Research Article
Year 2023,
, 235 - 240, 17.03.2023
Abstract
References
- 1. Alsalimy N, Madi L, Awaisu A. Efficacy and safety of laxatives for chronic constipation in long-term care settings: A systematic review. J Clin Pharm Ther. 2018 Oct;43(5):595-605. doi: 10.1111/jcpt.12721. Epub 2018 Jun 9. PMID: 29885259.
- 2. Bharucha AE, Wald A. Chronic Constipation. Mayo Clin Proc. 2019 Nov;94(11):2340-2357. doi: 10.1016/j.mayocp.2019.01.031. Epub 2019 May 1. PMID: 31054770; PMCID: PMC6829047.
- 3. Aziz I, Whitehead WE, Palsson OS, Törnblom H, Simrén M. An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Expert Rev Gastroenterol Hepatol. 2020 Jan;14(1):39-46. doi: 10.1080/17474124.2020.1708718. Epub 2020 Jan 2. PMID: 31893959.
- 4. Werth BL, Williams KA, Fisher MJ, Pont LG. Use of over-the-counter laxatives by community-dwelling adults to treat and prevent constipation: a national cross-sectional study. Eur J Clin Pharmacol. 2020 Jul;76(7):1003-1010. doi: 10.1007/s00228-020-02865-5. Epub 2020 Apr 15. PMID: 32296858.
- 5. Roerig JL, Steffen KJ, Mitchell JE, Zunker C. Laxative abuse: epidemiology, diagnosis and management. Drugs. 2010 Aug 20;70(12):1487-503. doi: 10.2165/11898640-000000000-00000. PMID: 20687617.
- 6. Bohlin J, Dahlin E, Dreja J, Roth B, Ekberg O, Ohlsson B. Longer colonic transit time is associated with laxative and drug use, lifestyle factors, and symptoms of constipation. Acta Radiol Open. 2018 Oct 22;7(10):2058460118807232. doi: 10.1177/2058460118807232. PMID: 30364803; PMCID: PMC6198400.
- 7. Hazzard VM, Simone M, Austin SB, Larson N, Neumark-Sztainer D. Diet pill and laxative use for weight control predicts first-time receipt of an eating disorder diagnosis within the next 5 years among female adolescents and young adults. Int J Eat Disord. 2021 Jul;54(7):1289-1294. doi: 10.1002/eat.23531. Epub 2021 May 5. PMID: 33949709; PMCID: PMC8273146.
- 8. Levinson JA, Sarda V, Sonneville K, Calzo JP, Ambwani S, Austin SB. Diet Pill and Laxative Use for Weight Control and Subsequent Incident Eating Disorder in US Young Women: 2001-2016. Am J Public Health. 2020 Jan;110(1):109-111. doi: 10.2105/AJPH.2019.305390. Epub 2019 Nov 21. PMID: 31751147; PMCID: PMC6893330.
- 9. Gibson D, Benabe J, Watters A, Oakes J, Mehler PS. Personality characteristics and medical impact of stimulant laxative abuse in eating disorder patients-a pilot study. J Eat Disord. 2021 Nov 4;9(1):146. doi: 10.1186/s40337-021-00502-9. PMID: 34736530; PMCID: PMC8567337.
- 10. Bonilla S, Nurko S, Rodriguez L. Long-term Use of Bisacodyl in Pediatric Functional Constipation Refractory to Conventional Therapy. J Pediatr Gastroenterol Nutr. 2020 Sep;71(3):288-291. doi: 10.1097/MPG.0000000000002795. PMID: 32459741.
- 11. Ferlay J, Bray F, Pisani P, Parkin DM. (2004)GLOBOCAN 2002 Cancer Incidence, Mortality and Prevalence Worldwide. International Agency for Research on Cancer CancerBase No. 5, version 2.0. Lyon: IARC.
- 12. Parkin DM, Whelan SL, Ferlay J, Teppo L. and Thomas DB. (2002).Cancer incidence in five continents. Lyon: International Agency for Research on Cancer. Vol. VIII. International Agency for Research on Cancer, 155.
- 13. American Cancer Society. What causes cancer?, 2018. https://www.cancer.org/ cancer/cancercauses.html. Son Erişim Tarihi: 05.06.2022
- 14. Lengvenyte A, Strumila R, Maimoun L, Seneque M, Olié E, Lefebvre P, Renard E, Courtet P, Guillaume S. A specific association between laxative misuse and suicidal behaviours in patients with anorexia nervosa and bulimia nervosa. Eat Weight Disord. 2022 Feb;27(1):307-315. doi: 10.1007/s40519-021-01180-x. Epub 2021 Apr 1. PMID: 33797033.
