Research Article
BibTex RIS Cite

Correlation of tumor necrosis factor-α and sclerostin in bone turnover process of premenopausal women with rheumatoid arthritis

Year 2024, Volume: 41 Issue: 1, 60 - 64, 29.03.2024

Malikul Chair Rudy Hidayat Sumariyono Sumariyono Murdani Abdullah Faisal Parlindungan

Abstract

Rheumatoid arthritis is associated with systemic bone mass loss due to stimulation of osteoclastogenesis and suppression of osteoblastogenesis through inhibition of Wingless (Wnt)/β catenin canonical and bone morphogenetic proteins (BMP) pathways by sclerostin. Our study assessed the correlation between tumor necrosis factor (TNF)-α and sclerostin with bone resorption markers C-terminal telopeptides of type 1 collagen (CTX) and procollagen type 1 N-terminal propeptide (P1NP) in pre-menopausal rheumatoid arthritis patients. This cross-sectional study involved 38 premenopausal women with RA. Serum TNF-α, sclerostin, P1NP, and CTX level were examined by ELISA method. This study revealed high level of serum CTX (mean 2.74 ng/mL) and a low level of P1NP (median 34.04 pg/mL). There was a significant negative correlation (r = -0.388) between TNF-α and sclerostin levels (p = 0.016), as well as a significant positive correlation (r = 0.362) between TNF-α and P1NP levels (p = 0.026). There was a significant negative correlation between TNF-α and sclerostin, and also a significant positive correlation between TNF-α and P1NP in our study.

Keywords

Bone remodelling premenopause rheumatoid arthritis tumor necrosis factor-alpha Wnt signaling pathway

Ethical Statement

This study had been approved by the Medical Research Ethics Committee of Universitas Indonesia Protocol Number KET- 377/UN2.F1/ETIK/ PPM.00.02/2019

Supporting Institution

Universitas Indonesia

Thanks

The authors wish to thank Harry Isbagio, Zuljasri Albar, Bambang Setyohadi, Suryo Anggoro, and Anna Ariane for their time and tremendous support in the field. This study was supported by Universitas Indonesia PITTA B Grant Scheme (Grant Number PENG- 1/UN2.R3.1/PPM.00/2019)

