Abstract
References
- Referances 1. Perez GF, Pancham K, Huseni S, Jain A, Rodriguez-Martinez CE, Preciado D et al. Rhinovirus-induced airway cytokines and respiratory morbidity in severely premature children. Pediatr Allergy Immunol. 2015; 26: 145-152.
- 2. Jackson DJ. Early-life viral infections and the development of asthma: a target for asthma prevention. Curr Opin Allergy Clin Immunol 2014;14:131-136
- 3. Liolios L, Jenney A, Spelman D, Kotsimbos T, Catton M, Wesselingh S. Comparison of a multiplex reverse transcription PCRenzyme hybridization assay with conventional viral culture immunofluorescence techniques for the detection of seven viral respiratory pathogens. J Clin Microbiol 2001;39:2779-278
- 4. William BG, Gouws E, Boschi-Pinto C, Bryce J, Dye C. Estimates of world-wide distrubution of child deaths from acute respiratory infections. Lancet Infect Dis 2012;2:25-32
- 5. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2095-2128
- 6. Hacımustafaoğlu M, Celebi S, Bozdemir SE, Ozgür T, Ozcan I, Güray A, et al. RSV frequency in children below 2 years hospitalized for lower respiratory tract infections. Turk J Pediatr 2013;55:130-139
- 7. Alan S, Erdeve O, Cakir U, Akduman H, Zenciroglu A, Akcakus M, et al. Outcome of the respiratory syncytial virus related acute lower respiratory tract infection among hospitalized newborns: a prospective multicenter study. J Matern Fetal Neonatal Med 2016;29:2186-2193
- 8. Türk Neonatoloji Derneği Palivizumab ile RSV proflaksisi önerileri. 2018.11 Temmuz. http=//www.neonatology.org.tr/
- 9. Baraldi E, Lanari M, Manzoni P, Rossi GA, Vandini S, Rimini A et al. Inter-society consensus document on treatment and prevention of bronchiolitis in newborns and infants. Ital J Pediatr 2014;40:65
- 10. Cho HJ, Shim SY, Son DW, Sun YH, Tchah H, Jeon IS. Respiratory viruses in neonates hospitalized with acute lower respiratory tract infections. Pediatr Int 2013;55:49-53
- 11. Okulu E, Akduman H, Tunç G, Çiftçi E, İnce E, Erdeve Ö ve ark. Viral alt solunum yolu enfeksiyonu nedeniyle yatırılan yenidoğanların epidemiyolojik ve klinik özellikleri. Türkiye Çocuk Hast Derg 2018;1: 31-35.
- 12. Celik K, Olukman O, Demirol H, Terek D, Gulfidan G, Devrim I et al. Prevalence of respiratory pathogens during two consecutive respiratory syncytial virus seasons at a tertiary medical care center. Arch Argent Pediatr 2019;117:356-362
- 13. Rogers BB, Shankar P, Jerris RC,Kotzbauer D, Anderson EJ, Watson JR et al. Impact of a rapid respiratory panel test on patient outcomes. Arch Pathol Lab Med 2015;139:636–644
- 14. Nair H, Nokes DJ, Gessner BD,Dherani M, Madhi SA, Singleton RJ, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta–analysis. Lancet 2010;375:1545-1555
- 15. Cangiano G, Nenna R, Frassanito A, Evangelisti M, Nicolai A, Scagnolari C, et al. Bronchiolitis: Analysis of 10 consecutive epidemic seasons. Pediatr Pulmonol 2016;51:1330-1335
- 16. Lim JS,Woo SI, Kwon HI, Baek YH, Choi YK, Hahn YS. Clinical characteristics of acute lower respiratory tract infection due to 13 respiratory viruses detected by multiplex PCR in children. Korean J. Pediatr 2010;53:373–379
- 17. Khadadah M, Essa S, Higazi Z, Behbehani N, Al-Nakib W. Respiratory syncytial virus and human rhinoviruses are the major causes of severe lower respiratory tract infections in Kuwait. J Med Virol 2010;82:1462–1467
- 18. Cox DW, Khoo SK, Zhang G, et al. Rhinovirus is the most common virus and rhinovirus-C is the most common species in paediatric intensive care respiratory admissions. Eur Respir J 2018;52
- 19. Chen J, Hu P, Zhou T, Zheng T, Zhou L, Jiang C, et al. Epidemiology and clinical characteristics of acute respiratory tract infections among hospitalized infants and young children in Chengdu, West China, 2009-2014. BMC Pediatr 2018;18:216
- 20. Wilkinson DJ, Buttery JP, Andersen CC. Influenza in the neonatal intensive care unit. J Perinatol 2006;26:772-776.
