Research Article
Year 2023,
, 502 - 507, 01.10.2023
Abstract
Purpose: We aimed to investigate the effect of Helicobacter Pylorii (HP) on the development of gallbladder diseases and cholelithiasis and its relationship with gastritis.
Methods: 282 gastritis cases with follow-up and operated gallbladder material were included in the study. All histomorphological findings, presence of HP and other variables were compared. Active inflammation and presence of HP were examined in the gastritis group. The gallbladder (GB) disease group was evaluated in terms of cholelithiasis, inflammation, cholesterolosis, intestinal and pyloric metaplasia, and the presence of HP.
Results: Gallbladder HP (+) was higher in female patients than in male patients. The presence of HP in the GB was significantly higher in patients with cholelithiasis than patients without cholelithiasis. The incidence of HP in the GB was higher in patients with active gastritis than in patients with inactive gastritis. The presence of HP in the GB was found to be higher in patients with HP on gastric biopsy. HP was found to be less in cases without cholesterolosis in the GB (p <0.05). Acute inflammation in the gallbladder, pyloric and intestinal metaplasia were not associated with the presence of HP. In HP (+) gastritis cases, the rate of stone and HP association in the GB was higher than the patients with HP (-) gastritis (p <0.05). However, the presence or absence of HP in gastritis cases was not found to affect the rate of cholelithiasis or HP status in the group without cholelithiasis.
Conclusion: In our study, correlation with the presence of HP is clearly seen in patients with gastritis and accompanying cholelithiasis. However, there are many parameters affecting the formation of cholelithiasis and other diseases. Therefore, it will be more useful to interpret the effect of HP presence on the GB with prospective studies in series with more cases, using the control group and limiting the number of variables as much as possible.
References
- Marshall BJ and Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984;1:1311-5. DOI:10.1016/s0140-6736(84)91816-6
- Gravina AG, Zagari RM, De Musis C, et al. Helicobacter pylori and extragastric diseases: A review. World J Gastroenterol. 2018;24:3204-21. DOI:10.3748/wjg.v24.i29.3204
- Roubaud Baudron C, Franceschi F, Salles N, et al. Extragastric diseases and Helicobacter pylori. Helicobacter. 2013;18 Suppl 1:44-51. DOI:10.1111/hel.12077
- Ansari S and Yamaoka Y. Current understanding and management of Helicobacter pylori infection: an updated appraisal. F1000Res. 2018;7. DOI:10.12688/f1000research.14149.1
- Franceschi F, Gasbarrini A, Polyzos SA, et al. Extragastric Diseases and Helicobacter pylori. Helicobacter. 2015;20 Suppl 1:40-6. DOI:10.1111/hel.12256
- Goni E and Franceschi F. Helicobacter pylori and extragastric diseases. Helicobacter. 2016;21 Suppl 1:45-8. DOI:10.1111/hel.12340
- Cen L, Pan J, Zhou B, et al. Helicobacter Pylori infection of the gallbladder and the risk of chronic cholecystitis and cholelithiasis: A systematic review and meta-analysis. Helicobacter. 2018;23. DOI:10.1111/hel.12457
- Zhou D, Zhang Y, Gong W, et al. Are Helicobacter pylori and other Helicobacter species infection associated with human biliary lithiasis? A meta-analysis. PLoS One. 2011;6:e27390. DOI:10.1371/journal.pone.0027390
- Takahashi Y, Yamamichi N, Shimamoto T, et al. Helicobacter pylori infection is positively associated with gallstones: a large-scale cross-sectional study in Japan. Journal of Gastroenterology. 2014;49:882-9. DOI:10.1007/s00535-013-0832-z
- Zhang FM, Yu CH, Chen HT, et al. Helicobacter pylori infection is associated with gallstones: Epidemiological survey in China. World J Gastroenterol. 2015;21:8912-9. DOI:10.3748/wjg.v21.i29.8912
- Xu MY, Ma JH, Yuan BS, et al. Association between Helicobacter pylori infection and gallbladder diseases: A retrospective study. J Gastroenterol Hepatol. 2018;33:1207-12. DOI:10.1111/jgh.14054
- Guraya SY, Ahmad AA, El-Ageery SM, et al. The correlation of Helicobacter Pylori with the development of cholelithiasis and cholecystitis: the results of a prospective clinical study in Saudi Arabia. Eur Rev Med Pharmacol Sci. 2015;19:3873-80.
- Dar MY, Ali S, Raina AH, et al. Association of Helicobacter pylori with hepatobiliary stone disease, a prospective case control study. Indian J Gastroenterol. 2016;35:343-6. DOI:10.1007/s12664-016-0675-7
- Motie M, Rezapanah A, Abbasi H, et al. The relationship between cholecystitis and presence of Helicobacter pylori in the gallbladder. Zahedan Journal of Research in Medical Sciences. 2017;19.
- Khan SA, Mushtaq H, Raza A, et al. Association of Clinicopathological features of Cholecystitis with Helicobacter Pylori Infection in Gall Bladders. Journal of Islamabad Medical & Dental College. 2019;8:117-22.