References

  • Bugatti S, Bogliolo L, Montecucco C, Manzo A. B cell autoimmunity and bone damage in rheumatoid arthritis. Reumatismo. 2016 Dec;68(3):117–25.
  • Parlindungan F, Hidayat R, Ariane A, Shatri H. Association between Proinflammatory Cytokines and Anxiety and Depression Symptoms in Rheumatoid Arthritis Patients: A Cross-sectional Study. Clinical Practice & Epidemiology in Mental Health. 2023 Jun 22;19(1).
  • Cutolo M, Kitas GD, van Riel PLCM. Burden of disease in treated rheumatoid arthritis patients: going beyond the joint. Seminars in Arthritis and Rheumatism. 2014 Feb;43(4):479–88.
  • Manara M, Sinigaglia L. Bone and TNF in rheumatoid arthritis: clinical implications. RMD Open. 2015;1(Suppl 1):e000065.
  • Lerner UH, Ohlsson C. The WNT system: background and its role in bone. Journal of Internal Medicine. 2015 Jun;277(6):630–49.
  • Coates P. Bone turnover markers. Australian Family Physician. 2013 May;42(5):285–7.
  • Szulc P, Naylor K, Hoyle NR, Eastell R, Leary ET. Use of CTX-I and PINP as bone turnover markers: National Bone Health Alliance recommendations to standardize sample handling and patient preparation to reduce pre-analytical variability. Osteoporosis International: A Journal Established As Result of Cooperation Between The European Foundation for Osteoporosis and The National Osteoporosis Foundation of The USA. 2017 Sep;28(9):2541–56.
  • Suryana BPP, Hidayat R, Sarmidi S, Wibowo SAK, Hamijoyo L, Rahmadi AR, et al. Characteristics and prevalence of clinical remission of rheumatoid arthritis in a nationwide study from Indonesia. Int J Rheum Dis. 2024 Feb 1;27(2).
  • Thilagar S, Theyagarajan R, Sudhakar U, Suresh S, Saketharaman P, Ahamed N. Comparison of serum tumor necrosis factor-α levels in rheumatoid arthritis individuals with and without chronic periodontitis: A biochemical study. Journal of Indian Society of Periodontology. 2018;22(2):116–21.
  • Handono K, Suryana BP, Sulistyorini. Korelasi kadar CRP, TNF-α dan bone mineral density dengan carboxyterminal crosslinked telopeptide type 1 of collagen di penderita artritis reumatoid. Indonesian Journal Of Clinical Pathology And Medical Laboratory. 2012;18(2):77–82.
  • Temiz A, Gazi E, Güngör Ö, Barutçu A, Altun B, Bekler A, et al. Platelet/lymphocyte ratio and risk of in-hospital mortality in patients with ST-elevated myocardial infarction. Medical Science Monitor. 2014;20:660–5.
  • Ardawi MSM, Al-Kadi HA, Rouzi AA, Qari MH. Determinants of serum sclerostin in healthy pre- and postmenopausal women. Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research. 2011 Dec;26(12):2812–22.
  • Fassio A, Idolazzi L, Viapiana O, Benini C, Vantaggiato E, Bertoldo F, et al. In psoriatic arthritis Dkk-1 and PTH are lower than in rheumatoid arthritis and healthy controls. Clinical Rheumatology. 2017 Oct;36(10):2377–81.
  • Kalem MN, Kalem Z, Akgun N, Bakırarar B. The relationship between postmenopausal women’s sclerostin levels and their bone density, age, body mass index, hormonal status, and smoking and consumption of coffee and dairy products. Archives of Gynecology and Obstetrics. 2017 Mar;295(3):785–93.
  • Ke HZ, Richards WG, Li X, Ominsky MS. Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases. Endocrine Reviews. 2012 Oct;33(5):747–83.
  • Mödder UI, Hoey KA, Amin S, McCready LK, Achenbach SJ, Riggs BL, et al. Relation of age, gender, and bone mass to circulating sclerostin levels in women and men. Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research. 2011 Feb;26(2):373–9.
  • Singh A, Gupta MK, Mishra SP. Study of correlation of level of expression of Wnt signaling pathway inhibitors sclerostin and dickkopf-1 with disease activity and severity in rheumatoid arthritis patients. Drug Discov Ther. 2019;13(1):22–7.
  • Botella S, Restituto P, Monreal I, Colina I, Calleja A, Varo N. Traditional and novel bone remodeling markers in premenopausal and postmenopausal women. The Journal of Clinical Endocrinology and Metabolism. 2013 Nov;98(11):E1740-8.
  • Gutierrez-Buey G, Restituto P, Botella S, Monreal I, Colina I, Rodríguez-Fraile M, et al. Trabecular bone score and bone remodelling markers identify perimenopausal women at high risk of bone loss. Clinical Endocrinology. 2019 Sep;91(3):391–9.
  • Farrugia M, Baron B. The role of TNF-α in rheumatoid arthritis: a focus on regulatory T cells. Journal of Clinical and Translational Research. 2016 Nov;2(3):84–90.
  • Rauch F, Adachi R. Sclerostin: More than a bone formation brake. Science Translational Medicine. 2016 Mar;8(330):330fs7.
  • Wehmeyer C, Frank S, Beckmann D, Böttcher M, Cromme C, König U, et al. Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction. Science Translational Medicine. 2016 Mar;8(330):330ra35.
  • Briolay A, Lencel P, Bessueille L, Caverzasio J, Buchet R, Magne D. Autocrine stimulation of osteoblast activity by Wnt5a in response to TNF-α in human mesenchymal stem cells. Biochemical and Biophysical Research Communications. 2013 Jan;430(3):1072–7.
  • Lim MJ, Kwon SR, Joo K, Son MJ, Park SG, Park W. Early effects of tumor necrosis factor inhibition on bone homeostasis after soluble tumor necrosis factor receptor use. The Korean Journal of Internal Medicine. 2014 Nov;29(6):807–13.

Year 2024, Volume: 41 Issue: 1, 60 - 64, 29.03.2024

Malikul Chair Rudy Hidayat Sumariyono Sumariyono Murdani Abdullah Faisal Parlindungan