- 21. Puck JM, Glezen WP, Frank AL, Six HR. Protection of infants from infection with influenza A virus by transplacentally acquired antibody. J Infect Dis 1980;142:844-849
- 22. Vij NK, Stryker CC, Esper FP, Jacobs MR, Gonzalez BE. Influenza A/H1N1/09-10 infections in a NICU during the 2009-2010 H1N1 pandemic. Pediatrics 2011;128:1297-1301
- 23. Pichler K, Assadian O, Berger A. Viral Respiratory Infections in the Neonatal Intensive Care Unit-A Review. Front Microbiol 2018;9:2484
- 24. Sirimi N, Miligkos M, Koutouzi F, Petridou E, Siahanidou T, Michos A. Respiratory syncytial virus activity and climate parameters during a 12-year period. J Med Virol 2016;88:931–937
- 25. Turkish Neonatal Society. The seasonal variations of respiratory syncytial virus infections in Turkey: a 2-year epidemiological study. Turk J Pediatr 2012;54:216–222
- 26. García CG, Bhore R, Soriano-Fallas A, Trost M, Chason R, Ramilo O, et al. Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis. Pediatrics 2010;126:1453-1460
- 27. Fattouh AM, Mansi YA, El-Anany MG, El-Kholy AA, El-Karaksy HM. Acute lower respiratory tract infection due to respiratory syncytial virus in a group of Egyptian children under 5 years of age. Ital J Pediatr 2011;37:14
- 28. Manley BJ, Arnolda GRB, Wright IMR, Owen LS, Foster JP, Huang L, et al. HUNTER Trial Investigators. Nasal High-Flow Therapy for Newborn Infants in Special Care Nurseries. N Engl J Med 2019;380:2031-2040
- 29. Milési C, Essouri S, Pouyau R, Liet JM, Afanetti M, Portefaix A, et al. Groupe Francophone de Réanimation et d’Urgences Pédiatriques (GFRUP). High flownasal cannula (HFNC) versus nasal continuouspositive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: amulticenter randomized controlled trial (TRAMONTANE study). Intensive Care Med 2017;43:209–216
- 30. Franklin D, Babl FE, Schlapbach LJ, Oakley E, Craig S, Neutze J, et al. A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis. N Engl J Med. 2018;378:1121-1131
- 31. Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med 2009;360:588–598
- 32. Garcia CG, Bhore R, Soriano-Fallas A, Trost M, Chason R, Ramilo O, et al. Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis. Pediatrics 2010;126:1453-1460
- 33. Hall CB, Weinberg GA, Blumkin AK, Edwards KM, Staat MA, Schultz AF, et al. Respiratory syncytial virus-associated hospitalizations among children less than 24 months of age. Pediatrics 2013;132:341-348
- 34. Cetinkaya M, Oral TK, Karatekin S, Cebeci B, Babayigit A, Yesil Y. Efficacy of palivizumab prophylaxis on the frequency of RSV-associated lower respiratory tract infections in preterm infants: determination of the ideal target population for prophylaxis. Eur J Clin Microbiol Infect Dis 2017;36:1629-1634
Abstract
Background: In recent years, detection of viruses by multiplex real time polymerase chain reaction allowed the isolation of causative viral agents.
Objectives: The primary objectives of this study were to determine the distribution of causative respiratory viruses in acute lower respiratory tract infections in the NICU and to compare the demographic and clinical characteristics of infants with RSV and non-RSV infections. The secondary aim was to determine risk factors requiring respiratory support.
Methods: This retrospective observational study was conducted between January 2016 and June 2019. The infants were divided into two groups as RSV and non-RSV, and compared. Risk factors for respiratory support by means of invasive/non-invasive ventilation were determined.
Results: Two hundred forty-three infants were hospitalized with the diagnosis of viral lower respiratory tract infections and a total of 119 infants, in which a causative viral agent could be isolated, were included in the study. RSV was the most common isolated virus (n=93, 78%). The demographic characteristics of infants in RSV and non-RSV groups were similar, except postnatal age. Infants were hospitalized most frequently in between December and February. In multivariate analysis, apnea and RSV were found to be risk factors for respiratory support requirement.
