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Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi

Year 2020, Volume: 9 Issue: 2, 118 - 126, 30.12.2020
https://doi.org/10.46810/tdfd.809220

Abstract

Bortezomib (BTZ), proteazom sistemini bloke ederek hücresel protein yıkımını engelleyen yeni nesil bir antineoplastik ilaçtır. Bu çalışmada BTZ kaynaklı kalp hasarına karşı bir izokinolin alkaloid olan berberinin (BBR) koruyucu etkileri araştırılmıştır. Çalışmada erkek Sprague Dawley cinsi ratlara 1., 3., 5. ve 7. günlerde periton içi 0,2 mg kg-1 BTZ ve 10 gün boyunca her gün 50 ve 100 mg kg-1 dozlarda BBR verildi. Ratların kalp dokularında malondialdehit (MDA), glutatyon (GSH), total antioksidan kapasite (TAK), total oksidan kapasite (TOK) ve nitrik oksit (NO) seviyeleri ile süperoksit dismutaz (SOD), katalaz (KAT), glutatyon peroksidaz (GPx) ve laktat dehidrogenaz (LDH) aktiviteleri biyokimyasal yöntemler ile analiz edildi. Veriler BTZ’nin kalp dokusunda MDA, NO ve TOK seviyelerini, serumda LDH aktivelerini ve oksidatif stres indeksini (OSI) önemli ölçüde arttırdığını, GSH ve TAK seviyeleri ile SOD, KAT ve GPx aktivitelerini azaltarak oksidatif stresi tetiklediğini buna bağlı olarak dokuda hasar oluşturduğunu gösterdi. Buna karşın BBR, BTZ’nin neden olduğu oksidatif stresi ve nitrozatif stresi hafifleterek kalp hasarına karşı koruyucu etki gösterdi. Sonuçlara göre BBR’nin, BTZ ile indüklenen kardiyak toksisiteye karşı daha ileri çalışmalardan sonra koruyucu olarak kullanılabileceğini gösterdi.

References

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Year 2020, Volume: 9 Issue: 2, 118 - 126, 30.12.2020
https://doi.org/10.46810/tdfd.809220