- 15. Elran-Barak R, Goldschmidt AB, Crow SJ, Peterson CB, Hill L, Crosby RD, Mitchell JE, Le Grange D. Is laxative misuse associated with binge eating? Examination of laxative misuse among individuals seeking treatment for eating disorders. Int J Eat Disord. 2017 Sep;50(9):1114-1118. doi: 10.1002/eat.22745. Epub 2017 Aug 2. PMID: 28766762; PMCID: PMC5861734.
- 16. de Souza ALG, de Almeida AA, Noll PRES, Noll M. Unhealthy life habits associated with self-induced vomiting and laxative misuse in Brazilian adolescents. Sci Rep. 2021 Jan 28;11(1):2482. doi: 10.1038/s41598-021-81942-w. PMID: 33510267; PMCID: PMC7843628.
- 17. Guérin A, Mody R, Fok B, Lasch KL, Zhou Z, Wu EQ, Zhou W, Talley NJ. Risk of developing colorectal cancer and benign colorectal neoplasm in patients with chronic constipation. Aliment Pharmacol Ther. 2014 Jul;40(1):83-92. doi: 10.1111/apt.12789. Epub 2014 May 15. PMID: 24832002.
- 18. Citronberg JS, Hardikar S, Phipps A, Figueiredo JC, Newcomb P. Laxative type in relation to colorectal cancer risk. Ann Epidemiol. 2018 Oct;28(10):739-741. doi: 10.1016/j.annepidem.2018.06.011. Epub 2018 Jul 9. PMID: 30150160; PMCID: PMC6415945.
The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast
Abstract
Objective: It is estimated that the use of wrong laxatives will increase the probability of developing an eating disorder by affecting the disorder in eating behavior and the physiological disorder of digestion. Long-term use of laxatives is known by many to impair normal colonic function and producing laxative dependence. In our study, it was aimed to determine the effect of the Folliculj sennae plant, which is used for laxative and slimming purposes, on the CCD-18Co (normal colon epithelium) cell line.
Materials and Methods: The effect of Folliculj sennae plant. Its antiproliferative effect on CCD-18Co cell line was determined by MTT test.
Results: According to the concentrations used in the CCD-18Co cell line, the % viability activities were determined between 73 and 54 and the 50% inhibitory concentration value (IC50) was calculated as 47 ppm.
Conclusion: It is thought that the Folliculj sennae plant, which is used as a laxative and has a negative effect on the CCD18-Co cell line, will make an important contribution by health professionals to raise the awareness of their patients about laxatives.
References
- 1. Alsalimy N, Madi L, Awaisu A. Efficacy and safety of laxatives for chronic constipation in long-term care settings: A systematic review. J Clin Pharm Ther. 2018 Oct;43(5):595-605. doi: 10.1111/jcpt.12721. Epub 2018 Jun 9. PMID: 29885259.
- 2. Bharucha AE, Wald A. Chronic Constipation. Mayo Clin Proc. 2019 Nov;94(11):2340-2357. doi: 10.1016/j.mayocp.2019.01.031. Epub 2019 May 1. PMID: 31054770; PMCID: PMC6829047.
- 3. Aziz I, Whitehead WE, Palsson OS, Törnblom H, Simrén M. An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Expert Rev Gastroenterol Hepatol. 2020 Jan;14(1):39-46. doi: 10.1080/17474124.2020.1708718. Epub 2020 Jan 2. PMID: 31893959.
- 4. Werth BL, Williams KA, Fisher MJ, Pont LG. Use of over-the-counter laxatives by community-dwelling adults to treat and prevent constipation: a national cross-sectional study. Eur J Clin Pharmacol. 2020 Jul;76(7):1003-1010. doi: 10.1007/s00228-020-02865-5. Epub 2020 Apr 15. PMID: 32296858.
- 5. Roerig JL, Steffen KJ, Mitchell JE, Zunker C. Laxative abuse: epidemiology, diagnosis and management. Drugs. 2010 Aug 20;70(12):1487-503. doi: 10.2165/11898640-000000000-00000. PMID: 20687617.
- 6. Bohlin J, Dahlin E, Dreja J, Roth B, Ekberg O, Ohlsson B. Longer colonic transit time is associated with laxative and drug use, lifestyle factors, and symptoms of constipation. Acta Radiol Open. 2018 Oct 22;7(10):2058460118807232. doi: 10.1177/2058460118807232. PMID: 30364803; PMCID: PMC6198400.