- Yucebilgili K, Mehmetoğlu T, Gucin Z, et al. Helicobacter pylori DNA in gallbladder tissue of patients with cholelithiasis and cholecystitis. The Journal of Infection in Developing Countries. 2009;3:856-9.
- Erden E and Kiyan M. Evaluation of the presence of Helicobacter species in the biliary system of Turkish patients with cholelithiasis. Turk J Gastroenterol. 2010;21:421-7.
- Bansal VK, Misra MC, Chaubal G, et al. Helicobacter pylori in gallbladder mucosa in patients with gallbladder disease. Indian Journal of Gastroenterology. 2012;31:57-60.
- Attaallah W, Yener N, Ugurlu MU, et al. Gallstones and concomitant gastric Helicobacter pylori infection. Gastroenterology research and practice. 2013;2013.
- Gunasekaran P and Vinson I. Helicobacter pylori colonization of gallbladder in patients with symptomatic cholelithiasis. International Surgery Journal. 2017;4:2194-6.
- Helaly G, El-Ghazzawi E, Kazeiw A, et al. Detection of Helicobacter pylori infection in Egyptian patients with chronic calcular cholecystitis. British journal of biomedical science. 2014;71:13-8.
- Fikry AA, Kassem AA, Shahin D, et al. Helicobacter pylori infection in patients with chronic calcular cholecystitis a cross-sectional study. Journal of Surgery. 2014;2:58-62.
- Ari A, Tatar C and Yarikkaya E. Relationship between Helicobacter pylori-positivity in the gallbladder and stomach and effect on gallbladder pathologies. Journal of International Medical Research. 2019;47:4904-10.
- Javaherzadeh M, Shekarchizadeh A, Sabet B, et al. Simultaneous Helicobacter Pylori Infection in Gastric Mucosa and Gallbladder Mucosa in Patients with Cholecystitis; Is There Any Relationship? Academic Journal of Surgery. 2016;3:12-4.
- Misra V, Prakash Misra S, Dwivedi M, et al. <em>Helicobacter pylori</em> in areas of gastric metaplasia in the gallbladder and isolation of <em>H. pylori</em> DNA from gallstones. Pathology. 2007;39:419-24. DOI:10.1080/00313020701444473
- Liew P-L, Wang W, Lee Y-C, et al. Gallbladder disease among obese patients in Taiwan. Obesity surgery. 2007;17:383-90.
- Feng H, Zhou X and Zhang G. Association between cirrhosis and Helicobacter pylori infection: a meta-analysis. European journal of gastroenterology & hepatology. 2014;26:1309-19.
- Zhou D, Wang J-D, Weng M-Z, et al. Infections of Helicobacter spp. in the biliary system are associated with biliary tract cancer: a meta-analysis. European journal of gastroenterology & hepatology. 2013;25:447-54.
- Hassan EH, Gerges SS, El-Atrebi KA, et al. The role of H. pylori infection in gall bladder cancer: clinicopathological study. Tumor Biology. 2015;36:7093-8.
- Dutta U. Gallbladder cancer: can newer insights improve the outcome? Journal of gastroenterology and hepatology. 2012;27:642-53.
Year 2023,
, 502 - 507, 01.10.2023
Abstract
References
- Marshall BJ and Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984;1:1311-5. DOI:10.1016/s0140-6736(84)91816-6
- Gravina AG, Zagari RM, De Musis C, et al. Helicobacter pylori and extragastric diseases: A review. World J Gastroenterol. 2018;24:3204-21. DOI:10.3748/wjg.v24.i29.3204
- Roubaud Baudron C, Franceschi F, Salles N, et al. Extragastric diseases and Helicobacter pylori. Helicobacter. 2013;18 Suppl 1:44-51. DOI:10.1111/hel.12077
- Ansari S and Yamaoka Y. Current understanding and management of Helicobacter pylori infection: an updated appraisal. F1000Res. 2018;7. DOI:10.12688/f1000research.14149.1
- Franceschi F, Gasbarrini A, Polyzos SA, et al. Extragastric Diseases and Helicobacter pylori. Helicobacter. 2015;20 Suppl 1:40-6. DOI:10.1111/hel.12256
- Goni E and Franceschi F. Helicobacter pylori and extragastric diseases. Helicobacter. 2016;21 Suppl 1:45-8. DOI:10.1111/hel.12340
- Cen L, Pan J, Zhou B, et al. Helicobacter Pylori infection of the gallbladder and the risk of chronic cholecystitis and cholelithiasis: A systematic review and meta-analysis. Helicobacter. 2018;23. DOI:10.1111/hel.12457
- Zhou D, Zhang Y, Gong W, et al. Are Helicobacter pylori and other Helicobacter species infection associated with human biliary lithiasis? A meta-analysis. PLoS One. 2011;6:e27390. DOI:10.1371/journal.pone.0027390
- Takahashi Y, Yamamichi N, Shimamoto T, et al. Helicobacter pylori infection is positively associated with gallstones: a large-scale cross-sectional study in Japan. Journal of Gastroenterology. 2014;49:882-9. DOI:10.1007/s00535-013-0832-z
- Zhang FM, Yu CH, Chen HT, et al. Helicobacter pylori infection is associated with gallstones: Epidemiological survey in China. World J Gastroenterol. 2015;21:8912-9. DOI:10.3748/wjg.v21.i29.8912
- Xu MY, Ma JH, Yuan BS, et al. Association between Helicobacter pylori infection and gallbladder diseases: A retrospective study. J Gastroenterol Hepatol. 2018;33:1207-12. DOI:10.1111/jgh.14054
- Guraya SY, Ahmad AA, El-Ageery SM, et al. The correlation of Helicobacter Pylori with the development of cholelithiasis and cholecystitis: the results of a prospective clinical study in Saudi Arabia. Eur Rev Med Pharmacol Sci. 2015;19:3873-80.