Abstract

References

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  • [14] Javad-Mousavi SA, Hemmati AA, Mehrzadi S, Hosseinzadeh A, Houshmand G, Nooshabadi MRR, et al. Protective effect of Berberis vulgaris fruit extract against Paraquat-induced pulmonary fibrosis in rats. Biomed Pharmacother. 2016;81:329-336.
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  • [22] Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 1968;25:192-205.
  • [23] Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-275.
  • [24] Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004;37(4):277-285.
  • [25] Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103-1111.
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  • [27] Caglayan C, Temel Y, Kandemir FM, Yildirim S, Kucukler S. Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy, and DNA damage. Environ. Sci. Pollut. Res. 2018;25(21):20968-20984.
  • [28] Aybek H, Temel Y, Ahmed BM, Ağca CA, Çiftci M. Deciphering of the effect of chemotherapeutic agents on human glutathione s-transferase enzyme and MCF-7 cell line. Protein Pept. Lett. 2020;27(9):888-894.
  • [29] Hanedan B, Kirbas A, Kandemir FM, Ozkaraca M, Kilic K, Benzer F. Arginase activity and total oxidant/antioxidant capacity in cows with lung cystic echinococcosis. Med Weter. 2015;71(3):167-170.
  • [30] Aksu EH, Kandemir FM, Küçükler S. Naringin'in erkek ratlarda methotreaxte indüklü testis apoptosisi ve otofajisi üzerine oksidatif stresi azaltmak yoluyla koruyucu etkisi. FÜ Sağ Bil Derg. 2018;32(3):179-183.
  • [31] Özdemir S, Kucukler S, Çomaklı S, Kandemir FM. The protective effect of Morin against ifosfamide-induced acute liver injury in rats associated with the inhibition of DNA damage and apoptosis. Drug Chem Toxicol. 2020:1-10.
  • [32] Kucukler S, Caglayan C, Darendelioğlu E, Kandemir FM. Morin attenuates acrylamide-induced testicular toxicity in rats by regulating the NF-κB, Bax/Bcl-2 and PI3K/Akt/mTOR signaling pathways. Life Sci. 2020;261:118301.
  • [33] Sangomla S, Saifi MA, Khurana A, Godugu C. Nanoceria ameliorates doxorubicin induced cardiotoxicity: possible mitigation via reduction of oxidative stress and inflammation. J Trace Elem Med Biol. 2018;47:53-62.
  • [34] Songbo M, Lang H, Xinyong C, Bin X, Ping Z, Liang S. Oxidative stress injury in doxorubicin-induced cardiotoxicity. Toxicol Lett. 2019;307:41-48.
  • [35] Aktas MS, Kandemir FM, Kirbas A, Hanedan B, Aydin MA. Evaluation of oxidative stress in sheep infected with Psoroptes ovis using total antioxidant capacity, total oxidant status, and malondialdehyde level. J Vet Res. 2017;61(2):197-201.
  • [36] Erişir M, Kandemir FM, Benzer F. Koç katımının kandaki malondialdehit ve bazı antioksidanlar üzerine etkileri. Atatürk Üniversitesi Vet Bil Derg.5(2):49-54.
  • [37] Yardim A, Kandemir FM, Ozdemir S, Kucukler S, Comakli S, Gur C, et al. Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-κB, ATF-6 pathways and activating Nrf2, Akt pathways. NeuroToxicology. 2020.
  • [38] Kandemir FM, Erişir M, Yüksel M. Comparison of lipid peroxidation and several antioxidants in blood of normally calved and dystocia affected cows and their newborn calves. Isr J Vet Med. 2016;71(2):19-23.
  • [39] Kandemir FM, Küçükler S, Çağlayan C. Beneficial effects of silymarin and naringin against methotrexate-induced hepatotoxicity in rats. Atatürk Üniversitesi Vet Bil Derg. 2017;12(2):167-177.
  • [40] Kaymaz MB, Kandemir FM, Pamukcu E, Eröksüz Y, Özdemir N. Effects of aqueous artichoke (Cynara scolymus) leaf extract on hepatic damage generated by alpha-amanitine. Kafkas Univ Vet Fak Derg. 2017;23(1):155-160.
  • [41] Aktaş MS, Kandemir FM, Özkaraca M, Hanedan B, Kırbaş A. Protective effects of rutin on acute lung injury induced by oleic acid in rats. Kafkas Univ Vet Fak Derg. 2017;23(3):443-451.
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There are 67 citations in total.

Details

Primary Language Turkish
Subjects Veterinary Surgery
Journal Section Articles
Authors

Cihan Gür 0000-0001-6775-7858

Fatih Kandemir 0000-0002-8490-2479

Aydın Genç This is me 0000-0001-5367-0743

Publication Date December 30, 2020
Published in Issue Year 2020 Volume: 9 Issue: 2

Cite

APA Gür, C., Kandemir, F., & Genç, A. (2020). Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. Türk Doğa Ve Fen Dergisi, 9(2), 118-126. https://doi.org/10.46810/tdfd.809220
AMA Gür C, Kandemir F, Genç A. Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. TJNS. December 2020;9(2):118-126. doi:10.46810/tdfd.809220
Chicago Gür, Cihan, Fatih Kandemir, and Aydın Genç. “Bortezomib Ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif Ve Nitrozatif Stres Üzerine Etkisi”. Türk Doğa Ve Fen Dergisi 9, no. 2 (December 2020): 118-26. https://doi.org/10.46810/tdfd.809220.
EndNote Gür C, Kandemir F, Genç A (December 1, 2020) Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. Türk Doğa ve Fen Dergisi 9 2 118–126.
IEEE C. Gür, F. Kandemir, and A. Genç, “Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi”, TJNS, vol. 9, no. 2, pp. 118–126, 2020, doi: 10.46810/tdfd.809220.
ISNAD Gür, Cihan et al. “Bortezomib Ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif Ve Nitrozatif Stres Üzerine Etkisi”. Türk Doğa ve Fen Dergisi 9/2 (December 2020), 118-126. https://doi.org/10.46810/tdfd.809220.
JAMA Gür C, Kandemir F, Genç A. Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. TJNS. 2020;9:118–126.
MLA Gür, Cihan et al. “Bortezomib Ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif Ve Nitrozatif Stres Üzerine Etkisi”. Türk Doğa Ve Fen Dergisi, vol. 9, no. 2, 2020, pp. 118-26, doi:10.46810/tdfd.809220.
Vancouver Gür C, Kandemir F, Genç A. Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. TJNS. 2020;9(2):118-26.

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