- 7. Hazzard VM, Simone M, Austin SB, Larson N, Neumark-Sztainer D. Diet pill and laxative use for weight control predicts first-time receipt of an eating disorder diagnosis within the next 5 years among female adolescents and young adults. Int J Eat Disord. 2021 Jul;54(7):1289-1294. doi: 10.1002/eat.23531. Epub 2021 May 5. PMID: 33949709; PMCID: PMC8273146.
- 8. Levinson JA, Sarda V, Sonneville K, Calzo JP, Ambwani S, Austin SB. Diet Pill and Laxative Use for Weight Control and Subsequent Incident Eating Disorder in US Young Women: 2001-2016. Am J Public Health. 2020 Jan;110(1):109-111. doi: 10.2105/AJPH.2019.305390. Epub 2019 Nov 21. PMID: 31751147; PMCID: PMC6893330.
- 9. Gibson D, Benabe J, Watters A, Oakes J, Mehler PS. Personality characteristics and medical impact of stimulant laxative abuse in eating disorder patients-a pilot study. J Eat Disord. 2021 Nov 4;9(1):146. doi: 10.1186/s40337-021-00502-9. PMID: 34736530; PMCID: PMC8567337.
- 10. Bonilla S, Nurko S, Rodriguez L. Long-term Use of Bisacodyl in Pediatric Functional Constipation Refractory to Conventional Therapy. J Pediatr Gastroenterol Nutr. 2020 Sep;71(3):288-291. doi: 10.1097/MPG.0000000000002795. PMID: 32459741.
- 11. Ferlay J, Bray F, Pisani P, Parkin DM. (2004)GLOBOCAN 2002 Cancer Incidence, Mortality and Prevalence Worldwide. International Agency for Research on Cancer CancerBase No. 5, version 2.0. Lyon: IARC.
- 12. Parkin DM, Whelan SL, Ferlay J, Teppo L. and Thomas DB. (2002).Cancer incidence in five continents. Lyon: International Agency for Research on Cancer. Vol. VIII. International Agency for Research on Cancer, 155.
- 13. American Cancer Society. What causes cancer?, 2018. https://www.cancer.org/ cancer/cancercauses.html. Son Erişim Tarihi: 05.06.2022
- 14. Lengvenyte A, Strumila R, Maimoun L, Seneque M, Olié E, Lefebvre P, Renard E, Courtet P, Guillaume S. A specific association between laxative misuse and suicidal behaviours in patients with anorexia nervosa and bulimia nervosa. Eat Weight Disord. 2022 Feb;27(1):307-315. doi: 10.1007/s40519-021-01180-x. Epub 2021 Apr 1. PMID: 33797033.
- 15. Elran-Barak R, Goldschmidt AB, Crow SJ, Peterson CB, Hill L, Crosby RD, Mitchell JE, Le Grange D. Is laxative misuse associated with binge eating? Examination of laxative misuse among individuals seeking treatment for eating disorders. Int J Eat Disord. 2017 Sep;50(9):1114-1118. doi: 10.1002/eat.22745. Epub 2017 Aug 2. PMID: 28766762; PMCID: PMC5861734.
- 16. de Souza ALG, de Almeida AA, Noll PRES, Noll M. Unhealthy life habits associated with self-induced vomiting and laxative misuse in Brazilian adolescents. Sci Rep. 2021 Jan 28;11(1):2482. doi: 10.1038/s41598-021-81942-w. PMID: 33510267; PMCID: PMC7843628.
- 17. Guérin A, Mody R, Fok B, Lasch KL, Zhou Z, Wu EQ, Zhou W, Talley NJ. Risk of developing colorectal cancer and benign colorectal neoplasm in patients with chronic constipation. Aliment Pharmacol Ther. 2014 Jul;40(1):83-92. doi: 10.1111/apt.12789. Epub 2014 May 15. PMID: 24832002.
- 18. Citronberg JS, Hardikar S, Phipps A, Figueiredo JC, Newcomb P. Laxative type in relation to colorectal cancer risk. Ann Epidemiol. 2018 Oct;28(10):739-741. doi: 10.1016/j.annepidem.2018.06.011. Epub 2018 Jul 9. PMID: 30150160; PMCID: PMC6415945.
There are 18 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Nutrition and Dietetics, Clinical Sciences |
| Journal Section | Research Article |
| Authors | |
| Publication Date | March 17, 2023 |
| Submission Date | August 1, 2022 |
| Published in Issue | Year 2023 |