- Dar MY, Ali S, Raina AH, et al. Association of Helicobacter pylori with hepatobiliary stone disease, a prospective case control study. Indian J Gastroenterol. 2016;35:343-6. DOI:10.1007/s12664-016-0675-7
- Motie M, Rezapanah A, Abbasi H, et al. The relationship between cholecystitis and presence of Helicobacter pylori in the gallbladder. Zahedan Journal of Research in Medical Sciences. 2017;19.
- Khan SA, Mushtaq H, Raza A, et al. Association of Clinicopathological features of Cholecystitis with Helicobacter Pylori Infection in Gall Bladders. Journal of Islamabad Medical & Dental College. 2019;8:117-22.
- Yucebilgili K, Mehmetoğlu T, Gucin Z, et al. Helicobacter pylori DNA in gallbladder tissue of patients with cholelithiasis and cholecystitis. The Journal of Infection in Developing Countries. 2009;3:856-9.
- Erden E and Kiyan M. Evaluation of the presence of Helicobacter species in the biliary system of Turkish patients with cholelithiasis. Turk J Gastroenterol. 2010;21:421-7.
- Bansal VK, Misra MC, Chaubal G, et al. Helicobacter pylori in gallbladder mucosa in patients with gallbladder disease. Indian Journal of Gastroenterology. 2012;31:57-60.
- Attaallah W, Yener N, Ugurlu MU, et al. Gallstones and concomitant gastric Helicobacter pylori infection. Gastroenterology research and practice. 2013;2013.
- Gunasekaran P and Vinson I. Helicobacter pylori colonization of gallbladder in patients with symptomatic cholelithiasis. International Surgery Journal. 2017;4:2194-6.
- Helaly G, El-Ghazzawi E, Kazeiw A, et al. Detection of Helicobacter pylori infection in Egyptian patients with chronic calcular cholecystitis. British journal of biomedical science. 2014;71:13-8.
- Fikry AA, Kassem AA, Shahin D, et al. Helicobacter pylori infection in patients with chronic calcular cholecystitis a cross-sectional study. Journal of Surgery. 2014;2:58-62.
- Ari A, Tatar C and Yarikkaya E. Relationship between Helicobacter pylori-positivity in the gallbladder and stomach and effect on gallbladder pathologies. Journal of International Medical Research. 2019;47:4904-10.
- Javaherzadeh M, Shekarchizadeh A, Sabet B, et al. Simultaneous Helicobacter Pylori Infection in Gastric Mucosa and Gallbladder Mucosa in Patients with Cholecystitis; Is There Any Relationship? Academic Journal of Surgery. 2016;3:12-4.
- Misra V, Prakash Misra S, Dwivedi M, et al. <em>Helicobacter pylori</em> in areas of gastric metaplasia in the gallbladder and isolation of <em>H. pylori</em> DNA from gallstones. Pathology. 2007;39:419-24. DOI:10.1080/00313020701444473
- Liew P-L, Wang W, Lee Y-C, et al. Gallbladder disease among obese patients in Taiwan. Obesity surgery. 2007;17:383-90.
- Feng H, Zhou X and Zhang G. Association between cirrhosis and Helicobacter pylori infection: a meta-analysis. European journal of gastroenterology & hepatology. 2014;26:1309-19.
- Zhou D, Wang J-D, Weng M-Z, et al. Infections of Helicobacter spp. in the biliary system are associated with biliary tract cancer: a meta-analysis. European journal of gastroenterology & hepatology. 2013;25:447-54.
- Hassan EH, Gerges SS, El-Atrebi KA, et al. The role of H. pylori infection in gall bladder cancer: clinicopathological study. Tumor Biology. 2015;36:7093-8.
- Dutta U. Gallbladder cancer: can newer insights improve the outcome? Journal of gastroenterology and hepatology. 2012;27:642-53.
There are 30 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Surgery (Other), Pathology |
| Journal Section | Research Article |
| Authors | |
| Early Pub Date | September 23, 2023 |
| Publication Date | October 1, 2023 |
| Submission Date | July 12, 2023 |
| Published in Issue | Year 2023 |