Conclusion: Since RSV-associated acute lower respiratory tract infections are the most common and require more respiratory support in the neonatal period, risk factors should be identified and preventive measures should be developed. Preventive strategies, raising awareness of families, careful and meticulous attitudes especially during high season might reduce the incidence and hospitalizations of the infants.
References
- Referances 1. Perez GF, Pancham K, Huseni S, Jain A, Rodriguez-Martinez CE, Preciado D et al. Rhinovirus-induced airway cytokines and respiratory morbidity in severely premature children. Pediatr Allergy Immunol. 2015; 26: 145-152.
- 2. Jackson DJ. Early-life viral infections and the development of asthma: a target for asthma prevention. Curr Opin Allergy Clin Immunol 2014;14:131-136
- 3. Liolios L, Jenney A, Spelman D, Kotsimbos T, Catton M, Wesselingh S. Comparison of a multiplex reverse transcription PCRenzyme hybridization assay with conventional viral culture immunofluorescence techniques for the detection of seven viral respiratory pathogens. J Clin Microbiol 2001;39:2779-278
- 4. William BG, Gouws E, Boschi-Pinto C, Bryce J, Dye C. Estimates of world-wide distrubution of child deaths from acute respiratory infections. Lancet Infect Dis 2012;2:25-32
- 5. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2095-2128
- 6. Hacımustafaoğlu M, Celebi S, Bozdemir SE, Ozgür T, Ozcan I, Güray A, et al. RSV frequency in children below 2 years hospitalized for lower respiratory tract infections. Turk J Pediatr 2013;55:130-139
- 7. Alan S, Erdeve O, Cakir U, Akduman H, Zenciroglu A, Akcakus M, et al. Outcome of the respiratory syncytial virus related acute lower respiratory tract infection among hospitalized newborns: a prospective multicenter study. J Matern Fetal Neonatal Med 2016;29:2186-2193
- 8. Türk Neonatoloji Derneği Palivizumab ile RSV proflaksisi önerileri. 2018.11 Temmuz. http=//www.neonatology.org.tr/
- 9. Baraldi E, Lanari M, Manzoni P, Rossi GA, Vandini S, Rimini A et al. Inter-society consensus document on treatment and prevention of bronchiolitis in newborns and infants. Ital J Pediatr 2014;40:65
- 10. Cho HJ, Shim SY, Son DW, Sun YH, Tchah H, Jeon IS. Respiratory viruses in neonates hospitalized with acute lower respiratory tract infections. Pediatr Int 2013;55:49-53
- 11. Okulu E, Akduman H, Tunç G, Çiftçi E, İnce E, Erdeve Ö ve ark. Viral alt solunum yolu enfeksiyonu nedeniyle yatırılan yenidoğanların epidemiyolojik ve klinik özellikleri. Türkiye Çocuk Hast Derg 2018;1: 31-35.
- 12. Celik K, Olukman O, Demirol H, Terek D, Gulfidan G, Devrim I et al. Prevalence of respiratory pathogens during two consecutive respiratory syncytial virus seasons at a tertiary medical care center. Arch Argent Pediatr 2019;117:356-362
- 13. Rogers BB, Shankar P, Jerris RC,Kotzbauer D, Anderson EJ, Watson JR et al. Impact of a rapid respiratory panel test on patient outcomes. Arch Pathol Lab Med 2015;139:636–644
- 14. Nair H, Nokes DJ, Gessner BD,Dherani M, Madhi SA, Singleton RJ, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta–analysis. Lancet 2010;375:1545-1555
- 15. Cangiano G, Nenna R, Frassanito A, Evangelisti M, Nicolai A, Scagnolari C, et al. Bronchiolitis: Analysis of 10 consecutive epidemic seasons. Pediatr Pulmonol 2016;51:1330-1335
- 16. Lim JS,Woo SI, Kwon HI, Baek YH, Choi YK, Hahn YS. Clinical characteristics of acute lower respiratory tract infection due to 13 respiratory viruses detected by multiplex PCR in children. Korean J. Pediatr 2010;53:373–379
- 17. Khadadah M, Essa S, Higazi Z, Behbehani N, Al-Nakib W. Respiratory syncytial virus and human rhinoviruses are the major causes of severe lower respiratory tract infections in Kuwait. J Med Virol 2010;82:1462–1467
- 18. Cox DW, Khoo SK, Zhang G, et al. Rhinovirus is the most common virus and rhinovirus-C is the most common species in paediatric intensive care respiratory admissions. Eur Respir J 2018;52
- 19. Chen J, Hu P, Zhou T, Zheng T, Zhou L, Jiang C, et al. Epidemiology and clinical characteristics of acute respiratory tract infections among hospitalized infants and young children in Chengdu, West China, 2009-2014. BMC Pediatr 2018;18:216
- 20. Wilkinson DJ, Buttery JP, Andersen CC. Influenza in the neonatal intensive care unit. J Perinatol 2006;26:772-776.
