Research Article
Year 2023,
, 528 - 533, 01.10.2023
Abstract
References
- GBD 2019 Stroke Collaborators. “Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.” The Lancet. Neurology vol. 20,10 (2021): 795-820. DOI:10.1016/S1474-4422(21)00252-0
- Nestico PF, Depace NL, Morganroth J et al. Mitral annular calcification: clinical, pathophysiology, and echocardiographic review. Am Heart J. 1984 May;107(5 Pt 1):989-96. DOI:10.1016/0002-8703(84)90840-8
- Adler Y, Fink N, Spector D et al. Mitral annulus calcification--a window to diffuse atherosclerosis of the vascular system. Atherosclerosis. 2001 Mar;155(1):1-8. DOI:10.1016/s0021-9150(00)00737-1
- Kanjanauthai S, Nasir K, Katz R, et al. Relationships of mitral annular calcification to cardiovascular risk factors: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2010 Dec;213(2):558-62. DOI:10.1016/j.atherosclerosis.2010.08.072
- Hamirani YS, Nasir K, Blumenthal RS et al. Relation of mitral annular calcium and coronary calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Am J Cardiol. 2011 May 1;107(9):1291-4. DOI:10.1016/j.amjcard.2011.01.005
- Abramowitz Y, Jilaihawi H, Chakravarty T et al. Mitral Annulus Calcification. J Am Coll Cardiol. 2015 Oct 27;66(17):1934-41. DOI:10.1016/j.jacc.2015.08.872
- Willens HJ, Chirinos JA, Schob A et al. The relation between mitral annular calcification and mortality in patients undergoing diagnostic coronary angiography. Echocardiography. 2006 Oct;23(9):717-22. DOI:10.1111/j.1540-8175.2006.00300.x
- Domienik-Karłowicz J, Kupczyńska K, Michalski B, et al. Fourth universal definition of myocardial infarction. Selected messages from the European Society of Cardiology document and lessons learned from the new guidelines on ST-segment elevation myocardial infarction and non-ST-segment elevation-acute coronary syndrome. Cardiol J. 2021;28(2):195-201. DOI: 10.5603/CJ.a2021.0036
- Roberts WC: Morphologic features of the normal and abnormal mitral valve. Am J Cardiol 1983;51:1005–1028. DOI: 10.1016/s0002-9149(83)80181-7
- Gardin JM, McClelland R, Kitzman D et al: M-mode echocardiographic predictors of six- to seven year incidence of coronary heart disease, stroke, congestive heart failure, and mortality in an elderly cohort (the Cardiovascular Health Study). Am J Cardiol 2001;87:1051–1057. DOI: 10.1016/s0002-9149(01)01460-6
- Adler Y, Herz I, Vaturi M et al: Mitral annular calcium detected by transthoracic echocardiography is a marker for high prevalence and severity of coronary artery disease in patients undergoing coronary angiography. Am J Cardiol 1998;82:1183–1186. DOI: 10.1016/s0002-9149(98)00596-7
- Fox CS, Vasan RS, Parise H et al: Mitral annular calcification predicts cardiovascular morbidity and mortality: The Framingham Heart Study. Circulation 2003;107:1492–1496. DOI: 10.1161/01.cir.0000058168.26163.bc
- Ali M, Lange SA, Wittlinger T et al. In-hospital mortality after acute STEMI in patients undergoing primary PCI. Herz. 2018 Dec;43(8):741-745. DOI: 10.1007/s00059-017-4621-y
- Morrow DA, Antman EM, Charlesworth A et al. TIMI risk score for ST-elevation myocardial infarction: A convenient, bedside, clinical score for risk assessment at presentation: An intravenous nPA for treatment of infarcting myocardium early II trial substudy. Circulation. 2000 Oct 24;102(17):2031-7. DOI: 10.1161/01.cir.102.17.2031
- McNamara RL, Kennedy KF, Cohen DJ et al. Predicting In-Hospital Mortality in Patients With Acute Myocardial Infarction. J Am Coll Cardiol. 2016 Aug 9;68(6):626-635. DOI: 10.1016/j.jacc.2016.05.049
- Saluveer O, Redfors B, Angerås O et al. Hypertension is associated with increased mortality in patients with ischaemic heart disease after revascularization with percutaneous coronary intervention - a report from SCAAR. Blood Press. 2017 Jun;26(3):166-173. DOI: 10.1080/08037051.2016.1270162
- Paul GK, Sen B, Bari MA et al. Correlation of platelet count and acute ST-elevation in myocardial infarction. Mymensingh Med J. 2010 Jul;19(3):469-73.
The Role of Mitral Annular Calcification in Predicting One-Month Mortality in Patients with STEMI Undergoing Primary Percutaneous Coronary Intervention
Abstract
Purpose: Numerous cardiovascular disorders have been related to mitral annular calcification (MAC). This study looked at the effects of mitral annular calcification on one-month mortality in ST-segment elevation myocardial infarction (STE-MI) patients.
Methods: This single-center, retrospective observational study was carried out between 2017 and 2021. The study included 1541 patients who presented to the Dr. Siyami Ersek Hospital emergency department with a diagnosis of STE-MI and underwent primary percutaneous intervention. The patients' clinical and demographic characteristics were investigated. Images taken during percutaneous intervention using angiography were used to assess the presence of MAC in patients. According to death, the patients were split into two groups, and a statistical analysis was done.