Abstract

References

  • Bugatti S, Bogliolo L, Montecucco C, Manzo A. B cell autoimmunity and bone damage in rheumatoid arthritis. Reumatismo. 2016 Dec;68(3):117–25.
  • Parlindungan F, Hidayat R, Ariane A, Shatri H. Association between Proinflammatory Cytokines and Anxiety and Depression Symptoms in Rheumatoid Arthritis Patients: A Cross-sectional Study. Clinical Practice & Epidemiology in Mental Health. 2023 Jun 22;19(1).
  • Cutolo M, Kitas GD, van Riel PLCM. Burden of disease in treated rheumatoid arthritis patients: going beyond the joint. Seminars in Arthritis and Rheumatism. 2014 Feb;43(4):479–88.
  • Manara M, Sinigaglia L. Bone and TNF in rheumatoid arthritis: clinical implications. RMD Open. 2015;1(Suppl 1):e000065.
  • Lerner UH, Ohlsson C. The WNT system: background and its role in bone. Journal of Internal Medicine. 2015 Jun;277(6):630–49.
  • Coates P. Bone turnover markers. Australian Family Physician. 2013 May;42(5):285–7.
  • Szulc P, Naylor K, Hoyle NR, Eastell R, Leary ET. Use of CTX-I and PINP as bone turnover markers: National Bone Health Alliance recommendations to standardize sample handling and patient preparation to reduce pre-analytical variability. Osteoporosis International: A Journal Established As Result of Cooperation Between The European Foundation for Osteoporosis and The National Osteoporosis Foundation of The USA. 2017 Sep;28(9):2541–56.
  • Suryana BPP, Hidayat R, Sarmidi S, Wibowo SAK, Hamijoyo L, Rahmadi AR, et al. Characteristics and prevalence of clinical remission of rheumatoid arthritis in a nationwide study from Indonesia. Int J Rheum Dis. 2024 Feb 1;27(2).
  • Thilagar S, Theyagarajan R, Sudhakar U, Suresh S, Saketharaman P, Ahamed N. Comparison of serum tumor necrosis factor-α levels in rheumatoid arthritis individuals with and without chronic periodontitis: A biochemical study. Journal of Indian Society of Periodontology. 2018;22(2):116–21.
  • Handono K, Suryana BP, Sulistyorini. Korelasi kadar CRP, TNF-α dan bone mineral density dengan carboxyterminal crosslinked telopeptide type 1 of collagen di penderita artritis reumatoid. Indonesian Journal Of Clinical Pathology And Medical Laboratory. 2012;18(2):77–82.
  • Temiz A, Gazi E, Güngör Ö, Barutçu A, Altun B, Bekler A, et al. Platelet/lymphocyte ratio and risk of in-hospital mortality in patients with ST-elevated myocardial infarction. Medical Science Monitor. 2014;20:660–5.
  • Ardawi MSM, Al-Kadi HA, Rouzi AA, Qari MH. Determinants of serum sclerostin in healthy pre- and postmenopausal women. Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research. 2011 Dec;26(12):2812–22.
  • Fassio A, Idolazzi L, Viapiana O, Benini C, Vantaggiato E, Bertoldo F, et al. In psoriatic arthritis Dkk-1 and PTH are lower than in rheumatoid arthritis and healthy controls. Clinical Rheumatology. 2017 Oct;36(10):2377–81.
  • Kalem MN, Kalem Z, Akgun N, Bakırarar B. The relationship between postmenopausal women’s sclerostin levels and their bone density, age, body mass index, hormonal status, and smoking and consumption of coffee and dairy products. Archives of Gynecology and Obstetrics. 2017 Mar;295(3):785–93.
  • Ke HZ, Richards WG, Li X, Ominsky MS. Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases. Endocrine Reviews. 2012 Oct;33(5):747–83.
  • Mödder UI, Hoey KA, Amin S, McCready LK, Achenbach SJ, Riggs BL, et al. Relation of age, gender, and bone mass to circulating sclerostin levels in women and men. Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research. 2011 Feb;26(2):373–9.
  • Singh A, Gupta MK, Mishra SP. Study of correlation of level of expression of Wnt signaling pathway inhibitors sclerostin and dickkopf-1 with disease activity and severity in rheumatoid arthritis patients. Drug Discov Ther. 2019;13(1):22–7.
  • Botella S, Restituto P, Monreal I, Colina I, Calleja A, Varo N. Traditional and novel bone remodeling markers in premenopausal and postmenopausal women. The Journal of Clinical Endocrinology and Metabolism. 2013 Nov;98(11):E1740-8.
  • Gutierrez-Buey G, Restituto P, Botella S, Monreal I, Colina I, Rodríguez-Fraile M, et al. Trabecular bone score and bone remodelling markers identify perimenopausal women at high risk of bone loss. Clinical Endocrinology. 2019 Sep;91(3):391–9.
  • Farrugia M, Baron B. The role of TNF-α in rheumatoid arthritis: a focus on regulatory T cells. Journal of Clinical and Translational Research. 2016 Nov;2(3):84–90.
  • Rauch F, Adachi R. Sclerostin: More than a bone formation brake. Science Translational Medicine. 2016 Mar;8(330):330fs7.
  • Wehmeyer C, Frank S, Beckmann D, Böttcher M, Cromme C, König U, et al. Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction. Science Translational Medicine. 2016 Mar;8(330):330ra35.
  • Briolay A, Lencel P, Bessueille L, Caverzasio J, Buchet R, Magne D. Autocrine stimulation of osteoblast activity by Wnt5a in response to TNF-α in human mesenchymal stem cells. Biochemical and Biophysical Research Communications. 2013 Jan;430(3):1072–7.
  • Lim MJ, Kwon SR, Joo K, Son MJ, Park SG, Park W. Early effects of tumor necrosis factor inhibition on bone homeostasis after soluble tumor necrosis factor receptor use. The Korean Journal of Internal Medicine. 2014 Nov;29(6):807–13.
There are 24 citations in total.

