 1, 2024) Naringin protects against colistin-induced sciatic nerve damage by reducing oxidative stress, apoptosis and inflammation damage. Journal of Experimental and Clinical Medicine 41 1 53–59.
IEEE S. Yılmaz, S. Küçükler, H. Şimşek, S. Aygörmez, and F. M. Kandemir, “Naringin protects against colistin-induced sciatic nerve damage by reducing oxidative stress, apoptosis and inflammation damage”, J. Exp. Clin. Med., vol. 41, no. 1, pp. 53–59, 2024.
ISNAD Yılmaz, Selçuk et al. “Naringin Protects Against Colistin-Induced Sciatic Nerve Damage by Reducing Oxidative Stress, Apoptosis and Inflammation Damage”. Journal of Experimental and Clinical Medicine 41/1 (March 2024), 53-59.
JAMA Yılmaz S, Küçükler S, Şimşek H, Aygörmez S, Kandemir FM. Naringin protects against colistin-induced sciatic nerve damage by reducing oxidative stress, apoptosis and inflammation damage. J. Exp. Clin. Med. 2024;41:53–59.
MLA Yılmaz, Selçuk et al. “Naringin Protects Against Colistin-Induced Sciatic Nerve Damage by Reducing Oxidative Stress, Apoptosis and Inflammation Damage”. Journal of Experimental and Clinical Medicine, vol. 41, no. 1, 2024, pp. 53-59.
Vancouver Yılmaz S, Küçükler S, Şimşek H, Aygörmez S, Kandemir FM. Naringin protects against colistin-induced sciatic nerve damage by reducing oxidative stress, apoptosis and inflammation damage. J. Exp. Clin. Med. 2024;41(1):53-9.
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