Purpose: We aimed to investigate the effect of Helicobacter Pylorii (HP) on the development of gallbladder diseases and cholelithiasis and its relationship with gastritis.
Methods: 282 gastritis cases with follow-up and operated gallbladder material were included in the study. All histomorphological findings, presence of HP and other variables were compared. Active inflammation and presence of HP were examined in the gastritis group. The gallbladder (GB) disease group was evaluated in terms of cholelithiasis, inflammation, cholesterolosis, intestinal and pyloric metaplasia, and the presence of HP.
Results: Gallbladder HP (+) was higher in female patients than in male patients. The presence of HP in the GB was significantly higher in patients with cholelithiasis than patients without cholelithiasis. The incidence of HP in the GB was higher in patients with active gastritis than in patients with inactive gastritis. The presence of HP in the GB was found to be higher in patients with HP on gastric biopsy. HP was found to be less in cases without cholesterolosis in the GB (p <0.05). Acute inflammation in the gallbladder, pyloric and intestinal metaplasia were not associated with the presence of HP. In HP (+) gastritis cases, the rate of stone and HP association in the GB was higher than the patients with HP (-) gastritis (p <0.05). However, the presence or absence of HP in gastritis cases was not found to affect the rate of cholelithiasis or HP status in the group without cholelithiasis.
Conclusion: In our study, correlation with the presence of HP is clearly seen in patients with gastritis and accompanying cholelithiasis. However, there are many parameters affecting the formation of cholelithiasis and other diseases. Therefore, it will be more useful to interpret the effect of HP presence on the GB with prospective studies in series with more cases, using the control group and limiting the number of variables as much as possible.
Birincil Dil | İngilizce |
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Konular | Cerrahi (Diğer), Patoloji |
Bölüm | Research Article |
Yazarlar | |
Erken Görünüm Tarihi | 23 Eylül 2023 |
Yayımlanma Tarihi | 1 Ekim 2023 |
Gönderilme Tarihi | 12 Temmuz 2023 |
Yayımlandığı Sayı | Yıl 2023 |