- 21. Puck JM, Glezen WP, Frank AL, Six HR. Protection of infants from infection with influenza A virus by transplacentally acquired antibody. J Infect Dis 1980;142:844-849
- 22. Vij NK, Stryker CC, Esper FP, Jacobs MR, Gonzalez BE. Influenza A/H1N1/09-10 infections in a NICU during the 2009-2010 H1N1 pandemic. Pediatrics 2011;128:1297-1301
- 23. Pichler K, Assadian O, Berger A. Viral Respiratory Infections in the Neonatal Intensive Care Unit-A Review. Front Microbiol 2018;9:2484
- 24. Sirimi N, Miligkos M, Koutouzi F, Petridou E, Siahanidou T, Michos A. Respiratory syncytial virus activity and climate parameters during a 12-year period. J Med Virol 2016;88:931–937
- 25. Turkish Neonatal Society. The seasonal variations of respiratory syncytial virus infections in Turkey: a 2-year epidemiological study. Turk J Pediatr 2012;54:216–222
- 26. García CG, Bhore R, Soriano-Fallas A, Trost M, Chason R, Ramilo O, et al. Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis. Pediatrics 2010;126:1453-1460
- 27. Fattouh AM, Mansi YA, El-Anany MG, El-Kholy AA, El-Karaksy HM. Acute lower respiratory tract infection due to respiratory syncytial virus in a group of Egyptian children under 5 years of age. Ital J Pediatr 2011;37:14
- 28. Manley BJ, Arnolda GRB, Wright IMR, Owen LS, Foster JP, Huang L, et al. HUNTER Trial Investigators. Nasal High-Flow Therapy for Newborn Infants in Special Care Nurseries. N Engl J Med 2019;380:2031-2040
- 29. Milési C, Essouri S, Pouyau R, Liet JM, Afanetti M, Portefaix A, et al. Groupe Francophone de Réanimation et d’Urgences Pédiatriques (GFRUP). High flownasal cannula (HFNC) versus nasal continuouspositive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: amulticenter randomized controlled trial (TRAMONTANE study). Intensive Care Med 2017;43:209–216
- 30. Franklin D, Babl FE, Schlapbach LJ, Oakley E, Craig S, Neutze J, et al. A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis. N Engl J Med. 2018;378:1121-1131
- 31. Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med 2009;360:588–598
- 32. Garcia CG, Bhore R, Soriano-Fallas A, Trost M, Chason R, Ramilo O, et al. Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis. Pediatrics 2010;126:1453-1460
- 33. Hall CB, Weinberg GA, Blumkin AK, Edwards KM, Staat MA, Schultz AF, et al. Respiratory syncytial virus-associated hospitalizations among children less than 24 months of age. Pediatrics 2013;132:341-348
- 34. Cetinkaya M, Oral TK, Karatekin S, Cebeci B, Babayigit A, Yesil Y. Efficacy of palivizumab prophylaxis on the frequency of RSV-associated lower respiratory tract infections in preterm infants: determination of the ideal target population for prophylaxis. Eur J Clin Microbiol Infect Dis 2017;36:1629-1634
Details
| Primary Language | English |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | ORIGINAL ARTICLES |
| Authors | |
| Publication Date | March 18, 2020 |
| Submission Date | January 23, 2020 |
| Published in Issue | Year 2020 Volume: 14 Issue: 2 |
Cited By
Clinical and Virological Characteristics of Neonates Admitted with Acute Lower Respiratory Tract Infections
Türk Kadın Sağlığı ve Neonatoloji Dergisi
https://doi.org/10.46969/ezh.946825
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