Details

Primary Language English
Subjects Rheumatology and Arthritis
Journal Section Research Article
Authors

Malikul Chair 0000-0003-2011-2512

Rudy Hidayat 0000-0003-4895-2409

Sumariyono Sumariyono 0000-0002-0094-6264

Murdani Abdullah 0000-0003-4565-1520

Faisal Parlindungan 0000-0003-0762-0408

Publication Date March 29, 2024
Submission Date February 7, 2024
Acceptance Date March 18, 2024
Published in Issue Year 2024 Volume: 41 Issue: 1

Cite

APA Chair, M., Hidayat, R., Sumariyono, S., Abdullah, M., et al. (2024). Correlation of tumor necrosis factor-α and sclerostin in bone turnover process of premenopausal women with rheumatoid arthritis. Journal of Experimental and Clinical Medicine, 41(1), 60-64.
AMA Chair M, Hidayat R, Sumariyono S, Abdullah M, Parlindungan F. Correlation of tumor necrosis factor-α and sclerostin in bone turnover process of premenopausal women with rheumatoid arthritis. J. Exp. Clin. Med. March 2024;41(1):60-64.
Chicago Chair, Malikul, Rudy Hidayat, Sumariyono Sumariyono, Murdani Abdullah, and Faisal Parlindungan. “Correlation of Tumor Necrosis Factor-α and Sclerostin in Bone Turnover Process of Premenopausal Women With Rheumatoid Arthritis”. Journal of Experimental and Clinical Medicine 41, no. 1 (March 2024): 60-64.
EndNote Chair M, Hidayat R, Sumariyono S, Abdullah M, Parlindungan F (March 1, 2024) Correlation of tumor necrosis factor-α and sclerostin in bone turnover process of premenopausal women with rheumatoid arthritis. Journal of Experimental and Clinical Medicine 41 1 60–64.
IEEE M. Chair, R. Hidayat, S. Sumariyono, M. Abdullah, and F. Parlindungan, “Correlation of tumor necrosis factor-α and sclerostin in bone turnover process of premenopausal women with rheumatoid arthritis”, J. Exp. Clin. Med., vol. 41, no. 1, pp. 60–64, 2024.
ISNAD Chair, Malikul et al. “Correlation of Tumor Necrosis Factor-α and Sclerostin in Bone Turnover Process of Premenopausal Women With Rheumatoid Arthritis”. Journal of Experimental and Clinical Medicine 41/1 (March 2024), 60-64.
JAMA Chair M, Hidayat R, Sumariyono S, Abdullah M, Parlindungan F. Correlation of tumor necrosis factor-α and sclerostin in bone turnover process of premenopausal women with rheumatoid arthritis. J. Exp. Clin. Med. 2024;41:60–64.
MLA Chair, Malikul et al. “Correlation of Tumor Necrosis Factor-α and Sclerostin in Bone Turnover Process of Premenopausal Women With Rheumatoid Arthritis”. Journal of Experimental and Clinical Medicine, vol. 41, no. 1, 2024, pp. 60-64.
Vancouver Chair M, Hidayat R, Sumariyono S, Abdullah M, Parlindungan F. Correlation of tumor necrosis factor-α and sclerostin in bone turnover process of premenopausal women with rheumatoid arthritis. J. Exp. Clin. Med. 2024;41(1):60-4.
 Download Cover Image

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.