Results: The median age of 1541 STE-MI patients included in the study was 59 years (51, 68) and 78% were male. While MAC was present in 134 patients (8.7%) in the whole group, the frequency of MAC was significantly higher in the deceased compared to the survivors (19% vs. 7.8%, p<0.001). The presence of MAC (OR = 2.84, 95% CI 1.68-4.63, p<0.001) was associated with death. In multivariable analysis hypertension (OR = 1.6, 95% CI 1.02-2.54, p = 0.043), platelet count (OR = 1, 95% CI 1.00-1.01, p = 0.02), LVEF (OR = 0.98, 95% CI 0.96-) 1.00, p = 0.024) and MAC (OR = 2.68, 95% CI 1.55- 4.50, p<0.001) were found to be independent predictors of death.
Conclusion: In STE-MI patients, increased one-month mortality is strongly correlated with the presence of MAC during fluoroscopic primary percutaneous intervention.
References
- GBD 2019 Stroke Collaborators. “Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.” The Lancet. Neurology vol. 20,10 (2021): 795-820. DOI:10.1016/S1474-4422(21)00252-0
- Nestico PF, Depace NL, Morganroth J et al. Mitral annular calcification: clinical, pathophysiology, and echocardiographic review. Am Heart J. 1984 May;107(5 Pt 1):989-96. DOI:10.1016/0002-8703(84)90840-8
- Adler Y, Fink N, Spector D et al. Mitral annulus calcification--a window to diffuse atherosclerosis of the vascular system. Atherosclerosis. 2001 Mar;155(1):1-8. DOI:10.1016/s0021-9150(00)00737-1
- Kanjanauthai S, Nasir K, Katz R, et al. Relationships of mitral annular calcification to cardiovascular risk factors: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2010 Dec;213(2):558-62. DOI:10.1016/j.atherosclerosis.2010.08.072
- Hamirani YS, Nasir K, Blumenthal RS et al. Relation of mitral annular calcium and coronary calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Am J Cardiol. 2011 May 1;107(9):1291-4. DOI:10.1016/j.amjcard.2011.01.005
- Abramowitz Y, Jilaihawi H, Chakravarty T et al. Mitral Annulus Calcification. J Am Coll Cardiol. 2015 Oct 27;66(17):1934-41. DOI:10.1016/j.jacc.2015.08.872
- Willens HJ, Chirinos JA, Schob A et al. The relation between mitral annular calcification and mortality in patients undergoing diagnostic coronary angiography. Echocardiography. 2006 Oct;23(9):717-22. DOI:10.1111/j.1540-8175.2006.00300.x
- Domienik-Karłowicz J, Kupczyńska K, Michalski B, et al. Fourth universal definition of myocardial infarction. Selected messages from the European Society of Cardiology document and lessons learned from the new guidelines on ST-segment elevation myocardial infarction and non-ST-segment elevation-acute coronary syndrome. Cardiol J. 2021;28(2):195-201. DOI: 10.5603/CJ.a2021.0036
- Roberts WC: Morphologic features of the normal and abnormal mitral valve. Am J Cardiol 1983;51:1005–1028. DOI: 10.1016/s0002-9149(83)80181-7
- Gardin JM, McClelland R, Kitzman D et al: M-mode echocardiographic predictors of six- to seven year incidence of coronary heart disease, stroke, congestive heart failure, and mortality in an elderly cohort (the Cardiovascular Health Study). Am J Cardiol 2001;87:1051–1057. DOI: 10.1016/s0002-9149(01)01460-6
- Adler Y, Herz I, Vaturi M et al: Mitral annular calcium detected by transthoracic echocardiography is a marker for high prevalence and severity of coronary artery disease in patients undergoing coronary angiography. Am J Cardiol 1998;82:1183–1186. DOI: 10.1016/s0002-9149(98)00596-7
- Fox CS, Vasan RS, Parise H et al: Mitral annular calcification predicts cardiovascular morbidity and mortality: The Framingham Heart Study. Circulation 2003;107:1492–1496. DOI: 10.1161/01.cir.0000058168.26163.bc
- Ali M, Lange SA, Wittlinger T et al. In-hospital mortality after acute STEMI in patients undergoing primary PCI. Herz. 2018 Dec;43(8):741-745. DOI: 10.1007/s00059-017-4621-y
- Morrow DA, Antman EM, Charlesworth A et al. TIMI risk score for ST-elevation myocardial infarction: A convenient, bedside, clinical score for risk assessment at presentation: An intravenous nPA for treatment of infarcting myocardium early II trial substudy. Circulation. 2000 Oct 24;102(17):2031-7. DOI: 10.1161/01.cir.102.17.2031
- McNamara RL, Kennedy KF, Cohen DJ et al. Predicting In-Hospital Mortality in Patients With Acute Myocardial Infarction. J Am Coll Cardiol. 2016 Aug 9;68(6):626-635. DOI: 10.1016/j.jacc.2016.05.049
- Saluveer O, Redfors B, Angerås O et al. Hypertension is associated with increased mortality in patients with ischaemic heart disease after revascularization with percutaneous coronary intervention - a report from SCAAR. Blood Press. 2017 Jun;26(3):166-173. DOI: 10.1080/08037051.2016.1270162
- Paul GK, Sen B, Bari MA et al. Correlation of platelet count and acute ST-elevation in myocardial infarction. Mymensingh Med J. 2010 Jul;19(3):469-73.
There are 17 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Cardiovascular Medicine and Haematology (Other) |
| Journal Section | Research Article |
| Authors | |
| Early Pub Date | September 21, 2023 |
| Publication Date | October 1, 2023 |
| Submission Date | August 16, 2023 |
| Published in Issue | Year 2023 |